查找使用阿拉丁产品的科研文献

Construction and biological effects of a redox-enzyme dual-responsive lufenuron nano-controlled release formulation

Qianwei Liang,Chaoqun Hou,Yifei Tan,Nuo Wei,Shaoyang Sun,Shengfu Zhang,Jianguo Feng

Background Pesticide formulations based on nanotechnology can effectively improve the efficiency of pesticide utilization and reduce pesticide residues in the environment. In this study, mesoporous silica nanoparticles containing disulfide bonds were synthesized by the sol–gel method, carboxylated and adsorbed with lufenuron, and grafted with cellulose to obtain a lufenuron-loaded nano-controlled release formulation (Luf@MSNs-ss-cellulose). Results The structure and properties of Luf@MSNs-ss-cellulose were characterized. The results showed that Luf@MSNs-ss-cellulose exhibits a regular spherical shape with 12.41% pesticide loading. The highest cumulative release rate (73.46%) of this pesticide-loaded nanoparticle was observed at 7 days in the environment of glutathione and cellulase, which shows redox-enzyme dual-responsive performance. As a result of cellulose grafting, Luf@MSNs-ss-cellulose had a small contact angle and high adhesion work on corn leaves, indicating good wetting and adhesion properties. After 14 days of spraying with 20 mg L −1 formulations in the long-term control efficacy experiment, the mortality of Luf@MSNs-ss-cellulose against Ostrinia furnacalis larvae (56.67%) was significantly higher than that of commercial Luf@EW (36.67%). Luf@MSNs-ss-cellulose is safer for earthworms and L02 cells. Conclusion The nano-controlled release formulation obtained in this study achieved intelligent pesticide delivery in time and space under the environmental stimulation of glutathione and cellulase, providing an effective method for the development of novel pesticide delivery systems. © 2023 Society of Chemical Industry.

Synthesis and Application of Modified Lignin Polyurea Binder for Manufacturing a Controlled-Release Potassium Fertilizer

Mingyang Li,Gaoyang E,Conghui Wang,Ruolin Shi,Junxi Wang,Shuo Wang,Yu Wang,Qi Chen,Zeli Li,Zhiguang Liu

Conventional potassium chloride granules have inefficient applications in agricultural production due to particle irregularity and low fluidity. The application of controlled-release potassium chloride could increase the potassium-use efficiency and alleviate the shortage of potassium ore resources. In this study, a well-rounded potassium chloride fertilizer core was prepared, using the graft modification of polyurea to enhance the coating rate and release performance. The adhesive and tensile characteristics of the modified polyurea binder, as well as the granule properties of modified polyurea binder potassium chloride, were studied to determine the ideal lignin-grafted ratio. The effect of the modified polyurea binder with potassium chloride on the properties of coated fertilizer was investigated. The findings, shown by radar maps of the binder’s properties, demonstrated that the ideal mass ratio of the modified lignin polyurea binder to urea is 1:2. The Fourier-transform infrared spectroscopy results demonstrated that the amino functional groups of lignin were enhanced, improving the product’s interfacial compatibility with the polyurea matrix. Compared to humic acid (HA; 12%) and bentonite (Ben; 30%) treatments, the granule intensity of the 9.9%—1:2 treatment considerably increased by 139.10% and 38.86%, respectively, while the static angle of the granules reduced by 16.67% and 3.81%. The 28-day cumulative release rate of the modified polyurea (9.9%—2:1) with a 5% coating thickness was the lowest (28%), 42% lower than that of the lowest conventional treatment. In summary, the creation of a bio-lignin polyurea binder under the optimum conditions reduced the need for petrochemical-based materials, allowed the preparation of fertilizer with granules of increased fluidity, and enabled the successful coating of a high-salt potassium fertilizer, offering a novel technique for the high-value application of potash fertilizer coating.Keywords:lignin;modified polyurea;binder;potassium chloride;controlled-release fertilizer

Preparation of a novel alginate hydrogel microspheres covered by hollow silica for controlled-release application

