Bioactive Materials
·
2023
·
IF 18.9
Jianqiu Yang,Zhenzhen Huang,Jiang Tan,Jingye Pan,Shixuan Chen,Wenbing Wan
Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel and antibacterial gallic acid/copper MOFs. The hybrid wound dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells and can stimulate fibroblast migration, endothelial angiogenesis, and M2 macrophage polarization. Additionally, the dressing can scavenge reactive oxygen species (ROS) and provide antioxidant effects. Furthermore, DPP + MOF@Gel effectively inhibits the viability of S. aureus and E. coli in vitro and in vivo. The histological observations revealed enhanced granulation tissue formation, re-epithelialization, and angiogenesis in the DPP + MOF@Gel group compared to other groups. The local immune response also shifted from a pro-inflammatory to a pro-regenerative status with DPP + MOF@Gel treatment. The skin incision stitching experiment further exhibits DPP + MOF@Gel could reduce scar formation during wound healing. Taken together, the hybrid DPP + MOF@Gel holds great promise for treating bacteria-infected skin wounds and inhibiting scar formation during wound healing.
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PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2023
·Vol. 63
·期 8
·2596-2612
·
IF 3.2
Chengde Liu,Wanting Du,Luyao Jiang,Yizheng Li,Cheng Liu,Xigao Jian
Medical devices and human implant materials carry a risk of bacterial infection. Biocompatible and adhesive antibacterial materials that prevent biofilm formation are commonly used to reduce the risk. Herein, a crosslinked chitosan/gelatin (CG) hybrid hydrogel with antibacterial and adhesive properties was developed by introducing berberine hydrochloride (BBR) and adhesive prepolymerized gallic acid (PGA) to the hydrogel. BBR self-assembles into nanoparticles and imparts AIE function to hydrogels by intermolecular electrostatic interactions and π–π stacking. The hydrogel was used as a stable carrier for BBR. The antibiofilm performance against Escherichia coli and Staphylococcus aureus after light exposure increased from 20% and 30% (CG hydrogel) to 74% and 85% (CGBBRPGA hydrogel), respectively. When used as a photodynamic agent, the hybrid hydrogel exhibited enhanced antibacterial and antibiofilm capabilities against both Gram-negative ( E. coli ) and Gram-positive ( S. aureus ) bacteria. The CGBBRPGA hydrogel showed strong adhesion to the surfaces of pig skin (9.2 kPa), glass (7.6 kPa), steel sheet (5.8 kPa), and PEEK sheet (5.5 kPa). Furthermore, it exhibits cell adhesion and shows negligible cytotoxicity, which indicates its cytocompatibility. Consequently, the fabricated hybrid hydrogel offers potential applications in biomedicine, particularly in wound dressing and surface modification of medical implants.
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Journal of Materials Research and Technology-JMR&T
·
2023
·
IF 6.4
Hongyuan Zhao,Meimei Guo,Fang Li,Yu Zhou,Gan Zhu,Yunhang Liu,Qiwen Ran,Fuquan Nie,Volodymyr Dubovyk
The efficient and accurate detection of gallic acid (GA) is particularly important for human health. Herein, a simple and low-cost ultrasonic-assisted strategy was proposed for the preparation of multifunctional nanocomposite of Super-P carbon black (SPCB) nanoparticles and mesoporous silica nanoparticles (MSNs), which was used to modify the glassy carbon electrode (GCE) for the fabrication of GA electrochemical sensor (SPCB@MSNs/GCE). SPCB with pearl-chain nanostructure presented an interconnected highly conductive carbon network, which significantly improved the charge transfer efficiency. MSNs with spherical morphology and mesoporous structure exhibited uniform particle dispersion and high active surface area, which remarkably improved the surface accumulation effect of sensing electrode towards GA. Moreover, the excellent electrical conductivity of SPCB compensated for the non-conductive property of MSNs. Under the optimized condition, the electrochemical response of SPCB@MSNs/GCE sensor had a good linear relationship with GA concentration (0.5–10 μM), and the corresponding limit of detection could reach up to 4.911 nM. The fabricated nanohybrid sensor showed good reproducibility, repeatability and anti-interference property. Moreover, the satisfactory GA recoveries and RSD values were achieved for the electrochemical detection of GA in tea samples. This work provides an important reference for the highly sensitive analysis of GA in the field of food safety.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Xiaorong Song,Zhihui Chai,Yuan Zhu,Chenglin Li,Xinquan Liang
The phenolic substances in sugar cane juice affect the color value of white sugar. A magnetic chitosan-modified-diatomite (MCMD), as a new type of clarifying agent for sugar, prepared via a co-precipitation method combined with cross-linking treatment was firstly used to adsorb two primary phenolic acids of sugarcane juice: gallic acid (GA) and caffeic acid (CA). The maximum adsorption capacities for GA and CA by MCMD were 31.949 mg g –1 and 27.640 mg g –1 , respectively. Additionally, our results showed that adsorption of GA and CA on MCMD fitted well with the pseudo-second-order model and Langmuir equation, respectively. The adsorption, a physical spontaneous endothermic process, might have involved electrostatic attraction and micropore filling. Importantly, MCMD has good regenerability and achieves better sulfur-free clarification of sugar cane juice and improves more significantly the food safety of white sugar than the traditional decolorization method.
