Materials Today Bio
·
2025
·
IF 10.2
Zijuan Qi,Yuanliang Yan,Zhijie Xu,Wei Chong,Yuchen Qiu,Xiaofeng Huang,Jiajun Jing,Huancai Fan,Qiuju Liang,Sijin Liu,Li Yan,Leping Li,Ming Gao
Two-dimensional sheet-like nanomaterial molybdenum disulfide (MoS 2 ) has extensive potential applications in the biomedical field. Nevertheless, upon entering the body, MoS 2 tends to accumulate markedly in the liver, drawing increasing attention to its potential hepatotoxicity. In this study, we demonstrated that MoS 2 nanosheets exerted cytotoxic effects on the liver both in vitro and in vivo . Further exploration of the toxicity mechanism, utilizing genome-wide CRISPR-Cas9 screening and molecular biological techniques, uncovered that MST2 protein is crucial in mediating MoS 2 -induced cytotoxicity. Moreover, protein mass spectrometry and molecular dynamics simulation results indicated that MoS 2 directly binds to MST2 protein, thereby promoting its phosphorylation and activation. Subsequently, phosphorylated MST2 protein activates the Hippo signaling pathway, which in turn suppresses liver cell proliferation. Our in vivo experiments revealed that MST2 is indispensable for MoS 2 -induced impairment of liver regeneration in mice and disordered liver development in zebrafish. Meanwhile, the MoS 2 /MST2 axis was to found induce hepatocyte death via activation of autophagy dependent on LC3 protein. Collectively, this study provides a foundation for a comprehensive understanding of the biological behavior and hepatotoxicity of MoS 2 , offering valuable insights for the safety assessment of nanomaterials and the rational design of future nanomedicines.
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2022
·
IF 3.318
Zong-Qin Ma,Ying-Hui Wang,Yuan Peng,Xin Guo,Zhe Meng
In this paper, we developed a facile route for the preparation of a novel bimetal oxide affinity chromatography (MOAC) material. The TiO 2 /ZrO 2 @MoS 2 was constructed by the electrostatic interaction between titanium oxide/zirconia ( w : w , 10:1) and molybdenum disulfide nanosheet. The nanocomposite has the large specific surface area (186.30 m 2 ⋅g −1 ) and pore volume (0.37 cm 3 ⋅g −1 ). Compared with single-metal probes, the combination of bimetallic oxides probe (TiO 2 /ZrO 2 ) and hydrophilicity MoS 2 support offered multitudinous affinity sites for phosphopeptides capturing from tryptic digests of protein samples under 50% acetonitrile-1% trifluoroacetate conditions. Singnificant feasibility of the TiO 2 /ZrO 2 @MoS 2 nanomaterial for the enrichment of phosphopeptides under optimal conditions was proved via the bovine serum albumin (BSA) and the mixtures of β-casein. The phosphopeptide expression was identified using ultra-performance liquid chromatography (uHPLC) separation and-linear ion trap mass spectrometry (MS n ). With these affinity characters of TiO 2 /ZrO 2 @MoS 2 , it exhibited higher binding capacity (25 mg⋅g −1 ), better selectivity for phosphopeptides from β-casein/BSA (1:2000) tryptic digests, high sensitivity (1 fmol⋅µL −1 ) towards phosphopeptides from β-casein tryptic digests, and great reusability of 8 cycles test for capturing phosphopeptides. In addition, the TiO 2 /ZrO 2 @MoS 2 with high sensitivity and selectivity was successfully applied to enriching phosphopeptides from nonfat milk and human serum samples. More importantly, the TiO 2 /ZrO 2 @MoS 2 was further successfully applied to multi-phosphopeptides enrichment, 1779 serine, threonine and tyrosine phosphosites can be identified in A549 cell protein tryptic digest. Compared with commercial TiO 2 from enrichening 416 phosphopeptide from A549 cell lysates, the successful locating of 44 phosphosites were overlapped.