Xiang-Hua Ling,Man-Ke Zhang,Hao-Yu Zhou,Guo-Zhi Han

Sodium alginate hydrogel has been widely used in the field of controlled-release. In this paper, in order to prevent the negative effect of fast degradation and explosive release of pure sodium alginate hydrogel in the drug delivery process, we developed a novel alginate hydrogel supported by hollow silica microsphere for drug delivery. Briefly, the drugs were fused with sodium alginate and the hollow silica microspheres followed by ion crosslinking to form a composite hydrogel microsphere with a core–shell structure (SA@SiO 2 ). The structure and morphology of the composite hydrogel were characterized by Fourier infrared spectroscopy (FT-IR), thermogravimetric analysis (TG), scanning electron microscope (SEM), transmission electron microscope (TEM) along with fluorescence microscope. On this basis, using three different types of organic compounds (rhodamine B, Indocyanine green and salicylic acid) as model molecules, the controlled-release performance of the SA@SiO 2 microspheres were investigated in detail. The research results show that the drug delivery system has broad-spectrum controlled-release performance for different types of molecules, and the controlled-release time can exceed 40 h. At the same time, the pH- responsive property of the sodium alginate hydrogel endows the delivery system with a certain targeting function. This study provides a new strategy for constructing an efficient targeted drug controlled-release system.

Comparative study on temperature/pH sensitive xylan-based hydrogels: their properties and drug controlled release

Cundian Gao,Junli Ren,Weiqing Kong,Runcang Sun,Qifeng Chen

Temperature/pH dual-responsive hydrogels were prepared by the grafting copolymerization of xylan possessing different functional groups with N-isopropylacrylamide and acrylamide using N,N′-methylenebis-acrylamide as a cross-linker and 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator via ultraviolet irradiation. The influence of xylan and glycidyl methacrylate-modified xylan (GMAX) as the raw materials on the mechanical properties of hydrogels was comparatively investigated. Hydrogels were characterized by SEM, FTIR, TGA and XRD. The prepared hydrogels demonstrated a rapid phase transition temperature around 35 °C. The cumulative release rate of acetylsalicylic acid for xylan-based hydrogels and GMAX-based hydrogels reached to 77.5% and 84.2% in the intestinal fluid, respectively. GMAX-based hydrogels had a drug encapsulation efficiency of 95.21% and low drug release rate in gastric fluid. NIH3T3 cells in GMAX-based hydrogels had the high cell viability by MTT essay. Therefore, GMAX-based hydrogels had the good biocompatibility which make them promising in biomedical applications, especially as intestinal-targeted drug carriers.

Composite of Functional Mesoporous Silica and DNA: An Enzyme-Responsive Controlled Release Drug Carrier System

Guilong Zhang,Minglei Yang,Dongqing Cai,Kang Zheng,Xin Zhang,Lifang Wu,Zhengyan Wu

An efficient enzyme-responsive controlled release carrier system was successfully fabricated using single-stranded DNA encapsulated functional mesoporous silica nanoparticles. Mesoporous silica nanoparticles were initially fabricated through hydrolysis of tetraethyl orthosilicate (TEOS) in cetyltrimethylammonium chloride (CTAC) solution, and the surface of nanoparticles could be encapsulated with single-stranded DNA. This nanomaterial has excellent bioactivity and its hydrolysate cannot cause damage to normal cell, thus the biocompatibility of the nanomaterial is improved. In addition, this nanomaterial showed an excellent drug release performance when loaded with drugs, which would be helpful to increase the treatment efficiency and decrease side effects of drugs.

pH and hydrogen peroxide dual responsive supramolecular prodrug system for controlled release of bioactive molecules

