JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2023
·
IF 10.9
Tao Xiang,Jie Chen,Weizong Bao,Shuyan Zhong,Peng Du,Guoqiang Xie
Stress shielding is caused by the mismatch of stiffness between bone and implant materials, which may give rise to bone resorption and loosening, thereby causing implantation failure. There is a huge gap between Young's modulus of human bone and low Young's modulus β Ti alloys. A porous structure design can achieve the target of low Young's modulus, and thus achieve the matching between human bone and implant materials. However, a suitable space holder (SH) that can be applied at high temperatures and sintering pressure has not been reported. In this study, the TiZrNbTa/Ti titanium matrix composite (TMC) with high strength and large ductility was used as scaffold materials and combined the SH technique with the spark plasma sintering (SPS) technique to obtain a porous structure. A novel space holder, i.e., MgO particles was adopted, which can withstand high-temperature sintering accompanied by a sintering pressure. The porous TiZrNbTa/Ti with 40 vol.% MgO added exhibits a maximum strength of 345.9 ± 10.4 MPa and Young's modulus of 24.72 ± 0.20 GPa, respectively. It possesses higher strength compared with human bone and matches Young's modulus of human bone, which exhibits great potential for clinical application.
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高影响因子
RSC Advances
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2019
·Vol. 9
·期 4
·2325-2331
·
IF 3.049
Yitong Chen,Baodi Ma,Songshuang Cao,Xiaomei Wu,Yi Xu
The production of (S)-N-boc-3-hydroxy piperidine (NBHP) via asymmetric bioreduction of 1-boc-3-piperidinone with reductase is impeded by the need for expensive coenzymes NAD(P)H. In order to regenerate the coenzyme in situ, the gene of alcohol dehydrogenase from Thermoanaerobacter brockii and glucose dehydrogenase from Bacillus subtilis were ligated into the multiple cloning sites of pRSFDuet-1 plasmid to construct the recombinant Escherichia BL21 (DE3) that co-expressing alcohol dehydrogenase and glucose dehydrogenase. Different culture conditions including the medium composition, inducer and pH etc were systematically investigated to improve the enzyme production. The enzyme activity was increased more than 11-fold under optimal culture condition, from 12.7 to 139.8 U L−1. In the further work, the asymmetric reduction of 1-boc-3-piperidinone by whole cells of recombinant E. coli was systematic optimized to increase the substrate concentration and reaction efficiency. At last, S-NBHP (>99% ee) was prepared at 500 mM substrate concentration without external addition of cofactors. The conversion of S-NBHP reached 96.2% within merely 3 h, corresponding a high space-time yield around 774 g L−1 d−1. All these results demonstrated the potential of recombinant E. coli BL21 (DE3) coupled expressing alcohol dehydrogenase and glucose dehydrogenase for efficient synthesis of S-NBHP.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2022
·
IF 6.371
Haoxiang Zhong,Lingzhi Zhang
The low sulfur utilization and the serious shuttle effect of polysulfides severely hamper practical application of Li-S batteries. Herein, sulfur cathodes with the multi-functional structures, featured with double-layered hollow carbon sphere with up to 50 nm interlayer space (DLHC-50) in situ grown Co-SnS catalytic layer is designed and synthesized for lithium sulfur batteries. Co-SnS/DLHC-50 can encapsulate 72% sulfur, higher than 63% for Co-SnS/DLHC-20 due to the large interlayer spaces of DLHC-50. Meanwhile, polysulfides are also effectively restricted via physical entrapment from DLHC-50 as well as chemical binding between Co-SnS and polysulfides. Benefiting from the well-constructed host framework, Co-SnS/DLHC-50 @S shows higher specific capacity/capacity retention of 760.4 mA h g −1 /72.9% after 500 cycles at 0.5 C, than that of 546.5 mA h g −1 /62.2% and 668.9 mA h g −1 /62.2%, for DLHC-50 @S, and Co-SnS/DLHC-20 @S, respectively. In addition, the strategy can be also extended to prepare other metal oxides (sulfides)/DLHC-50 for wide applications. Therefore, this work demonstrates a promising route to combat some bottlenecks such as low sulfur utilization, and the shuttle effect of polysulfides for Li-S batteries.
