MICROCHEMICAL JOURNAL
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2021
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IF 4.821
Wenzhi Zhang,Tian Jiang,Xiuxiu Sun,Ani Zhou,Maoguo Li
Peracetic acid (PAA) is commonly used as the strong oxidant in many areas. However, high concentration of PAA can be harmful to health of people. The quantitative determination of PAA is of great significance. Here, a metal–organic framework (MOF) is introduced into the electrochemical sensor for PAA detection. The influence of common transition metal centers on the performance of electrochemical detection of PAA was investigated and the results showed the Cu-1,3,5-trimesic acid (Cu-BTC) was the best original MOF. Ag nanoparticles were decorated in the Cu-BTC to further improve the electrocatalytical activity. The concentration of the added Ag salt and the quality of the reducing agent tannic acid (TA) had a great impact on the performance. The final sample optimized for the synthesis conditions was named as Ag NPs/Cu-BTC. The electrochemical sensor based on Ag NPs/Cu-BTC/GCE was fabricated for sensing PAA with a wide linear range (0.1–5000 μM), low detection limit (0.046 μM, S/N = 3) and high sensitivity (1013.4 μA mM −1 cm −2 ). The water stability of Ag NPs/Cu-BTC and the anti-interference ability of the sensor were good. The electrochemical sensor could be applied in detecting the concentration of PAA in the commercially available peracetic acid, suggesting the practical application value.
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CARBON
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2021
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IF 9.594
Yiou Ma,Haiyun Fan,Chao Wu,Mingdao Zhang,Jianghua Yu,Li Song,Kuiran Li,Jianping He
Single-atom catalysts have been extensively studied due to the high atom utilization efficiency. However, the atomically dispersed dual-metal-site material for bifunctional catalysis in zinc-air battery is still rare. Herein, taking advantage of the trapping ability of graphene oxide to anchor metal ions, a dual-metal-site bifunctional catalyst with atomically dispersed FeN 4 and NiN 4 in the nitrogen doped graphene (Fe/Ni(1:3)-NG) is developed. Benefiting from the synergy effect between Fe and Ni, the catalytic performance can be greatly enhanced. The resultant catalyst exhibits highly efficient bifunctional catalytic activity , with the half-wave potential of 0.842 V for oxygen reduction reaction (ORR) and an overpotential of 480 mV at the current of 10 mA cm -2 for oxygen evolution reaction (OER). On the basis of bifunctional catalytic activities, the Fe/Ni(1:3)-NG based zinc-air battery shows an excellent power density (164.1 mW cm -2 ), outstanding specific capacity (824.3 mAh g -1 ) along with the prominent durability.
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Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 4
·1292-1301
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IF 5.693
Zhang Pengxiang,Zhang Xihua,Li Bin,Xu Lingan,Dang Feng,Li Bao-Wen
Improving the interfacial impedance matching and attenuation ability of a microwave absorber is an important strategy to obtain excellent microwave absorbing performance. Here, we prepared an ultralight, hierarchical porous single-atom Co–N–C microwave absorber, in which evenly distributed single-atom Co is anchored in a porous N-doped carbon framework by N–Co bond via a facile bio-inspired method. These doped single atoms provide abundant highly active atomic absorption sites on the carbon skeleton, and considerable defects including pyridinic-N, pyrrolic-N, oxidized N, and so forth are introduced into the carbon framework owing to single Co atom doping. These doped single Co atoms and introduced defects act together as strong dipolar/interfacial polarization units, which lead to better impedance matching and a significant increase in attenuation capability of the absorber. The metal Co exists in form of a single atom, benefiting light weight of the absorber. Therefore, an extremely strong reflection loss (RL) value of − 60.9 dB is achieved at a lower filler content of 10 wt% with the absorber thickness of 2.5 mm, and the effective frequency bandwidth covered from 10.4 to 15.1 GHz with a thickness of 2.0 mm at a low filler content of 10 wt%. This research offers a novel route for designing a microwave absorber to improve microwave absorption performance and is expected to a wider range of absorbing materials with different structures. Graphical abstract
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VACUUM
·
2021
