COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
·
IF 5.6
Zhenyu Wang,Jianxiang Li,Sihan Li,Diwei Li,Yunyi Zhao,Ling Xu,Gang Liu,Zhaoqiong Chen,Xiaoming Luo
Wound infection represents a prevalent and pressing clinical challenge, resulting in delayed wound healing and severe complications. In this study, a novel wound dressing was fabricated through a combination of electrospinning and acid etching techniques. First, nanofibers were fabricated by blending electrospun polyacrylonitrile/Polyvinylpyrrolidone (PAN/PVP) polymers with copper-based metal organic frameworks (Cu-MOFs). Subsequently, tannic acid was employed to etch the surface sites of Cu-MOFs on the fibers. The obtained nanofibers exhibited a typical porous structure, superior water absorption and gas permeability, with the average water vapor transmission rate was 2170.6 gm -2 day -1 . Additionally, the release behavior of copper ions can be modulated by altering the mass ratio of PVP to PAN, the amount of Cu-MOFs and the use of tannic acid. In vitro antibacterial assays revealed that the antibacterial efficacy of nanofibers increased with the addition of Cu-MOFs, after 48 hours of treatment, the inhibition rates of the nanofibers against E. coli and S. aureus reached over 79.5 % and 90 %, respectively. In vivo experiments demonstrated that these nanofibers alleviated wound inflammation and promoted collagen and angiogenesis, exhibition superior anti-inflammatory and wound-healing effects. The biosafety tests indicated that the nanofibers loaded with 1 % and 3 % Cu-MOFs exhibited good biocompatibility, while the nanofibers loaded with 5 % Cu-MOFs showed slight cytotoxicity. This study provides a novel strategy for the design and fabrication of advanced wound dressings in biomedical applications.
研究领域:
生物材料学
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医学
·
组织工程
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产品关联
DOI
PubMed
高影响因子
EMBO Molecular Medicine
·
2025
·
IF 8.3
HouYibo,WangZixian,WangWenlin,TangQing,CaiYongde,YuSiyang,WangJin,YanXiu,WangGuocai,LobiePeter E,ZhangYubo,DaiXiaoyong,MaShaohua
Advanced algorithms have significantly improved the efficiency of in vitro screening for protein-interactive compounds. However, target antigen (TAA/TSA)-based drug discovery remains challenging, as predictions of compound-protein interaction (CPI) based solely on molecular structure fail to fully elucidate the underlying mechanisms. In this study, we utilized deep learning, specifically TransformerCPI to screen active molecules from a Chinese herb compound library based on protein sequences. Two natural products, Polyphyllin V and Polyphyllin H, were identified as targeting the pan-cancer marker CD133. Their anti-tumor efficacy and safety were confirmed across validation in cancer cell lines, tumor patient-derived organoids, and animal models. Despite their analogous structures and binding affinity to CD133, Polyphyllin V suppresses the PI3K-AKT pathway, inducing pyroptosis and blockage of mitophagy, whereas Polyphyllin H inhibits the Wnt/β-catenin pathway and triggers apoptosis. These distinct mechanisms underscore the potential of combining AI-driven screening with biological validation. This AI-to-patient pipeline identifies Polyphyllin V and Polyphyllin H as CD133-targeted drugs for pan-cancer therapy, and reveals the limitations of virtual screening alone and emphasizes the necessity of live model evaluation in AI-based therapeutic discovery.
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yang Hu,Yan kui Cheng,Shuang Li,Lunfeng Liu,Xiaoyan Lin
Oily dyeing wastewater poses significant environmental hazards and therefore requires effective treatment. Although electrospun fiber membranes (EFMs) have been employed for oily dyeing wastewater treatment, conventional approaches typically involve a two-step process. This study presents a novel single-step modification method for EFMs, enabling efficient treatment of oily dyeing wastewater through a simplified single-membrane separation process. Experimental results demonstrated that spontaneous self-assembly occurs between ethyl cellulose (EC) colloids and hydrophilic SiO₂ nanoparticles in mixed solutions. Furthermore, these self-assembled colloids can undergo liquid-phase-induced self-organization on polyacrylonitrile (PAN) electrospun fiber membranes (EFMs), leading to a "welding" effect that firmly immobilizes both EC and hydrophilic SiO₂ nanoparticles onto the PAN fibers.The self-assembly process effectively prevented the agglomeration of SiO₂ nanoparticles, resulting in their uniform and stable fixation on the PAN fibers. Compared to the pristine PAN EFM, the PAN-EC-SiO₂ EFM exhibited significantly enhanced tensile strength, pH tolerance, surface roughness, hydrophilicity, hydration capacity, and methylene blue adsorption performance. Consequently, this modified membrane demonstrated dual functionality, effectively separating both oil-water emulsions and oily dyeing wastewater. During oily dyeing wastewater treatment, the PAN-EC-SiO₂ EFM achieved a methylene blue rejection rate of 92 %, an oil separation efficiency of 97.2 %, and a high flux of 153 L/m²·h.