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高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Wei Wang,Weiyang Li,Haotian Li,Bowen Cheng,Yunbin Zhou,Xingyu Ma,Jinwei Chen
Water is a precious resource in space stations, and wastewater recycling is necessary to meet the needs of astronauts. In that respect, applying the high anti-pollution disk tubular reverse osmosis (DTRO) technique is a reliable way to remove pollutes from wastewater. Thin film composite (TFC) membrane treatment is the most frequently employed solution for purifying wastewater in industry; however, the intrinsic weaknesses of polymer membrane substrates, e.g., poor mechanical property, foulant adsorption and low resistance to acidic/basic conditions, greatly hamper their applications. In this study, the novel polysulfate (PSE) membrane substrates were prepared via non-solvent induced phase separation (NIPS) method. The microstructure and performance of PSE membrane substrates were comprehensively investigated at varying polymer concentration and nanoparticle types. The results showed that adding nanosilver to the support layer significantly enhanced the TFC- PSE/Ag membrane performance (up to 57 %) and tensile strength (by 4.57 ± 0.13). According to computational fluid dynamics (CFD) simulations, the optimized geometric design of deflectors would have noticeably improved the flow field distribution and strength, which was consistent with experimental data. The DTRO modules enabled the effective management of wastewater using simulated space bathing wastewater. The effluent met the water reuse criteria in terms of COD concentration, NH 3 -N concentration, conductivity and turbidity whose respective values were 15 mg/L, 0.21 mg/L, 60 μS/cm, and 0.9 NTU. The proposed DTRO modules own antifouling and acid/alkaline-resistance, indicating their remarkable application potential in the large-scale recovery of bathing wastewater from the earth or space station.
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DESALINATION
·
2025
·
IF 9.8
Huan Jiao,Xinyu Guo,Chaofeng Zhang,Sha Wang,Wenjuan Wu,Yongcan Jin,Zhiqiang Liang,Bo Jiang
With natural hierarchical porous and anisotropic cellular structure, wood yields a great opportunity for solar-driven water desalination but is limited in interfacial evaporation efficiency due to its inherent low photothermal conversion. Although the photothermal materials decoration and the high-temperature carbonization have been proposed, these methods often lead to poor interfacial compatibility and thermal management. Herein, a space-confined carbonization strategy of wood cellular structure was developed to construct an all-in-one solar-driven evaporator for efficient water desalination and evaporative power generation. The gradient carbonization of cellular structure caused by immersed wood into concentrated H 2 SO 4 endows wood surface with improved photothermal conversion efficiency (91.6 %), and the interior cellular structure with natural hydrophilic (hemi)cellulose enables rapid water transportation. As a result, the space-confined carbonized wood exhibits high evaporation performance, with the evaporation rate up to 2.1 kg m −2 h −1 under 1 sun. The concentration difference of ions caused by water evaporation can also achieve power generation, with the timing current and voltage up to 34 mA and 1187 mV, respectively. In addition, the H 2 SO 4 is reusable without affecting the evaporation stability. The developed space-confined carbonized wood also demonstrates good adaptability to various water environment. This feasible space-confined carbonization strategy provides a new sight to construct all-in-one wood-based solar-driven evaporators for improving the water desalination and evaporative power generation performance.
