TALANTA
·
2025
·
IF 6.1
Xiao Liang,Cheng-Guo Zhan,Juan Yang,Ji-Tao Li,Wen-Bo Zhao,De-Zhi Yang,Ya-Ling Yang,Zi-Tao Zhong
Transferrin (TRF) is the main iron-containing protein in plasma, responsible for carrying iron from digestive absorption and released from the erythrocyte degradation. The plasma TRF levels can be used to diagnose anemia and monitor treatment. Herein, a sandwich type biosensor was developed for the sensitive and efficient TRF detection utilizing the affinity of boronic acid and specific recognition of antibody. TRF can be captured by the facilely synthesized phenylboronic acid decorated SiO 2 @Fe 3 O 4 magnetic nanoparticle (PBA-SiO 2 @Fe 3 O 4 ), and then the antibody functionalized Au,Pt,Cu@polydopamine (Ab-Au,Pt,Cu@PDA) with peroxidase-like activity was bond to TRF to form the sandwich conjugate. After the prompt magnetic separation and catalysis with the chromogenic substrates (TMB and H 2 O 2 ), the distinct color development can be observed and measured for the TRF quantification. The proposed method shows satisfied performance with a detection range of 0.128–2000 ng/mL and LOD of 0.051 ng/mL. Moreover, this approach possesses excellent stability and simple operation, without complicated sample pretreatment. Consequently, this biosensor poses a significant potential for the diagnosis and monitoring of abnormal TRF levels-related diseases.
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DOI
PubMed
高影响因子
Environmental Science-Nano
·
2025
·
IF 5.1
Lu Wang,Siyuan Zhang,Jukun Xiong,Meicheng Wen
Formaldehyde (HCHO), a prevalent indoor volatile organic compound, poses significant health risks to humans even at very low concentrations. As a result, its efficient degradation at room temperature is of utmost importance. However, the detailed mechanism for catalytic oxidation of formaldehyde remains unclear, particularly regarding the role of water vapor, which has been subject to considerable debate. In this study, we synthesized Pt-supported TiO2 glass fiber catalysts (Pt/TiO2 GF) via NaBH4 reduction to investigate the reaction pathways and clarify the influence of water vapor on the oxidation process. The reaction mechanism and intermediates were systematically studied at room temperature using in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), kinetic isotope effect (KIE) analysis, and density functional theory (DFT) calculations. Results revealed a clear reaction pathway of HCHO → DOM → HCOO− → CO2, with formate C–H bond cleavage (HCOO−* + O* → CO2 + OH*) identified as the rate-determining step. Both experimental KIE results and theoretical calculations confirmed that water vapor substantially reduces the activation barrier for this step, significantly promoting formate decomposition and subsequent CO2 formation. This work provides critical insights into the role of water in enhancing formaldehyde oxidation and offers theoretical support for developing efficient catalysts suitable for humid environments.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Yaming Liu,Xinyu Li,Yutian Zhao,Zhenle Hu,Xinrui Zhu,Kemeng Chen,Yuxuan Lu,Guoqiang Liu,Chao Zhi,Yongzhen Wang,Jiaguang Meng,Xiang Li
The H 2 -induced attachment of nanoparticles (NPs) to nanowires (NWs) has become a new method for fabricating Pt-based alloy NWs. However, it is still unclear how the surface structure influences the attachment process. Herein, we introduced Ag, Pd and Rh elements into PtIr alloy to fabricate PtIrM (M = Ag, Pd, Rh) materials with similar compositions but different structure, to investigate the effects of changing the surface structures on the morphologies of the products. The results show that both excessive surface oxidation and the strong anchoring ability of Pt atoms are detrimental to the formation of NWs. Based on the special surface structure, the ethylene glycol oxidation reaction (EGOR) was used as a model catalytic reaction to evaluate the catalytic performance of these materials. The Pt 70 Ir 13 Pd 17 NWs deliver a mass activity of 8.93 A mg −1 , a Faradaic efficiency (FE) for glycolic acid of 96 % and the FE is still above 90 % after 50 hours of stability test, outperforming most previously reported electrocatalysts. Finally, in situ experiments and DFT calculations were used to reveal the reaction route of EGOR, where favorable adsorption in the key intermediate promotes activity, high energy barrier for C-C bond cleavage increases selectivity.