研究领域:
环境科学
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膜技术
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纳米技术
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化学工程
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材料科学
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产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2025
·
IF 9.8
Siwen Deng,Mingyao Dai,Bodu Fang,Yanqin Huang,Shulong Zeng,Zhunan Huang,Jiahui Xue,Xiaodong Li,Shaohong Shi,Fangchao Cheng
Creating novel, high-efficiency and multi-functional electromagnetic interference (EMI) shielding materials with high absorption attenuation is crucially important for integrated electronic devices. Herein, heterogeneous polyacrylonitrile (PAN)/graphene (Gr)@multi-walled carbon nanotubes (MWCNTs)/CoFe 2 O 4 multilayer films featuring electric-magnetic coupling were fabricated through a facile vacuum filtration method. The asymmetric layered architecture was composed of a flexible PAN electrospun nanofiber mat, an electrically conductive hybrid of Gr@MWCNTs, and a layer of insulating CoFe 2 O 4 particles. The nanosized magnetic CoFe 2 O 4 particles with unique magnetic hysteresis loss and natural resonance were synthesized by hydrothermal method and deposited on the conductive layer, to improve the impedance matching and reduce the electromagnetic wave (EMW) reflection. As a consequence, after incorporating the CoFe 2 O 4 layer, the EMW absorption loss (SE A ) was improved from 21.7 to 25.7 dB. Furthermore, the hybrid conductive network was regulated by altering the ratio of two-dimensional (2D) Gr to one-dimensional (1D) MWCNTs, to endow the well-designed multilayer films with a high EMI shielding effectiveness (SE) of 40.1 dB and a superior specific shielding effectiveness (SSE) of 326.3 dB/mm. By virtue of the fine-tuned Gr@MWCNTs conductive network, the PAN/Gr@MWCNTs/CoFe 2 O 4 multilayer films exhibited excellent Joule heating performance, with high sensitivity, low driving voltage, rapid response, superior cycling stability and long-term durability. The multilayer films could be controllably heated to 114.1 °C within 5 s under a low input voltage of 3.00 V. This work presents a viable strategy for exploiting functional materials that exhibit excellent EMI shielding and thermal management performance, suitable for applications in electronics operating at extremely low temperatures.
研究领域:
材料科学
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电子工程
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Qing Li,Jie Sheng,Wen-Qing Fei,Chun-Miao Zhang,Zhang-Hong Wan,Xin Wu,Xue-Fei Sun
Metal-organic framework (MOF)-derived catalysts have received growing attention as promising materials for wastewater decontamination . However, the practical use of these catalysts still encounters many challenges, such as poor separation from the reaction mixture, sub-ideal catalytic performance of monometallic MOFs, and large consumption of organic solvents in the preparation process. To address these issues, we adopted a “seed-growth epitaxial” strategy, substituting MeOH with the green solvent H 2 O to synthesize an environmentally friendly leaf-like vine-weaved fiber membrane, composed of two-dimensional bimetallic zeolitic imidazolate framework (ZnCo-ZIF) and polyacrylonitrile (PAN), which was utilized to activate peroxymonosulfate (PMS) for the degradation of norfloxacin (NOR). The ZnCo-ZIF/PAN fiber membrane possesses a substantial specific surface area , facilitating the uniform and efficient exposure of bimetallic active sites. The results showed that ZnCo-ZIF/PAN was highly efficient in PMS activation, achieving a 93 % NOR removal within 120 min. The removal efficiency of NOR increased in accordance with doped Co. The catalyst demonstrated relatively high activity in the pH range of 3.0∼7.0. The radicals quenching experiments proved that SO 4 · − and ·OH were the crucial reactive oxygen species (ROS), which confirmed by electron paramagnetic resonance spectroscopy (EPR). The degradation pathways were proposed according to the intermediates identified by high-performance liquid chromatography-coupled mass spectrometry , including dehydrogenation , defluorination , hydroxylation , piperazinyl ring transformation, and quinolone group transformation. Importantly, the flexible ZnCo-ZIF/PAN composite nanofiber membrane can be separated 100 % from treated wastewater to solve the recycling and reuse problem of nanopowders . This study provides a new perspective for the design of bimetallic ZIF composite fibers with excellent catalytic properties and offers new ideas for their application in practical production.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2023