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IF 3.627
Zhiruo Shen,Changhua Xu,Sumin Wang,Jian Chen,Siqin Jia,Qiguan Wang
Electrolysis of water is a promising method for production of the green-energy hydrogen, which is commonly assisted by high powerful catalyst. At present, developing low-cost and highly efficient electrocatalysts has attracted increasing attention. Herein, a novel composited catalyst of Zn x Ni 1-x S@Mo 2 C loaded on conductive carbon cloth (Zn x Ni 1-x S@Mo 2 C/CC) is successfully prepared by the hydrothermal method . Due to the abundant active sites of defect structures induced by the surface engineering, the prepared Zn x Ni 1-x S@Mo 2 C/CC shows outstanding electrocatalytic performances in hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) of water splitting, with low overpotential of 230 mV and 150 mV at 10 mA cm −2 , respectively. The Zn x Ni 1-x S@Mo 2 C/CC as an OER/HER bifunctional catalyst for overall water splitting affords a stable voltage of 1.56 V @current density of 10 mA cm −2 . Moreover, the catalyst shows an outstanding stability after a series of electrochemical tests. This work expands the multi-field applications of carbon cloth-supported materials as efficient non-precious metal-based electrocatalysts , with great importance in sustainable energy-relative technologies.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 11
·1-10
·
IF 5.833
Xie Jiaojiao,Mu Zhaode,Yan Bin,Wang Jie,Zhou Jing,Bai Lijuan
A label-free electrochemical aptasensor is reported for sensitive detection of the 6-kDa early secreted antigenic target (ESAT-6). For the first time, the bimetallic organic framework (b-MOF) of Zr-MOF-on-Ce-MOF was decorated with nitrogen-doped graphene (NG) and applied as the matrix for electroactive toluidine blue (Tb) to form the NG@Zr-MOF-on-Ce-MOF@Tb nanohybrid. The prepared nanohybrid with excellent hydrophilicity, dispersibility, and large specific surface exhibited significant electrochemical response. This nanohybrid could be directly used for anchoring ESAT-6 binding aptamers (EBA) through the interaction between the 5′-phosphate group (PO 4 3− ) of EBA and Zr 4+ of Zr-MOF. The signal response before and after incubating the ESAT-6 antigen has been evaluated by cyclic voltammetry at a scan rate of 100 mV s −1 from − 0.7 to 0.3 V (vs. SCE). Under optimal conditions, the proposed aptasensor displayed a wide linear range from 100 fg mL −1 to 10 ng mL −1 with a limit of detection (LOD) of 12 fg mL −1 . The developed method showed good reproducibility with a relative standard deviation (RSD) of 2.27%. The aptasensor showed favorable results in the analysis of the real samples. With these merits, the aptasensor has exceptional potential as a diagnostic tool for tuberculosis in clinical practice. Graphical abstract
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Drug Design Development and Therapy
·
2021
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IF 4.162
Shuo Wang,Ping Zhao,Ying Zhang,Lianhua Zhu,Jianing Zhu,Yukun Luo,Qiuyang Li
Purpose Sepsis is the leading condition associated with acute kidney injury (AKI) in the hospital and intensive care unit (ICU), sepsis-induced AKI (S-AKI) is strongly associated with poor clinical outcomes. Curcumin possesses an ability to ameliorate renal injury from ischemia-reperfusion, but it is still unknown whether they have the ability to reduce S-AKI. The aim of this study was to investigate the protective effects of curcumin on S-AKI and to assess its therapeutic potential on renal function, inflammatory response, and microcirculatory perfusion.Methods Male Sprague-Dawley (SD) rats underwent cecal ligation and puncture (CLP) to induce S-AKI and immediately received vehicle (CLP group) or curcumin (CLP+Cur group) after surgery. At 12 and 24h after surgery, serum indexes, inflammatory factors, cardiac output (CO), renal blood flow and microcirculatory flow were measured.Results Serum levels of creatinine (Scr), cystatin C (CysC), IL-6 and TNF-α were significantly lower in the CLP+Cur group than those in the CLP group (P < 0.05). Treatment with curcumin improved renal microcirculation at 24h by measurement of contrast enhanced ultrasound (CEUS) quantitative parameters [peak intensity (PI); half of descending time (DT/2); area under curve (AUC); P < 0.05]. In histopathological analysis, treatment with curcumin reduced damage caused by CLP.Conclusion Curcumin can alleviate S-AKI in rats by improving renal microcirculatory perfusion and reducing inflammatory response. Curcumin may be a potential novel therapeutic agent for the prevention or reduction of S-AKI.
