International Journal of Nanomedicine
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2024
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IF 6.6
Yan Yang,Yiling Wang,Xinran Jiang,Jiahao Mi,Dizhang Ge,Yuna Tong,Yuxuan Zhu
Introduction Alzheimer’s disease (AD), a neurodegenerative condition, stands as the most prevalent form of dementia. Its complex pathological mechanisms and the formidable blood-brain barrier (BBB) pose significant challenges to current treatment approaches. Oxidative stress is recognized as a central factor in AD, underscoring the importance of antioxidative strategies in its treatment. In this study, we developed a novel brain-targeted nanoparticle, Ce/Zr-MOF@Cur-Lf, for AD therapy.Methods Layer-by-layer self-assembly technology was used to prepare Ce/Zr-MOF@Cur-Lf. In addition, the effect on the intracellular reactive oxygen species level, the uptake effect by PC12 and bEnd.3 cells and the in vitro BBB permeation effect were investigated. Finally, the mouse AD model was established by intrahippocampal injection of Aβ1-42, and the in vivo biodistribution, AD therapeutic effect and biosafety of the nanoparticles were researched at the animal level.Results As anticipated, Ce/Zr-MOF@Cur-Lf demonstrated efficient BBB penetration and uptake by PC12 cells, leading to attenuation of H2O2-induced oxidative damage. Moreover, intravenous administration of Ce/Zr-MOF@Cur-Lf resulted in rapid brain access and improvement of various pathological features of AD, including neuronal damage, amyloid-β deposition, dysregulated central cholinergic system, oxidative stress, and neuroinflammation.Conclusion Overall, Ce/Zr-MOF@Cur-Lf represents a promising approach for precise brain targeting and multi-target mechanisms in AD therapy, potentially serving as a viable option for future clinical treatment.
研究领域:
神经科学
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药学
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纳米技术
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痴呆症研究
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产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
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IF 6.3
Fangfang Liu,Mengnan Lu,Xiao Yang,Yuedi Wang,Chunmei Wang,Xiaomin Dou
This work proposed introducing nanoscale Fe-Zr oxides onto the layered-surfaces of MXene carriers to maintain well dispersion and anchoring stabilization. The results indicated that Fe-Zr oxide/MXene has a superior adsorption capacity of 209.1 mg/g at pH 7.0. The mass transfer of antimonite onto Fe-Zr oxide/MXene was investigated by numerical solving the homogeneous surface diffusion model. The external mass transfer coefficient ( k f ) and surface diffusion coefficient ( D S ) were determined to be 6.48 × 10 −4 and 1.86 × 10 −8 cm/min, respectively, and the latter was rate-limited. The 2-D profiles of Sb(III) diffusion within the adsorbents were visualized. Data mining and knowledge discovery using machine learning models indicated that the gradient boosting regression (GBR) model successfully predicted the test datasets. The operational conditions outweigh adsorbent properties in capacity prediction, and equilibrium concentration and adsorbent dose, are the most two important features. Using the trained GBR model, the Sb(III) adsorption capacities of MXene (Ti 3 C 2 ) and Fe-Zr/MXene were well predicted. This work provides insights on understanding the mass transfer mechanisms of Sb(III) in functionalized-MXene adsorbents and employing machine learning models for tuning the treatments for better achievements.
研究领域:
环境科学
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材料科学
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化学工程
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数据科学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
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2024
·
IF 8.5
Xuemei Pi,Yuanyuan Wang,Xianwen Kan
Exploring novel and sensitive analysis methods for monitoring lincomycin (Lin) residues is of great significance since overuse of it would cause a serious threat to public health. Herein, a Zr-porphyrin metal-organic frameworks (Zr-TCPP) with covalently modified polyamidoamine (PAMAM) dendrimers was synthesized as a novel intramolecular self-enhanced ECL reagent, which exhibited greatly improved ECL response due to the promotion of SO 4 •– generation and the shortening of the electron transfer distance. Graphene oxide modified with gold nanoparticles (Au@GO) was synthesized as the quencher for the ECL sensor construction based on the quenching strategy. The present aptasensor achieved a wide linear range of 1.0 × 10 −14 − 5.0 × 10 −9 g/mL and a low detection limit of 1.7 fg/mL, which was applied for the determination of Lin in different real samples with satisfactory results.
