Food and Bioprocess Technology
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2026
·Vol. 19
·期 8
·424
·
IF 5.6
Zhang Hao,Chen Fenlin,Sun Shangde,Chen Xiaowei,Bi Yanlan,Qiu Shaohua,Yan Chao,Wang Mingfu,Zhao Yueliang
Black chokeberry pomace (BCB) and its water-insoluble fraction (IBCB) were incorporated into potato crisps to evaluate their effects on α,β-unsaturated aldehyde formation during frying and simulated gastrointestinal digestion. Water washing converted BCB into an insoluble fraction with undetectable soluble sugars and free amino acids, while enriching dietary fiber and nonextractable phenolics. Compared with BCB, IBCB showed higher retention of anthocyanins and flavonols during frying and greater reductions in five aldehyde endpoints, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal, acrolein, and 2,4-decadienal. During the static enzyme-assisted digestion model, IBCB-20 reduced late-stage MDA accumulation by 88.4% and HNE accumulation by approximately 93.1% at the 16-h simulated colonic phase. In the co-digestion experiment, the IBCB insoluble matrix decreased MDA and HNE by 63.1% and 83.9%, respectively, whereas an ABTS-matched Trolox dose decreased them by 52.5% and 53.0%. Because phenolic-aldehyde adducts were not directly characterized, these results should be interpreted as indirect evidence that the IBCB fiber matrix may provide sustained antioxidant effects and may contribute to matrix-associated carbonyl interactions. Overall, water-insoluble chokeberry pomace represents a promising formulation strategy for lowering aldehyde burden in fried snacks, but sensory evaluation, microbiota-based fermentation, cellular assays, and in vivo studies are still required to establish practical and biological relevance. Graphical
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International Journal of Nanomedicine
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2023
·
IF 8
Jing Lin,Chaoyue Zhao,Cuijuan Liu,Shiyao Fu,Luying Han,Xinping Lu,Chunrong Yang
Introduction The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR).Materials and methods This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity. Moreover, the redox-responsive mixed micelles, F127-folate (FA)/FSST/P123 (FFSSTP), based on FSST, Pluronic F127-FA, and Pluronic P123, were prepared to load paclitaxel (PTX).Results The in vitro release study demonstrated that FFSSTP/PTX accelerated the PTX release through the breakage of disulfide bond in reductive environment. In cellular experiment, FFSSTP/PTX induced significant apoptosis in PTX-resistant MCF-7/PTX cells through inhibiting adenosine triphosphate (ATP)-binding cassette proteins from pumping out PTX by interfering with the mitochondrial function and ATP synthesis. Furthermore, FFSSTP/PTX induced apoptosis through elevating the intracellular levels of ROS.Conclusion FFSSTP could become a potential carrier for the treatment of MDR tumors.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 20
·8015-8027
·
IF 4.569
Zongyu Zhang,Xiuling Xue,Xiaoyi Chen
A novel ternary dual Z-scheme 2D g-C3N4 nanosheet/Ag3PO4/α-Bi2O3 (CNN/AP/BO) photocatalyst was successfully synthesized by an in situ deposition and hydrothermal–calcination method. The coupling of AP and BO remarkably enhanced the photocatalytic tetracycline (TC) degradation under visible light illumination, with an optimal removal efficiency of 91.6% (60 min), which can be attributed to the extended visible-light absorption and increased specific surface area owing to the interfacial intimate coupling with well-matched energy band positions between semiconductors. The improved photocatalytic activity resulted from the abundant free radicals by the order of ˙O2− > h+ > ˙OH based on the electron spin resonance (ESR) and quenching experiment results. In addition, the possible mechanism of TC degradation over the ternary dual Z-scheme heterojunction CNN/AP/BO was proposed.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiongfang An,Yang Chen,Minghui Ao,Yahui Jin,Liwei Zhan,Bing Yu,Zhansheng Wu,Peikun Jiang