Yin Wang,Haibo Wang,Yangjun Chen,Xiangsheng Liu,Qiao Jin,Jian Ji

Nowadays, cancer is one of the most fatal threatens to human health. By utilizing the differences of cell environment between cancer cells and their normal counterparts as assembly-disassembly triggers, various smart drug nanocarriers have been designed to fight the cancer. Nevertheless, most of them are still not robust enough. One important reason is that they merely focus on a single stimulus. Thus, in order to achieve a better therapeutic effect, constructing multi responsive polymers is of great significance. However, most of multi responsive polymers used, up until now, are mainly based on block polymers synthesized via traditional polymerization methods, which are relatively time-consuming and laborious. Here in this article, a facile strategy preparing smart polymers with dual responsiveness (endosomal pH and over produced H 2 O 2 ) was proposed and realized by orthogonal assembly of β-CD-hydrazone-DOX and PEG-Fc. The obtained polymers were found to be able to spontaneously assemble into micelles in water, indicating their potential applications as drug nanocarriers. In vitro study revealed that the release of the encapsulated DOX was significantly enhanced by both H 2 O 2 and low pH at 5.0. Furthermore, fluorescence microscopy and flow cytometry analysis showed that the assembled supramolecular prodrug micelles could be internalized into cancer cells. These properties suggested their promising application in cancer therapy.

Biodegradable depsipeptide–PDO–PEG-based block copolymer micelles as nanocarriers for controlled release of doxorubicin

Juan Lv,Li Zhang,Musammir Khan,Xiangkui Ren,Jintang Guo,Yakai Feng

Nowadays, biodegradable amphiphilic block copolymers with stable performance and adjustable structure have attracted the interests of researchers in the field of drug delivery. In this work, the triblock copolymer , P(SBMD- co -PDO)- b -PEG- b -P(SBMD- co -PDO), was successfully synthesized by ring-opening polymerization of 3(S)- sec -butyl-morpholine-2,5-dione (SBMD) and p -dioxanone (PDO) with poly(ethylene glycol) (PEG) as the initiator. In phosphate buffered solution (PBS), these copolymers could self-assemble into nano-sized micelles that have a hydrophobic P(SBMD- co -PDO) core surrounded by a hydrophilic PEG shell. Because of the strong hydrogen bonding and hydrophobic interactions, doxorubicin (DOX) was loaded into the micelles with high loading capacity (LC, up to 28.4%) and encapsulation efficiency (EE, up to 62.5%). The drug-loaded micelles showed sustained-release of DOX along with the hydrolytic degradation of the micelles in PBS. Therefore, these amphiphilic triblock copolymers have potential as drug matrix for controlled release.

Fluorescent polymeric assemblies as stimuli-responsive vehicles for drug controlled release and cell/tissue imaging

Ying Chang,Yang Li,Shirong Yu,Jie Mao,Cheng Liu,Qi Li,Conghui Yuan,Ning He,Weiang Luo,Lizong Dai

Polymer assemblies with good biocompatibility, stimuli-responsive properties and clinical imaging capability are desirable carriers for future biomedical applications. Herein, we report on the synthesis of a novel anthracenecarboxaldehyde-decorated poly(N-(4-aminophenyl) methacryl amide-oligoethyleneglycolmonomethylether methacrylate) (P(MAAPAC-MAAP-MAPEG)) copolymer, comprising fluorescent chromophore and acid-labile moiety. This copolymer can assemble into micelles in aqueous solution and shows a spherical shape with well-defined particle size and narrow particle size distribution. The pH-responsive property of the micelles has been evaluated by the change of particle size and the controlled release of guest molecules. The intrinsic fluorescence property endows the micelles with excellent cell/tissue imaging capability. Cell viability evaluation with human hepatocellular carcinoma BEL-7402 cells demonstrates that the micelles are nontoxic. The cellular uptake of the micelles indicates a time-dependent behavior. The H22-tumor bearing mice treated with the micelles clearly exhibits the tumor accumulation. These multi-functional nanocarriers may be of great interest in the application of drug delivery.

β-Cyclodextrin grafted polypyrrole magnetic nanocomposites toward the targeted delivery and controlled release of doxorubicin

