PROGRESS IN ORGANIC COATINGS
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2023
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IF 6.6
Jialiang Kang,Xueting Wang,Xiaoxiang He,Cun Lv,Caixia He,Zhanxiong Li
In this study, the perfluoropolyether carboxylic acid (PFPE-COOH) was used to react with polycaprolactone (PCL) to synthesise the hydrophobic block copolymer PCL- b -PFPE. The esterification reaction was performed successfully with the terminated hydroxyl group in the PCL-OH after activation of PFPE-COOH with N, N′ -dicyclohexyl carbon diimide. The PCL- b -PFPE was dissolved in various solvents to prepare microspheres using electrostatic spraying technology, and the flow rate, voltage, temperature and humidity parameters were optimised. The findings demonstrated that the solvent and ambient humidity had a substantial influence on the microspheres' surface morphology . Through smooth surface morphology, chloroform (CF) single solvent formed an ideal microsphere and DMF/CF mixed solvent produced a ‘pit’ surface morphology. Furthermore, the surface roughness of microspheres increases with an increase in humidity. The static contact angles of electrostatic spraying polyester fabric were 147.1° ± 1.8°, 150.9° ± 1.5°, 156.3° ± 2.6° and 155.9° ± 3.3°, under 20 %, 40 %, 60 % and 80 % humidity, respectively. The findings demonstrated that during the electrostatic spraying, the PFPE chain's introduction into PCL helped construct the secondary rough morphology on the microsphere surface and substantially enhanced the hydrophobicity of coatings, providing the finished polyester fabric super-hydrophobicity. The PCL-b-PFPE microspheres were directly sprayed and coated with the developed spray solution via electrostatic spraying. The water contact angle of the finished polyester fabric was found to be ≥140°, which provided hydrophobicity after 5 cycles of laundry. Following the sandpaper abrasion and adhesion tests, the contact angle of the fabrics coated with the microspheres remained ≥145°, indicating a good mechanical stability.
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Materials
·
2023
·Vol. 16
·期 3
·947
·
IF 3.4
Yanlong Wu,Ruomeng Chen,Xu Chen,Yongqiang Yang,Jian Qiao,Yaxiong Liu
Strong and tough β-TCP/PCL composite scaffolds with interconnected porosity were developed by combining digital light processing and vacuum infiltration. The composite scaffolds were comprised of pure β-TCP, β-TCP matrix composite and PCL matrix composite. The porous β-TCP/PCL composite scaffolds showed remarkable mechanical advantages compared with ceramic scaffolds with the same macroscopic pore structure (dense scaffolds). The composite scaffolds exhibited a significant increase in strain energy density and fracture energy density, though with similar compressive and flexural strengths. Moreover, the composite scaffolds had a much higher Weibull modulus and longer fatigue life than the dense scaffolds. It was revealed that the composite scaffolds with interconnected porosity possess comprehensive mechanical properties (high strength, excellent toughness, significant reliability and fatigue resistance), which suggests that they could replace the pure ceramic scaffolds for degradable bone substitutes, especially in complex stress environments.Keywords:porous composite scaffolds;mechanical properties;digital light processing;infiltration;gradient structure
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POLYMER TESTING
·
2022
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IF 4.931
Yuezhou Liu,Yanjing Liu,Xiyue Li,Yongfang Qian,Lihua Lv,Ying Wang
In order to fabricate antibacterial nanofiber membranes for tissue engineering field, the oxidative damage of magnesium hydroxide nanoparticles (Mg(OH) 2 NPs) against the model system of Escherichia coli ( E. coli ) was researched by measuring the oxidative stress response, oxidative stress products and glucose metabolism. The toxicity of Mg(OH) 2 NPs to a normal biological system was evaluated in vivo through the acute oral toxicity, blood physiological and serum biochemical markers and acute skin irritation, indicating that the Mg(OH) 2 NPs exhibited great biosafety. The Mg(OH) 2 NPs with antibacterial property and biosafety were loaded on PCL/PVP nanofiber substrates through electrospinning technology to fabricate the Mg(OH) 2 /PCL/PVP nanofiber membranes. The results of characterization and antibacterial test showed that the Mg(OH) 2 /PCL/PVP nanofiber membranes with 8.0 wt% Mg(OH) 2 NPs present excellent antibacterial rate of 100% against E. coli that the Mg(OH) 2 NPs can be physically and evenly loaded on nanofiber substrates.
