Journal of Functional Biomaterials
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2026
·Vol. 17
·期 6
·260
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IF 5.9
Ruoxue Guo,Zihan Wu,Zirui He,Changsheng Liu,Yuan Yuan
Uncontrolled bleeding, coagulation disorders, and infection-related complications still present substantial challenges in emergency medicine and trauma care. Developing multifunctional hemostatic materials represent an effective strategy for addressing clinical hemostasis problems. In this study, Galla chinensis polyphenols, the effective extract of Galla chinensis, were loaded onto calcium alginate-mesoporous silica granules (CMS-GC). The CMS granules were prepared by in situ liquid-phase technology and GC was loaded by impregnation methods. In vitro and in vivo studies showed that CMS-GC not only activate the endogenous coagulation pathway via GC, but also the multi-level interconnected pores of CMS granules can promote the cross-linking of GC with plasma proteins and formation of a three-dimensional network structure, which further enhances the coagulation effect and shortens the blood clotting time to less than 80 s. In rat liver and femoral artery hemorrhage models, CMS-GC significantly shortened hemostasis time and reduced blood loss, demonstrating superior hemostatic performance. Moreover, within the moist environment sustained by alginate, GC mitigates inflammatory responses via its antibacterial and free-radical clearance properties, and synergistically facilitates wound healing. This CMS-GC multifunctional granule provides an efficient new strategy for traumatic bleeding and subsequent repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Liyuan Yin,Zhenjia Zheng,Qiannan Liu,Wei Liu,Ruixuan Zhao,Honghai Hu
The purpose of this study was to investigate the effect of starch gelatinization degree on the complexation mode and complexation strength of polyphenols (chlorogenic acid), as well as the changes in the physicochemical properties of potato starch with varying degrees of gelatinization before and after the addition of chlorogenic acid. The result show that the degree of gelatinization of potato starch increased from 0 % to 100 %, while the recombination rate of chlorogenic acid increased from 21.92 ± 0.67 % to 40.93 ± 0.15 %. An increase in gelatinization degree enhances the interaction between chlorogenic acid and potato starch, resulting in the formation of V-type complexes. The setback value of potato starch with 100 % pasting degree decreased from 27.74 ± 3.65 (×10 2 mPa s) to 24.78 ± 0.73 (×10 2 mPa s) after chlorogenic acid was added. The results showed that chlorogenic acid delayed the retrogradation of potato starch. The addition of chlorogenic acid enhanced the thermal stability of potato starch. The markedly bound water content (A 21 ) of potato starch-chlorogenic acid complex gels increased from 0.96 ± 0.10 % to 2.24 % ± 0.14 % as the degree of gelatinization from 0 % to 100 %, indicative of an enhanced water-holding capacity of potato starch gels by chlorogenic acid. These findings provide a theoretical foundation for expanding the use of potato starch in the food industry and improving the quality of starch-based foods.
研究领域:
食品科学
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生物化学
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Current Research in Food Science
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2025
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IF 7
Le Cheng,Haoyue Bai,Mingfang Zhang,Fengping Yang,Difeng Ren,Yunpeng Du
The emerging technology of inhibiting polyphenol oxidase (PPO) is crucial for preventing enzymatic browning in food. This study aimed to investigate the effects of 4.5 kJ/m 2 ultraviolet (UV)-C radiation and 0.02 mg/mL L-cysteine (L-cys) treatment on the enzyme activity, physico-chemical properties, thermal properties, structure, and molecular microstructure of PPO. UV-C/L-cys decreased PPO activity and had the highest aggregation index and turbidity of PPO. UV-C/L-cys further reduced the denaturation temperature point and increased the denaturation enthalpy of PPO. UV-C/L-cys turned the α-helix to random coil of PPO and destroyed the tertiary structure. This combined treatment aggregated the microstructure of PPO, which led to covering the active center of the enzyme, leading to its inactivation. Molecular docking simulation confirmed that L-cys bound to PPO through hydrogen bonding and ionic contact. This study established a foundation for the application of UV-C radiation and L-cys treatment to control food browning.
研究领域:
食品科学
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生物化学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Feng Li,Youhui Huang,Zhiqiang Zhu,Jiayi Zhang,Lihui Chen,Mizi Fan,Nairong Chen
Developing adaptable adhesives that can resist the rigors of environments is essential to many applications but remains challenging. Herein, inspired by polyphenol-enabled adaptable mussel adhesives, an efficient strategy is proposed for fabricating self-adaptable bio-based adhesives (BIOAs). This approach rationally leverages low-molecule-weight tea polyphenols (TPs) to mediate camellia meal (CM, a low-cost biological macromolecules) systems. Benefiting from TPs' superior molecular compliance, the incorporation enables a highly adaptable CM network that combines structural reliability and dynamicity, providing the resultant adhesive with high-strength yet multi-purposed adhesion (up to 1.12 MPa on wood substrates even under hydrothermal conditions at 100 °C), long-term stability (retaining 0.88 MPa on wood substrates after immersing in water for 30 days), tolerance to harsh environments (i. e., temperature, pH, salt and organic solvent), and resistance to mildew and flame. This TP-mediated design could be extended to more BIOA systems with much-enhanced adhesion properties, offering a promising alternative to construct adaptable adhesives with excellent performances for the better response to complex application scenarios.
