ACS Applied Nano Materials
·
2024
·
IF 5.3
Qiuping Yang,Haixia Kong,Liwei Tang,Yanyun Ma,Feng Liu,Maochang Liu,Yi Wang,Pu Zhang,Yiqun Zheng
Metal nanoparticles have been found to exhibit a broad spectrum of antibacterial activities, yet not all metals possess the captivating plasmonic properties necessary for effective interaction with incident light. In this study, we demonstrate the feasibility of synergistically enhancing the Cu-induced antibacterial activity through the incorporation of plasmonic photothermal therapy by hybridlike anchoring the Cu component on a gold (Au) nanoplate that can effectively absorb near-infrared light. To fabricate the Janus structure, plate-like Au seeds were mixed with copper(ii) nitrate, cetyltrimethylammonium bromide, ascorbic acid, and hexamethylenetetramine, resulting in the formation of Au–Cu Janus nanostructures (JNSs). Notably, the plasmonic absorption of Au was preserved without being hindered by the Cu coating. Photothermal measurements revealed that the temperature rise of Au–Cu JNSs aqueous suspensions could reach up to 28.3 °C in just 10 min when exposed to 1064 nm laser light at a power density of 1 W·cm–2, with a photothermal conversion efficiency of 42.14%. Additionally, they show broad-spectrum antibacterial properties, making them potential contenders for addressing a wide range of bacterial infections. Our findings demonstrate that the antibacterial performance of metal nanoparticles composed of less plasmon-active components but with exceptional antibacterial properties can be significantly enhanced by coupling them with a plasmon-active nano-antenna through a Janus architecture. The Au–Cu JNSs possess potential application prospects in photothermal therapy, broad-spectrum antibacterial treatments, biomedical imaging, targeted drug delivery, sensitive diagnostics, and the development of advanced materials.
研究领域:
纳米医学
·
生物材料学
·
抗菌研究
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Kangli Xue,Rui Yang,Yanli An,Yinan Ding,Su Li,Fengqin Miao,Dongfang Liu,Daozhen Chen,Qiusha Tang
Ferroptosis, a unique iron-dependent mode of cell death characterized by lipid peroxide accumulation, holds significant potential for the treatment of glioblastoma (GBM). However, the effectiveness of ferroptosis is hindered by the limited intracellular ferrous ions (Fe 2+ ) and hydrogen peroxide (H 2 O 2 ). In this study, a novel near-infrared (NIR)-light-responsive nanoplatform (ApoE-UMSNs-GOx/SRF) based on upconversion nanoparticles (UCNPs) was developed. A layer of mesoporous silica and a lipid bilayer were coated on UCNPs sequentially and loaded with glucose oxidase (GOx) and sorafenib, respectively. Further attachment of the ApoE peptide endowed the nanoplatform with BBB penetration and GBM targeting capabilities. Our results revealed that ApoE-UMSNs-GOx/SRF could efficiently accumulated in the orthotopic GBM and induce amplified ferroptosis when combining with NIR irradiation. The UCNPs mediated the photoreduction of Fe 3+ to Fe 2+ by converting NIR to UV light, and excess H 2 O 2 was produced by the reaction of glucose with the loaded GOx. These processes greatly promoted the production of ROS, which together with inhibition of system Xc − by the loaded sorafenib, leading to enhanced accumulation of lipid peroxides and significantly improved the antiglioma effect both in vitro and in vivo . Our strategy has the potential to enhance the effectiveness of ferroptosis as a therapeutic approach for GBM.