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Journal of Magnesium and Alloys
·
2021
·
IF 10.088
Shibo Chen,Changqing Yin,Yi Wang,Shuang Yi,Xiang Gao,Xujuan Zhang,Qiyu Liao,Yuxin Zhang,Xia Zhao,Jinsong Rao,Baorong Hou
Epoxy resin powder coating has been successfully applied on the corrosion protection of magnesium lithium alloys. However, poor wear resistance and microcracks formed during the solidification have limited it extensive application. There are limited approaches to exploit such anti-corrosion and mechanical properties of magnesium lithium alloys. Herein, the epoxy resin powder coating with polydopamine modified molybdenum disulfide (MoS 2 @PDA-EP powder coating with 0, 0.1, 0.2, 0.5, 1.0 wt.% loading) was well prepared by melt extrusion to investigate its anticorrosion performance and wear resistance. The results revealed that the addition of MoS 2 @PDA enhanced the adhesion strength between coatings and alloys, wear resistance and corrosion protection of the powder coatings. Among them, the optimum was obtained by 0.2 wt.% MoS 2 @PDA-EP powder coating which could be attributed to well dispersion and efficient adhesion with coating matrix. To conclude, MoS 2 @PDA-EP powder coating is meaningfully beneficial for the anticorrosive and wear performance improvement of magnesium lithium alloys.
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Food Analytical Methods
·
2020
·Vol. 13
·期 3
·811-822
·
IF 2.667
Cheng Fuliang,Liao Xiaoning,Huang Zhiwen,Xu Liting,Zhou Ying,Zhang Xue
Thiabendazole (TBZ), a widely used agricultural antifungal, has been evidenced to pose serious threat to human health. However, highly sensitive detection of it in food samples is difficult owing to the complexity of food matrix. Herein, an electrochemical sensor, based on multiwall carbon nanotubes (MWCNTs) decorated two-dimensional layered molybdenum disulfide (MoS 2 ), was firstly developed for rapid detection of TBZ using square wave voltammetry method. It is demonstrated that the modification of MoS 2 with MWCNTs enhances the catalytic performance to TBZ oxidation. Under optimized conditions, the electrochemical sensor shows admirable linearity range, high selectivity and low detection limit. In pear, water spinach and tap water sample analyses, satisfactory recoveries from 92.83 to 101.92% with coefficients of variation less than 5% were obtained, showing high consistence with the HPLC results. This work puts forward a rapid and reliable method for the highly sensitive screening of the residues of TBZ in food resource.
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Small
·
2023
·Vol. 19
·期 37
·2301085
·
IF 13.3
Guo Liu,Qi Zeng,Xinyi Sui,Shuhao Tian,Xiao Sun,Qingfeng Wu,Xijuan Li,Yuhao Zhang,Kun Tao,Erqing Xie,Zhenxing Zhang
Polysulfide shuttle effect and sluggish sulfur reaction kinetics severely impede the cycling stability and sulfur utilization of lithium-sulfur (Li-S) batteries. Modulating d-band electronic structures of molybdenum disulfide electrocatalysts via p/n doping is promising to boost polysulfide conversion and suppress polysulfide migration in lithium-sulfur batteries. Herein, p-type V-doped MoS 2 (V-MoS 2 ) and n-type Mn-doped MoS 2 (Mn-MoS 2 ) catalysts are well-designed. Experimental results and theoretical analyses reveal that both of them significantly increase the binding energy of polysulfides on the catalysts’ surface and accelerate the sluggish conversion kinetics of sulfur species. Particularly, the p-type V-MoS 2 catalyst exhibits a more obvious bidirectional catalytic effect. Electronic structure analysis further demonstrates that the superior anchoring and electrocatalytic