研究领域:
材料科学
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胶粘剂技术
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仿生学
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可持续化学
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高分子科学
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INORGANIC CHEMISTRY
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2025
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IF 4.7
Xin Wan,Wensong Wang,Enze Tian,Jun Zhou,Congqiang Long,Fan Liu,Qiao Zhang,Jinxuan Fan,Feipeng Du,Bin Li,Si Chen
Nanomaterials offer enhanced stability and functionality for photothermal agents; however, their efficacy is often limited by suboptimal cellular internalization and photothermal conversion efficiency. To address these challenges, we designed a multicomponent inorganic–organic hybrid photothermal agent that integrates a virus-mimicking morphology and stimuli-responsive components. Gold nanostars (GNS) were functionalized with a pH-responsive epigallocatechin gallate (EGCG) polyphenol network, followed by in situ growth of CuS, yielding star-shaped GEC nanoassemblies with a rough surface. This biomimetic design leverages (i) the plasmonic photothermal properties of the GNS core, (ii) the acid-triggered disassembly of the EGCG network (mimicking viral protein shells), and (iii) the in situ synthesized CuS layer exhibiting a virus-mimetic rough surface and targeting capability, which enhances near-infrared light absorption and promotes endocytosis by the target cells. The synergistic integration of GNS and CuS significantly enhanced the photothermal conversion efficiency. Under tumor acidic conditions, the EGCG network disintegrated, leading to the shedding of the CuS shell and a reduction in overall size, which facilitated deep tissue penetration. Structural characterization confirmed the hierarchical architecture and pH-responsive size transition. Compared to unmodified GNS, the cellular uptake of GEC by 4T1 cells was approximately 4.5-fold higher, attributable to its virus-like rough surface, acid-responsive disintegration, and targeting ability. This work demonstrates a rational biomimetic strategy for engineering stimuli-responsive inorganic–organic hybrids with optimized photothermal performance through biomimetic component engineering.
研究领域:
纳米医学
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光热治疗
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生物材料
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癌症纳米技术
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刺激响应材料
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JOURNAL OF FOOD ENGINEERING
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2025
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IF 5.8
Yu Chen,Qingyao Jiang,Yan Lu,Qiao Zeng,Ping Liu,Jiaxin Chen,Hongbin Lin,Jie Tang,Jie Zhao
The impact of different doses of protocatechuic acid (PCA), caffeic acid (CFA) and apigenin (AP) on the structural and in vitro digestive characteristics of pork myofibrillar proteins (MP). Results showed that the formation of complexes led to a 9 %–23.5 % increase in turbidity compared with the control group. Spectroscopic analysis revealed that polyphenols caused a static quenching of MP and altered the tertiary structure, which exposed the MP in a hydrophilic environment ( H 0 = 45.91) as shown by a redshift of 14 nm for the MP/CFA sample at high concentration (100 μmol/g). The addition of PCA/CFA/AP promoted the molar ellipticity of CD decrease from −12 mdeg to −16.4 mdeg, indicating that the MP molecular tended to be disordered. Molecular docking and thermodynamic studies confirmed that the formation of the MP/AP complex was mainly through hydrogen bonds, whereas hydrophobic interactions were the primary driving force for MP/PCA and MP/CFA samples. Furthermore, the interaction between polyphenols and MP enhanced the digestive properties of MP as manifested by decreasing the particle size from 851 nm (control) to 594 nm (MP/AP-100), and weakened the high molecular weight bands (170 kDa) observed in SDS-PAGE. The binding of polyphenols to MP at low concentration (20 μmol/g protein) was more conducive to the in vitro gastrointestinal digestion of MP compared to the high dosage.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Tianyu Zou,Bingchun Jiang,Qian Qu,Bozhong Cao,Jingyu Xu,Shubing Zhen,Jincheng Zhang,Lei Ling,Yusheng Lu,Tong Zhang
The aqueous zinc-ion battery (AZIB) is regarded as one of the most promising energy storage solutions. However, its widespread adoption is hindered by challenges such as zinc dendrite formation and undesirable side reactions, primarily caused by excess free water molecules and ions. This study introduces an ethylene oxide (PEO)-based gel electrolyte designed to address these limitations. By incorporating a zinc-rich ionic conductor (TP-Zn) that establishes a cross-linked hydrogen bond network, we successfully reduce the crystallinity of the PEO matrix and enhance the ionic conductivity and mechanical strength of the electrolyte. The resulting PGPS@TP-Zn gel electrolyte exhibits a remarkable tensile deformation of up to 1785%. The incorporation of TP-Zn significantly alleviates interfacial challenges between the electrolyte and electrode, leading to a more uniform zinc ion flux distribution. This, in turn, improves ion transport kinetics, resulting in a high ionic conductivity of 1.32 × 10–3 S cm–1 and a zinc ion transference number of 0.86. Furthermore, the Zn||Zn symmetrical cell shows exceptional stability when using PGPS@TP-Zn, with a cycle life exceeding 3000 h at a current density of 1 mA cm–2 and a capacity of 1 mAh cm–2. In addition, the Zn||PGPS@TP-Zn||α-MnO2 full cell maintains a capacity retention of 76.9% even after 1000 cycles at a current of 2 A g–1. Remarkably, the assembled pouch cell functions normally even when bent to a maximum angle of 180 degrees. This study highlights the significant practical advantages of the PGPS@TP-Zn gel electrolyte design for advanced AZIB applications.