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高影响因子
RSC Advances
·
2014
·Vol. 4
·期 44
·23036-23042
·
IF 3.708
Songqi Ma,Yanhua Jiang,Xiaoqing Liu,Libo Fan,Jin Zhu
The utilization of soybean oil-based UV coatings depends on the introduction of petroleum-based comonomers or crosslink agents. Thus, in this paper, a bio-based crosslink agent (GACA) for UV curable coatings was synthesized from gallic acid and its chemical structure was confirmed by FT IR, 1H NMR and 13C NMR. Crosslinked networks with high biobased content of more than 88% were obtained after co-photopolymerization between acrylated epoxidized soybean oil (AESO) and GACA. The thermal, mechanical and coating properties of these GACA crosslinked AESO networks were investigated and a commonly used crosslink agent triallyl isocyanurate (TAIC) was used as the control. GACA exhibited more functional groups and better copolymerization with AESO than TAIC, resulting in the higher gel content, crosslink density, tensile strength and modulus as well as much better coating properties (reflected by the higher pencil hardness, better wear resistance and adhesion) of GACA crosslinked AESO networks than TAIC crosslinked AESO networks. These results indicated that GACA exhibited great potential to replace petroleum-based crosslink agents such as TAIC, and high-performance soybean oil-based UV-cured coatings with high biobased content could be achieved after introducing GACA.
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Food Packaging and Shelf Life
·
2024
·
IF 8.5
Jing Yi,Shuqi Zhang,Xuanxuan Yuan,Zhilong Zhang,Zhongguo Shan,Haihua Wang
The increasing emphasis on food quality and consumer safety has prompted researchers to explore green manufacturing techniques for packaging materials. In this study, γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) were prepared as promising nanocarriers for gallic acid (GA) and silver nanoparticles (Ag NPs). These nanocarriers (GA-Ag@CD-MOFs) were further incorporated into a zein matrix to fabricate multifunctional composite films, referred to as MOFs-Zein. Scanning electron microscopy (SEM) and atomic force microscope (AFM) analysis indicated that the fabricated composite film exhibited excellent biocompatibility, with GA-Ag@CD-MOFs uniformly dispersed within the film matrix. Fourier transform infrared spectroscopy (FT-IR) result revealed that the incorporation of GA-Ag@CD-MOFs facilitated the formation of intermolecular hydrogen bonds with the matrix polymer. The addition of GA-Ag@CD-MOFs enhanced the tensile strength of the composite film by 19.70 %, improved the water barrier performance by 57.76 %, and provided almost 100 % UV protection. The exceptional controlled release capability of γ-CD-MOFs for GA empowered the composite films to maintain their robust initial antioxidant capacity even after 100 days of storage. Moreover, the composite films performed high-efficiency antibacterial activity against Escherichia coli O157:H7 and Salmonella enterica . Acute toxicological studies showed no histopathology related toxicity was found in GA-Ag@CD-MOFs treated mice. When applied to fresh pork, the composite films significantly reduced the key quality indicators of raw meat, compared to the control film. Overall, this work presents a promising approach to fabricate the composite films as a sustainable and functional solution for green functional food packaging.