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International Journal of Nanomedicine
·
2015
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IF 4.383
Tianpeng Zhang,Huan Wang,Yanghuan Ye,Xingwang Zhang,Baojian Wu
Polymeric micelles receive considerable attention as drug delivery vehicles, depending on the versatility in drug solubilization and targeting therapy. However, their use invariably suffers with poor stability both in in vitro and in vivo conditions. Here, we aimed to develop a novel nanocarrier (micellar emulsions, MEs) for a systemic delivery of genistein (Gen), a poorly soluble anticancer agent. Gen-loaded MEs (Gen-MEs) were prepared from methoxy poly(ethylene glycol)-block-(ε-caprolactone) and medium-chain triglycerides (MCT) by solvent-diffusion technique. Nanocarriers were characterized by dynamic light scattering, transmission electron microscopy, and in vitro release. The resulting Gen-MEs were approximately 46 nm in particle size with a narrow distribution. Gen-MEs produced a different in vitro release profile from the counterpart of Gen-ME. The incorporation of MCT significantly enhanced the stability of nanoparticles against dilution with simulated body fluid. Pharmacokinetic study revealed that MEs could notably extend the mean retention time of Gen, 1.57- and 7.38-fold as long as that of micelles and solution formulation, respectively, following intravenous injection. Furthermore, MEs markedly increased the elimination half-life (t1/2β) of Gen, which was 2.63-fold larger than that of Gen solution. Interestingly, Gen distribution in the liver and kidney for MEs group was significantly low relative to the micelle group in the first 2 hours, indicating less perfusion in such two tissues, which well accorded with the elongated mean retention time. Our findings suggested that MEs may be promising carriers as an alternative of micelles to systemically deliver poorly soluble drugs.
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NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 24
·15072-15078
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IF 3.269
Lihua Wang,Huan Yang,Jiazi Hou,Wanxi Zhang,Chunhui Xiang,Lili Li
Core–shell structured cellulose acetate-polycaprolactone/chitosan (CA-PCL/CS) composite nanofibers were electrospun via coaxial electrospinning. Different solvents were used in core solutions, which led to different electrical conductivities in core solutions. The effect of the electrical conductivity on the morphology and structure of core–shell fibers was studied emphatically. As shown in the scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images, the increasing electrical conductivity of core solutions would result in smaller diameter ratios of core to shell, thinner overall diameters and more inhomogeneous diameter distributions. Additionally, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and differential scanning calorimetry (DSC) all demonstrated that the interactions between cores and shells weakened with the increase of electrical conductivity of core solutions, and this might lead to different diameter ratios of cores to shells in the fibers. The results provide a basis for further design and optimization of processing conditions to control the nanostructure of core–shell composite nanofibers.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Jie Liao,Xiaoming Li,Huiqi Yang,Wei He,Bingbing Wang,Shuyu Liu,Yubo Fan
Postoperative adhesion (POA) has emerged as a prevalent clinical challenge in soft tissue repair, emphasizing the critical need for preventive measures. However, the complex POA development process makes POA prevention from a single aspect insufficient. Hence, a curcumin-loaded poly-L-lactic acid-poly (caprolactone) micro-nano conjugated fibrous membrane (PAPC MCFM (cur)) is engineered to synergistically prevent POA from multiple perspectives, in which poly (caprolactone) (PCL) nanofibers (118 ± 12 nm) with low orientation traverse the oriented poly-L-lactic acid (PLLA) microfibers (2.0 ± 0.3 µm). The PAPC MCFM not only significantly improves the mechanical properties of the anisotropic fibrous membrane (AIFM) that the modulus of elasticity and the tensile strength in the direction vertical to microfiber orientation increase by 4.5 and 13.0 times, respectively, but also can further enhance the “contact guidance effect” of AIFM, i.e., hindering fibroblast adhesion, proliferation, and differentiation to myofibroblast through inhibiting integrin β1 activation, vinculin expression and focal adhesion (FA) formation, and the nuclear localization activation of yes-associated protein (YAP). Except for these effects, PAPC MCFM loading with 2.5 mg mL −1 curcumin can further prevent POA by delivering anti-inflammatory, antioxidant, and antibacterial properties, and by suppressing fibrosis through decreased transforming growth factor-β1(TGF-β1) expression, showing effective POA prevention in rat abdominal cavity and rabbit dura mater models.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Menglu Wu,Zi-An Deng,Chaoyi Shen,Zhichao Yang,Zihan Cai,Di Wu,Kunsong Chen
Fruit is susceptible to various postharvest pathogens; thus, the development of multifunctional preservation materials that can achieve the broad-spectrum inhibition of different pathogens is a current research hotspot. Here, microfluidic blow spinning was used to create a biodegradable polycaprolactone/ethyl cellulose (PCL/EC) nanofibrous film that incorporated two naturally-sourced compounds, natamycin and trans -cinnamic acid, resulting in multi-microbial inhibition. The PCL/EC-based film had a smooth and even morphology, indicating the favorable integration of PCL and EC. After the incorporation of ingredients, the film exhibited good inhibitory activity against Escherichia coli , Staphylococcus aureus , and Botrytis cinerea , and it had finer fiber diameters, higher permeability, and antioxidant properties. We further demonstrated that strawberries that were padded with the film had good resistance to Botrytis cinerea . Also, the film did not interference with the qualities of the strawberries during storage. The study demonstrates a promising application for multi-antimicrobial and bio-friendly packaging materials in postharvest fruit preservation.
