INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2020
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IF 4.845
Parbeen Singh,Li Wu,Xiaohong Ren,Wei Zhang,Yan Tang,Yongli Chen,Andrew Carrier,Xu Zhang,Jiwen Zhang
Hyaluronic acid (HA), a common biopolymer found in the extracellular fluid, was grafted with β-cyclodextrin (β-CD) to form a composite polymer that could form inclusion complexes with tocopherol (VE), enhancing its water-solubility and serving as a model drug delivery system . Herein, different copolymers were prepared with varying HA:β-CD ratios and characterized. VE loading capacity was directly correlated with increased β-CD composition in the polymers and morphological changes were observed upon VE binding. The host materials and their VE inclusion complexes are not cytotoxic, and are thus useful for VE and drug delivery.
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BIOMACROMOLECULES
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2018
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IF 5.738
Yuchen Guo,Sha Wang,Hanhan Du,Xiaolong Chen,Hao Fei
Understanding the chemical absorption process of silver ions helps the rational design of functional materials for effective release to minimize unwanted toxicity. To this end, a histidine-containing aliphatic peptide (IH6) was designed to immobilize the silver ion (Ag+) through coordinate interaction. Using circular dichroism spectroscopy, Ag+ was found to dose-dependently induce parallel β-sheet conformation of IH6 to a saturation molar ratio of 1:2. A conformational switch of IH6 from antiparallel to parallel β-sheet assembly upon Ag + coordination was further revealed by Fourier transform infrared spectroscopy. The resultant Ag-IH6 hydrogel displayed substantially enhanced mechanical strength as well as controlled release of Ag+. Ag-IH6 hydrogel thus exhibited strong dose-dependent bactericidal activities that can be tuned selectively, sparing the cocultured human keratinocytes in normal. Overall, the study demonstrates an unusual silver ion-induced peptide conformational switch between β-structure subtypes and the bilateral effects on hydrogel-based chemical control of silver ion absorption and release, thus, revealing the potential in antibacterial applications.
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FOOD CHEMISTRY
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2016
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IF 4.052
Chun-Ling Zhang,Jie-Chao Liu,Wen-Bo Yang,Da-Lei Chen,Zhong-Gao Jiao
Phloridzin is a nutraceutical. Its use in food, medicine and cosmetics is limited because of its low aqueous solubility and stability limits, but it can be improved by complexing with cyclodextrins. In this study, we investigated the inclusion mechanism between phloridzin and hydroxylpropyl-β-cyclodextrin (HP-β-CD) using isothermal titration calorimetry (ITC), ultraviolet–visible spectrometry (UV), infrared spectrometry (IR), proton nuclear magnetic resonance spectroscopy ( 1 H NMR) and molecular docking simulations. The ITC results found that the equilibrium binding constant of HP-β-CD with phloridzin was higher than that of β-CD. Their inclusion was a spontaneous process with negative ΔG, ΔH and ΔS values. UV spectra showed that the aqueous solubility of phloridzin was enhanced by HP-β-CD. Our IR analysis verified the inclusion complexation of phloridzin into the HP-β-CD cavity. The Autodock determined that the substitution distribution of HP-β-CD influenced not only the orientation and depth degree of phloridzin within the cavity, but also the binding energies.
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Catalysis Science & Technology
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2023
·Vol. 13
·期 20
·5902-5911
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IF 5
Haoxi Jiang,Liping Yi,Guochao Yang,Lingtao Wang
Hierarchical Zr-β zeolite is a promising catalyst in the conversion of ethanol to 1,3-butadiene owing to the improved accessibility of active sites inside the zeolite to bulky substrates. Accordingly, hierarchical nanocrystalline Zr-β zeolite with sufficient intercrystalline mesoporosity and microporosity was prepared in this work via silanization-based hydrothermal synthesis. A systematic investigation was conducted to determine the effect of the secondary porosity on the textural, acidic and catalytic properties. The results suggested that neither acid amount, strength nor location varied with the additional secondary porosity. However, an appropriate proportion of micropores and mesopores would provide significant contributions to enhanced catalytic performance, arising from the available confined environment around the active sites inside the micropores, enhanced accessibility of such sites and improved diffusion of reactants and products due to mesopores.
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REACTIVE & FUNCTIONAL POLYMERS
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2024
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IF 4.5
Jie Xu,Huaming Wang,Tao Zhang,Lei Li,Sixun Zheng
In this contribution, we reported a novel strategy to crosslink polyurethane (PU) via host-guest inclusion complexations. First, a linear PU with adamantane (Ad) as side groups was synthesized with a 1,3-diol bearing adamantane as the chain extender . Thereafter, this linear PU was crosslinked with a poly( β -cyclodextrin) through host-guest inclusion complexations to afford PU-Ad-CD networks. In comparison with the linear PU, the PU-Ad-CD networks exhibited improved mechanical properties with the Young's modulus of 43.21 MPa, which was more than eight times as that of the linear PU. The formation of inclusion complexes enabled the PU-Ad-CD networks to display reprocessing properties. In addition, the shape memory properties of the networks featured the reconfigurability of original shape with the aid of the exchange of the host-guest inclusion complexations. This study provides new insights into the development of high-performance PU materials.