·Vol. 32
·期 10
·1291-1306
·
IF 3.1
Bao Cun,Yuan Haikuan,Huang Feili,Shi Jianghuan,Hao Ruiran,Zhang Yadi,Chen Xinyi,Lu Jie
In this work, we proposed a self-assembly method to fabricate a novel pervaporative membrane for desalination. The graphene oxide (GO) layer was deposited on polyacrylonitrile (PAN) ultrafiltration membrane support by vacuum assistance, and then a thin cross-linked sodium alginate (SA) layer was coated on the GO/PAN membrane surface to form a sandwich-like SA–GO/PAN composite membrane. The morphology and physicochemical structure of the composite membrane were characterized using attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electronic microscopy (SEM), and atomic force microscopy (AFM) techniques and contact angle measurement. The thin SA layer would stabilize and protect the structure of GO layer of SA–GO/PAN membrane, thus GO layer was not easy to fall off or crack during pervaporation desalination. The effects of SA coating concentration, feed temperature, salt concentration, and multicomponent salt solutions on the desalination performance of the prepared membrane were investigated. SA–GO/PAN membrane showed a good desalination performance for high salt concentration solutions and multicomponent salt solutions. When the feed temperature raised from 30 to 80 °C, the flux of the SA–GO/PAN composite membrane increased from 5.61 to 18.35 kg m −2 h −1 , while the rejection still remained above 99.8%. The experimental results showed that SA–GO/PAN composite membrane performed well in pervaporative desalination of salt solution with excellent long-term stability. Graphical abstract
研究领域:
材料科学
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环境工程
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化学工程
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DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2019
·Vol. 61
·期 1
·77-85
·
IF 0.907
Yanfei Wang,Mo Gaoming,He Liu,Huang Qing
Abstract Isothermal gelation processes for relatively low concentration PAN/DMSO/H 2 O solutions are studied by rheology. Winter–Chambon criterion is unitedly used to investigate the rheological kinetics and the structural and mechanical characteristics of the resulted gels are evaluated. It is found that during the isothermal gelation procedure, two coincident points appear sequentially, where loss tangent tan δ is independent of frequency. The occurrence of two coincident points suggests that the critical gel forms first, then it evolves into the second self-similar structure, and the average distance between crosslinks of network becomes shorter. The results also show that decreasing temperature, increase of PAN concentration or H 2 O content will lead to faster gelation kinetics and formation of more elastic and compact critical gel and the second self-similar structure. At the same temperature, the later formed second self-similar structure is always more elastic and compact than the critical gel, and the corresponding gel stiffness is stronger.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2015
·Vol. 308
·期 1
·155-163
·
IF 1.034
Ma Fuyin,Shi Wanlong,Meng Hu,Li Zheng,Zhou Wei,Zhang Lan
An organic–inorganic composite ion exchanger of polyantimonic acid-polyacrylonitrile (PAA–PAN) was synthesized to remove strontium(II) from radioactive waste water. Ion exchange behavior of the composite toward strontium(II) were investigated and the results indicated that the composite presents excellent performance in 0.1 mol L −1 nitric acid. The maximum uptake capacity of strontium(II) can reach up to 49 mg g −1 on composite. Adsorption thermodynamic parameters showed that the ion exchange was endothermic and spontaneous reaction and equilibrium adsorption data fit well with the Langmuir adsorption isotherms. In addition, PAA–PAN beads were found to have chemical and adsorption stability under irradiation and acidic media.
