JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Ru Zhang,Xiaoxia Wang,Meichen Dong,Qingqing Tan,Anni Wang,Tingxi Zhu,Zhen Gu,Jiaxuan Xia,Jianxin Wang
Effective topical management of psoriasis is significantly hindered by the robust stratum corneum barrier and the complex inflammatory network residing in the dermis. To overcome these challenges, we developed a novel transfersomes (TFs) - based delivery system for the co-delivery of Ginsenoside CK (CK) and JAK inhibitor Tofacitinib (TOF). Uniquely, CK was employed to substitute cholesterol in the lipid bilayer. This design leveraged the unique pharmacological and structural properties of CK to modulate membrane properties while functioning as a potent immune regulator. The optimized TFs exhibited a uniform nanosize and exceptional deformability, enabling them to squeeze through the skin barrier and achieve superior drug deposition in deep dermal layers compared to conventional controls. This co-delivery strategy demonstrated remarkable therapeutic efficacy, significantly alleviating erythema and scaling while drastically reducing the thickening of the stratum corneum and Severity Index (PASI) scores in psoriatic mouse model. Distinct from conventional treatments, mechanistic evaluations revealed that the system synergistically remodeled the immune microenvironment. In psoriasis recurrence model, the co-delivery system significantly mitigated the re-activated cutaneous immune responses. It effectively blocked the JAK/STAT signaling pathway and suppressed the infiltration of key pathogenic cells, including IL-17 A + T cells, Langerhans cells, effector memory T-cells and tissue-resident T cells, which are notoriously difficult to target topically. Furthermore, CK potentiated the activity of TOF, leading to a marked reduction of IL-17 and upregulation of IL-10. These findings suggest that CK/TOF-co-loaded TFs represent a promising strategy for targeted psoriasis immunotherapy, leveraging nanocarrier-mediated permeation to significantly inhibit deep-seated dermal inflammation.
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PubMed
高影响因子
INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 35
·20464-20471
·
IF 4.6
Sun Ling,Gao Zhanyong,Li Huimin,Xu Xinyi,Zhao Di,Li Huanrong
Silver nanoclusters (AgNCs) with
exceptional luminescence
suffer
from an aggregation-induced loss of their unique quantum confinement
effects. LTA zeolites are ideal hosts for stabilizing AgNCs, yet most
reported water-responsive AgNC@LTA systems only exhibit binary luminescence
switching, restricting high-resolution multilevel environmental monitoring.
Herein, we construct a Mg 2+ -regulated AgNC@LTA system via
sequential ion exchange and thermal treatment. The as-prepared Ag-LTA(Na/Mg)
achieves continuous three-state luminescence switching with yellow
emission in dehydration, red in slight hydration, and green in full
hydration. Mechanistic studies reveal that Mg 2+ isolates
AgNCs, blocks framework-to-cluster charge transfer, and stabilizes
the intermediate excited state. The luminescence was confirmed as
phosphorescence. This material realizes a naked-eye-resolvable color
transition over 0%–60% relative humidity with excellent reversibility,
breaking the binary limitation and offering an avenue for high-precision
visual humidity sensors.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124738
·
IF 7.5
Xinyi Tao,Weiwei Chen,Xuehong Fan,Rui Hu,Xuejian Wang,Shiquan Sun,Yu-Hong Cui,Zheng-Qian Liu
Waste-derived biochar catalysts are widely used in catalytic ozonation. However, biochar is often constrained by insufficient surface active sites and low interfacial electron transfer efficiency. In this work, nitrogen (N) and sulfur (S) co-doped sediment-derived biochar (C-N 1 S 2 -600) was prepared by one-step pyrolysis using a mixed compost of black-odorous sediment, reed straw, and food waste as precursors, with melamine and thiourea using as the N and S sources, respectively. The optimized C-N 1 S 2 -600 has a well-developed mesoporous structure, abundant structural defects, and numerous reactive sites originating from N/S–C coordination. Ozonation with C-N 1 S 2 -600 achieved 62.8% Deethylatrazine degradation, which was significantly higher than that of ozonation alone (13.9%) and ozonation with pristine biochar (33.1%). C-N 1 S 2 -600 also exhibited excellent reusability over five consecutive cycles and maintained high performance in secondary effluent. Reactive species identification confirmed that C-N 1 S 2 -600 facilitated the conversion of O 3 into • OH. Theoretical calculations further revealed that N, S co-doping induced a more non-uniform surface charge distribution and narrowed the orbital energy gap, providing electronic-level insights into enhanced O 3 adsorption, interfacial electron transfer, and reactive oxygen species generation. C-N 1 S 2 -600 exhibited good operational stability and tolerance to matrix interference under the tested conditions. This study provides a feasible strategy for converting solid-waste-derived biochar into efficient carbonaceous catalysts for advanced wastewater treatment, and offers a promising strategy for micropollutant abatement and wastewater purification by catalytic ozonation with high-performance biochar catalyst.
