JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yuanpeng Cai,Danyang Li,Yufei Ling,Huihui Jiang,Hui Liu
A novel triple-responsive composite hydrogel, p(NIPAM-co-MAA-co-SPMA), was designed and synthesized via free radical polymerization, incorporating N-isopropylacrylamide (NIPAM) for temperature responsiveness, methacrylic acid (MAA) for pH sensitivity, and spiropyran methacrylate (SPMA) for light responsiveness. This study aimed to develop a novel stimuli-responsive sustained release drug delivery system. The composition and structure of the hydrogel were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Doxorubicin (DOX) was used as a model drug to evaluate loading and release behavior. The hydrogel achieved a drug loading content (DLC) of 25.7% and a drug loading efficiency (DLE) of 74.3% and enabled controlled release with approximately 89% cumulative DOX release within 6 h under combined thermal, acidic, and ultra-violet light stimuli. Cytotoxicity assays and cellular uptake studies confirmed the excellent biocompatibility of the hydrogel and its efficacy in suppressing cancer cell growth. These results highlight the potential of p(NIPAM-co-MAA-co-SPMA) as an intelligent platform for on-demand targeted anticancer therapy.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Qingqing Liu,Lan Zhou,Yuhua Zeng,Qiaolan Fang,Xing Deng,Wenzhou Zhong,Liqiu Mao
Developing low-cost and efficient metal-free carbon-based photocatalysts is of great significance but remains a challenge for light-driven selective organic synthesis integrated with CO 2 reduction. Herein, the N/O functional groups and high specific surface areas of porous biochars are dexterously designed by one-pot pyrolysis of waste coconut shell with combining tripolycyanamide and K 2 CO 3 co-modification, and demonstrate the high performance of the obtained porous biomass-derived biochar photocatalysts with photogenerated holes and electrons on the synergistic coupling amine dehydrogenation oxidation and reaction of CO 2 reduction to HCOOH, which can swiftly convert 86.0 % of benzylamine into N-benzylidenebenzylamine with a selectivity of 99.9 % under visible-light radiation. This coconut shell-derived biochar exhibits a wide generality for various aromatic amines, accompanied by the advantages of good recyclability and stability. Structure analysis and theoretical calculations reveal that the construction of the orbital interaction between the p-orbital on nitrogen and π-orbitals of polyaromatics with the terminal carboxylic acid groups greatly boosts the photogenerated charge-carrier separation, and reduce the possibility of recombination of photogenerated electrons and holes along with the layered graphitic structure. Meanwhile, the polyaromatic carboxylic acid groups and graphitic-N moieties serve as active sites with the π-π electron-donor-acceptor interactions for the adsorption/activation of amines and CO 2 , which promotes the synergistic oxidation-reduction process.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Shuhong Yi,Chenlong Gao,Qingfeng Fu,Shiru Wu,Jian-Fang Wu,Yan Duan,Menghao Yang,Jilei Liu
Solid-state potassium-ion batteries are promising options for large-scale energy storage due to their high safety and abundance of potassium resources. However, solid-state potassium-ion batteries are still in their infancy and the reported electrolyte materials are very limited, making the exploration of solid electrolytes with high ionic conductivity and physical/electrochemical stability a major challenge. Here novel triclinic K 3 LnSi 3 O 9 (Ln = Y and Gd) potassium-ion solid electrolyte is reported with low activation energy and high stability. A rational vacancy design strategy is adopted to synthesize K 3−x GdP x Si 3−x O 9 and the result of DFT calculation shows that the diffusion pathways of potassium ions on the ac plane exhibit a fish scale-like network structure. Specifically, the K 2.8 GdP 0.2 Si 2.8 O 9 delivers a high ionic conductivity of 2.9 × 10 −5 S cm −1 at 25 °C, accompanied by a stable potassium stripping/plating (a long-life cycle over 2000 h). As a result, the assembled quasi-solid-state KC/K 2.8 GdP 0.2 Si 2.8 O 9 /PB cell achieves a remarkable cycling performance at a high current density of 1 C (500 cycles, 95.9% capacity retention). These results would no doubt boost research for high-safety and high-energy-density solid-state potassium-ion batteries.