Shasha Hong,Zengbo Li,Chenzhong Li,Chuan Dong,Shaomin Shuang

The Fe 3 O 4 @PPy-HA-β-CD nanocomposites as the novel nanocarrier were prepared by grafting ethylenediamine derivative of​ β-​CD to the surface of polypyrrole-coated magnetic nanoparticles (Fe 3 O 4 @PPy) via using hyaluronan (HA) as the intermediate linker. HA was also the efficient target ligand for CD44. The as-prepared drug carrier was characterized by TEM, TGA, XRD, and VSM and used for the delivery of doxorubicin hydrochloride (DOX) with the high loading content of 447   mg/g. The multilayer Freundlich isotherm model was found to be a good fit for the loading of the drug carrier for DOX. Significant NIR-triggered release of DOX was observed in a weak acidic pH. And the release data in vitro was well described using the Retiger-Pepper kinetic model. Furthermore, MTT assay and confocal microscopy against Hep-G2 cells clearly illustrated that the drug carrier had no associated cytotoxicity and could easily enter the cells. The release and accumulation of DOX were observed in the cell nuclei. Thus, the DOX-loaded drug carrier killed the cancer cells efficaciously and minimized adverse side effects due to its target effect. These results suggested the as-prepared drug carrier would be of great potential for the controlled release and targeted delivery of DOX.

Fabrication of High-Performance Magnetic Lysozyme-Imprinted Microsphere and Its NIR-Responsive Controlled Release Property

Jinxing Chen,Shan Lei,Yunyun Xie,Mozhen Wang,Jun Yang,Xuewu Ge

The preparation of efficient and practical biomacromolecules imprinted polymer materials is still a challenging task because of the spatial hindrance caused by the large size of template and target molecules in the imprinting and recognition process. Herein, we provided a novel pathway to coat a NIR-light responsive lysozyme-imprinted polydopamine (PDA) layer on a fibrous SiO2 (F-SiO2) microsphere grown up from a magnetic Fe3O4 core nanoparticle. The magnetic core–shell structured lysozyme-imprinted Fe3O4@F-SiO2@PDA microspheres (MIP-lysozyme) can be easily separated by a magnet and have a high saturation adsorption capacity of lysozyme of 700 mg/g within 30 min because of the high surface area of 570 m2/g and the mesopore size of 12 nm of the Fe3O4@F-SiO2 support. The MIP-lysozyme microspheres also show an excellent selective adsorption of lysozyme (IF > 4). The binding thermodynamic parameters studied by ITC proves that the lysozyme should be restricted by the well-defined 3D structure of MIP-lysozyme microspheres. The MIP-lysozyme can extract lysozyme efficiently from real egg white. Owing to the efficient NIR light photothermal effect of PDA layer, the MIP-lysozyme microspheres show the controlled release property triggered by NIR laser. The released lysozyme molecules still maintain good bioactivity, which can efficiently decompose E. coli. Therefore, this work provides a novel strategy to build practical NIR-light-responsive MIPs for the extraction and application of biomacromolecules.

Preparation of pH-sensitive zwitterionic nano micelles and drug controlled release for enhancing cellular uptake

Luyan Wu,Caihua Ni,Liping Zhang,Gang Shi

Ion-pairing design of covalent organic framework membranes for separation and controlled release of pharmaceuticals

Xingyuan Wang,Xiansong Shi,Zhe Zhang,Congcong Yin,Zhipeng Zhang,Yong Wang

Intrinsically charged covalent organic frameworks (COFs) afford specific ionic nanochannels for mass transport, and thus become promising platforms to design membranes with unique selectivity. However, internal electrostatic repulsion and large-pore frameworks cause significant barriers that greatly limit membrane performances. Herein, we report a novel strategy to synchronously crystallize and upgrade cationic COF membranes by ion-pairing design. Ion-paired guest molecules are involved in electric-driven interfacial crystallization to offset the charges of the ionic monomers and host frameworks. This host-guest neutralization promotes the crystallization of compact COF membranes. Lateral dimension and charge nature of guest molecules fundamentally affect the ion-pairing efficiency. Tight encapsulation of the large-sized electronegative molecules effectually narrows the molecular sieving channels, yielding a significant elevation in membrane selectivity. The membrane rejection of organic ions with a size larger than 1.2 nm thus can be improved from below 50 % to above 85 % with a water permeance of ∼10 L m −2  h −1 bar −1 . Prominently, our membranes demonstrate efficient recovery and pH-dependent release of bioactive pharmaceuticals, with a release rate that is 12 times higher in an acidic solution compared to a neutral environment. This work provides an ion-pairing strategy to regulate COF membranes for pharmaceutical industries and beyond.