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高影响因子
Sustainable Chemistry and Pharmacy
·
2025
·
IF 5.8
Qianwei Li,Bowen Deng,Ru Feng,Di Chen,Linlin Hua
Extracting antidepressants from biological samples is challenging due to their low concentrations and complex matrices. Pipette-tip solid-phase microextraction (PT-μSPE) simplifies the process, reducing solvent use and enabling automation, but challenges like custom adsorbents and toxic solvents limit its broader application. Melt-blown polypropylene nonwoven, sourced from the middle layer of 3-ply disposable non-woven face masks, was employed as the sorbent material. The extraction tip was easily assembled by combining a 200 μL pipette tip, the melt-blown polypropylene nonwoven, and a 1 mL pipette tip. This method provides a cost-effective and sustainable alternative to conventional adsorbents. A 90% ethanol solution was selected as the desorption solvent to comply with green chemistry principles, with the volume minimized to 100 μL to reduce waste. The pH adjustment was achieved using low-toxicity sodium carbonate (Na₂CO₃). The developed PT-μSPE method proved excellent linearity, sensitivity, accuracy, precision, and robustness, making it suitable for routine antidepressant monitoring in plasma and urine. It offers a practical, scalable, and environmentally friendly solution for therapeutic drug monitoring.
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高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Kejun Luo,Wenxuan Guo,Yanting Yu,Simeng Xu,Min Zhou,Keqi Xiang,Kun Niu,Xianqi Zhu,Guangying Zhu,Zheng An,Qingsong Yu,Zhihua Gan
Cisplatin is widely used in the chemoradiotherapy (CRT) of cervical cancers . However, despite the severe systemic side effects, the therapeutic efficacy of cisplatin is often compromised by the development of drug resistance, which is closely related to the elevated intracellular thiol-containing species (especially glutathione (GSH)) and the adenosine triphosphate (ATP)-dependent glutathione S-conjugate pumps . The construction of a safe and redox-sensitive nano-sensitizer with high disulfide density and high Pt(IV) prodrug loading capacity (up to 16.50% Pt and even higher), as described herein, is a promising way to overcome the cisplatin resistance and enhance the CRT efficacy. The optimized nanoparticles (NPs) (referred to as SS CV 5 ) with moderate Pt loading (7.62% Pt) and median size (c.a. 40 nm) was screened out and used for further biological evaluation. Compared with free cisplatin, more drugs could be transported and released inside the cisplatin resistant cells (Hela-CDDP) by SS CV 5 NPs. With the synergistic effect of GSH scavenging and mitochondrial damage, SS CV 5 NPs can easily reverse the cisplatin resistance. Moreover, the higher nucleus DNA binding Pt content of SS CV 5 NPs not only caused the DNA damage and apoptosis of Hela-CDDP cells but also sensitized these cells to X-Ray radiation . The in vivo safety and efficacy results showed that SS CV 5 NPs effectively accumulated inside tumor and inhibited the growth of cisplatin resistant xenograft models while alleviating the serious side effect associated with cisplatin (the maximum tolerated cisplatin equivalent of single injection is higher than 20 mg/kg body weight). The intervention of exogenous radiation further improved the anticancer efficacy of SS CV 5 NPs and caused the shrinkage of tumor volume, thus making this safe and facile nano-sensitizer a promising route for the neoadjuvant CRT of cervical cancers.
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PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 48
·23206-23216
·
IF 6.97
Tao Yang,Yihui Wang,Wenxian Wei,Xinran Ding,Maoshuai He,Tingting Yu,Hong Zhao,Dongen Zhang
Fuel cells are expected to be one of the most promising alternatives to the increasingly scarce fossil fuels, and Pt is the most commonly used catalyst for anodic and cathodic electrochemical reactions. To realize large-scale commercialization, it is most urgent to improve the efficiency of Pt and reduce the cost. Here, we synthesized an octahedral Pt–Ni–Ir yolk–shell catalyst through stepwise co-deposition (SCD), surface-limited Pt deposition (SLPD) and Ni-coordinating etching (NCE) processes. Experimental studies showed that the catalytic activities of the as-prepared trimetal yolk–shell catalyst were several times higher than that of the commercial Pt/C towards oxygen reduction and methanol oxidization under both acidic and alkaline conditions. This work may be extended to designing other multimetallic functional materials with complex hierarchical nanostructures, which is conducive to greatly enhancing the performance.
