RSC Advances
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2024
·Vol. 14
·期 48
·36063-36072
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IF 3.9
Xuebin Hou,Wei Chen,Meihong Fan,Chen Shi
Chitosan (CS) is regarded as a promising sorbent due to its biodegradability, wide availability, easy processing, and multiple active groups. In this work, CS-based porous fibers (ZIF-n@CS) consisting of CS and zeolitic imidazolate frameworks (ZIFs) were fabricated through wet spinning and self-assembly methods. This combination effectively utilizes the dual advantages of CS and ZIFs, which effectively remove dyes from water and exhibit excellent recyclability. In addition, the adsorption mechanism of the adsorbent was explored through the analysis of adsorption kinetics, thermodynamics, isotherms, and chemical characterization after adsorption. This work provides an operable and universal strategy for the efficient adsorption of dyes, promoting the further promotion and application of MOFs and CS materials.
研究领域:
材料科学
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环境科学
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生物化学
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PubMed
高影响因子
ACS Applied Bio Materials
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2024
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IF 4.6
Shuang Sun,Yongyao Tan,Qikuan Cheng,Yuchen Cai,Jiaqi Zheng,Wei Wang,Lingjuan Xu,Guigang Li,Dong Wang,Lu Zhang,Yunming Wang
Flexible and wearable pressure sensors have attracted significant attention in the fields of smart medicine and human health monitoring. Nevertheless, the design and fabrication of degradable disposable pressure sensors still face urgent challenges. Herein, we fabricated poly(3-hydroxybutyrate) (PHB)-reinforced chitosan (CS) piezoelectric films for intelligent sensors through a simple, low-cost, and environmentally friendly roll-forming method. The results show that PHB doping successfully increased the effective piezoelectric coefficient of the chitosan-based film from 40.12 to 49.38 pm/V (a 23% increase). Simultaneously, the pressure sensor based on the CS/PHB film exhibited excellent response sensitivity (484 mV/kPa) and a wide linear response range (0–130 kPa), which could be used as haptic sensors and motion monitoring sensors for the fast response to human motion signals. Additionally, the CS/PHB film could be completely degraded within 18 days in a natural soil environment, demonstrating outstanding degradability. Therefore, chitosan-based piezoelectric films with excellent biodegradability and piezoelectric characteristics have been successfully fabricated in this work, which will promote the innovative development of green chitosan-based electronic devices and disposable pressure sensors.
研究领域:
材料科学
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生物医学工程
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环境科学
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传感器与执行器
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Shourui Liu,Ruibao Ju,Zhenguo Zhang,Zhen Jiang,Jingzhao Cui,Wanshun Liu,Baoqin Han,Shuo Wang
Endoscopic submucosal dissection (ESD) is an effective treatment for polyps and early gastrointestinal cancers, but requires a high level of operator skill. Injecting submucosal materials (SIM) helps create a fluid cushion between the mucosal and muscular layers, making the procedure easier and reducing associated risks. However, SIMs commonly used in current clinical practice tend to spread quickly and fail to provide long-lasting submucosal fluid cushions (SFC). Thus, there is a critical need for a material that is easy to inject while also maintaining a durable barrier. We prepared succinylated hydroxybutyl chitosan (HBC-SA) by adding succinic anhydride (SA) to hydroxybutyl chitosan (HBC). The hydrogel had excellent temperature-sensitive properties and was able to be injected via an endoscopic injection needle even after gel formation. In vitro and in vivo studies showed that it has satisfactory biocompatibility. Functional experiments showed that the submucosal lifting properties of this hydrogel were significantly better than that of normal saline (NS) and sodium hyaluronate (SH), two commonly used clinical materials. In addition, the hydrogel possessed excellent hemostatic properties. Based on these results, HBC-SA is a promising candidate for submucosal injection during ESD.