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高影响因子
ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Yueru Fang,Zhiqiang Guo,Tanveer Hussain,Xiaoyong Lv,Ronghua Li
Organoarsenical contaminants such as roxarsone (ROX) pose a persistent challenge in water treatment because oxidative degradation of the parent compound inevitably generates inorganic arsenic (iAs), whereas adsorption-based processes immobilize iAs without removing the organoarsenical precursor. As a result, arsenic is redistributed among species rather than eliminated, and its overall fate during transformation and immobilization remains poorly quantified. Here, we develop a Co-doped LaOCl catalyst (Co 0.5 LOC) that enables coupled oxidative transformation and arsenic immobilization under peroxymonosulfate (PMS) activation via spatially integrated Co and La sites. Critically, a complete time-resolved arsenic mass balance is achieved throughout the reaction, with total arsenic recovery maintained at 100 ± 2%, thereby directly linking ROX degradation, iAs formation, and final immobilization. The catalyst exhibits a pseudo-first-order ROX degradation rate of 0.2935 min −1 , 2.2-fold higher than pristine LaOCl, with >96% removal across pH 5–9 and >81% activity retention after five cycles. Mechanistic analysis identifies surface-confined singlet oxygen ( 1 O 2 ) as the dominant reactive species, providing strong resistance to chloride ions and natural organic matter. A synergy index of 6.72 quantifies non-additive oxidation–adsorption coupling. Total organic carbon monitoring reveals that structural transformation substantially exceeds mineralization, with approximately 26% of the initial carbon remaining at 120 min; LC-HRMS tentatively identifies four aromatic intermediates in the residual fraction, consistent with the limited ring-opening capability of surface-confined 1 O 2 . Overall, this work establishes a unified strategy for organoarsenic remediation by integrating oxidative destruction with quantitative arsenic sequestration, enabling comprehensive contaminant fate accountability in advanced water treatment systems.
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高影响因子
POLYMER
·
2026
·
IF 5.1
Canzhang Wang,Liang Xu,Junfeng Qian,Qun Chen,Jing Zhang
High-performance epoxy resins (EPs) are indispensable matrices for advanced load-bearing composites, such as wind turbine blades and automotive lightweight structures. Achieving concurrent improvements in the mechanical and thermal performance of EP remains challenging for conventional toughening approaches. In this study, divinylbenzene (DVB)-crosslinked poly(styrene-co-maleic anhydride) (SMA) microspheres were synthesized via self-stabilized precipitation polymerization (2SP) and subsequently incorporated into the EP matrix. The microspheres combine reactive surface anhydride groups with a rigid aromatic backbone. The anhydride groups can participate in the epoxy–anhydride curing reaction, thereby improving the interfacial compatibility between the microspheres and the EP matrix. Meanwhile, the rigid benzene rings restrict segmental mobility and increase the rigidity of the crosslinked network. Curing kinetic analysis revealed that the incorporation of SMA microspheres reduced the apparent activation energy of the SMA/EP system, suggesting that the curing reaction was facilitated. This reduction may be attributed to the participation of surface anhydride groups in the cross-linking reaction and hydroxyl-mediated autocatalytic effects. Mechanical evaluations showed that, at an SMA loading of 2 wt%, the tensile strength of the SMA/EP composite reached 72.0 MPa, corresponding to a 48.8% increase compared with neat EP. At a loading of 3 wt%, the impact strength reached a maximum value of 19.2 kJ/m 2 , indicating a substantial improvement in toughness. In addition, dynamic mechanical analysis (DMA) indicated that SMA microspheres increased the crosslinking density, while differential scanning calorimetry (DSC) showed that the glass transition temperature (T g ) increased by approximately 9 °C compared with neat EP. These results highlight reactive SMA microspheres as promising modifiers for epoxy composites requiring balanced strength, toughness, and thermal performance.