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POLYMER
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2024
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IF 4.1
Yong Chen,An Liu
As a natural isoflavone compound, glabridin (GLD) has excellent skin-whitening properties, but its biomedical applications are greatly limited due to its poor water solubility and low skin permeability. In the current work, GLD was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a GLD/HP-β-CD inclusion complex that would improve the water solubility and skin permeability by changing the physicochemical properties of GLD, including the formation of intermolecular hydrogen bonds and amorphous transformation. The cytotoxicity of GLD/HP-β-CD on HaCaT keratinocytes is lower than that of GLD, while it has a more substantial inhibitory effect on melanin than GLD. Furthermore, a dual thermo- and pH-responsive hydrogel called PCG was established as the carrier of GLD/HP-β-CD. The PCG hydrogel presented a porous structure, biodegradability, and excellent biocompatibility. GLD had a dual thermo- and pH-responsive release behavior from the PCG hydrogel and displayed an accelerated release rate at weakly acidic pH conditions compared to the neutral pH environment. Moreover, GLD/HP-β-CD/PCG hydrogel can significantly inhibit melanin deposition in vivo . Taken together, this study provides a low toxicity and high efficiency new method for the application of GLD in biomedical fields, demonstrating its enormous potential in skin-whitening.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Sichen Li,Huihui Peng,Yuning Sun,Jiali Yang,Juan Wang,Fuqing Bai,Chuanyi Peng,Shuzhen Fang,Huimei Cai,Guijie Chen
Yeast β-glucan intervention offers a promising strategy for managing colitis; however, the mechanisms remain unknown. In the present work, the protective effects of yeast β-glucan on DSS-induced colitis in mice was evaluated, focusing on its interaction with gut microbiota. The result showed yeast β-glucan significantly alleviated colitis symptoms, evidenced by reduced weight loss, lower disease activity index (DAI) scores, and minimized intestinal damage. It enhanced intestinal barrier integrity via upregulation of tight junction proteins, suppressed lipopolysaccharide (LPS) release, and decreased pro-inflammatory cytokines production. Additionally, yeast β-glucan boosted short-chain fatty acids (SCFAs) production, and activated their receptors, increased the relative abundances of beneficial microbes like Lactobacillus and Lachnospiraceae_UCG-006 . Transcriptomic analyses suggest that yeast β-glucan mitigates inflammation by downregulating gene expression related to IL-17 pathway. Our findings highlight potential of yeast β-glucan as a therapeutic agent for colitis through modulation of gut microbiota and inflammatory responses.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
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IF 11.3
Siyi Wang,Min Nian,Yu Ma,Xiaojia Chen,Xiaotong Ji,Changzhi Shi,Xing Chen,Mingliang Fang
Thyroid disorders are among the most prevalent endocrine conditions worldwide, exhibiting a rising incidence and disproportionately affecting women. In this study, we hypothesized that cosmetics may contain previously unidentified thyroid-disrupting chemicals. To evaluate this possibility, we compiled a comprehensive data set of cosmetic ingredients and developed a random forest regression-based machine learning model to predict their potential to disrupt thyroid hormone receptor β (TRβ), a critical regulator of thyroid function. From the top 40 compounds ranked by the model, 12 frequently used cosmetic ingredients were selected for experimental validation. Of these, six demonstrated measurable binding affinity toward TRβ. Notably, Vat Blue 6 (VB6), a colorant utilized in cosmetic formulations, exhibited structural characteristics potentially mimicking thyroid hormones and displayed potent TRβ binding with an affinity (Kd) as low as 0.7 μM. Subsequent in vitro assays and in vivo experiments in mice confirmed VB6’s thyroid-disrupting effects, evidenced by dose-dependent reductions in serum thyroid hormone concentrations and morphological alterations of thyroid tissue. This study highlights the efficacy of machine learning approaches in rapidly screening large chemical inventories to identify potential thyroid disruptors and underscores the critical need for further toxicological assessment of cosmetic ingredients, particularly considering their frequent and prolonged exposure among female populations.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Wen Teng,Haipei Xu,Shun Wen,Xiang Yu,Yanrong Yang,Jing Zhang
Organophosphorus pesticides (OPPs) seriously threaten human health and ecosystems due to their environmental persistence, creating an urgent demand for highly efficient and sensitive detection technologies in environmental monitoring. UL-AuAgMSs@β-CD composite substrate was fabricated through the integration of urchin-like Au-Ag microspheres (UL-AuAgMSs) with β-cyclodextrin (β-CD) to overcome three persistent challenges in surface-enhanced Raman scattering (SERS) detection, i.e., low molecular selectivity, substrate instability, and complex matrix interference. Optimizing the three-dimensional branched structure of UL-AuAgMSs through controlled silver nitrate (AgNO 3 ) addition, a dual enhancement becomes available from both electromagnetic effects (nanotip-localized hotspots) and chemical effects (β-CD's molecular recognition capabilities). The composite substrate presented superior performances, a detection limit of 10⁻ 13 M for crystal violet (CV), excellent reproducibility (RSD = 9.10%, n = 13), and long-term stability (73.35% signal retention after 21 days), surpassing conventional single-metal substrates. Its versatility is further demonstrated in detecting methylene blue (MB), methyl orange (MO), the OPP chlorpyrifos (CPF), and the pesticide intermediate 4-aminothiophenol (4-ATP). This study proposes a synergistic strategy combining morphological engineering and molecular recognition. It offers a stable and adaptable SERS platform for rapid trace pollutant monitoring in food safety and complex environments.