研究领域:
胃肠病学
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生物医学工程
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材料科学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yejun Zhong,Shan Sun,Taotao Dai,Hui Zhang,Jianyong Wu,Er Sheng Gong
Phycocyanin is a natural pigment protein with antioxidant, anti-tumor, and anti-inflammatory properties, but its relatively poor emulsibility limits its use in the food industry. In order to improve the emulsifying capacity of phycocyanin, a novel phycocyanin-chitosan complex was prepared, and the characteristics, digestibility, and stability of emulsion containing oil droplets stabilized by the complex were investigated. The results showed that the phycocyanin-chitosan complex had better stability and lower interfacial tension at pH 6.5 than phycocyanin, and it significantly improved the stability of emulsion and inhibited the aggregation of oil droplets. The phycocyanin-chitosan complex stabilized emulsion showed better physical stability, digestibility, and oxidation stability than the phycocyanin emulsion. The particle size of the phycocyanin-chitosan complex stabilized emulsion was very small (from 0.1 to 2 μm), and its absolute value of zeta potential was high. Overall, this study suggests that the phycocyanin-chitosan complex effectively improved the emulsifying capacity of phycocyanin.
研究领域:
食品科学
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生物化学
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PubMed
高影响因子
Scientific Reports
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2024
·Vol. 14
·期 1
·1-13
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IF 3.8
Mu Dehong,Zhou Li,Shi Lingyu,Liu Ting,Guo Ying,Chen Hao,Luo Hongping,Ma Junhao,Zhang Hui,Xiong Peizheng,Tian Li
Allergic rhinitis (AR) remains a major health problem worldwide. Compared with traditional oral drugs, nasal administration avoids first-pass metabolism and achieve faster and more effective efficacy. In this study, we used the ion crosslinking method to prepare quercetin–chitosan nasal adaptive nanomedicine (QCS) delivery system and evaluated in the treatment of allergic rhinitis mice models. The obtained positively charged nanoparticles with a particle size of 229.2 ± 0.2 nm have excellent characteristics in encapsulation efficiency (79.604%), drug loading rate (14.068%), drug release (673.068 μg) and stability(> 7 days). Excitingly, QCS treatment significantly reduced the number of sneezing and nasal rubbing events in AR mice, while reducing the levels of inflammatory factors such as immunoglobulin E (IgE), interleukin (IL)-17, tumor necrosis factor (TNF)-α, and (IL)-6 to alleviate AR symptoms. Hematoxylin–eosin (HE) staining also showed the damaged nasal mucosa was improved. These experimental results suggest that QCS can effectively suppress allergic inflammation in a mouse model and hold promise as a therapeutic option for allergic rhinitis.
研究领域:
药剂学
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免疫学
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生物医学工程
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PubMed
高影响因子
Bioactive Materials
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2024
·
IF 18
Zhenhua Huang,Dong Zhang,Laiqiang Tong,Fan Gao,Shaozan Zhang,Xinqing Wang,Yina Xie,Fangping Chen,Changsheng Liu
Hemostatic materials are essential for managing acute bleeding in medical settings. Chitosan (CS) shows promise in hemostasis but its underlying mechanism remains incompletely understood. We unexpectedly discovered that certain protonated-chitosan (PCS) rapidly assembled plasma proteins to form protein membrane (PM) upon contact with platelet-poor plasma (PPP). We hypothesized that the novel observation was intricately related to the procoagulant effect of chitosan. Herein, the study aimed to elucidate the conditions necessary and mechanism for PM formation, identify the proteins within the PM and PCS's procoagulant action at the molecule levels. We confirmed that the amount of –NH 3 + groups (>4.9 mmol/g) on PCS molecules played a crucial role in promoting coagulation. The –NH 3 + group interacted with blood's multiple active components to exert hemostatic effects: assembling plasma proteins including coagulation factors such as FII, FV, FX, activating blood cells and promoting the secretion of coagulation-related substances (FV, ADP, etc) by platelets. Notably, the hemostatic mechanism can be extended to protonated-chitosan derivatives like quaternized, alkylated, and catechol-chitosan. In the blood clotting index (BCI) experiment, compared to other groups, PCS95 achieved the lowest BCI value (∼6 %) within 30 s. Protonated-chitosan exhibited excellent biocompatibility and antibacterial properties, with PCS95 demonstrating inhibition effectiveness of over 95 % against Escherichia coli ( E.coil ) and Staphylococcus aureus ( S. aureus ). Moreover, PCS performed enhanced hemostatic effectiveness over chitosan-based commercially agents (Celox™ and ChitoGauze®XR) in diverse bleeding models. In particular, PCS95 reduced bleeding time by 70 % in rabbit models of coagulopathy. Overall, this study investigated the coagulation mechanism of materials at the molecular level, paving the way for innovative approaches in designing new hemostatic materials.