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Materials Today Bio
·
2025
·
IF 10.2
Jupei Zhang,Hangbin Xia,Xuerui Zhou,Zhaoxu Meng,Qishu Jin,Dongmin Chen,Xiaojuan Xia,Yiren Jiao,Jiang Chang,Zhihong Dong,Zhen Zeng,Hongshi Ma,Chen Yang
Breast reconstruction after mastectomy aims to restore breast appearance and function. Current scaffolds often fail to meet the complex clinical demands of post-mastectomy breast reconstruction, which include personalized shaping, prevention of tumor recurrence and metastasis, and promotion of adipose tissue regeneration. This study aims to address these challenges by combining a readily processable biopolymer, polycaprolactone (PCL), with a multifunctional bioactive ceramic, cobalt orthosilicate (Co 2 SiO 4 , CoSi) to form a multi-functional CoSi/PCL composite scaffold through 3D printing technology. The scaffold exhibits a controllable shape with designed macroporous architecture. Its photothermal performances are well presented in both near-infrared (NIR) I and NIR-II regions, enabling effective tumor ablation with minimal side effects. Additionally, the release of bioactive silicate and cobalt ions promotes adipogenesis and angiogenesis, thereby enhancing the integration of the scaffold with surrounding tissues. This approach offers a promising strategy for combining tumor therapy with breast reconstruction, providing a clinically relevant solution for post-mastectomy patients.
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PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Yinfu Lu,Yinghao Li,Yang Zhao,Zixuan Zhou,Xiangtian Bai,Hao Luo,Zhou Yang,Dong Wang,Yuzhen Zhao
Optimized formulations produce RGB structural colors and dual visible‑UV encryption signals from fluorescent PDLC. • Wavelength-selective Bragg reflection enables multi-stage decryption for high-security anti-counterfeiting. • A ternary PSCLC/PDLC/PCL composite is prepared via two‑step polymerization to achieve tunable cholesteric helical pitch. Liquid crystals (LC) are regarded as promising candidates for optical encryption on account of their distinctive stimulus-responsive structural coloration. However, single-component polymer-stabilized cholesteric liquid crystal (PSCLC) systems suffer from limited information encoding dimensions. Polymer-dispersed liquid crystals (PDLC) can only achieve basic light scattering modulation and cannot meet the requirements of complex multi-channel encryption. To circumvent these drawbacks, a synergistic PSCLC/PDLC/polycaprolactone (PCL) composite thin film is fabricated for optical anti-counterfeiting. Laser-patterned PDLC templates are filled with PSCLC precursors, and S5011-loaded PCL thin films laminated on independent glass substrates serve as sustainable chiral donors. Regulated interlayer chiral diffusion enables continuous tuning of structural hues within predefined laser-etched cavities. Incorporation of red fluorescent powder imparts dual visible and ultraviolet imaging capacity to the composite. Tunable color variation in designated regions is realized via precise modulation of diffusion temperature and duration. Benefiting from the wavelength-selective Bragg reflection effect of cholesteric liquid crystals (CLCs), multi-layered information encryption is accomplished. Colored patterned regions can only be visualized under matching monochromatic illumination. Benefiting from facile manufacturing, large information storage capacity and diversified encryption modes, the proposed composite presents great application potential in premium anti-counterfeiting tags, encrypted two-dimensional codes and intelligent display devices. Download: Download high-res image (211KB) Download: Download full-size image
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ACS Applied Bio Materials
·
2021
·
IF 0
Linzhi Jing,Xiang Wang,Bin Leng,Ningping Zhan,Hang Liu,Shifei Wang,Yuyun Lu,Jie Sun,Dejian Huang