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ACS Applied Polymer Materials
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2025
·
IF 4.7
Xinyue Zhang,Xueqiong Yin,Shujun Li,Zhijun Chen
The growing global demand for clean water and sustainable energy necessitates the development of eco-friendly technologies for seawater desalination. A green and efficient photothermal conversion aerogel (CFA) is developed for incorporating naturally derived chlorogenic acid (CA) and Fe3+ ions into an acrylamide (AM) matrix via chelation and freeze-drying. CFA broadens light absorption and enhances solar-to-thermal conversion efficiency. Under one sun (100 mW·cm–2) irradiation, CFA heats up to 127.4 and 63.9 °C in the dry and wet states, respectively. The water evaporation rate reaches 3.367 kg·m–2·h–1. CFA exhibits excellent stability during long-term use and repeated recycling. Even in an extreme salt environment (25 wt % NaCl), the evaporation rate remains at 3.166 kg·m–2·h–1. A small-scale desalination device confirms effective ion removal (>96% for Ca2+ and >99.9% for K+, Na+, and Mg2+), meeting WHO drinking water standards. CFA serves as a sustainable, cost-effective, and scalable solution for solar-driven desalination with potential applications in off-grid or resource-limited settings.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Jie-Ping Jia,Ling-Ping Xiao,Hui-Tong Jiang,Shao-Fei Sun,Zhi-Hong Ren,Hui He,Chengrong Qin,Julio Sánchez,Run-Cang Sun
The excessive release of heavy metals and organic dyes in water poses a serious threat to the ecosystem. However, most synthetic adsorbents are unsatisfactory in terms of preparation, economy and properties. Developing an inexpensive and excellent adsorbent that is easy to synthesize is urgent. Fortunately, sugarcane bagasse (SB), a cheap biomass material, can remove a few wastewater pollutants, but it fails to achieve practical application needs. Herein, we proposed a strategy for SB-Fe-TA preparation by precipitation complexation of tannic acid (TA) on SB. Batch experiments showed that the maximum theoretical removals of Pb(II) and methylene blue (MB) by SB-Fe-TA were 797.72 mg/g and 758.95 mg/g, respectively. Moreover, the practical performance test results showed that SB-Fe-TA had high efficiency and universality for mixed pollutants. The continuous-flow reaction testing of the solutions showed that the removal rate of MB was still close to 100 % within 100 h. The excellent properties of SB-Fe-TA were due to the abundant functional groups on the surface. This work provides a novel avenue for developing multi-functional, cheap and efficient bio-based adsorbent for wastewater treatment.
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ACS Applied Materials & Interfaces
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2025
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IF 8.2
Yiyan Xu,Ying Wang,Li Guan,Peng Zhang,Zhen Wu,Shah Jehan,Chao Peng,Bohan Yang,Ye Yao,Peipei Zhuang,Wenhu Zhou,Wayne W. Zhang,Haiyang Wang
Abdominal aortic aneurysm (AAA) poses a critical and imminent threat due to the potential for rupture, presenting a life-threatening scenario. Despite the urgency, there is a lack of an effective clinical drug to impede aneurysm growth and prevent rupture. Addressing the intricate pathological changes inherent in AAA lesions, this project introduces a multifunctional nanomedicine utilizing tea polyphenol nanoparticles as carriers for doxycycline (DC) targeted specifically to AAA. Through SH-PEG-cRGD modification, the nanoparticles (NPs) demonstrate a remarkable 5-fold increase in accumulation at AAA lesions, achieving precise delivery by recognizing the overexpressed integrin αvβ3 receptors on lesion cell membranes. This nanomedicine achieves controlled DC release at the AAA site triggered by elevated reactive oxygen species (ROS) levels, which synergizes with the inherent antioxidant prowess of the nanocarrier. The combined effect encompasses anti-inflammatory, antioxidant, macrophage repolarization, antiapoptotic, and anticalcification capabilities, along with matrix metalloproteinase (MMP) inhibition, effectively addressing diverse AAA-associated pathological changes and therapy. Notably, nanocarrier delivery significantly mitigates the hepatic and renal toxicity induced by DC, highlighting exceptional biocompatibility. This study propounds a targeted nanomedicine with substantial potential for aneurysm treatment and serves as a blueprint for the development of targeted drugs for various vascular diseases.