研究领域:
材料科学
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能源工程
·
环境科学
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高影响因子
MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Ying Yang,Liang Qi,Guanhua Xu,Zheng Li,Yi Tao
Ethanol precipitation is a pivotal manufacturing step in the production of Guanxinning tablets (GXN). However, current quality control methods for this process remain inadequate. To address this gap, we propose a novel analytical framework that combines Raman spectroscopy with state-of-the-art deep learning architectures, specifically integrating a Mamba State Space model with a Transformer model, to enable non-destructive and real-time monitoring of seven critical quality attributes (CQAs) throughout the ethanol precipitation process of GXN. A total of 160 ethanol precipitation samples were collected, and their Raman spectra were acquired using a 785 nm laser (35 mW) across a wavenumber range of 200–3200 cm −1 , enabling rapid spectral acquisition within 1 s per sample. The content of five bioactive compounds (danshensu, ligustrazine, ferulic acid, rosmarinic acid, and salvianolic acid B) was quantified via HPLC, while solid content and alcohol content were determined using standard methods. Spectral outliers were removed using PCA-Mahalanobis distance analysis, and the Kennard-Stone algorithm was employed to partition datasets into training and test sets (4:1 ratio) to ensure model generalizability. Comparative model evaluation revealed that Mamba State Space model outperformed Transformer model and linear models, achieving prediction coefficients ( R p 2 ) of 0.9419–0.9978 and root mean square error of prediction (RMSEP) values of 0.0129–0.0501, with exceptional accuracy for solid content ( R p 2 > 0.99). This approach reduces reliance on time-consuming HPLC analytical method, offering a 99.9 % reduction in analysis time while maintaining predictive accuracy (RMSEP ≤0.0501) and robustness ( R p 2 > 0.94). By embedding the Mamba State Space model into Raman spectroscopy-based ethanol precipitation process monitoring, this study establishes a robust quality by artificial intelligence framework for real-time quality control in traditional Chinese medicine (TCM) manufacturing, paving the way for smart process analytical technology (PAT) applications.
研究领域:
分析化学
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制药工程
·
中药学
·
人工智能
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高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Yu Mu,Jun Huang,Rongqing Zhou,Suyi Zhang,Hui Qin,Yi Dong,Chao Wang,Xiaojun Wang,Qianglin Pan,Huifang Tang
Daqu , an indispensable starter, significantly affects the quality and yield of Chinese baijiu. To explore the bioturbation effect of space mutation and biofortification on strong-flavor Daqu , the microbial community, physicochemical properties and overall metabolic profile were investigated. Lactobacillus and Aspergillus were significantly reduced after bioturbation, while seven genera (e.g., Bacillus and Pichia ) and five genera (e.g., Enterococcus and Thermomyces ) were enriched by space mutation and biofortification, respectively, resulting in improved enzymatic activities. Among the 14 aroma-active volatiles and 51 differential metabolites identified, most had a higher content after bioturbation, including pyrazines, alcohols, small peptides and carbohydrates. Moreover, correlation analysis and integrated metabolic pathway showed that differences in flavor quality among these Daqu were mainly associated with bacterial communities, especially Bacillus , Kroppenstedtia , Thermoactinomyces and Scopulibacillus . These results are useful for elucidating the mechanism of flavor formation in Daqu and promoting the further application of bioturbation technology in the traditional fermentation industry.
