COLLOIDS AND SURFACES B-BIOINTERFACES
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2018
·
IF 3.997
Xin Jin,Sajid Asghar,Mei Zhang,Zhipeng Chen,Lin Huang,Qineng Ping,Yanyu Xiao
N -acetylcysteine modified hyaluronic acid-paclitaxel (NAC-HA-PTX) conjugate was designed to improve the water solubility and oral bioavailability of PTX through mucosal bioadhesion ability. The average size of spherical NAC-HA-PTX micelles was 187 nm with a zeta potential of -25.38 mV. Mucin adhesion study showed that the amount of mucin adhered to NAC-HA-PTX micelles was 1.98-fold greater than that of hyaluronic acid-paclitaxel (HA-PTX) micelles. The fluorescence micrographs showed that the biodistribution sequence of coumarin 6-loaded micelles in the gastrointestinal tract was duodenum > jejunum > ileum, and NAC-modified micelles significantly exhibited better mucoadhesive properties than the corresponding unmodified ones. The pharmacokinetic study showed that the area under the curve (AUC 0-24h ) of NAC-HA-PTX micelles was 2.32-fold and 2.56-fold higher compared to that of HA-PTX micelles and PTX solution (Taxol) after oral administration, respectively. NAC-HA-PTX micelles appear to be a promising drug delivery system to improve the bioavailability of insoluble drugs for efficient tumor therapy via oral administration.
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高影响因子
Inorganic Chemistry Frontiers
·
2018
·Vol. 5
·期 9
·2211-2217
·
IF 5.106
Xianghong Li,Xu Sun,Xiang Ren,Dan Wu,Xuan Kuang,Hongmin Ma,Tao Yan,Qin Wei
Electrochemical oxygen reduction is a key process for many energy storage and conversion devices, and finding highly efficient, economical, and durable electrocatalysts to replace the Pt-based catalyst for the oxygen reduction reaction (ORR) is a critical obstacle. In this article, porous Fe–N-codoped materials are obtained by pyrolysis of a defined precursor of polydopamine-coated Fe3O4 as not only template but also nitrogen and iron source. In 0.1 M KOH, the as-prepared catalyst exhibited high ORR activity (onset potential of 0.949 V and half-wave potential of 0.836 V vs. RHE), with excellent electrochemical stability, durability and remarkable tolerance toward methanol. The successful synthesis of porous nanospheres provides a novel way to explore a series of mesoporous metal electrocatalysts for energy conversion.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 136
·期 46
·48237
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IF 2.188
Feng Gao,Yifang Mi,Xinlei Wu,Jun Yao,Qi Qi,Zhihai Cao
Stimuli-responsive polymeric nanogels hold great potential in biological applications. In this work, thermoresponsive polymeric nanogels were conveniently prepared through inverse miniemulsion polymerization of two monomers with a good biocompatibility, N -vinylcaprolactam and 2-methoxyethyl acrylate. A macromolecular crosslinker, poly(ethylene glycol) dimethacrylate (PEGDMA), was used to achieve a better thermoresponsiveness, compared with low-molecular-weight crosslinkers. The prepared poly( N -vinylcaprolactam- co -2-methoxyethyl acrylate) (poly(NVCL- co -MEA)) nanogels could be well redispersed in aqueous systems, displaying a reversible thermoresponsive transition behavior. The influences of the synthesis parameters including the emulsifier content, PEGDMA content, and monomer composition on the particle properties of poly(NVCL- co -MEA) nanogels both in inverse emulsions and in aqueous dispersions were systematically investigated. Furthermore, the impacts of the monomer composition and PEGDMA content on the thermoresponsiveness of poly(NVCL- co -MEA) nanogels were also studied. Promisingly, the introduction of MEA monomeric units to the copolymer chains only slightly reduced the thermoresponsiveness of poly(NVCL- co -MEA) nanogels. This feature allows to improve the biocompatibility of polymeric nanogels by using MEA as the comonomer without need to compromise the thermoresponsiveness of nanogels. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48237.
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CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Hanqin Liang,Huilu Guo,Jinwei Yin,Kaihui Zuo,Yongfeng Xia,Dongxu Yao,Jian Zhang,Yuping Zeng,Shiwei Wang
Transparent AlON ceramics were bonded with Lu-Al-Si-O-N oxynitride glass interlayer at 1450 °C in nitrogen atmosphere in this investigation. The Lu-Al-Si-O-N oxynitride glass showed good wettability on the AlON substrate and had strong interface adhesion with each other. The joining process had no detrimental effect on the in-line transmittance of transparent AlON ceramics but caused slight decrease of flexural strength due to the partial decomposition. The bonding strength of AlON/AlON joint was 142.7 ± 6.3 MPa at room temperature and 110.1 ± 9.6 MPa at 1200 °C in situ, which were comparable with those of the parent AlON ceramics. Some Lu 2 Si 2 O 7 grains crystallized out from the glass interlayer after joining.