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DENTAL MATERIALS
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2025
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IF 6.3
Yan Wang,Li Liu,Liyuan Zhou,Huan Cheng,Yifan Li,Anni Wu,Senjeet Sreekissoon,Xiao Chen,Peng Gao,Lei Lu,Zhennan Deng,Jinsong Liu
Postoperative infection significantly increases the risk of failure in titanium (Ti) dental implants. While the local application of antimicrobial agents can effectively mitigate these infections. Electrospinning has gained considerable attention for its ability to produce high-performance nanofibers suitable for localized drug release. Nevertheless, challenges such as weak interfacial bond with Ti surface limits its application as a surface coating strategy. In this study, we developed a novel electrospun coating composed of a plant polyphenol, epigallocatechin gallate (EGCG)-modified polycaprolactone (PCL) and gelatin (Gel), which enhanced its adhesion to the Ti surface through phenol-amine chemistry. This innovative approach significantly enhanced the interfacial bond strength between the nanofibers and the Ti surface, thereby improving the wear resistance of the coating. Additionally, the incorporation of rifampicin (Rif), a broad-spectrum antibiotic, into the EGCG-modified electrospun coating (Ti/NFs-0.5 %EG@Rif) enabled sustained Rif release over 28 days, providing potential long-term antibacterial activity. Both in vitro and in vivo studies demonstrated that the Ti/NFs-0.5 %EG@Rif coating exhibited significantly enhanced antibacterial and anti-inflammatory efficacy, along with excellent biocompatibility. In conclusion, the EGCG-modified electrospun coating represented a promising and cost-effective strategy for enhancing the functionality of Ti implants, with the potential to improve clinical outcomes in dental applications.
研究领域:
生物材料
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纳米技术
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牙科
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药剂学
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表面工程
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生物医学工程
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Biomaterials Research
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2025
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IF 9.6
Yangjing Su,Yunong Zeng,Minjie Zhou,Meihui Liao,Ping Qin,Rong Wu,Jiaochan Han,Xiaoqi Liang,Ze Wang,Jingjing Jiang,Zhichao Yu,Xintao Huang,Kaixin Ding,Peiheng Guo,Yi He,Ying Du,Tingting Duan,Haitao Yuan,Yuewei Ge,Ali Chen,Wei Xiao
Acetaminophen (APAP) overdose has long been recognized as the main cause of drug-induced liver injury (DILI), characterized by glutathione (GSH) depletion and reactive oxygen species (ROS) accumulation, leading to ferroptosis and inflammatory responses. There is an urgent need for liver-protective agents to combat ferroptosis, modulate oxidative stress, and ameliorate inflammation. Catechin, a well-known polyphenol compound, has been shown to have antioxidant potential. However, its protective role on APAP-induced liver injury (AILI) has not been elucidated. In this study, we evaluated the modulating effects of catechin on AILI and observed that catechin attenuated liver injury by reducing inflammation. Mechanistically, catechin alleviated hepatic oxidative stress by inhibiting ROS accumulation, malondialdehyde (MDA) production, and GSH depletion. Furthermore, catechin, as a hepatic injury reparative agent, could counteract APAP-induced hepatocyte ferroptosis by activating the xCT/GPX4 pathway, and is expected to be a novel natural inhibitor of ferroptosis. Additionally, the transcriptomic results indicated that the inhibition of Stat1 by catechin is important for the management of AILI. Inhibition of signal transducer and activator of transcription 1 (STAT1) expression, achieved through the use of the STAT1 inhibitor fludarabine in vivo and small interfering RNA (siRNA) in vitro, was confirmed to attenuate APAP-induced ferroptosis. In conclusion, the present study identified a novel natural drug inhibitor of ferroptosis and revealed its mechanism of action to inhibit ferroptosis, regulate oxidative stress, and ameliorate inflammation in AILI. This further provides new insights into the novel natural ferroptosis inhibitors for the treatment of ROS-related inflammatory diseases.
研究领域:
药理学
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肝脏病学
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分子生物学
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