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PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Shangyu Hu,Bao Ren,Fanfei Min,Mingkang Xu,Xiaowei Huang,Jiaqiang Zhu
The intractable mineral processing wastewater poses severe challenges to ecological environments and resource utilization. Developing novel flocculants for efficient treatment of complex mineral processing wastewater is an urgent problem that demands immediate resolution. In this study, a novel cationic polyacrylamide flocculant with hydrophobic modification, designated P(AM-MAPTAC-TEMAC 6 ), was synthesized via low-pressure ultraviolet (UV) -initiated polymerization using methacrylamido propyl trimethyl ammonium chloride (MAPTAC), acrylamide (AM), and perfluorohexyl ethyl methacrylate (TEMAC 6 ) as comonomers, with irgacure 2959 as the photo-initiator. The synthesis conditions were systematically optimized through single-factor experiments, culminating in optimal parameters: total monomer concentration of 35%, TEMAC 6 content of 10 wt%, photo-initiator dosage of 0.3 wt%, surfactant dosage of 0.8 wt%, UV irradiation time of 4 h, and urea dosage of 0.3 wt%. The successful synthesis of the copolymer was confirmed by ¹H nuclear magnetic resonance (¹H NMR) and Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed a well-developed porous structure, while thermogravimetric analysis (TG/DTG) demonstrated enhanced thermal stability. Flocculation and dewatering tests showed that P(AM-MAPTAC-TEMAC 6 ) exhibited superior turbidity removal and moisture reduction compared to three commercial flocculants in kaolinite, quartz, and montmorillonite suspensions. At a dosage of 50 g/t, residual turbidity values reached 99.63 NTU, 110.5 NTU, and 63.35 NTU, respectively, while the increments in moisture content of filter cakes consistently lower than that achieved by three commercial flocculants.
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高影响因子
NATURE MATERIALS
·
2024
·Vol. 23
·期 12
·1686-1694
·
IF 37.2
Shi Jie,Koketsu Toshinari,Zhu Zhenglu,Yang Menghao,Sui Lijun,Liu Jie,Tang Mingxue,Deng Zhe,Liao Mengyi,Xiang Jingwei,Shen Yue,Qie Long,Huang Yunhui,Strasser Peter,Ma Jiwei
‘Anode-free’ Li metal batteries offer the highest possible energy density but face low Li coulombic efficiency when operated in carbonate electrolytes. Here we report a performance improvement of anode-free Li metal batteries using p -block tin octoate additive in the carbonate electrolyte. We show that the preferential adsorption of the octoate moiety on the Cu substrate induces the construction of a carbonate-less protective layer, which inhibits the side reactions and contributes to the uniform Li plating. In the mean time, the reduction of Sn 2+ at the initial charging process builds a stable lithophilic layer of Cu 6 Sn 5 alloy and Sn, improving the affinity between the Li and the Cu substrate. Notably, anode-free Li metal pouch cells with tin octoate additive demonstrate good cycling stability with a high coulombic efficiency of ~99.1%. Furthermore, this in situ p -block layer plating strategy is also demonstrated with other types of p -block metal octoate, as well as a Na metal battery system, demonstrating the high level of universality.
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BIOCHEMICAL ENGINEERING JOURNAL
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2022
·
IF 4.446
Ying Zhang,Yucui Jiang,Bin Wei,Mingming Su,Hao Liang
Enzyme is an efficient green catalyst, but its vulnerability and difficulties of separation from products limited the application in industry. Furthermore, a large number of oxidase enzymes rely on dihydronicotinamide adenine dinucleotide (NADH) or dihydronicotinamide adenine dinucleotide phosphate (NADPH) cofactors . These cofactors are too expensive to be used in industrial processes. Thus, cofactor regeneration is an important method to avoid the consumption of large quantities of oxidized cofactor NAD(P) + in enzyme-catalyzed reactions. In this paper, Cu based metal nucleotides coordination polymers (MNCPs) with NAD(P)H oxidase activity were constructed by self-assembly of copper ions and nucleotides. Cu 2+ /AMP and Cu 2+ /GMP showed high catalytic activity and high reusability. Then, Cu 2+ /AMP with NADH oxidase activity was combined with NAD + dependent alcohol dehydrogenase (ADH) to construct a bienzyme cascade system with circulating cofactor, which applied to the conversion of benzyl alcohol to benzaldehyde. In this system, ADH exhibited high activity due to the increase of substrate concentration and the inhibition of the diffusion of intermediate products. Besides, the bienzyme cascade system also showed high stability and reusability. After 8 cycles, the immobilized ADH remained more than 57% of the initial activity. The prepared bienzyme cascade system can extensively extended its application in industrial production.