研究领域:
肿瘤学
·
纳米医学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jiwei Jiang,Jing Hu,Mingtong Li,Mingzhi Luo,Bin Dong,Metin Sitti,Xiaohui Yan
Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active photothermal agent able to perform thermophoretic propulsion along the irradiation direction in subcutaneous tissue, while the ICG fluorescence can direct the subcutaneous propulsion of motors toward specific tumor through real-time NIR-II imaging. These functions endow the motor with the ability of moving to tumor after being injected at peritumoral site, enabling an enhanced photothermal therapy (PTT). The results demonstrated herein suggest an integrated nanorobotic tool for the superficial PTT using peritumoral administration, highlighting an NIR-II imaging-directed subcutaneous propulsion.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-11
·
IF 10.435
Xu Zhourui,Zhang Yinling,Zhou Weixiao,Wang Lijian,Xu Gaixia,Ma Mingze,Liu Fenghua,Wang Zan,Wang Yucheng,Kong Tiantian,Zhao Binyuan,Wu Weiping,Yang Chengbin
Photothermal therapy has attracted extensive attentions in cancer treatment due to its precise spatial-temporal controllability, minimal invasiveness, and negligible side effects. However, two major deficiencies, unsatisfactory heat conversion efficiency and limited tissue penetration depth, hugely impeded its clinical application. In this work, hollow carbon nanosphere modified with polyethylene glycol-graft-polyethylenimine (HPP) was elaborately synthesized. The synthesized HPP owns outstanding physical properties as a photothermal agent, such as uniform core-shell structure, good biocompatibility and excellent heat conversion efficiency. Upon NIR-II laser irradiation, the intracellular HPP shows excellent photothermal activity towards cancer cell killing. In addition, depending on the large internal cavity of HPP, the extended biomedical application as drug carrier was also demonstrated. In general, the synthesized HPP holds a great potential in NIR-II laser-activated cancer photothermal therapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2020
·Vol. 16
·期 48
·2004118
·
IF 11.459
Meiling Tan,Feng Li,Ning Cao,Hui Li,Xin Wang,Chenyang Zhang,Daniel Jaque,Guanying Chen
Luminescence nanothermometry is promising for noninvasive probing of temperature in biological microenvironment at nanometric spatial resolution. Yet, wavelength- and temperature-dependent absorption and scattering of tissues distort measured spectral profile, rendering conventional luminescence nanothermometers (ratiometric, intensity, band shape, or spectral shift) problematic for in vivo temperature determination. Here, a class of lanthanide-based nanothermometers, which are able to provide precise and reliable temperature readouts at varied tissue depths through NIR-II luminescence lifetime, are described. To achieve this, an inert core/active shell/inert shell structure of tiny nanoparticles (size, 13.5 nm) is devised, in which thermosensitive lanthanide pairs (ytterbium and neodymium) are spatially confined in the thin middle shell (sodium yttrium fluoride, 1 nm), ensuring being homogenously close to the surrounding environment while protected by the outmost calcium fluoride shell (CaF 2 , ≈2.5 nm) that shields out bioactive milieu interferences. This ternary structure enables the nanothermometers to consistently resolve temperature changes at depths of up to 4 mm in biological tissues, having a high relative temperature sensitivity of 1.4–1.1% °C −1 in the physiological temperature range of 10–64 °C. These lifetime-based thermosensitive nanoprobes allow for in vivo diagnosis of murine inflammation, mapping out the precise temperature distribution profile of nanoprobes-interrogated area.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2016
·
IF 4.342
Ahu Yuan,Wei Huan,Xiang Liu,Zhicheng Zhang,Yifan Zhang,Jinhui Wu,Yiqiao Hu
Nanocarriers like PEGylated liposomes have achieved enhanced drug accumulation in tumors and reduced systemic side effects, but failed to actively release the carried drug into cancer cells. To obtain improved therapeutic efficacy, we designed a novel liposome that was inserted by the amphiphilic agent PEG-IR780-C13 (PIC-Lipo) and encapsulated therapeutic agent doxorubicin (DOX), termed as DOX@PIC-Lipo. Upon NIR laser irradiation, the novel liposomes could generate hyperthermia and facilitate the release of encapsulated DOX from PIC-Lipo, which were confirmed by photothermal curves and the DOX release assay in vitro, respectively. In addition, the enhanced DOX release and sufficient hyperthermia have performed synergetic therapeutic efficacy both in vitro and in vivo. Therefore, DOX@PIC-Lipo might provide an active strategy to release the loaded drug for synergetic chemo–photothermal combined therapy.