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Foods
·
2025
·Vol. 14
·期 18
·3209
·
IF 5.1
Fuchao Zhan,Jing Li,Bin Li
The interfacial and foam properties of proteins can be enhanced by altering the interactions between polyphenols and proteins. The aim of this study was to determine the influence of gallic acid (GA) on the structural properties of whey protein isolate (WPI), specifically focusing on particle size, potential, and surface hydrophobicity, as well as the subsequent alterations in its interfacial and foam properties when utilized as a foaming agent. An increase in turbidity and a decrease in particle size suggested the formation of a soluble complex between GA and WPI at a pH of 6. The results from fluorescence spectroscopy and surface hydrophobicity analyses indicated that the primary interactions between GA and WPI are characterized by hydrogen bonding and hydrophobic interactions. The reduction in particle size enhances the capacity of WPI/GA complexes to lower the surface pressure, thereby demonstrating significant efficacy at the macroscopic scale. Furthermore, the structural connectivity of GA facilitates the formation of a stable interfacial film at the air–water interface by WPI/GA, resulting in high foam stability at a macroscopic level. This research contributes to a deeper understanding of the application of protein–polyphenol complexes as surfactants and provides theoretical support for their use in food applications.
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高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Bo Zhou,Chen Zhang,Sheng Dai,Jin Zhao,Huaiyu Li,Yanbin Peng,Yunfeng Chu,Zhong Chen,Haotian Qin,Hui Zeng
Background: Chronic diabetic wounds remain a major clinical challenge due to persistent ischemia, oxidative stress, and impaired angiogenesis. Injectable hydrogels capable of adapting to irregular wound beds and delivering bioactive cues offer promising therapeutic potential for enhancing tissue regeneration.Methods: We developed a multifunctional injectable hydrogel by incorporating cinnamaldehyde-loaded ZIF-8 nanoparticles (CA@ZIF-8) into a gallic acid–grafted gelatin (GGA) matrix, followed by transglutaminase-mediated crosslinking. The physicochemical characteristics, drug release behavior, and mechanical performance of the CA@ZIF-8/GGA hydrogel were systematically evaluated. In vitro assays using human umbilical vein endothelial cells (HUVECs) were conducted to assess cytocompatibility and angiogenic activity. A full-thickness skin wound model in streptozotocin-induced diabetic rats was employed to evaluate in vivo wound healing efficacy and biocompatibility.Results: The CA@ZIF-8/GGA hydrogel exhibited favorable injectability, enhanced mechanical strength, and sustained release of both cinnamaldehyde and Zn2+. In vitro, the hydrogel significantly promoted HUVEC proliferation, migration, and tube formation, accompanied by upregulated expression of CD31 and VEGF. In vivo, CA(0.6)@ZIF-8/GGA-treated wounds demonstrated accelerated closure, enhanced granulation tissue formation, increased neovascularization, and re-epithelialization compared with control groups. No histological abnormalities were observed in major organs, indicating good systemic biocompatibility.Conclusion: This study presents an injectable CA@ZIF-8/GGA composite hydrogel that effectively promotes angiogenesis and diabetic wound regeneration. The synergistic integration of MOF-based controlled release and polyphenol-enhanced bioactivity highlights its potential as a clinically translatable platform for chronic wound management.
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ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Shunying Li,Yuanhao Zhou,Qiangqiang Xu,Haoxiang Chen,Shengpeng Shi,Ruobing Jia,Yingying Zhang,Hong Ye
Phthalate esters (PAEs) are plasticizers widely used in the industry and easily released into the environment, posing a serious threat to human health. Molecularly imprinted polymers (MIPs) are important as selective adsorbents for the removal of PAEs. In this study, three kinds of mussel-inspired MIPs for the removal of PAEs were first prepared with gallic acid (GA), hexanediamine (HD), tannic acid (TA), and dopamine (DA) under mild conditions. The adsorption results showed that the MIP with low cost derived from GA and HD (GAHD-MIP) obtained the highest adsorption capacity among these materials. Furthermore, 97.43% of equilibrium capacity could be reached within the first 5 min of adsorption. Especially, the dummy template of diallyl phthalate (DAP) with low toxicity was observed to be more suitable to prepare MIPs than dibutyl phthalate (DBP), although DBP was the target of adsorption. The adsorption process was in accordance with the pseudo-second-order kinetics model. In the isotherm analysis, the adsorption behavior agreed with the Freundlich model. Additionally, the material maintained high adsorption performance after 7 cycles of regeneration tests. The GAHD-MIP adsorbents in this study, with low cost, rapid adsorption equilibrium, green raw materials, and low toxicity dummy template, provide a valuable reference for the design and development of new MIPs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yu Wang,Shengjun Han,Zongwei Hao,Zongyan Gu,Chao Li,Zongjun Wu,Zhongyun Zhao,Yaqing Xiao,Yingnan Liu,Kang Liu,Mingming Zheng,Yiqun Du,Yibin Zhou,Zhenyu Yu