研究领域:
分析化学
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生物医学工程
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食品安全检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2023
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IF 6.2
Kaiyi Chen,Liang Zhang,Xin Huang,Fuchun Zhang,Gangqiang Zhu,Qizhao Wang
Zr-doped BiVO 4 photoanodes modified with CoF 2 co-catalyst (Zr-CoF 2 /BiVO 4 ) were designed and synthesized by a simple two-step hydrothermal and calcination method. The photocurrent density of the prepared Zr-CoF 2 /BiVO 4 photoanode is as high as about 3.6 mA/cm 2 at 1.23 V vs. RHE (AM 1.5 G). The excellent PEC performance benefits from the cocatalyst loading and the formation of heterojunction . The Zr-CoF 2 /BiVO 4 composite photoanode improves the transfer efficiency of photogenerated carriers and the yield of water splitting. Co 2+ site in the CoF 2 co-catalyst has excellent water oxidation activity. The metal Zr doping further improves charge separation and conduction, thereby reducing the electron-hole complexation rate to affect PEC performance, enhancing photocurrent as well as oxygen release and providing an effective reference method for exploring solar water decomposition. This scheme provides an effective reference method for exploring solar water decomposition.
研究领域:
材料科学
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光电化学
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太阳能转换
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Zhaojie Fang,Zetong Liu,Joe Yeang Cheah,Xinyi Guan,Huijuan Li,Tao Jiang,Shengping Wang,Xinbin Ma
A novel core–shell CaO based adsorbent with Al-Zr co-modification was synthesized via a facile one-pot calcination method. The CO 2 capture capacity and long-term stability of the adsorbents with different Ca/Al/Zr molar ratios were investigated. The co-doping strategy significantly enhanced the CO 2 capture capacity of the calcium-based adsorbents. Specifically, the optimized Ca24Al1Zr0.3 adsorbent exhibited excellent CO 2 adsorption performance in long-term adsorption–desorption cycles, with the CO 2 capacity of 0.53 g-CO 2 /g-ads after 40 cycles. The synergistic effects of Al-Zr co-doping were analyzed from a microstructural perspective. The core–shell Ca24Al1Zr0.3 adsorbent with a CaZrO 3 outer shell featured minimized particle size, abundant mesoporous and macroporous structures, and uniformly distributed doping components. Under the combined effects of structural modification and metal doping, it manifested enhanced CO 2 capture capacity. Based on the CO 2 adsorption mechanism of CaO, this study revealed that Al-Zr co-doping promotes oxygen vacancy generation and improves CO 2 adsorption performance. The Ca24Al1Zr0.3 adsorbent demonstrated the highest oxygen vacancy content and the most pronounced positive shift in Ca 2p binding energy. This shift enhanced electron-donating capability of calcium, effectively facilitating O 2− migration and CO 2 diffusion. Furthermore, the Ca24Al1Zr0.3 adsorbent exhibited superior carbonation reaction kinetics during long-term cyclic operation.
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产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Qiuju Fu,Dandan Liu,Weijing Niu,Shuo Zhang,Ruihua Chen,Yujia Wang,Pengze Zhao,Huimin Jiang,Yanchao Zhao,Lingzhi Yang,Liting Yan,Haiyan Wang,Xuebo Zhao
The highly efficient production of furfuryl alcohol (FFA) from biomass-derived furfural (FFR) is attracting increasing attention due to its wide application in the production of value-added chemicals. Zr-based MOF-808 is promising for liquid catalytic transfer hydrogenation (CTH) of FFR to FFA in terms of possessing a great number of Lewis-acid sites. Herein, a series of defective MOF-808 (D x -MOF-808) samples were prepared via a competitive coordination-removal strategy by modulating with benzoic acid (HBC). HBC was introduced as the temporary ligand for competing with formal ligand 1,3,5-benzenetricarboxylic acid (H 3 BTC) to coordinate with metal clusters and then it was removed with methanol to obtain the D x -MOF-808. The results showed that HBC serves not only as a temporary ligand participating in the synthesis of MOF-808 to obtain defective structure but also as a modulator controlling the particle size by terminating the growth of crystals. By changing the amount of HBC addition, the degree of ligand deficiency and the number of exposed Zr sites can be well regulated. Especially, excellent performance of FFR conversion (99%), FFA selectivity (94.4%) and FFA formation rate (48.6 mmol·g −1 ·h −1 ) was achieved over D 40 -MOF-808 sample with 2-propanol as a hydrogen donor under mild conditions (90 °C, 2 h), ranking it the best among the reported catalysts. Detailed characterizations proved that the high activity of D 40 -MOF-808 was jointly influenced by the high surface area, the high content of exposed Zr metal sites and ligand deficiency.