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BIOCHEMICAL PHARMACOLOGY
·
2024
·
IF 5.3
Li Hu,Haiping Liu,Haixiang Ma,Xingyue Zeng,Yongkai Cao,Bing Liu,Huijun Li,Xiaohan Zhang
AKT, also known as protein kinase B (PKB), serves as a crucial regulator of numerous biological functions, including cell growth, metabolism, and tumorigenesis. Increasing evidence suggests that the kinase activity of AKT is regulated via ubiquitination by various E3 ligase enzymes in response to different stimuli. However, the molecular mechanisms underlying insulin-induced AKT ubiquitination are not yet fully understood. Here, we show that activation of the insulin receptor (IR) leads to enhanced ubiquitination of AKT1 at K8 and K14 residues, facilitated by the cytosolic E3 ubiquitin ligase enzyme, TRAF6. Further investigation using AKT1 mutants with modified nucleocytoplasmic shuttling properties reveals that TRAF6-mediated AKT1 ubiquitination occurs within the nucleus in a β-Arr2-dependent manner. The nuclear entry of TRAF6 depends on importin β1, while β-Arr2 regulates this process by facilitating the interaction between TRAF6 and importin β1. Additionally, the ubiquitination of AKT1 is essential for its translocation to the activated IR on the plasma membrane, where it plays a functional role in recruiting Glut4 and facilitating glucose uptake. This study uncovers the cellular components and processes involved in insulin-induced ubiquitination and activation of AKT1, providing insights and detailed strategies for manipulating AKT1.
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FOOD CHEMISTRY
·
2025
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IF 9.8
Jialong Shen,Yubin Bai,Gaiming Zhao,Yan Li,Qiuhui Zhang,Xiaopeng Wang
β-Lactoglobulin (β-Lg) was modified with glucosamine (GlcN) or chitosan oligosaccharide (COS) via transglutaminase catalysis to generate the glycated and crosslinked β-Lg (GC-β-Lg), which was investigated for possible property changes. Compared with β-Lg, GC-β-Lg showed more open and disordered secondary structure, enhanced thermal stability within 25–105 °C temperature range, increased particulate size, and higher apparent viscosity in water. Moreover, the used amino-saccharides affected GC-β-Lg's gelation, because COS and GlcN increased gel strength by 158–276 % and 642 %, respectively. Additionally, the gels from the GlcN-glycated β-Lg showed a denser micro-structural feature than those from the COS-glycated β-Lg. Interestingly, this used modification endowed GC-β-Lg with higher ability than β-Lg to form the heat-induced gels with better water holding capacity and less protein leachability. The results highlighted that this transglutaminase-mediated modification could alter β-Lg functionalities efficiently and could generate novel protein ingredients in the food industry, which was influenced by the used amino-saccharides.
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ULTRASONICS SONOCHEMISTRY
·
2025
·
IF 9.7
Yuexin Pan,Wenhao Zhang,Wanzhou Yang,Zhiyuan Tai,Xia Liu,Jia Ran,Xiaodong Yu,Qiyi He
Mangoes are highly susceptible to post-harvest spoilage, leading to significant losses. This study aimed to optimize the encapsulation of lemongrass essential oil (LEO) using ultrasonic-assisted hydroxypropyl-β-cyclodextrin (HP-β-CD) and response surface methodology (RSM). The ultrasonic-assisted inclusion complex (UIC) was characterized through various techniques including particle size analysis, SEM, UV–vis, FTIR, XRD, and TGA. The antibacterial activity of the UIC was evaluated, and its effectiveness in prolonging mango shelf life was assessed by monitoring parameters such as weight loss, firmness, total soluble solids (TSS), titratable acidity (TA), malondialdehyde (MDA), vitamin C (VC) content, and external appearance. The results indicated that ultrasonic-assisted encapsulation significantly improved the encapsulation efficiency (EE), with optimal conditions of a core-wall ratio of 9:1, ultrasonic power of 150 W, and temperature of 36 °C. The UIC exhibited sustained release of LEO and enhanced antimicrobial activity, resulting in significant reductions in weight loss, firmness degradation, and metabolic changes during mango storage. Treated mangoes also showed improved appearance, with delayed onset of black spots and browning. These findings suggest that ultrasonic-assisted HP-β-CD encapsulation of LEO is an effective, eco-friendly strategy for postharvest preservation of mangoes, offering substantial potential for extending shelf life and maintaining fruit quality.
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