activities are originated from the upward shift of the d-band center and the optimized electronic structure induced by duplex metal coupling. As a result, the Li-S batteries with V-MoS 2 modified separator exhibit a high initial capacity of 1607.2 mAh g −1 at 0.2 C and excellent rate and cycling performance. Moreover, even at a high sulfur loading of 6.84 mg cm −2 , a favorable initial areal capacity of 8.98 mAh cm −2 is achieved at 0.1 C. This work may bring widespread attention to atomic engineering in catalyst design for high-performance Li-S batteries.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Honglei Shuai,Renzhi Liu,Wenxuan Li,Xiaojian Yang,Hui Lu,Yongping Gao,Jing Xu,Kejing Huang
Layered molybdenum disulfide (MoS 2 ) shows tremendous prospect as cathode material for aqueous zinc-ion batteries (AZIBs) due to the two-dimensional zinc ions (Zn 2+ ) diffusion channels and tunable interlayer spacing. However, it is subjected to sluggish insertion/extraction kinetics, inferior electronic conductivity and inadequate active capacities. Herein, a three-dimensional (3D) interconnected MoS 2 /multi-walled carbon nanotubes (MWCNTs) framework is proposed to address these issues. Importantly, the MWCNTs cores offer interconnection routes for fast electrons and zinc ions transport, the expanded spacing of MoS 2 interlayer with 1.05 nm can facilitate rapid Zn 2+ intercalation/extraction, and the confined MoS 2 layers in inner MWCNTs can mitigate the agglomeration and restacking of MoS 2 nanosheets. Benefitting from the confined structural configuration, sufficient active surface and 3D structural stability, the MoS 2 /MWCNTs as AZIBs cathode delivers a large initial reversible capacity of 218.3 mAh/g and high coulombic efficiency of 78.2 % at 0.1 A/g. Additionally, the 3D interconnected cathode maintains nearly intact structure after a fierce galvanostatic charge/discharge process, resulting in large retained capacities of 126.3 mAh/g at 1 A/g after 650 cycles and 101.1 mAh/g at 3 A/g after 1000 cycles. This work offers a novel strategy for the structure design of two-dimensional materials to develop high-performance cathodes for AZIBs.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 40
·6391-6398
·
IF 4.776
Yiming Yu,Bin Chi,Leping Lin,Zhe Yang,Qianyuan He,Zushun Xu,Changfeng Yi,Jing Wang
Magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) has recently attracted tremendous attention. In this study, a paramagnetic zwitterionic amphiphilic copolymer (PZAC) was successfully prepared and utilized as a multifunctional surfactant to form micelles in diethylene glycol to coordinate with a molybdenum disulfide precursor (MoS2). Uniform spherical MoS2 nanohybrids (MoS2@PZAC) were first prepared by a microwave-assisted solvothermal process, which is simpler, easier and more efficient than hydrothermal methods or exfoliation processes. In this nanoplatform, MoS2 serves as a phototherapeutic agent possessing a high photothermal conversion efficiency (33.8%), while PZAC acts as a T1-weighted MRI contrast agent. This nanoplatform has the advantages of ultralow toxicity, prolonged circulation time and bio-imaging guided capability. The cytotoxicity assessment showed the good cytocompatibility of MoS2@PZAC. Furthermore, MoS2@PZAC could effectively kill cancer cells upon 2 W cm−2 808 nm laser irradiation for 10 min in both in vitro and in vivo experiments. This work provides a novel and efficient solution to synthesize a multifunctional and uniform theranostic agent, and the results show that the as-prepared MoS2@PZAC can be used as a promising theranostic agent for T1-weighted MRI-guided PTT of cancer cells.