研究领域:
化学工程
·
环境科学
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 84
·53157-53163
·
IF 3.108
Zhongbo Li,Zhaofang Du,Kexi Sun,Xuan He,Bensong Chen
We report a facile and low-cost approach for fabrication of large-scale surface-enhanced Raman scattering (SERS) active substrates composed of Ag-nanoplates (Ag-NPs) decorated polyacrylonitrile nanopillar (denoted as Ag-NPs@PAN-nanopillar) arrays, via a consecutive process of molding PAN-nanopillar arrays, sputtering Au-nanoparticles onto the PAN-nanopillar arrays as a conducting layer, and decorating the PAN-nanopillars with Ag-nanoplates. The Ag-nanoplate distribution density on the PAN-nanopillars can be tailored by tuning the concentration of citric acid and the Ag-deposition duration, and high SERS sensitivity can thus be achieved by optimizing the density of Ag-nanoplates. The adjacent Ag-nanoplates induced “hot spots” are densely and uniformly distributed in the three dimensional (3D) space around the PAN-nanopillar arrays, and thus Ag-NPs@PAN-nanopillar arrays generated sensitive and homogenous SERS signals when using rhodamine 6G as a probed molecule. Using the Ag-NPs@PAN-nanopillar arrays as SERS substrates, 10−7 M methyl parathion (organophosphorus insecticide) and 10−6 M PCB-77 (one congener of polychlorinated biphenyls belonging to persistent organic pollutants) are identified. Therefore the SERS-active substrates have potential in SERS-based rapid detection of environmental organic pollutants.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Applied Sciences-Basel
·
2023
·Vol. 13
·期 11
·6682
·
IF 2.7
Shunqi Mei,Teng Liu,Long Chen,Yifan Wang
The diaphragm is a key component of the lithium-ion battery and largely determines its performance. Currently, commercial diaphragms suffer from poor thermal stability, low porosity, and low liquid absorption rate. In this study, we prepared a polyurethane/polyacrylonitrile (PU/PAN) lithium-ion battery diaphragm using a centrifugal spinning method with PU as the main substrate and PAN as the additive. The results showed that the PU/PAN nanofiber diaphragm prepared by centrifugal spinning had a 3D porous structure, and when using 18% PU:PAN = 7:3, the porosity of the fiber diaphragm was 83.9%, the liquid absorption rate was 493%, and the ionic conductivity was 1.79 mS/cm. The battery system had good electrochemical performance and thermal stability, with an electrochemical stability window of 5.2 V. The diaphragm did not shrink when heated at 160 °C. In a lithium-ion battery system with lithium iron phosphate (LiFePO4) as the cathode material, the capacity remained at 147.1 mAh/g after 50 cycles at a 0.2 C rate, with a capacity retention rate of 95.8%. This indicated excellent cycle stability and a multiplicative performance with good application potential.Keywords:centrifugal spinning;nanofiber;lithium-ion battery separator;polyurethane;polyacrylonitrile
研究领域:
材料科学
·
能源存储
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DOI
高影响因子
Batteries-Basel
·
2023
·Vol. 9
·期 3
·166
·
IF 4
Ting Liu,Xuemei Hu,Yadong Zhang,Ting He,Jianping Zhou,Junqiang Qiao
Lithium metal battery (LMB) is a topic receiving growing attention due to the high theoretical capacity, while its practical application is seriously hindered by the lithium dendrites issue. As the physical barrier between two electrodes, the separator can achieve dendrite suppression by means of providing higher mechanical strength, regulating ion transport and facilitating homogeneous lithium deposition. Based on this, a composite separator is fabricated with zeolitic imidazolate framework (ZIF-8) and polyacrylonitrile (PAN) via electrospinning techniques, and its physical properties and electrochemical performances, together with its dendrite suppression mechanism, are investigated. The ZIF8-PAN separator possesses a unique 3D interconnected porous skeleton, displaying higher electrolyte uptake, preferable electrolyte wettability, and lower thermal shrinkage compared with the commercial polypropylene separator. In addition, a battery assembled with the ZIF8-PAN separator can effectively regulate ion transport and suppress dendrites growth, which exhibits an enhanced ionic conductivity (1.176 mS/cm), an increased lithium-ion transference number (0.306), a wider electrochemical stability window (5.04 V), and superior cycling stability (over 600 h with voltage hysteresis of 30 mV). This work offers a promising strategy to realize safe separator for dendrite suppression in LMB.Keywords:composite separator;electrospinning techniques;electrolyte wettability;ion-transport regulation;lithium dendrites suppression
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yisong Pan,Cai Cheng,Yibin Chen,Jiayi He,Ziming Zhu,Han Wang
Traditional carbon nanofiber carbonization processes are often energy-intensive and inefficient, which limits their scalability for applications in flexible electronics and energy storage. In this study, polyacrylonitrile (PAN) nanofiber precursors were fabricated using centrifugal spinning, and an innovative and efficient carbonization process based on rapid Joule heating (RJH) was developed. The effects of carbonization temperature (900°C, 1200°C, 1500°C) and duration (10, 30, 60, and 120 s) on the microstructure and electrical conductivity of the resulting carbon fibers were systematically investigated. Multi-scale characterization techniques, including SEM, EDS, XRD, Raman spectroscopy, and conductivity testing, were employed to investigate how temperature and duration influence graphitization, defect density, and electrical properties. Experimental results showed that under optimal conditions (1200°C for 60 s), the degree of graphitization reached 91.12%. The conductivity reached 8.9 S cm −1 , which is more than 27.1% higher than that achieved using the traditional tube furnace carbonization process (2 h/1200°C). Moreover, the carbonization time was reduced to just 0.8% of the traditional process, while energy consumption dropped to only 1.39%. This study presents an efficient and low-energy method for producing high-performance carbon nanofibers, demonstrating strong potential for applications such as supercapacitor electrodes.
研究领域:
材料科学
·
纳米技术
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储能
·
柔性电子
·
碳纳米材料
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）