研究领域:
癌症治疗
·
药剂学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemical Science
·
2019
·Vol. 10
·期 21
·5452-5460
·
IF 9.556
Yu Gao,Renfu Li,Wei Zheng,Xiaoying Shang,Jiaojiao Wei,Meiran Zhang,Jin Xu,Wenwu You,Zhuo Chen,Xueyuan Chen
Near-infrared (NIR) photostimulated luminescence (PSL) nanocrystals (NCs) have recently evoked considerable interest in the field of biomedicine, but are currently limited by the controlled synthesis of efficient PSL NCs. Herein, we report for the first time the controlled synthesis of CaS:Eu2+,Sm3+ NIR PSL NCs through a high-temperature co-precipitation method. The role of Sm3+ co-doping and the effect of thermal annealing on the optical properties of the NCs as well as the charging and discharging processes, the trap depth distribution, and the underlying PSL mechanism are comprehensively surveyed by means of photoluminescence, persistent luminescence, thermoluminescence, and PSL spectroscopies. The as-prepared NCs exhibit intense PSL of Eu2+ at 650 nm with a fast response to stimulation in a broad NIR region from 800 nm to 1600 nm, a duration time longer than 2 h, and an extremely low power density threshold down to 10 mW cm−2 at 980 nm. Furthermore, by taking advantage of the intense NIR PSL, we demonstrate the application of CaS:Eu2+,Sm3+ NCs as sensitive luminescent nanoprobes for biotin receptor-targeted cancer cell imaging. These results reveal the great promise of CaS:Eu2+,Sm3+ nanoprobes for autofluorescence-free bioimaging, and also lay the foundation for future design of efficient NIR PSL nanoprobes towards versatile bioapplications.
研究领域:
材料科学
·
生物医学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
JongGuk Kim,HuiGwang Yun,KukChol Ri,JingYu Sun,HyoYong Kim,Lu Liu
Today, developing photocatalysts with high sterilization efficiency is still an urgent challenge. Currently photothermal therapy (PTT) and photodynamic therapy (PDT) are known as a promising candidate for eradicating bacteria because of strong reactivity, non-specific attack characteristics and minimal invasiveness . Therefore, the synergic effect of PTT and PDT can shorten the antibacterial time, increase the antibacterial rate, and reduce antibacterial agent dosage. Herein, SnSe samples with sphere, rod, plate, and surface wrinkled morphology were synthesized by a simple solvothermal method. The samples were denoted as SnSe-1, SnSe-2, SnSe-3, and SnSe-4, respectively. The morphology and size of the prepared samples greatly relied on the selection of surfactant and the reaction time. In addition, the size and morphological changes affected the photothermal properties and photodynamic properties of the prepared samples. Among the prepared samples, SnSe-1 showed the best photothermal effect (41.4%) and reactive oxygen species generating ability during the 808 nm laser irradiation. Consequently, SnSe-1 exhibited sterilization rates of 99.99% against Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis) during NIR irradiation (1.5 W/cm 2 ， 10 min) at a relatively low concentration (25 µg/mL). The result suggests that SnSe-1 nanoparticle with a spherical shape could be used as an effective antibacterial agent for the treatment of bacterial contamination, including rapid bacterial sterilization in water.
研究领域:
材料科学
·
微生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Yue Su,Lifang Yuan,Bo Wang,Sijian Wu,Yahong Jin
Metal halide perovskites (MHPs) have sparked ongoing research interest due to their high-performance optoelectronic properties. However, blue-light excitable near-infrared (NIR) emitting MHPs is still inaccessible and the achievement of robust thermal-quenching resistance so far remains a huge challenge. In this work, we report on the synthesis of lead-free all-inorganic Mn 2+ -based perovskite-like single crystals using the designed nonstoichiometric precursor ratio. The special crystal structure endows Mn 2+ with efficient blue light excitation and red emission, which enables the capabilities of a good matching with commercial blue LED chips and an efficient sensitization for Ln 3+ emitters. The incorporations of Yb 3+ , Er 3+ , and Ho 3+ functionalize the CsMnCl 3 single crystals with multiple NIR emissions by virtue of feeding the energy from Mn 2+ to Ln 3+ via multi-channels. Most remarkable is the achievement of the robust thermal-quenching resistance, exhibiting (near-) zero-thermal-quenching and even anti-thermal quenching, of the Ln 3+ NIR emissions above room temperature . Finally, as a proof-of-concept study, a prototype of an NIR-LED device was fabricated. This work not only provides a general strategy to unlock the blue-light excitable NIR emission from f-f transitions of Ln 3+ ions, and a fundamental understanding of the sensitization-activation mechanisms in Ln 3+ -functionalized manganese (Ⅱ)-based perovskite-like phosphor, but also endows the MHPs with optical functionalities for the future high-potential applications, such as NIR phosphor-converted LEDs, and optical telecommunication.