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MICROCHIMICA ACTA
·
2016
·Vol. 183
·期 8
·2481-2489
·
IF 4.831
Lu Yuan,Yu Jing,Ye Weichun,Yao Xin,Zhou Panpan,Zhang Haixia,Zhao Suqin,Jia Lipei
The authors describe a colorimetric method for the determination of Hg(II) ions by exploiting the peroxidase-lile activity of few-layered MoS 2 nanosheets (MoS2-NSs). These were prepared by sonication-induced exfoliation of bulk MoS 2 crystals in aqueous surfactant solution. The MoS2-NSs were found to acts as a peroxidase mimic that is capable of oxidizing the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2) to give a blue product with an absorption maximum at 652 nm. The addition of Hg(II) strongly accelerates the kinetics of this reaction. It is shown that the enzyme mimic possesses a high affinity for TMB and a lower pseudo-Michaelis-Menten constant. The stimulating effect of Hg(II) is seriously influenced by the change of surface charge. The use of nanosheets covered with (negatively charged) polystyrene sulfonate results in a decrease in the formation of blue dye, while those covered with (cationic) poly(diallyldimethyl ammonium) ions cause a small increase. Under optimal conditions, the peroxidase-like activity of MoS2-NSs is affected by Hg(II) in the 2.0 to 200 μM concentration range. The method has a detection limit (LOD) of 0.5 μM which is much below the allowed level in cosmetics (1 ppm; ca. 5 μM). The method display excellent sensitivity, selectivity and stability. It was applied to the determination of total mercury in cosmetic samples, and results compared well with results obtained by ICP-AES.
A spectrophotometric assay for mercury - (II) determination is reported that is based on Hg 2+ -stimulation effect on the 3,3′,5,5′-tetramethylbenzidine (TMB)-H 2 O 2 reaction system catalyzed by MoS 2 nanosheets.
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CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Shanshan Tong,Hongxia Deng,Lin Wang,Tao Huang,Shuhui Liu,Jinyi Wang
Molybdenum disulfide-based 2D nanomaterials have become an attractive target for investigations in various fields. However, their potential application in the important area of environmental science has not yet been effectively explored. In this work, ultrathin molybdenum disulfide nanosheets decorated with cerium oxide nanoparticles (MoS 2 /CeO 2 ) nanohybrids were synthesized using a two-step hydrothermal reaction and used to remove Pb 2+ as a representative heavy metal ion. A detailed characterization, including transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectrum, X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA), confirmed the formation of the MoS 2 /CeO 2 nanohybrids. Furthermore, different factors affecting the sorption process, such as pH, adsorbent amount, contact time, ion strength, and reusability, were studied in detail. The adsorption kinetic data were described well with the pseudo-second-order model, and the equilibrium data were fitted well to Langmuir isotherms. The as-prepared nanohybrids exhibited a high uptake ability (333 mg g −1 at pH 2.0) and excellent reusability. More importantly, hybrid materials showed preferential Pb 2+ uptake behaviour compared to other heavy metal ions such as Cd 2+ (3.24 mg g −1 ), Cu 2+ (5.3 mg g −1 ), Zn 2+ (3 mg g −1 ), Co 2+ (1.8 mg g −1 ), Ni 2+ (1.3 mg g −1 ), Mn 2+ (2.1 mg g −1 ), and Cr 3+ (1.76 mg g −1 ). The adsorption mechanism may be attributed to the intrinsically sulfur-rich characteristic, the strong soft-soft interactions between S atoms and Pb atoms, the interlayer spacing capture, and weak ion-exchange interaction. These findings open the possibility of expanding the applications of transition metal dichalcogenide-based materials in the environmental sciences.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Suling Huang,Dan Jia,Wengang Hu,Shengpeng Zhan,Tian Yang,Wulin Zhang,Bingwen Lu,Haitao Duan
Polyether ether ketone (PEEK) exhibits exceptional thermal stability but faces limitations in mechanical and tribological performance under harsh environments. This study introduces MoS 2 /MWCNTs hybrid nanomaterials with controlled morphologies (nanoflowers vs. nanotubes) and varying mass ratios to synergistically enhance both friction reduction and mechanical robustness of PEEK composites. Through a one-step hydrothermal synthesis and hot-pressing technique, the MoS 2 nanotubes/MWCNTs hybrid (MMT-5) demonstrated optimal performance, achieving a 23.73 % reduction in friction coefficient (0.225) and an 88.95 % decrease in wear rate compared to pure PEEK. Notably, MMT-5 exhibited a 23.77 % increase in compressive strength (184.79 MPa) and a 5.36 % improvement in Shore hardness (90.08 HD), attributed to the synergistic effect of MWCNTs' 3D network and MoS 2 's lubricating properties. In anhydrous ethanol, MMT-5 achieved an ultra-low friction coefficient of 0.029 and wear rate of 9.06 × 10 −6 mm 3 /(N·m), driven by ethanol-mediated lubrication and graphitized transfer films. These results highlight the critical role of nanomaterial morphology and hybrid ratio in balancing tribological efficiency, mechanical strength, and thermal properties, offering a sustainable pathway for high-performance PEEK composites in aerospace, marine engineering, and heavy-load applications.