This study aimed to investigate the multiscale structure, physicochemical properties, and in vitro digestibility of black rice starch (BRS) and gallic acid (GA) complexes prepared using varying ultrasound powers. The findings revealed that ultrasonic treatment disrupted BRS granules while enhancing the composite degree with GA. The starch granules enlarged and aggregated into complexes with uneven surfaces. Moreover, the crystallinity of the BRS-GA complexes increased to 22.73 % and formed V6-I-type complexes through non-covalent bonds. The increased short-range ordering of the complexes and nuclear magnetic resonance hydrogen ( 1 H NMR) further indicated that the BRS and GA molecules interacted mainly through non-covalent bonds such as hydrogen bonds. Additionally, ultrasound reduced the viscoelasticity of the complexes while minimizing the mass loss of the complexes at the same temperature. In vitro digestion results demonstrated an increase in resistant starch content up to 37.60 % for the BRS-GA complexes. Therefore, ultrasound contributes to the formation of V-typed complexes of BRS and GA, which proves the feasibility of using ultrasound alone for the preparation of starch and polyphenol complexes while providing a basis for the multiscale structure and digestibility of polyphenol and starch complexes.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haide Dong,Danyang Wang,Yuzhu Liu,Lijuan Yin,Xiongying Wang,Yu Lu,Li Liu,Huan Zhang,Quanfu Deng,Weihu Yang,Kaiyong Cai
Dentin hypersensitivity and dental caries are prevalent symptoms and diseases in the oral cavity that markedly affect quality of life. The etiology of these conditions is directly or indirectly associated with the process of dentin demineralization and exposure. It is therefore imperative to identify an effective method for mineralizing demineralized dentin and sealing exposed dentin tubules. This study examines the potential of gallic acid, a polyphenol with a strong affinity for type I collagen, as a building block for calcium phosphate nanoclusters, with varying ratios of gallic acid to calcium. The objective is to utilize gallic acid as a linker to facilitate the docking, deposition, and mineralization of calcium phosphate nanoclusters and type I collagen. The study revealed that when the ratio of calcium to gallic acid was 0.05, calcium phosphate nanoclusters with an approximate particle size of 11.62 nm were formed. The nanoclusters were observed to effectively mineralize the intrafibrillar and interfibrillar spaces of type I collagen fibers, as well as the dentin itself. Following the mineralization treatment, the mechanical properties of the demineralized dentin were restored, and the depth of dentin tubule occlusion of 46.84 ± 12.83 μm, significantly reducing the permeability of dentin. This strategy demonstrates potential for clinical applications in the restoration of demineralized dentin and the treatment of dentin hypersensitivity.
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高影响因子
CELLULOSE
·
2026
·
IF 4.8
Gu Chang-Chun,Han Zhen-Yu,Cao Meng-Nan,Xia Ya-Mu,Gao Wei-Wei
In this study, we formulated a series of multifunctional hydrogels, namely Ga 3+ -GA-CMCS-Oin hydrogels (GGCO), leveraging Schiff base reactions and metal-polyphenol coordination. These GGCO hydrogels were synthesized using oxidized inulin (Oin) and gallic acid-modified carboxymethyl chitosan (GA-CMCS) as key bio-based components, and the crosslinking was achieved through Schiff base bonds between Oin’s aldehyde groups and GA-CMCS’s amino groups, eliminating the need for additional crosslinking agents. Moreover, the phenolic hydroxy groups on GA formed metal-polyphenol coordination bonds with Ga 3 ⁺, endowing the hydrogels with potent antibacterial properties and photothermal conversion capabilities. GGCO hydrogels demonstrated exceptional multifunctionality, including superior self-healing, strong adhesion, pH sensitivity, biodegradability, and antioxidant activity. Antibacterial assessments highlighted GGCO’s photothermal antibacterial efficacy, reaching a sterilization rate as high as 99.7%. In a mouse infectious wound model, GGCO hydrogels effectively eradicated bacteria, mitigated inflammatory responses, and accelerated wound healing. Histological analysis further underscored the potential of these multifunctional GGCO hydrogels for advanced wound care solutions.
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