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高影响因子
MOLECULES
·
2017
·Vol. 22
·期 7
·1165
·
IF 2.861
Xican Li,Yage Tian,Tingting Wang,Qiaoqi Lin,Xiaoyi Feng,Qian Jiang,Yamei Liu,Dongfeng Chen
The aim of this study was to explore the role ofp-coumaroyl in the antioxidant and cytoprotective effects of flavonoid glycosides. The antioxidant effects of astragalin and tiliroside were compared using ferric ion reducing antioxidant power, DPPH• scavenging, ABTS•+scavenging, •O2–scavenging, and Fe2+-chelating assays. The results of these assays revealed that astragalin and tiliroside both exhibited dose-dependent activities; however, tiliroside exhibited lower IC50values than astragalin. In the Fe2+-chelating assay, tiliroside gave a larger shoulder-peak at 510 nm than astragalin, and was also found to be darker in color. Both of these compounds were subsequently evaluated in a Fenton-induced mesenchymal stem cell (MSC) damaged assay, where tiliroside performed more effectively as a cytoprotective agent than astragalin. Tiliroside bearing a 6′′-O-p-coumaroyl moiety exhibits higher antioxidant and cytoprotective effects than astragalin. The 6′′-O-p-coumaroyl moiety of tiliroside not only enhances the possibility of electron-transfer and hydrogen-atom-transfer-based multi-pathways, but also enhances the likelihood of Fe-chelating. Thep-coumaroylation of the 6"-OH position could therefore be regarded as a potential approach for improving the antioxidant and cytoprotective effects of flavonoid glycosides in MSC implantation therapy.Keywords:tiliroside;astragalin;p-coumaroyl;flavonoid glycoside;mesenchymal stem cells
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PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 46
·26729-26733
·
IF 3.049
Ya Zhu,Jialing Han,Qian Zhang,Zhou Zhao,Jin Wang,Xiaowei Xu,Haiping Hao,Jun Zhang
Human NAD(P)H:quinone oxidoreductase (hNQO1) can be used as a biomarker for the early diagnosis of cancer. In this article, a novel fluorescent probe 1 for detecting hNQO1 was designed and synthesized by using 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) derivative (TCF-OH) as a fluorophore and quinone propionic acid (QPA) as a recognition group. The probe, which has high selectivity for hNQO1 and a Stokes shift of about 117 nm, shows a linear relationship with hNQO1 concentrations in the range of 0.25–3 μg ml−1 with the color changes from yellow to red and was successfully applied to intracellular hNQO1 imaging.
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PubMed
高影响因子
Materials Today Bio
·
2022
·
IF 10.761
Lei Han,Xianzhen Dong,Tong Qiu,Zhaona Dou,Lin Wu,Honglian Dai
Wallerian degeneration after peripheral nerve injury (PNI), that is, the autonomous degeneration of distal axons, leads to an imbalance of iron homeostasis and easily induces oxidative stress caused by iron overload. Inspired by the process of nerve degeneration and regeneration, the design of a functional electrospinning scaffold with iron chelating ability exhibited the importance of reconstructing a suitable microenvironment. Here, an electrospinning scaffold based on deferoxamine and poly(3(S)-methyl-morpholine-2,5-dione -co- lactone) (PDPLA/DFO) was constructed. This work aims to explore the promotion of nerve regeneration by the physiological regulation of the scaffold. In vitro , PDPLA/DFO films mitigated the reduction of glutathione and the inactivation of Glutathione peroxidase 4 caused by iron overload. In addition, they decreased reactive oxygen species, relieve the stress of the endoplasmic reticulum and mitochondria, and reduce cell apoptosis. In vivo , PDPLA/DFO conduits constructed the anti-inflammatory microenvironment and promoted cell survival by alleviating iron overload and organelle stress. In conclusion, PDPLA/DFO guidance conduits targeted the distal iron overload and promoted nerve regeneration. It provides novel ideas for designing nerve conduits targeting the distal microenvironment.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Weiying Zhou,Fuwang Mo,Zishan Sun,Jiabao Luo,Jiaqi Fan,Hongni Zhu,Zhenpeng Zhu,Jinqing Huang,Xinguo Zhang