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高影响因子
Frontiers in Microbiology
·
2026
·
IF 5.8
Rongling Yang,Ziling Huang,Yuli Tong,Dong Xu,Xiaoyan Li,Yanjin Li,Chun Zhu,Xiangjie Zhao
Phillyrin is a critical bioactive constituent of Forsythiae Fructus, exhibiting multiple pharmacological properties, but suffers from poor membrane permeability and low oral bioavailability. In this study, we developed a novel, green method employing whole-cell biocatalysts and natural deep eutectic solvents (NADESs) for the cinnamoylation of phillyrin to improve its liposolubility and bioactivity. Aspergillus oryzae whole cells showed high catalytic activity and stability in co-solvent systems containing hydrophobic NADESs. The NADES-tetrahydrofuran (50%, v/v) mixture maintained a high conversion rate (97.32–99.00%) and excellent 6′-regioselectivity (>99%) under optimal conditions (20 mg·mL−1 whole-cell dosage, 15:1 vinyl cinnamate/phillyrin, at 50 °C). Crucially, Aspergillus oryzae whole-cell biocatalysts exhibited markedly enhanced operational stability across all tested NADES-tetrahydrofuran (50%, v/v) reaction systems, retaining 80.09–97.95% of their original activity after six consecutive batch cycles. This study successfully combined hydrophobic NADESs with a whole-cell biocatalytic system, achieving efficient and regioselective cinnamoylation of phillyrin.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yuhui Lv,Xinyu Gao,Binghui Guo,Xinyi Li,Chenhui Sun,Suhang Wang,Rongshi Jing,Jiaxin Chen,Liying Pu,Min Zhang,Yanyan Liu,Gang Wang,Yucheng Ren,Tiantian Gu
Organic materials have attracted considerable attention in rechargeable aqueous zinc-ion batteries (AZIBs) due to their sustainability and structural tunability. However, the electrochemical performance of existing organic electrodes is severely constrained by limited redox-active sites, high solubility and short conjugated backbones. Herein, a conjugated N-heterocyclic anhydride-based framework, benzoquinone-fused dianhydride (NTBQ), was constructed via solid-state condensation to enable highly reversible Zn 2+ /H + storage. The strategic integration of C=O groups triggers intramolecular electrostatic potential reconstruction and activates adjacent C=N sites, enabling fast and thermodynamically spontaneous multi-electron Zn 2+ /H + co-insertion. The rational structural design endows the NTBQ cathode with a remarkable initial discharge specific capacity of 434.6 mAh g −1 at 0.05 A g −1 and excellent rate capability. Moreover, the extended π-electron delocalization significantly strengthens intermolecular π-π interactions, enhancing the dissolution resistance of NTBQ in aqueous electrolytes and affording long-lasting cycling durability (88.1% retention after 10,000 cycles at 10 A g −1 ). Systematic mechanistic studies demonstrate that the superior electrochemical performance originates from the synergistic redox chemistry of C=O/C=N dual-active centers within the anhydride-based skeleton. These findings demonstrate that intramolecular electronic modulation can effectively evoke multi-electron redox activity, providing an effective avenue for designing high-performance organic cathodes toward advanced AZIBs. Structural optimization from NTPH to NTBQ via incorporation of additional C O groups induces intramolecular electrostatic potential redistribution, enhancing π-electron delocalization and activating adjacent C N sites. This creates synergistic C O/C N dual-redox centers for efficient multi-electron Zn 2+ /H + co-insertion. Download: Download high-res image (130KB) Download: Download full-size image
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Meng Yuan,Lingling Huang,Qi Zhang,Mingquan Huang,Baocai Xu,Liangyun Yu