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PubMed
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 11
·5762-5769
·
IF 6.739
Lihui Yuwen,Fei Xu,Bing Xue,Zhimin Luo,Qi Zhang,Biqing Bao,Shao Su,Lixing Weng,Wei Huang,Lianhui Wang
A general and facile method for water-dispersed noble metal (Au, Ag, Pd, Pt) nanocrystal modified MoS2 nanosheets (NM–MoS2 NSs) has been developed. By using sodium carboxymethyl cellulose as a stabilizer, well-dispersed NM–MoS2 NSs with homogeneously deposited noble metal nanocrystals (NM NCs) can be synthesized in aqueous solutions. Due to the transition from the semiconducting 2H phase to the metallic 1T phase, the chemically exfoliated MoS2 (ce-MoS2) NSs have improved electrochemical activity. The partially metallic nature of the ce-MoS2 NSs and the catalytic activity of the NM NCs synergistically make NM–MoS2 NSs a potential electrochemical catalyst. For the first time, Pd–MoS2 NSs were used as an electrocatalyst for methanol oxidation in alkaline media. The results showed that Pd–MoS2 NSs have enhanced catalytic activity with 2.8-fold anodic peak current mass density compared to a commercial Pd/C catalyst, suggesting potential for application in direct methanol fuel cells (DMFCs).
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 52
·期 13
·8207-8218
·
IF 2.599
Zhang Bin,Zhu Han,Zou MeiLing,Liu XinRong,Yang Hui,Zhang Ming,Wu WeiWei,Yao JuMing,Du MingLiang
Small-sized and well-dispersed Pt–Au nanoparticles (Pt–AuNPs) grown on carbon nanofibers (Pt–AuNPs/CNFs) with excellent electroanalytical and electrocatalytic performance in the detection of H 2 O 2 and the catalytic hydrogen evolution reaction (HER) were designed and fabricated via electrospinning technology and an in situ thermal reduction process. Large numbers of Pt–AuNPs were homogenously distributed on the CNFs. A Pt–AuNP/CNF hybrid with low Pt content was utilized as a bifunctional electrocatalyst, exhibiting a higher response current of 116 μA without an enzyme in the detection of H 2 O 2 and a lower overpotential ( j = 10 mA cm −2 at −235 mV) and Tafel slope (84 mV decade −1 ) for HER than the PtNPs/CNFs and the AuNPs/CNFs. These results were ascribed to the specific nanostructure of the well-dispersed Pt–AuNPs, the favorable electron transport capability, the excellent durability of the CNFs, and the enhanced surface-specific area of the Pt–AuNPs/CNFs. This study offers a green and facile method for constructing a specific bimetallic nanostructure for application in catalytic fields.