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PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2014
·
IF 0
Shuling Kan,Jing Lu,Jianping Liu,Junlin Wang,Yi Zhao
The study aims to prepare naproxen enteric-coated pellets (NAP-ECPs) by fluid-bed coating using QbD principle. Risk assessment was firstly performed by using failure mode and effect analysis (FMEA) methodology. A Plackett–Burman design was then used for assessment of the most important variables affecting enteric-coated pellets characteristics. A Box–Behnken design was subsequently used for investigating the main, interactive, and quadratic effects of these variables on the response. By FMEA we discovered that eight factors should be considered to be high/important risk variables as compared with others. The responses of acid resistance and cumulative drug release were taken as critical quality attributes (CQAs). Pareto ranking analyses indicated that the coating weight gain (X 7 ), triethyl citrate percentage (X 1 ) and glycerol monostearate percentage (X 2 ) were the most significant factors affecting the selected responses out of the eight high-risk variables. Optimization with response surface method (RSM) further fully clarified the relationship between X 7 , X 1 , X 2 and CQAs, and design space was established based on the constraints set on the responses. Due to the extreme coincidence of the predicted value generated by model with the observed value, the accuracy and robustness of the model were confirmed. It could be concluded that a promising NAP-ECPs was successfully designed using QbD approach in a laboratory scale.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ting Su,Yunhe Gong,Xue Cui,Xinhong Wang,Yanan Zhang,Hongbin Yu
Oxidizing ammonia to nitrogen is a challenge in wastewater treatment. For this challenge ammonia oxidation via chlorine oxide radicals has been proved to be a potential method. In this study, a space-confined photoanode was designed and prepared by loading RuO 2 nanoparticles on TiO 2 /WO 3 nanowires for in situ enhancing the generation of chlorine oxide radical. Scanning electron microscopy characterization confirmed that RuO 2 nanoparticles were uniformly deposited on TiO 2 /WO 3 nanowires. The generation of chlorine oxide radical was markedly boosted, and its steady-state concentration reached 2.76 × 10 −12 M. This value was 3 times that of the traditional bifacial electrode (a type of electrode that has been widely used for chlorine oxide radical-related research). As a result, ammonia oxidation was greatly enhanced. In 90 min, 31.9 mg/L ammonia nitrogen could be degraded, yet only 0.94 mg/L nitrate was accumulated. In addition, the space-confined photoanode exhibited good performance for real wastewater treatment, and 41.0 mg/L ammonia nitrogen could be oxidized in 135 min. During photoelectrocatalysis, a synergistic index (47.7 %) was obtained. Besides the synergistic effect between photocatalysis and electrocatalysis, the unique morphology and structural design (TiO 2 /WO 3 and RuO 2 were mainly responsible to hydroxyl radical generation and free chlorine production, respectively) also synergistically promoted the generation of chlorine oxide radical, thereby improving ammonia oxidation. The mechanism for ammonia oxidation via chlorine oxide radicals over the space-confined photoanode was proposed based on experimental results and theoretical calculations.
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高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Wenfei Ding,Zhaoyi Mo,Jia Qi,Mengying Wang,Junyu Zou,Kuo Wang,Daxiang Gong,Yongju Zhao,Hong Miao,Zhongquan Zhao
Cr(Ⅵ) residues in livestock and poultry wastewater are a rising concern for human health and biotic environments. For the removal of Cr(Ⅵ), its simultaneous reduction and adsorption represents a sustainable and efficient strategy. Herein, iron nodes on covalently bonded two-dimensional phthalocyanine organic polymer (PcOP-Fe) nanosheets with space-separated dual-active sites are developed for the simultaneous detection and removal of Cr(VI) from wastewater. In the FeN 4 structure of PcOP-Fe nanosheets, Fe acts as an electron capture center, effectively facilitating the accumulation of photogenerated electrons and transferring them to Cr(VI), thereby achieving its photocatalytic reduction. Meanwhile, pyrrolic nitrogen provides excellent adsorption sites, enabling the adsorption of Cr(III) or Cr(0). Fe accumulates the photogenerated electrons from pyrrole N and transfer them to Cr(Ⅵ). The formation of N-Cr(Ⅲ) bonds causes a space-separation between Cr(Ⅵ) and Cr(III). In addition, PcOP-Fe can be used for a Cr(Ⅵ) detection agent. The photoluminescence intensity decreases linearly with increasing Cr(Ⅵ) concentration from 80 μM to 2 mM, with a limit of detection of 0.18 μM. The PcOP-Fe nanosheets exhibit good Cr(Ⅵ) detection and reduction performance in livestock and poultry wastewater, suggesting their suitability for practical sensing applications. Thus, the PcOP-Fe nanosheets with space-separated dual-active sites are promising for the simultaneous detection and removal of Cr(Ⅵ) in water treatment processes.