Scaffold-based three-dimensional (3D) cell culture systems have gained increased interest in cell biology, tissue engineering, and drug screening fields as a replacement of two-dimensional (2D) monolayer cell culture and as a way to provide biomimetic extracellular matrix environments. In this study, microscale fibrous scaffolds were fabricated via electrohydrodynamic printing, and nanoscale features were created on the fiber surface by simply leaching gliadin of poly(ε-caprolactone) (PCL)/gliadin composites in ethanol solution. The microstructure of the printed scaffolds could be precisely controlled by printing parameters, and the surface nanotopography of the printed fiber could be tuned by varying the PCL/gliadin ratios. By seeding mouse embryonic fibroblast (NIH/3T3) cells and human nonsmall cell lung cancer (A549) cells on the printed scaffolds, the cellular responses showed that the fiber nanotopography on printed scaffolds efficiently favored cell adhesion, migration, proliferation, and tissue formation. Quantitative analysis of the transcript expression levels of A549 cells seeded on nanoporous scaffolds further revealed the upregulation of integrin-β1, focal adhesion kinase, Ki-67, E-cadherin, and epithelial growth factor receptors over what was observed in the cells grown on the pure PCL scaffold. Furthermore, a significant difference was found in the relevant biomarker expression on the developed scaffolds compared with that in the monolayer culture, demonstrating the potential of cancer cell-seeded scaffolds as 3D in vitro tumor models for cancer research and drug screening.
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NEUROSCIENCE LETTERS
·
2018
·
IF 2.159
Dongling Shi,Teng He,Weijian Tang,Heyangzi Li,Chao Wang,Mingzhi Zheng,Jue Hu,Xinghui Song,Yuemin Ding,Ying-ying Chen,Yueliang Shen,Hongfeng Jin,Lin-lin Wang
Neuronal death and organization degeneration can happen inordinately after spinal cord injury (SCI), which lead to nerve dysfunction. We aimed to determine whether local application of a cell permeable calpain I inhibitor (MDL28170) can promote SCI recovery by increasing neuronal cell viability. MDL28170-loaded polycaprolactone (PCL) film was fabricated. Scanning electron microscopy showed the surface of PCL film was smooth with holes (diameter at μM level). The PCL film was non-toxic, biological compatibility, and had good neuron adhension and slow release characteristic. MDL28170 increased VSC4.1 motor neurons’ viability under tunicamycin (an endoplasmic reticulum stress) induced injury. In a traumatic SCI rat model, MDL28170-loaded PCL film reduced the area of lesion cavity, and promoted recovery of locomotor behavior. Moreover, the expression of GAP-43 was upregulated after MDL28170-loaded PCL film treatment. Thus, our findings demonstrated that localized delivery of MDL28170 could promote SCI recovery by inhibiting endoplasmic reticulum stress, preserving survival of the motor neurons, which may point out a promising therapeutic target for treating SCI patient.
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Biomedical Materials
·
2024
·
IF 3.9
Kun Dai,Fujian Zhao,Wen Zhang,Dafu Chen,Fei Hang,Xuenong Zou,Xiao Feng Chen
Magnesium ions play an important immune-regulatory role during bone repair. For this study, we prepared micro-nano bioactive glass containing magnesium, which can release magnesium, silicon, and calcium ions and has a positive impact on osteogenic differentiation and vascular regeneration. In this study, MgMNBG was compounded and combined with PLGA and PCL for 3D printing. Afterwards, the physicochemical properties and bone repair performance of the scaffolds were evaluated through in vitro and in vivo experiments. We also investigated the effects of MgMNBG on osteogenic differentiation, immune regulation, and vascular regeneration. The results showed that MgMNBG can inhibit inflammation and promote osteogenesis and angiogenesis by regulating macrophages. PLGA/PCL/MgMNBG scaffolds have good osteogenic and angiogenic effects, and the composite scaffolds have excellent bone repair performance and potential application value.
研究领域:
生物材料
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组织工程
·
骨再生
·
免疫学
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