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高影响因子
Nano Research
·
2018
·Vol. 12
·期 1
·159-163
·
IF 7.994
Lu Wenli,Jiang Rui,Yin Xiong,Wang Leyu
Photocathode with superior catalytic activity, long-term stability, and fast mass/electron transfer is highly desirable but challenging for dye-sensitized solar cell (DSC). Herein, the ZIF-67 grown on carbon cloth is successfully transformed into CoSe 2 embedded in N-doped carbon nanocage (CoSe 2 /N-C) via a growth-carbonization-selenization process. The carbon cloth supported CoSe 2 /N-C, as photocathode of DSC, demonstrates a good long-term stability and high photovoltaic efficiency (8.40%), outperforming Pt. The good efficiency can be attributed to the high catalytic activity of CoSe 2 , fast mass transfer of porous 3D structure, and good electron transport derived from the intimate contact between CoSe 2 and highly conductive carbon cloth. The high stability would be ascribed to N-doped carbon coating that perfectly prevents CoSe 2 from decomposition. This work will pave the way to develop highly efficient and stable Pt-free photocathode for DSC.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2018
·
IF 11.698
Yunpeng Liu,Yuhang Li,Feng Peng,Yuan Lin,Siyuan Yang,Shengsen Zhang,Hongjuan Wang,Yonghai Cao,Hao Yu
Recently, MoS 2 as an efficient co-catalyst has attracted much attention for photocatalytic water splitting. MoS 2 has two polymorphs: semiconducting phase (2H) and metallic phase (1T). The 2H- and 1T- MoS 2 show different reaction mechanism in photocatalytic H 2 evolution. However, so far, very few experiments have clearly evidenced the electron transfer process between TiO 2 and mixed phase MoS 2 . This study for the first time has reported a simple hydrothermal synthesis method to prepare mixed phase few-layer MoS 2 nanosheets coated on TiO 2 nanorod arrays (MoS 2 @TiO 2 ) with a conductive fluorine-doped tin oxide (FTO) as a substrate. The structure of mixed phase MoS 2 was characterized carefully. The designed MoS 2 @TiO 2 exhibits two times higher activity than Pt@TiO 2 for photocatalytic H 2 evolution. The reliable conclusion that the photo-generated electrons from TiO 2 to MoS 2 nanosheets has clearly been evidenced by photoelectrochemical analyses and in-situ KPFM experiments, and the mixed phase MoS 2 here is a co-catalyst such like Pt rather than as a semiconductor. This study not only presents a series of solid experimental evidences to verify the electrons transfer process and photocatalytic mechanism, but also provides a new method in substituting MoS 2 for noble metal Pt as co-catalyst in high-efficiency photocatalytic water splitting into hydrogen.
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高影响因子
Functional Materials Letters
·
2024
·
IF 1.2
Shenwei Zhang,Dongrui Chen,Wenmin Guo,Xiaoming Wang,Zhibin Ding,Xiaofu Tang,Junxia Zhang,Haijiang Wu,Diping Zeng,Hongqing Wei,Wenjun Wang,Yi Ma,Jinhua Zhou,Zaijun Su
This paper employs electrochemical methods (linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS)) to investigate the electrochemical behavior of platinum, glassy carbon, 304 stainless steel, titanium, and copper in 21 and 1 M LiTFSI electrolytes. The LSV results indicate that the electrochemical stability window of the materials varies with the electrolyte concentration, and the stability window is wider in the high-concentration system. Through Tafel polarization curves and EIS analysis, the overpotential of the charge exchange process differs due to the type of material and the concentration of the electrolyte, mainly attributed to the influence of the proportion of free water, electrolyte viscosity, and SEI film formation on electrode process kinetics. After comparative analysis, glassy carbon exhibits a higher overpotential than other materials at both the cathode and anode, effectively suppressing water decomposition. These findings provide theoretical support for the development of high-performance aqueous lithium-ion battery current collector materials.
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高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2021
·
IF 3.407
Wenjia Li,Chang Liu,Dong Liu,Shuda Liu,Tianyan You
The demand for efficient methods to determine mercury ion (Hg 2+ ) is increasing. Herein, we developed a ratiometric fluorescence assay by the coupling of nanozyme and fluorescence resonance energy transfer (FRET) to determine Hg 2+ . Platinum nanoparticles (PtNPs) was synthesized as effective nanozyme to catalyze the oxidation of o-phenylenediamine (OPD) at the presence of hydrogen peroxide (H 2 O 2 ) to produce 2,3-diaminophenazine (DAP). The fluorescence emission of Si quantum dots (QDs) at 414 nm (I 414 ) was observed to be quenched by DAP (emission at 576 nm (I 576 )) via FRET mechanism, whereas Hg 2+ can depress the catalytic activity of PtNPs to generate DAP. Based on this principle, SiQDs/PtNPs/OPD/H 2 O 2 -based ratiometric fluorescence assay was developed that the emission ratio of DAP and SiQDs (I 576 /I 414 ) decreased with a higher concentration of Hg 2+ . Noteworthy, the sensitivity of such system was found to be related with the value of I 576 /I 414 . The developed assay offered a detection range of 20–3000 nM and a detection limit of 10.5 nM. This assay was applied to analyze Yangtze river water, and its reliability has been validated by the standard ICP-MS method. Our work provided an effective and convenient method for Hg 2+ detection.
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