Photocatalysis is regarded as one of the most promising techniques for degrading organophosphorus pesticides (OPs) from wastewater given its low-cost and environmental benignity. Yet, photocatalytic degradation of OPs is an incomplete process, since PO 4 3− is produced after photocatalysis. Here, biochar-supported α-Fe 2 O 3 /MgO composite (BC-α-Fe 2 O 3 /MgO) is developed for sequential photocatalytic degradation of OPs and recovery of the produced PO 4 3− . The degradation efficiency of N-phosphonomethyl iminodiacetic acid (NPA) by BC-α-Fe 2 O 3 /MgO based photocatalysis reaches 90.1% within 80 min, and the recovery ratio of the produced PO 4 3− by BC-α-Fe 2 O 3 /MgO is as high as 82.3%. Besides, the as-prepared BC-α-Fe 2 O 3 /MgO used in this integrated photocatalysis and adsorption process maintain a high stability towards NPA degradation and PO 4 3− recovery during five cycling experiments. The mechanistic study reveals that holes, •OH, and • O 2 – radicals generated in the photocatalytic process are responsible for NPA degradation. UV light can activate persistent free radicals on BC-α-Fe 2 O 3 /MgO surface, which provide O 2 with electrons for the generation of • O 2 – and subsequent yield of •OH. Moreover, the presence of α-Fe 2 O 3 and MgO on the surface of biochar leads to the excellent P adsorption performance of BC-α-Fe 2 O 3 /MgO. This study opens new possibilities for the recovery of P resource from organophosphorus polluted wastewater.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Dan Ye,Liyan Shen,Ying Sun,Di Zhang,Xiao Tan,Panpan Jing,Min Zhang,Qingping Tian
Herein, we have designed an alcohol-free and low-surfactant microemulsion to safely and effectively supply α-linolenic acid (ALA) and vitamin E (VE). Ternary phase diagrams show that the use of medium- or short-chain alcohols as the co-surfactant (CoS) was unfavorable for the formation of the ALA microemulsion due to the competitive hydrogen bonding effect and vitamin E succinate (VES) significantly increased the ALA microemulsion region by improving the hydrophilicity of the oil phase. The optimal microemulsion formulation (M av ) was 6.86% ALA, 1.14% VES, 12% surfactant and 80% water, with uniformly dispersed spherical particles with diameters of ~ 25.41 nm and viscosity of 35.17 mPa·s. The M av was stable to high temperature, ionic strength and pH, and exhibited good physical and anti-oxidation stability. The M av facilitated the release and hydrolysis of VES, indicating that the CoS-free microemulsion with low surfactant content is promising for the safe and effective supply of ALA and VE.
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DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 24
·8122-8135
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IF 4.174
Jialin Yu,Qi Gao,Lijuan Zhang,Yunshan Zhou,Yuxu Zhong,Jianbo Yin,Yuanyuan Zhou,Fangsheng Tao,Yong'an Wang
ε-[Al13O4(OH)24(H2O)12]7+, which shares similarity with the phosphotriesterase active site ZnII–OH–ZnII, was specially chosen to interact with the cluster α-PMo10V2O405− to form a new three-dimensional intercluster, which crystallized in the monoclinic space group P21/m with Z = 2, for the decontamination of chemical warfare agents. The experimental results showed that 50 mg of the compound decontaminated 96.4% (within 120 min) and 99.5% (within 40 min) of sulfur mustard (HD) (4 μL) and soman (GD) (4 μL), respectively, in ambient conditions. The decontamination processes followed first-order reaction kinetics with a rate constant and half-life of 0.01234 min−1 and 56.15 min for HD and 0.1198 min−1 and 5.78 min for GD, respectively. It was concluded that the α-PMo10V2O405− moiety was responsible for the catalytic oxidation of HD into non-toxic sulfoxide, while the ε-[Al13O4(OH)24(H2O)12]7+ moiety was responsible for the catalytic hydrolysis of HD and GD into nontoxic hydrolysates. Besides, the compound showed notable efficacy for the decontamination of HD on guinea pig skin and of GD on Kunming mouse skin, indicating high potential for use in human skin protection and treatment.