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PubMed
高影响因子
Nano Today
·
2022
·
IF 18.962
Xiuping Sun,Bo Zhang,Ming Chen,Lu Wang,Debao Wang,Ruxia Man,Sikandar Iqbal,Fang Tian,Yitai Qian,Liqiang Xu
Metal Selenides with layer structure has obvious advantages to store guest alkaline metal ions , promote cycling stability and accelerate diffusion kinetics when applied as electrode for batteries . Among them, layer structured Bi 2 Se 3 with large interlayer spacing is expect to have potential applications in rechargeable batteries . In this study, Bi 2 Se 3 @NC composite with lollipop-like structure was synthesized by conveniently hydrothermal combined subsequent selenization process and then applied as high-performance anodes for both PIBs and LIBs . The synergistic effects between Bi 2 Se 3 and N-doped carbon shell endow it excellent performances anode for PIBs (~ 201.2 mA h g −1 after 1200 cycles at 100 mA g −1 , and 130.5 mA h g −1 after 2000 cycles at high current density of 1000 mA g −1 ). Bi 2 Se 3 @NC also exhibited outstanding performance as anode for LIBs (~ 1005.8 mA h g −1 after 300 cycles at 100 mA g −1 ). The reaction kinetics analyses results revealed that pseudocapacitance contribution play important role for the excellent electrochemical performances. It is worth to note that the Bi 2 Se 3 @NC//PTCDA-450 potassium-ion full cells were successfully assembled, and 122.3 mA h g −1 was remained after 200 cycles at 100 mA g −1 (the coulombic efficiency can keep at ~ 100%). In addition, ex-situ X-ray diffraction and HRTEM were adopted to explore the phase evolution of Bi 2 Se 3 @NC during charge-discharge processes and density functional theory (DFT)-based first-principle calculations reveal that Bi 2 Se 3 has a lower diffusion barrier and adsorption energy than that of Bi 2 O 3 . These results prove the merits of Bi 2 Se 3 @NC and its application potential as suitable anode material for half/full PIBs and LIBs .
研究领域:
材料科学
·
电化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Lu-Yu Cao,Shuai-Chen Si,Jin-Bo Yu,Chong-Geng Ma,Jian-Bei Qiu,Jing Wang
Optical ions doped transparent glasses have attracted more and more attention because of their potential application in photonic applications. Unfortunately, optically active dopants occupy at non-crystalline coordination environment, which leads to their poor luminescence efficiency. Therefore, how to enhance luminescence efficiency of optically active dopants in glasses remains a great challenge. Here, we proposed a precisely space-separated strategy of donor-acceptor and successfully developed an intense red emitting composite borosilicate glass co-doped with CsPbCl 3 quantum dots and Mn 2+ ions. By rationally controlling post heat-treatment, CsPbCl 3 QDs acting as donor were uniformly precipitated in glass and Mn 2+ ions acting as acceptor are close to CsPbCl 3 QDs but not inside CsPbCl 3 QDs. Benefitted from high absorption efficiency of CsPbCl 3 QDs and efficient energy transfer from CsPbCl 3 QDs to Mn 2+ ions in glasses, Mn 2+ ions give an intense red broadband emission at 650 nm, 11 times as intense as the one without CsPbCl 3 QDs. The optimal external quantum yield of the as-synthesized composite borosilicate glass is estimated to be 28.5%, 9.5 times as large as 3% for the one without CsPbCl 3 QDs. The precise space-separation and energy transfer rate dependent non-radiative energy coupling mechanism was reasonably proposed to explain how CsPbCl 3 QDs highly absorb energy, efficiently transfer it and finally feeding Mn 2+ ion. These results demonstrate that the strategy of using microcrystalline with high absorption efficiency as donor, for instance, CsPbX 3 QDs, to pump optical activator ions as acceptor, for instance, Mn 2+ ion in glass may be very promising for developing high luminescent performance ions-doped transparent glasses.
研究领域:
光子学
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材料科学
·
光学材料
·
发光材料
·
量子点
·
能量传递
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高影响因子
危险品化学品经营许可证（带存储）