研究领域:
生物材料
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止血
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凝血
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生物医学工程
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药理学
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Zhiwei Wen,Shuiling Qin,Huajie Huang,Xingle Xia,Wei Zhang,Wei Wu
Anthracyclines belong to a class of anti-tumor antibiotics, and their severe cardiotoxicity significantly limits their clinical use. Exosomes play key roles in intercellular communication, characterized by high biocompatibility and specific tissue and organ homing effects. In this study, doxorubicin, an anthracycline anticancer drug widely used in clinical chemotherapy, was selected as a model drug. To address the significant cardiotoxicity associated with doxorubicin, tumor exosomes are utilized as drug carriers. The homing effect of autologous exosomes enhances drug uptake by tumor cells and reduces cardiotoxicity. To enhance the stability of exosomes, improve therapeutic effectiveness, and reduce toxic side effects, chitosan was utilized to modify the surface of exosomes. Chitosan has a specific anti-tumor effect because it can target the CD44 receptor of tumor stem cells and interact with tumor cells through charge adsorption. Through in vitro cell experiments, in vivo pharmacokinetic experiments, and an in situ ectopic nude mouse tumor model, the study demonstrated that chitosan-modified tumor exosomes significantly alleviated the severe cardiotoxicity of doxorubicin, while also showing remarkable anti-tumor efficacy. This study introduces a novel approach to reduce the adverse side effects of anthracycline chemotherapeutic drugs and presents a highly promising nanocarrier delivery system.
研究领域:
药理学
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肿瘤学
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纳米技术
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药物递送系统
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高影响因子
ACS Biomaterials Science & Engineering
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2024
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IF 5.4
Shasha Zhou,Jibing He,Quan Liu,Ting Chen,Xiangheng Guan,Haihan Gao,Jia Jiang,Jiaxing Wang,Xiaochun Peng,Jinglei Wu
Itaconic acid and its derivative 4-octyl itaconate (OI) represent a novel anti-inflammatory medication that has demonstrated efficacy in multiple inflammation models because of its minimal side effects. Recently, natural polymers conjugated with small molecule drugs, known as polymer-drug conjugates (PDCs), have emerged as a promising approach to sustained drug release. In this work, we reported an approach to prepare a PDC containing an OI and make it into an injectable hydrogel. Chitosan (CS) was selected for PDC synthesis because of its abundant free amino groups that can be conjugated with molecules containing carboxyl groups by carbodiimide chemistry. We used an ethanol/water cosolvent system to synthesize a CS-OI conjugate via EDC/NHS catalysis. The CS-OI conjugate had improved water solubility and unique anti-inflammatory activity and did not show compromised antibacterial activity compared with unmodified CS. Beta-glycerophosphate (β-GP) cross-linked CS-OI hydrogel exhibited good injectability with sustainable OI release and effectively modulated inflammatory response in a rat model. Therefore, this study provides valuable insights into the design of PDC hydrogels with inflammatory modulatory properties.
研究领域:
生物材料学
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药剂学
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炎症研究
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PubMed
高影响因子
ACS Applied Nano Materials
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2024
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IF 5.3
Huawei Zhuo,Yaoyao Chen,Hongtao Xie,Xueli Huang,Vitaliy P. Guro,Kamil Tadjiev,Yizhao Li
The significant accumulation of fly ash has resulted in serious environmental issues. It is imperative to find a safe and high-value method for reusing fly ash to effectively address this problem. Additionally, silica aerogels have gained attention as a promising material for energy conservation and thermal management. However, producing a silica aerogel with low production costs and superior overall properties is still a major challenge. In this study, silica–chitosan composite aerogels (SCA) were prepared from fly ash and chitosan. Amorphous silica is polymerized in situ on chitosan by hydrogen bonding and silyl-oxygen condensation. The resulting aerogels exhibited a fully formed block structure, extremely low density, exceptional flame retardancy, and notable mechanical properties (able to withstand 24,000 times the stress of its own mass). It is noteworthy that the nanopores and three-dimensional network structure endow SCA with excellent thermal insulation performance (with a thermal conductivity of 0.0474–0.0521 W m–1 K–1). The strategy presented here provides a cost-effective and straightforward approach to prepare SCA. The results demonstrate its considerable potential for practical use in energy-efficient and thermally insulated structures. Moreover, this approach offers a direct and high value-added solution to the problem of fly ash.