Novel S-scheme heterojunction boosts light absorption/charge separation. • In-situ Co-Pi co-catalyst reduced electron-hole recombination. • Polypyrrole-MIP membrane ensures DIM recognition with maintained conductivity. • The sensor achieves ultra-sensitivity: LOD 0.83 fmol/L, 1.0 fmol/L-100 pmol/L range. • The new sensors demonstrated reliable DIM detection in real samples. An S-scheme TpPzda-COF@ZnIn 2 S 4 @Co-Pi core–shell hybrid was fabricated via in situ growth of a ZnIn₂S₄ nanoflower shell on a β-ketoenamine-linked TpPzda-COF core, followed by photodeposition of a cobalt-phosphate (Co-Pi) cocatalyst. The resulting hierarchical architecture facilitated efficient interfacial charge transfer and synergistic effects, leading to enhanced light absorption, charge separation, and catalytic activity. Based on this photoactive material, a molecularly imprinted photoelectrochemical (MIP-PEC) sensor was constructed through electropolymerization using pyrrole as the functional monomer and dimethoate (DIM) as the template. The imprinted cavities enabled selective recognition of DIM, regulating interfacial electron transfer and producing distinct photocurrent responses. Benefiting from the π-conjugated structure of TpPzda-COF, the visible-light activity of ZnIn 2 S 4 , and the hole-extraction capability of Co-Pi, the proposed sensor exhibited high sensitivity, good stability, and satisfactory reproducibility. An ultralow detection limit of 0.83 fmol·L −1 was achieved over a wide linear range of 1.0 fmol·L −1 to 100 pmol·L −1 . Furthermore, successful determination of DIM in real fruit and vegetable samples demonstrated the applicability of the sensor for food safety and environmental monitoring. Download: Download high-res image (95KB) Download: Download full-size image
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高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2026
·
IF 17.2
Sen Feng,Cunyao Li,Benhan Fan,Guangjun Ji,Hong Wei,Xinyuan Liu,Yang Zhao,Miao Jiang,Li Yan,Qiang Zhou,Yunjie Ding
To replace scarce Rh resources and enhance the recyclability of the metal, we report a novel heterogeneous cobalt mononuclear complex catalyst, which possesses phosphorus-rich polymer backbone and P/S dual-atom coordination sites. This catalyst exhibited a much higher hydroformylation performance of 2,5-DHF compared to the Co-P homogeneous analogue, increasing conversion by 70% and shifting selectivity toward high-value-added 3-Formyl-THF by 15%. Under the optimal reaction conditions, the heterogeneous mononuclear complex Co 1 /POPs-PPh 3 -5P&2S catalyst displayed comparable performance of precious Rh-based catalysts, achieving a 96.8% conversion of 2,5-DHF and an 85.6% selectivity of 3-Formyl-THF for at least 5 runs. Comprehensive characterizations (extended X-ray absorption fine structure, X-ray photoelectron spectroscopy, in-situ Fourier transformed infrared, etc .) demonstrated that P/S dual-site coordination regulated the electronic structure of Co active centers. Notably, the incorporation of sulfur increased the difference in adsorption energy barriers between the substrate and its isomerized substrate, thereby promoting the massive generation of 3-Formyl-THF. Besides, time-of-flight secondary ion mass spectrometry and density functional theory calculations successfully evidenced the complete structure of the active center and established a coherent reaction mechanism. This study successfully developed a heterogeneous catalyst system based on a mononuclear cobalt complex, achieving a new strategy for non-noble metal catalysis and providing new insights into energy conservation and efficient resource utilization.