Carbon dots (CDs) with long-wavelength-emission and high quantum yield (QY) are the focus of current research, compared with widely-investigated blue-emitting CDs. Herein, bright red-emitting CDs were synthesized by hydrothermal reaction at 200 °C for 3 h. CDs prepared by p-Phenylenediamine (pPD) exhibits a weak red band at 635 nm under an excitation wavelength of 450 nm. Adding (NH 4 ) 2 HPO 4 and KBr as P and Br precursors, the red emission peak at 610 nm, which shows a peak blue-shift about 25 nm with a dramatic emission enhancement up to 20-folds by co-doping of P, Br atoms into CDs. The corresponding QY value of P, Br-doped CDs (P, Br-CDs) was greatly improved to 11.3% as compared to bare CDs’ (0.55%). Furthermore, P, Br-CDs show a remarkable luminescent turn-off response after adding copper ions (Cu 2+ ). In addition, the quenched luminescence of P, Br-CDs/Cu 2+ complex could be recovered by the chelation between Cu 2+ and L -cysteine ( L -Cys) after adding L -Cys. This fluorescence “ON-OFF-ON” protocol could be applied for sequent Cu 2+ and L -Cys detection, and offer a linear range of 0–150 μM and 0–100 μM with a limit of detection of 4.408 µM and 2.373 µM for Cu 2+ and L -Cys, respectively. All results indicate that P, Br-CDs are of great potential for further biological and environmental application.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Yang Liu,Weihua Chen,Lehui Lu,Bai Yang
Room temperature phosphorescence (RTP) materials have been widely noticed due to their superior optical properties in the past decade. Herein, we report the Si-assisted N, P co-doped RTP carbonized polymer dots (CPDs), prepared by one-step microwave assisted heating of 3-(2-Aminoethylamino)propyldimethoxymethylsilane and phosphoric acid aqueous solution. The obtained CPDs exhibit bright RTP with an absolute photoluminescence quantum yield 34.17%, absolute phosphorescence quantum yield 11.42% and long lifetime of 1.42 s, which lasts for about 16 s to the naked eyes. We apply the obtained CPDs into information encryption and Polyethylene terephthalate (PET) film graphic anti-counterfeiting with facile way. Additionally, we make more efforts to realize aqueous RTP CPDs composite. The obtained aqueous CPDs composite exhibits bright aqueous RTP with absolute photoluminescence quantum yield (QY) of 12.61%, absolute phosphorescence quantum yield (QY) of 5.08% and RTP lifetime of 1.46 s, which lasts for about 10 s to the naked eyes. The RTP CPDs composite is nontoxic and biocompatible. These brilliant characteristics allow CPDs composite to be applicable in biological imaging. Thisstudy affords a new RTP material which can be easily prepared and used for information encryption, graphic anti-counterfeiting and biological imaging
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PubMed
高影响因子
FIRE SAFETY JOURNAL
·
2022
·
IF 3.78
Qinyong Liu,Xingyu Chen,Guiyang Zhu,Xiaoyu Gu,Hongfei Li,Sheng Zhang,Jun Sun,Xiaodong Jin
A novel integrative supramolecular intumescent flame retardant was fabricated by self-assembly of melamine, p -aminobenzene sulfonic acid and phytic acid and was abbreviated as MAP. After chelation with Fe 3+ or Zn 2+ , the resulted products (MAP-Fe and MAP-Zn) were melt-blended with polylactic acid (PLA) to enhance the flame retardancy of PLA. The fire performance was characterized by limiting oxygen index (LOI), UL-94 vertical burning and cone calorimeter tests. The results showed that control PLA was flammable with a low LOI of 20.4%, and it cannot satisfy any UL-94 grade for its severe ignited dripping, whilst the incorporation of 3% MAP-Zn increased the LOI to 29.2％, upgraded the UL-94 rating to V-0, and reduced the peak heat release rate by 18.7%. It was proposed that MAP-Zn mainly promoted the formation of more graphitic carbon in the char residues . In addition, the presence of 3% MAP-Zn slightly reduced the tensile strength of PLA from 64.9 MPa of the control PLA to 60.1 MPa, which met the requirements of most practical applications.
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