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Rongfeng Tang,Xiaomin Wang,Chenhui Jiang,Shiang Li,Weifeng Liu,Huanxin Ju,Shangfeng Yang,Changfei Zhu,Tao Chen
Sb2S3 is a kind of new light-absorbing material possessing high stability in ambient environment, high absorption coefficient in the visible range, and abundant elemental storage. To improve the power conversion efficiency of Sb2S3-based solar cells, here we control the defect in Sb2S3 absorber films. It is found that the increase of sulfur vacancy is able to upgrade photovoltaic properties. With the increase in sulfur vacancy, the carrier concentrations are increased. This n-type doping gives rise to an upshift of the Fermi level of Sb2S3 so that the charge transport from Sb2S3 to the electron selection material becomes dynamically favorable. The introduction of ZnCl2 in film fabrication is also found to regulate the film growth for enhanced crystallinity. Finally, the photovoltaic parameters, short-circuit current density, open-circuit voltage, and the fill factor of the device based on the Sb2S3 film are all considerably enhanced, boosting the final power conversion efficiency from 5.15 to 6.35%. This efficiency is the highest value in planar heterojunction Sb2S3 solar cells and among the top values in all kinds of Sb2S3 solar cells. This research provides a fundamental understanding regarding the properties of Sb2S3 and a convenient approach for enhancing the performance of Sb2S3 solar cells.
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JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 13
·9690-9700
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IF 2.993
Huang Jinxin,Wang Jinglun,Zhong Haoxiang,Zhang Lingzhi
N -cyanoethyl polyethylenimine (CN-PEI) is synthesized by modifying polyethylenimine (PEI) with acrylonitrile through a Michael addition reaction. Depending on cyanoethylation level, CN-PEI can be obtained as a form of solution, micro-emulsion or emulsion in water. CN-PEI micro-emulsion is investigated as water-soluble binder for the application of lithium iron phosphate (LFP) cathode in lithium-ion batteries. CN-PEI binder not only maintains the outstanding dispersion capability of PEI but also exhibits an excellent adhesion strength and higher ionic conductivity because of the introduction of polar cyano groups. As a result, CN-PEI binder can effectively maintain the mechanical integrity and decrease the polarization of LFP electrode during the operation of the battery. LFP electrode with CN-PEI binder exhibits good cycle stability and enhanced rate performance delivering a capacity of 99.6% at a rate of 0.5 C after 100 cycles and a high discharge capacity of 102.4 mAh g −1 at 5 C.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2018
·
IF 4.229
Bin Wang,Tie-yan Chang,Zhao Jiang,Jin-jia Wei,Yong-hai Zhang,Sen Yang,Tao Fang
Through systematical experiments, a comparative study was conducted concerning several graphene-supported noble metal catalysts for dehydrogenation of dodecahydro-N-ethylcarbazole (12H-NEC). It was found that the catalytic activity of the prepared graphene-supported noble metal catalysts was following the order of Pd > Pt > Rh > Ru > Au for the dehydrogenation process. Pd supported on reduced graphene oxide (rGO) prepared by one-pot in situ synthesis has much more excellent catalytic performance than other kinds of catalysts investigated for comparison, simultaneously the using amount of noble metals can obviously be decreased. To be specific, at 453 K, the final dehydrogenation product catalyzed by the novel catalyst of Pd/rGO is N-ethylcarbazole (NEC) and the process selectivity was increased from 44.77% (commercial Pd/Al 2 O 3 ) to 97.65%, as well as the dehydrogenation ratio reached 99.14%. In addition, the novel catalyst is also superior to other reported catalysts in terms of dehydrogenation performance of 12H-NEC. Its dehydrogenation activity at 443 and 433 K of Pd/rGO was tested and the catalytic performance keeps stable at the two temperatures. Based on the experimental data, kinetic calculation was carried out and some fundamental parameters regarding reaction kinetics was obtained.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2013
·
IF 2.206
Yan Liu,Zhenhu Cao,Yan Zhang,Zhengping Fang
Cerium N-morpholinomethylphosphonic acid (MMPA-Ce) with fibrous structure was synthesized via hydrothermal reaction between cerium nitrate hexahydrate and N-morpholinomethylphosphonic acid. The thermal stability and flame retardancy of high density polyethylene (HDPE) containing various amounts of MMPA-Ce was investigated by thermal gravimetric analysis and cone calorimeter. It is found that even at low addition of MMPA-Ce into HDPE could increase the thermal stability of HDPE. The results of cone calorimeter showed that the emission of CO decreased while the emission of CO2 increased instead.