研究领域:
催化
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材料科学
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化学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Xiang Li,Xueqian Wang,Li Yuan,Langlang Wang,Yixing Ma,You Wu,Yibing Xie,Rui Cao,Yiran Xiong,Ping Ning
The lengthy processes and cumbersome operations for the separate removal of COS and H 2 S have severely limited the development of blast furnace gas recycling process. CuO exhibits excellent H 2 S oxidation performance, but weak COS hydrolysis performance; in contrast, ZrO 2 shows the opposite trend. However, the functional combination of CuO and ZrO 2 has never been used for simultaneous removal of COS and H 2 S. In this study, a Cu/Zr co-doped K@TiO 2 bifunctional catalyst was tailored to simultaneously remove COS and H 2 S. The combined COS and H 2 S capacity of this catalyst reaches 340.5 mg/g at a low temperature of 60 °C, which is much higher than those of other reported bifunctional catalysts. The microcrystal structure formed by Cu/Zr co-doping increases the specific surface area of the catalyst and promotes the adsorption of COS/H 2 S. Specifically, Zr doping increases the content of moderate basic sites and significantly improves the hydrolysis efficiency of COS. Moreover, Cu doping induces lattice distortion of TiO 2 , while CuO captures 4 s valence electrons of K to form Cu 2 O. These two processes lead to the release of lattice oxygen from TiO 2 and CuO, generating oxygen vacancies and ·O 2 − , which promotes H 2 S oxidation. By proposing a simple route for the bifunctionalization of a desulfurization catalyst, this study drives innovation in both the theory and application of simultaneous removal of COS and H 2 S.
研究领域:
环境科学
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催化化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2024
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IF 4.1
Qi Li,Senlin Deng,Junyang Liu,Tingting Yan,Jinguo Hao,Gang Wang,Guoliang Zhang,Jie Li,Chunshan Li
The dispersion of active sites plays an imperative role in the promotion of catalytic performance on methyl acrylate synthesis via direct vaporous aldol condensation. Herein, a novel PEG-assisted impregnation method was proposed to synthesize Cs/Zr-SiO 2 catalyst with high dispersion of acid and base sites. A series of characterization techniques including NMR, TEM, physical N 2 adsorption isotherms, XRD, XPS, NH 3 -/CO 2 -TPD, and Py-IR were used to investigate the physico-chemical properties of these prepared catalyst series. The introduction of PEG improved the specific surface area, dispersion of active sites, and density of acid and base sites, resulting in superior catalytic performance of Cs/PEG@Zr-SiO 2 by comparison with that of Cs/SiO 2 and Cs/Zr-SiO 2 . The kinetic experiments revealed that the activation energy of aldol condensation was 80.8 kJ/mol over the Cs/PEG@Zr-SiO 2 catalyst. The deactivation behavior derived from carbon deposition was discovered, and the spent catalyst could be regenerated by simple thermal treatment.
研究领域:
催化化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2017
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IF 1.174
Yuedong Zhou,Fengfu Li,Junwei Liu,Zhi Yun,Xia Gui
The liquid phase ring-opening of octamethylcy-clotetrasiloxane (D 4 ) was investigated over Pt-H 2 SO 4 /Zr-montmorillonite catalyst. Montmorillonite (Mt), Zr-Mt, H 2 SO 4 /Mt, H 2 SO 4 /Zr-Mt and Pt-H 2 SO 4 /Zr-Mt were also detected for evaluation. The catalysts were characterized by X-ray fluorescence, X-ray diffraction, nitrogen adsorption–desorption, NH 3 -TPD and pyridine-FTIR measurements. In comparison to activate clay which is used in the industry of catalyst, Zr-Mt catalyst displayed stronger acidity and more excellent catalytic activity in the polymerization of D 4 , polymethylhydrosiloxane (D 4 H ) and hexamethyldisiloxane (MM) to low-hydro silicone oil. Relative to Zr-Mt, the acidity of H 2 SO 4 /Zr-Mt was noticeably improved and the catalyst exhibited a higher capability of ring-opening of D 4 conversion and yield of low-hydro silicone oil. To enhance the stability of H 2 SO 4 /Zr-Mt catalyst, a small amount of metals (Pt) was doped. The nitrogen adsorption–desorption results indicated that pore textural parameters of the Pt-H 2 SO 4 /Zr-Mt had not changed with larger specific surface area. Compared with H 2 SO 4 /Zr-Mt, the total acidity of Pt-H 2 SO 4 -Zr/Mt catalyst retained, but the content of the Brønsted acid increased and the content of the Lewis acid decreased. The Pt-H 2 SO 4 -Zr/Mt catalyst displayed higher catalyst reproducibility. After 40 h reaction of polymerization, the yield of low-hydro silicone oil decreased from 93% to 42% over H 2 SO 4 /Zr-Mt catalyst, while the yield of low-hydro silicone oil reduced from 93% to 78% over Pt-H 2 SO 4 /Zr-Mt catalyst. A sharp decrease in catalytic activity after 35 h of Pt-H 2 SO 4 /Zr-Mt catalyst was detected. Furthermore, Pt-H 2 SO 4 /Zr-Mt was completely regenerated under appropriate condition and appeared good repeatability in the D 4 , D 4 H and MM to low-hydro silicone oil.