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高影响因子
Soft Science
·
2026
·Vol. 6
·期 3
·N
·
IF 15.9
Yexi Jin,Ruolin Wang,Jianyu Lin,Yu Lu,Jing Zhang,Xingwen Zhou,Baijie Cheng,Liguo Chen
Gait information is rooted in muscle contraction dynamics and neuromuscular regulation, and represents a reliable biometric. However, mechanical and bioelectrical signals acquired using conventional wearables are prone to replication and forgery during storage and transmission. Moreover, the degradation of recognition performance under standard encryption can occur due to limited feature dimensionality and fidelity. In this study, we present a spatiotemporally synchronous strain-surface electromyography (sEMG) co-sensing system (S-SESS), which co-locates and phase-aligns kinematic and neuromuscular signals from the gastrocnemius to deliver secure gait recognition. The strain sensing unit achieves a low hysteresis (1.6% at 100% strain) and high cyclic fidelity (> 10,000 cycles) using hierarchical supramolecular aggregates with multiple hydrogen bonds and dynamic π-π stacking that ensure precise phase tracking. The adaptive sEMG unit exhibits high interfacial conformity, suppresses motion artifacts, and achieves a signal-to-noise ratio (SNR) greater than 40 dB. The bimodal features are locally encrypted using the Advanced Encryption Standard-128 (AES-128) algorithm and processed directly in the ciphertext domain via a dedicated ByteEmbedded Temporal Convolutional Network (ByteEmbedded-TCN). This directly maps ciphertext streams into byte-embedded sequences and leverages causal and dilated convolutions to construct multi-scale receptive fields for temporal alignment and classification. The end-to-end framework achieves 89.7% ± 1.2% gait identification accuracy under encryption. The findings of this study provide a privacy-preserving wearable paradigm for trustworthy identity authentication.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Liang Zhou,Mingkang Zhang,Jingyi He,Hongbo Wang,Minjia Luo
• Co/TiO 2 @C composites are derived from bimetallic MOF. • • Minimum reflection loss of −64.5 dB at 1.8 mm thickness is achieved. • • Effective absorption bandwidth of 3.2 GHz in X-band. • • Hierarchical structure boosts interfacial and dipole polarization. In this study, disk-shaped MIL-125(Ti,Co)- x precursors were synthesized via a solvothermal method with varying CoCl 2 ·6H 2 O content, and subsequently Co/TiO 2 @C composites were fabricated through a two-step pyrolysis process. The precursor morphology transforms from intact micron-scale disks into thinner flakes, and ultimately into fragmented structures with increasing the cobalt content. The pyrolysis temperature concurrently governed the composition of TiO 2 phase, the degree of carbon graphitization, and the distribution of nanoparticles. The optimized Co/TiO 2 @C(700)-2 composite achieves a minimum reflection loss of −64.5 dB at a matching thickness of 1.8 mm, and exhibits an effective absorption bandwidth of 3.2 GHz at 2.1 mm. The outstanding electromagnetic wave absorption properties stem from a favorable synergy between adequate attenuation and satisfactory impedance matching, supported by the conductive carbon network, abundant defect sites, multiple TiO 2 /carbon heterointerfaces, and hierarchical porous architecture. These results establish the cooperative regulation of electromagnetic wave absorption properties by cobalt content and pyrolysis temperature, offering a strategy for the design of MOF-derived lightweight absorbers with tunable electromagnetic wave absorption. Download: Download high-res image (139KB) Download: Download full-size image
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高影响因子
Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 4
·340
·
IF 15.5
Wang Yanrong,Chen Qiuling
The strategic integration of metal-organic frameworks (MOFs) with MXenes presents a promising avenue to overcome charge separation bottlenecks in photocatalysis. This study constructs a hierarchical S-scheme heterojunction by in-situ growing ultrafine Zinc–Tetrakis(4-carboxyphenyl) porphyrin (Cobalt-incorporated) Zn-TCPP(Co) MOF nanoparticles (15 nm) on two-dimensional functionalized MXene nanosheets. This unique “particle-on-lamella” architecture is engineered with molecular bridges, establishing a chemically bonded interface via C–Ti–O and N–Ti bonds that facilitate rapid charge transfer. The optimized heterostructure exhibits a narrow bandgap of 1.95 eV, a significantly prolonged charge carrier lifetime of 35.5 ns, and a high photocurrent density of 1.7 µA cm − 2 . By leveraging synergistic S-scheme charge separation, MXene’s metallic conductivity, and molecular single-atom Co sites, the composite achieves an exceptional hydrogen evolution rate of 24.3 mmol g − 1 h − 1 with an apparent quantum efficiency of 10.2% at 420 nm—representing a sixfold enhancement over pristine Zn-TCPP(Co). This performance surpasses many recently reported MOF- and MXene-based photocatalysts. Combined density functional theory calculations and experimental analyses confirm the critical role of the internal electric field in driving the S-scheme mechanism, which effectively preserves strong redox potentials. This work provides a definitive blueprint for high-performance photocatalytic systems through molecular-level interfacial engineering.
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