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2021
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IF 4.384
Meng Tong,Xiaoyan Wu,Shuya Zhang,Di Hua,Shukun Li,Xiangyu Yu,Jing Wang,Zhenhai Zhang
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve its solubility and bioavailability. The hot-melt process and formulation were optimized, and a BAC-PVP VA64-TPGS solid dispersion (BPT-SD) was prepared. BAC exists in an amorphous or molecular state in BPT-SD. BPT-SD comprised irregular lumps and small particles without BAC or carrier characteristics. The dissolution efficiency of BPT-SD improved under sink conditions. FTIR showed a strong hydrogen bond between BAC and PVP-VA64 in BPT-SD. BPT-SD maintained good physical stability for 6 months. The apparent permeability coefficient of BAC in the Caco-2 cell model confirmed that BPT-SD had higher gastrointestinal membrane permeability. A rat pharmacokinetic study showed that BPT-SD had higher C max and AUC 0- 24h, shorter T max , and 2.88-fold higher bioavailability than BAC. A behavioral experiment in chronic unpredictable mild stress (CUMS) mice confirmed the antidepressant efficacy of BAC. BPT-SD reversed depression-like behavior in CUMS mice and improved BAC bioavailability. BAC preparation into a solid dispersion significantly enhanced dissolution performance and bioavailability.
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Microbiology Spectrum
·
2021
·Vol. 9
·期 3
·
IF 7.171
Alia Rizvi Syeda Kazim,Yuting Jiang,Shengnan Li,Xiaoxiao He
α-Glucan is a major cell wall component and a virulence and adhesion factor for fungal cells. However, the biosynthetic pathway of α-glucan was still unclear. α-Glucan was shown to be composed mainly of 1,3-glycosidically linked glucose, with trace amounts of 1,4-glycosidically linked glucose. Besides the α-glucan synthetases, amylase-like proteins were also important for α-glucan synthesis. In our previous work, we showed that Aspergillus nidulans AmyG was an intracellular protein and was crucial for the proper formation of α-glucan. In the present study, we expressed and purified AmyG in an Escherichia coli system. Enzymatic characterization found that AmyG mainly functioned as an α-amylase that degraded starch into maltose. AmyG also showed weak glucanotransferase activity. Most intriguingly, supplementation with maltose in shaken liquid medium could restore the α-glucan content and the phenotypic defect of a ΔamyG strain. These data suggested that AmyG functions mainly as an intracellular α-amylase to provide maltose during α-glucan synthesis in A. nidulans.IMPORTANCE Short α-1,4-glucan was suggested as the primer structure for α-glucan synthesis. However, the exact structure and its source remain elusive. AmyG was essential to promote α-glucan synthesis and had a major impact on the structure of α-glucan in the cell wall. Data presented here revealed that AmyG belongs to the GH13_5 family and showed strong amylase function, digesting starch into maltose. Supplementation with maltose efficiently rescued the phenotypic defect and α-glucan deficiency in an ΔamyG strain but not in an ΔagsB strain. These results provide the first piece of evidence for the primer structure of α-glucan in fungal cells, although it might be specific to A. nidulans.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-9
·
IF 14.919
He Hongping,Wu Xiao,Xian Haiyang,Zhu Jianxi,Yang Yiping,Lv Ying,Li Yiliang,Konhauser Kurt O.