研究领域:
材料科学
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催化化学
✓ 已验证
产品关联
DOI
高影响因子
Catalysis Science & Technology
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2022
·Vol. 12
·期 14
·4624-4636
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IF 6.177
Yi Yang,Weixin Qian,Haitao Zhang,Zhonghao Han,Hongfang Ma,Qiwen Sun,Weiyong Ying
FeMnxZr and FeMnxZr2Na catalysts prepared by coprecipitation and impregnation methods were applied to investigate the promoting effects of Zr on iron-based catalysts for high-temperature Fischer–Tropsch synthesis (HTFT). Ar physisorption and TEM demonstrated that Zr-promoted catalysts have a larger BET surface area and larger pore volume, which are more conducive to the distribution of active phases. Zr promoted the dispersity of iron particles and reduced the grain size of iron particles, resulting in the improvement of the FTS activity. The CO-TPD and MES results revealed that the introduction of Zr promoted the dissociative adsorption of CO, thereby promoting the formation of the active phase χ-Fe5C2 while suppressing the formation of ε′-Fe2.2C and further improving the FTS activity and the selectivity to C2=–C4= in the hydrocarbon distribution. However, the addition of an excessive amount of Zr caused the excess ZrO2 to cover the surface of the active site, inhibiting the CO dissociative adsorption and the formation of χ-Fe5C2, resulting in a decrease in the CO conversion and the selectivity to C2=–C4=. The XPS and H2-TPR results proved the interaction between Fe2O3 and ZrO2. And the Fe–ZrO2 interaction inhibited the coke deposition and aggregation of the Fe species, as confirmed by XRD and TEM, respectively. The FeMn5Zr2Na catalyst exhibited the highest C2=–C4= selectivity of 34.4% at a CO conversion of 96.3%. And FeMn5Zr2Na displayed the highest production of light olefins (441.6 g h−1 kgCat−1), which was significantly higher than FeMn2Na (162.2 g h−1 kgCat−1).
研究领域:
催化
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化学工程
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材料科学
✓ 已验证
DOI
高影响因子
ENERGY & FUELS
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2018
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IF 3.024
Lincai Peng,Xueying Gao,Xin Yu,Hui Li,Junhua Zhang,Liang He
An integrated multistep catalytic process in a one-pot cascade model to realize conversion is preferred in terms of process economics and energy efficiency. Here, we present the noble-metal-free but highly effective catalytic transfer hydrogenation and acid-catalyzed conversion of biomass-derived furfural for direct production of biofuel alkyl levulinate using alcohols as the hydrogen donor and reaction medium. With optimization of the process variables, a high yield of alkyl levulinate at up to 85.3% could be captured under mild conditions in isopropanol medium with the combination of Zr-MCM-41 and Amberlyst-15 catalysts. The reaction proceeds via the catalytic transfer hydrogenation of furfural to furfuryl alcohol over Zr-MCM-41, which is then converted to alkyl levulinate by an Amberlyst-15 acid catalyst. The spent hybrid catalysts could be effectively recovered from the resulting reaction mixture and reused 5 times with little deactivation after plain regeneration treatment.
研究领域:
化学工程
·
可再生资源与环境科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhen Wu,Jinlong Wang,Xing Cheng,Yue Tang,Lian Xia,Xiaojuan Niu,Yuangen Wu
Nanozyme-based sensors for detecting ascorbic acid (AA) generally depend on the reducibility of the analyte. However, these sensors are susceptible to interference from reducing substances in food. Herein, a novel fluorescent sensor for AA detection was developed based on inhibiting the phosphatase-like activity of a Zr-based metal-organic framework (Zr-CAU-28). Hydroxyl-rich AA molecules adsorb on the surface of Zr-CAU-28 through hydrogen bonding with [Zr 6 O 4 (OH) 4 ] cluster, leading to a decrease in the relative content of terminal hydroxyl groups within the catalytic sites. The constructed sensor exhibits a wide detection range (0.08–11 μg·mL −1 ) and low detection limit of 0.025 μg·mL −1 . Potential interfering studies demonstrated the good selectivity of the sensor. Moreover, the fluorescent sensor can effectively detect AA in juices and vitamin C tablets, with the recovery rate ranging from 96.25 % to 108.50 %. This work represents the first application of phosphatase mimics for AA detection, offering a new strategy for food analysis.
研究领域:
食品科学
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分析化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）