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Analytical Methods
·
2018
·Vol. 11
·期 2
·157-162
·
IF 2.073
Jimin Yang,Xuesong Yin,Wei Zhang
In our study, we report the development of molybdenum disulfide (MoS2) nanosheet-supported poly(indole-6-carboxylic acid) (PIn6COOH) and its usage for the electrochemical determination of circulating tumor DNA (ctDNA) such as PIK3CA gene associated with breast cancer. The MoS2 nanosheets prepared by the solvent exfoliation method from commercial bulk MoS2 were first immobilized on the surface of a carbon paste electrode; then, PIn6COOH, a novel electroactive material, was electropolymerized on the MoS2 substrate by the potentiostatic method to form a unique nanocomposite structure. The physical adsorption between aromatic In6COOH monomers and MoS2 efficiently improved the electropolymerization efficiency, resulting in increased electrochemical response of PIn6COOH. Owing to the presence of abundant carboxyl groups, probe ssDNA was covalently immobilized on the carboxyl-terminated PIn6COOH/MoS2 nanocomposite through free amines of DNA sequences based on 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydrosulfosuccinimide crosslinking reaction. The covalently immobilized probe ssDNA could selectively hybridize with its target DNA to form dsDNA on the surface of the PIn6COOH/MoS2 nanocomposite. The self-signal changes of PIn6COOH induced by DNA immobilization and hybridization could be sensitively recognized via cyclic voltammetry and electrochemical impedance spectroscopy. This developed biosensor showed high performance of DNA hybridization with a detection limit of 1.5 × 10−17 mol L−1 for the detection of PIK3CA gene. The easy construction of this biosensor besides its fine sensitivity and very low time consumption can make this PIn6COOH/MoS2 nanocomposite very highly competitive for further applications in carcinoma diagnostic and therapeutic fields.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Yanli Zhang,Meng Chen,Haiyan Li,Fuqing Yan,Pengfei Pang,Hongbin Wang,Zhan Wu,Wenrong Yang
A sensitive electrochemical immunosensor based on a molybdenum disulfide (MoS 2 ) and gold nanorods (AuNRs) composite was developed for the detection of microcystin-LR (MC-LR). The immunosensor was constructed by immobilizing MC-LR antibody on the MoS 2 /AuNRs nanocomposite modified gold electrode. Using a competitive immunoassay format, the coated MC-LR antibody competed for MC-LR antigen with added target MC-LR, forming an antibody-antigen immunocomplex. Subsequently, horseradish peroxidase-labeled anti-MC-LR antibody (HRP-Ab 2 ) was captured and detected. Under optimal conditions, the immunosensor exhibited a linear response to MC-LR ranging from 0.01 to 20 μg L −1 with a detection limit of 5 ng L −1 at a signal to noise of 3. This electrochemical immunosensor showed good performance with high sensitivity, good stability, accepted reusability and promising applications in routine water quality monitoring for various toxins.
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