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RSC Advances
·
2014
·Vol. 5
·期 5
·3122-3129
·
IF 3.708
Jinjuan Xue,Shuaishuai Ma,Yuming Zhou,Zewu Zhang,Xin Wu,Chenguang She
Novel Ag2O/N-doped helical carbon nanotubes (Ag2O/N–HCNTs) were successfully synthesized via a simple coprecipitation method and were well characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectroscopy (EDS). The photocatalytic activities were evaluated in the degradation of methylene blue (MB) aqueous solution. The results showed that Ag2O nanoparticles sized 3–10 nm were highly anchored on the surface and inner tubes of the N–HCNTs support, and significantly enhanced the visible-light photocatalytic activity compared to bare Ag2O. It was attributed to the combined effects, including highly dispersed smaller Ag2O particles and higher charge separation efficiency. The possible mechanism for the photocatalytic activity of Ag2O/N–HCNTs was also tentatively proposed. In particular, the rate of degradation of the as-prepared Ag2O/N–HCNTs was 3.9 times faster than that of using bare Ag2O nanoparticles under visible light irradiation. Furthermore, the Ag2O/N–HCNTs could be easily recycled in visible photocatalytic activity. In addition, the Ag2O/N–HCNTs could also degrade MB dye in different water sources like Changjiang River water and tap water with high efficiency as well as in deionized water and that will greatly promote their application in the area of environmental remediation.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Wei Wei,Xinyu Hu,Xiaoliang Qi,Hao Yu,Yucheng Liu,Junjian Li,Jianfa Zhang,Wei Dong
Salecan is a novel microbial polysaccharide produced by Agrobacterium sp. ZX09. The salt-tolerant strain was isolated from a soil sample in our laboratory and the 16S rDNA sequence was deposited in the GenBank database under the accession number GU810841 . Salecan is suitable to fabricate hydrogel for biomedical applications due to the excellent hydrophilicity and biocompatibility. Here, salecan has been introduced into poly(N-isopropylacrylamide) (PNIPAm) network to form novel thermo-sensitive semi-interpenetrating polymer networks (semi-IPNs). The structure of salecan/PNIPAm semi-IPNs was confirmed by Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Thermogravimetric analysis (TGA) proved the stability of the semi-IPNs. Rheological and compressive tests revealed an elastic solid-like behavior and good mechanical properties of the hydrogels. Swelling behavior test showed the hydrogels possessed high water content at room temperature. An excellent thermo-sensitive property of fast response rates to temperature had been demonstrated as well. In vitro degradation measurements ensured the semi-IPNs were degradable. Cytotoxicity and cell adhesion study suggested the synthesized salecan/PNIPAm hydrogels were non-toxic and biocompatibility. The results indicated the novel thermo-responsive hydrogels could be a suitable candidate for biomedical applications.
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FOOD AND CHEMICAL TOXICOLOGY
·
2013
·
IF 3.01
Hui Dong,Demei Xu,Lihua Hu,Lingrui Li,Erqun Song,Yang Song
Tetrachlorobenzoquinone (TCBQ) is an active metabolite of pentachlorophenol (PCP). Although the genotoxic effect of PCP has been comprehensively investigated, there is little known about TCBQ’s genotoxic effects. In the current study, TCBQ was tested for its genotoxicity using HepG2 cells as experimental model. To select the exposure concentration of interest, cell viability was measured and three concentrations were used for further investigation. In single cell gel electrophoresis (SCGE) assay, concentration-dependent increase in tail length, tail DNA percentage and tail moment were detected following TCBQ exposure. Micronucleus (MN) assay indicated TCBQ gradually increased MN frequency and decreased nuclear division index (NDI). Enzyme-linked immunosorbent assay (ELISA) and western blotting analyses both showed TCBQ caused histone H2AX phosphorylation (γ-H2AX). Furthermore, the elevation of 8-hydroxydeoxyguanosine (8-OHdG) and reactive oxygen species (ROS) level indicated TCBQ-induced genotoxicity is associated with oxidative stress. On the other hand, N-acetyl-cysteine (NAC) administration significantly protected cells from the genotoxic effect of TCBQ. Overall, our data suggested TCBQ exerted genotoxic effect possibly via an oxidative damage mechanism in HepG2 cells and this toxicity is prevented by pretreatment with NAC.
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RSC Advances
·
2015
·Vol. 5
·期 21
·16368-16375
·
IF 3.84
Yupeng Sun,Chen Shen,Jing Wang,Yun Lu
A facile, simple, effective and green method has been developed to synthesize nitrogen and sulfur co-doped carbon dots (N, S-CDs) from heparin sodium. The as-prepared N, S-CDs possess naked-eye observable blue-green luminescence, good biocompatibility, low toxicity and strong fluorescence in live cell imaging, indicating their great potential to serve as high quality optical imaging probes. Besides, the N, S-CDs can also be used as a competitive fluorescent sensing platform for the detection of Fe3+.
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