研究领域:
材料科学
·
光电学
·
光子学
·
固体物理
·
无机化学
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2022
·
IF 10.508
Lei Wang,Jingtao Jiang,Chenghao Dai,Huilan Zeng,Yifan Shang,Yongqi Liu,Qiyan Yin,Gengsheng Weng
The design of materials that can mimic the complex shape-morphing phenomena in nature is important for applications in soft robotics, biomedical devices, and sensors. Yet, morphing a two-dimensional thin plate into a programmed complex three-dimensional (3D) shape is still challenging. Herein, we demonstrate a new paradigm for designing a photothermal shape-transformable Fe3+-containing polymer film (FePF) coated with a patterned inactive black-tape strip layer. The near-infrared (NIR) light-triggered dehydrative shrinkage of the FePF layer drives the bending of the inactive layer toward the FePF layer. Various reversible 3D shapes, including a complex “human face” and gripping-force-tunable soft grippers, are fabricated by the experimental pattern design of the inactive layer with the aid of theoretical simulations. The white-light sensitive dynamic coordination of Fe3+–Alanine (Ala) enables tunability of the deformation degree under white-light irradiation. The deformation rate is also tunable by adjusting the Fe-to-Ala mole ratio, humidity, NIR light intensity, and FePF thickness. These shape transformations are reconfigurable through the simple peeling off and repatterning of the black-tape strip layers. Our simple and scalable design strategy without an intricate heterogeneity design in material properties provides guidance for fabricating new soft robotics and biomimetic systems.
研究领域:
材料科学
·
软机器人
·
生物医学工程
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2011
·
IF 7.883
Ao Xia,Yuan Gao,Jing Zhou,Chunyan Li,Tianshe Yang,Dongmei Wu,Limin Wu,Fuyou Li
New core–shell structured NaYF 4 :Yb 3+ ,Tm 3+ @Fe x O y nanocrystals , with 20 nm Yb 3+ ,Tm 3+ -co-doped NaYF 4 nanocrystals as a core and 5 nm Fe x O y nanocrystals as a shell, have been synthesized and characterized by TEM and XRD analysis . These core–shell nanocrystals exhibit excellent near-infrared upconversion luminescence (UCL) emission at 800 nm under excitation by a continuous-wave 980 nm laser and superparamagnetic properties with a saturation magnetization (Ms) of ∼12 emu/g. Water-soluble nanocrystals were obtained by surface ligand exchange of oleic acid-coated precursor nanocrystals, and their internalization within living cells has been investigated by laser scanning UCL microscopy. Furthermore, the obtained core–shell nanocrystals have been applied in dual-modality T 2 -enhanced magnetic resonance (MR) and UCL imaging in vivo of the lymphatic system. Moreover, the toxicity of NaYF 4 :Yb 3+ ,Tm 3+ @Fe x O y nanocrystals has also been evaluated by MTT assay, IC50 values, and histological analysis of lymphatic node sections.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 8
·3097-3111
·
IF 8.307
Lu Wang,Genhua Liu,Yunping Hu,Shuangquan Gou,Tingting He,Qian Feng,Kaiyong Cai
The lymphatic system provides a main route for the dissemination of most malignancies, which was related to high mortality in cancer patients. Traditional intravenous chemotherapy is of limited effectiveness on lymphatic metastasis due to the difficulty in accessing the lymphatic system. Herein, a novel lymphatic-targeting nanoplatform is prepared by loading doxorubicin (DOX) into sub-50 nm polypyrrole nanovesicles (PPy NVs). The PPy NVs possessed hollow spherical morphologies and a negative surface charge, leading to high drug loading capacity. These vesicles can also convert near-infrared (NIR) light into heat and thus can be used for tumor thermal ablation. DOX loaded PPy NVs (PPy@DOX NVs) along with NIR illumination are highly effective against 4T1 breast cancer cells in vitro. More importantly, following subcutaneous (SC) injection, a direct lymphatic migration of PPy@DOX NVs is confirmed through fluorescence observation of the isolated draining nodes. The acidic conditions in metastatic nodes might subsequently trigger the release of the encapsulated DOX NVs based on their pH-sensitive release profile. In a mouse model bearing 4T1 breast cancer, lymphatic metastases, as well as lung metastases, are significantly inhibited by nanocarrier-mediated trans-lymphatic drug delivery in combination with photothermal ablation. In conclusion, this platform holds great potential in impeding tumor growth and metastasis.
研究领域:
癌症治疗
·
纳米医学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）