研究领域:
材料科学
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环境科学
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FOOD CHEMISTRY
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2024
·
IF 8.5
Bodan Luo,Simin Xuan,Xiaotong Wang,Keying Ding,Peng Jin,Yonghua Zheng,Zhengguo Wu
Chitosan is an ideal coating film for food preservation, but the performance of a single chitosan coating film is not good. Herein, the liposome was prepared by embedding copper nanoparticles (CuNPs) and thyme essential oil (TEO) in the hydrophilic and hydrophobic double-domain structure formed by phospholipids, and combining with chitosan to obtain a chitosan-based coating film for litchi preservation. The liposome was well-dispersed and stable with an average particle size of about 190 nm. The liposome showed excellent controllable release properties, and the cumulative release rate of TEO was 65.17 % and that of CuNPs was 15.17 % after 7 days. Furthermore, the oxygen and water vapor barrier properties of the coating film were greatly improved. Importantly, the film possessed effective antioxidant, antibacterial activity and excellent safety, which presents a better fresh-keeping effect on litchi. This study provides insights into the design and manufacture of food packaging for controllable and long-lasting preservation.
研究领域:
食品科学
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材料科学
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生物技术
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2016
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IF 3.858
Huanle Chen,Xiaorong Hu,Enmin Chen,Shan Wu,David Julian McClements,Shilin Liu,Bin Li,Yan Li
Natural aldehydes, such as cinnamaldehyde , can be used to modify the properties of chitosan-based materials by covalent cross-linking the chitosan molecules. Due to the non-polarity and hydrophobicity of cinnamaldehyde, emulsification technique was used to prepare homogeneous cinnamaldehyde-chitosan films. Under optimized conditions, cinnamaldehyde nanoemulsions led to the successful fabrication of uniform and smooth chitosan films. FTIR analysis of the films indicated the formation of chitosan-cinnamaldehyde Schiff base. The cross-linked films strongly absorbed UV–visible light and inhibited the emission of fluorescent light, and may therefore provide good photo-protection. The thickness (26–61 μm) and transparency (clear to turbid) of the chitosan films were modulated by varying the aldehyde/amino group ratio. The mechanical properties and water vapor permeability of the films also depended on the amount of cinnamaldehyde nanoemulsion utilized. Chitosan films showed good antimicrobial activity, but had better antifungal than antibacterial activity.
研究领域:
食品科学
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材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yi Li,Tian Tu,Shasha Zhou,Aixia Jiang,Jinglei Wu
Hydrogels with anti-inflammatory and antibacterial capacity have gained increasing attention in regenerative medicine. Dimethyl itaconate (DMI), a derivative of itaconic acid, exhibits powerful anti-inflammatory activity. Herein, we report a green synthesis of a chitosan-dimethyl itaconate (CS-DMI) conjugate through a nucleophilic substitution reaction, where primary amines of chitosan attack the ester carbonyl groups of DMI to form conjugation under mild alkaline conditions. The resulting conjugate was subsequently crosslinked with genipin into a hydrogel. Our findings indicate that this reaction fundamentally changed the nature of CS, converting it from acidic aqueous solution into a nearly neutral aqueous CS-DMI solution. It improved the efficiency of genipin crosslinking while maintaining the robust antibacterial activity of CS. The CS-DMI hydrogel showed sustained drug release of DMI and greater compression strength over the CS hydrogel. The CS-DMI conjugate showed good cytocompatibility, significantly promoted macrophage polarization toward an M2-like phenotype, reducing reactive oxygen species and nitric oxide production in lipopolysaccharide-stimulated macrophages. In a murine subcutaneous implantation model, the CS-DMI hydrogel significantly reduced immune cell infiltration, primarily by suppressing neutrophil recruitment and promoting a shift in macrophage polarization toward the pro-healing M2 phenotype. These findings confirm a viable strategy for developing multifunctional hydrogels that simultaneously address anti-inflammatory and antibacterial needs for modulating inflammation in regenerative medicine.
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高影响因子
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