The evolution of oxygenic photosynthesis is a pivotal event in Earth’s history because the O 2 released fundamentally changed the planet’s redox state and facilitated the emergence of multicellular life. An intriguing hypothesis proposes that hydrogen peroxide (H 2 O 2 ) once acted as the electron donor prior to the evolution of oxygenic photosynthesis, but its abundance during the Archean would have been limited. Here, we report a previously unrecognized abiotic pathway for Archean H 2 O 2 production that involves the abrasion of quartz surfaces and the subsequent generation of surface-bound radicals that can efficiently oxidize H 2 O to H 2 O 2 and O 2 . We propose that in turbulent subaqueous environments, such as rivers, estuaries and deltas, this process could have provided a sufficient H 2 O 2 source that led to the generation of biogenic O 2 , creating an evolutionary impetus for the origin of oxygenic photosynthesis.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Yingfeng Qin,Gaojie Ye,Hao Liang,Ming Li,Jingjin Zhao
It is highly desirable to develop a simple, efficient and sensitive strategy for organophosphorus pesticides (OPs) in both environment pollution and human health. Herein, a novel amplified fluorescence polarization (FP) biosensor was established for highly sensitive detection of OPs using MnO 2 nanosheets as the signal enhancer. In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. TCh can lead the decomposition of MnO 2 nanosheets to manganese ions. So, without the influence of TCh, MnO 2 nanosheets can maintain its original shape and form a stable complex with FAM-DNA, which greatly enhanced the FP signal. This method can tremendously improve the sensitivity of FP with a detection limit of 0.01 ng/mL for diazinon. In addition, it was also applicable to determine other four OPs and investigate the level of diazinon in real water samples. Consequently, the proposed approach provides a new promising platform for detection of OPs and is expected to be used in application of environmental monitoring.
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COMPOSITES SCIENCE AND TECHNOLOGY
·
2021
·
IF 8.528
Xing-Yu Li,Pan-Pan Zhao,Lin-Xuan Han,Cong Deng
Flexible electromagnetic interference (EMI) shielding materials with low secondary electromagnetic radiation are urgently required for next-generation precise electronic devices and wearable electronics . However, realizing ultra-low microwave reflectivity and sustaining strong absorption feature in a wide frequency range remains a great challenge. Here, natural rubber-based flexible hierarchical composites were fabricated by combination of honeycomb-like 3D networks with selectively distributed ferro/ferric oxide modified graphene (F@rLG) magnetic particles and densely interconnected conductive networks (RL) with fulfilled multiwall carbon nanotubes (MWCNTs) via latex compounding together with co-vulcanization method. The resulting hierarchical bilayer elastomer has the EMI shielding coefficient of 34.4 dB at RL thickness of 0.18 mm, and achieves minimum electromagnetic wave reflection coefficient of 0.1. Moreover, in almost entire Ku band , over 80% incident electromagnetic waves can be absorbed, indicating its excellent capability in minimizing the secondary electromagnetic pollution . And this double-layered flexible material exhibits excellent stability in EMI shielding performance after the deformation cycles of 500 times. In addition, both the influence of precisely manipulated distribution of nanoparticles on the EMI property and the absorption-dominated approach via coupled layers were investigated in depth. This work paves a way for designing flexible EMI shielding materials with low secondary electromagnetic contamination.
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Frontiers in Aging Neuroscience
·
2021
·
IF 5.75
Bai Shuju,Wang Wenbo,Zhang Zhiwei,Li Mengyao,Chen Zehan,Wang Jiuqiao,Zhao Yanlin,An Lu,Wang Yuxiang,Xing Shu,Fu Xueqi,Ma Junfeng
Amyloid-β, a hallmark of Alzheimer’s disease, forms toxic intracellular oligomers and extracellular senile plaques resulting in neuronal toxicity. Ethanol is widely consumed worldwide. Moderate ethanol consumption has numerous benefits in humans. We found that ethanol could significantly extend the lifespan of Caenorhabiditis elegans in a previous study. Based on that study, we tested the effect of ethanol on Alzheimer’s disease transgenic Caenorhabiditis elegans strain CL4176, which expresses amyloid-β1-42 peptide in body wall muscle cells. Ethanol delayed paralysis and reduced amyloid-β oligomers in Caenorhabiditis elegans worms of the CL4176 strain. Moreover, ethanol could induce the nuclear translocation of DAF-16 in the nematodes. However, in worms that were fed daf-16 RNAi bacteria, ethanol no longer delayed the paralysis. The qPCR assays showed that ethanol increases the expression of daf-16, hsf-1 and their common target genes- small heat shock protein genes. In addition, we also found that ethanol could increase lysosome mass in the CL4176 worms. In summary, our study indicated that ethanol attenuated amyloid-β toxicity in the Alzheimer’s disease model of Caenorhabiditis elegans via increasing the level of lysosomes to promote amyloid-β degradation and upregulating the levels of small heat shock protein genes to reduce amyloid-β aggregation.
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