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JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Fengli Chen,Xinyu Yang,Yibo Ma,Xiaoxia Wang,Duqiang Luo,Lei Yang,Yongfan Yang
Silver magnetic amino silicone adhesive (Fe 3 O 4 @SiO 2 @NH 2 @Ag) particles were prepared for the purification of α-linolenic acid from tree peony seed oil under applied magnetic field. First, Fe 3 O 4 @SiO 2 @NH 2 @Ag particles were prepared and physicochemically characterized, including XRD, TG, FTIR, SEM, magnetic hysteresis curves and elemental analysis. The static process for the purification of α-linolenic acid using Fe 3 O 4 @SiO 2 @NH 2 @Ag particles was investigated, including adsorption curve, desorption curve, elution solvent composition and adsorption isotherm. The result indicated that 0-1–4% acetone- n -hexane elution solvent was selected for the gradient elution process, 2 h and 60 min were the time required to reach adsorption and desorption equilibrium, 20 °C was selected as the adsorption temperature, Langmuir model was suitable to fit and explain the equilibrium data, and the adsorption process was spontaneous and exothermic. Under applied magnetic field, the dynamic process for the purification of α-linolenic acid using Fe 3 O 4 @SiO 2 @NH 2 @Ag particles was investigated, and the optimum conditions were 20:1 µL/g loading amount, 0.5 mL/min flow rate and 51.73 Oe magnetic field intensity. After purification, the purity and recovery ratio of α-linolenic acid were calculated to be 94% and 74%, respectively. Furthermore, the recycled Fe 3 O 4 @SiO 2 @NH 2 @Ag particles still achieved better purification result. Therefore, the developed method shows a good application prospect in the field of separation and purification of α-linolenic acid.
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Journal of Functional Foods
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2019
·
IF 3.197
Jianzhong Zhu,Bin Zhang,Bingxu Wang,Chao Li,Xiong Fu,Qiang Huang
Inhibitory effects (IEs) of flavonoids from Rosa roxburghii and R. sterilis fruits against α-glucosidase were investigated. Crude extract of R. roxburghii fruits ( Rr CE) and R. sterilis fruits ( Rs CE) were extracted with ethanol. The n-butanol extraction of aqueous Rr CE dispersion ( Rr CE - B) showed the greatest inhibition of α-glucosidase. The most abundant three components in Rr CE - B were kaempferol hexose, rutin, and catechin (Cat). The predominant active compounds were characterized as flavonoids by UV–vis spectra. Combination analysis suggested that Rr CE was a favorable choice to combine with acarbose (Aca). After simulated gastric digestion, IEs of flavonoids decreased greatly, especially when sodium nitrite was supplemented in the simulated gastric fluid (SGF). The UV–vis spectra indicated that flavonoids were basically stable in the SGF without sodium nitrite, but were oxidized by the HNO 2 , a natural component in the gastric fluid. The results of this study will help food scientists design special foods for diabetic patients.
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JOURNAL OF ETHNOPHARMACOLOGY
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2017
·
IF 2.981
Rui Jiang,Xiao-Hao Xu,Ke Wang,Xin-Zhao Yang,Ying-Fei Bi,Yao Yan,Jian-Zeng Liu,Xue-Nan Chen,Zhen-Zhong Wang,Xiao-Li Guo,Da-Qing Zhao,Li-Wei Sun
Ethnopharmacological relevance Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener to inhibit melanin formation in China, Korea and some other Asian countries. However, the constituents and the molecular mechanisms by which they affect melanogenesis are not fully clear. Aim of the study The purpose of this study was to identify the active ingredient in Panax ginseng C.A. Meyer extract that inhibits mushroom tyrosinase activity and to investigate the antioxidative capacity and molecular mechanisms of the effective extract on melanogenesis in B16 mouse melanoma cells. Materials and methods Aqueous extracts of Panax ginseng C.A. Meyer were successively fractionated with an equal volume of chloroform, ethyl acetate , and n-butyl alcohol to determine the effects by examining the activity of mushroom tyrosinase. The effective fraction was analyzed using HPLC and LC-MS. The antioxidative capacity and the inhibitory effects on melanin content, cell intracellular tyrosinase activity, and melanogenesis protein levels were determined in α-melanocyte-stimulating hormone (α-MSH)-treated B16 mouse melanoma cells. Results The ethyl acetate extract from Panax ginseng C.A. Meyer (PG-2) had the highest inhibiting effect on mushroom tyrosinase, mainly contained phenolic acids, including protocatechuic acid , vanillic acid , p -coumaric acid, salicylic acid , and caffeic acid , and exhibited apparent antioxidant activity in vitro. PG-2 and its main constituents significantly decreased melanin content, suppressed cellular tyrosinase activity, and reduced expression of tyrosinase protein to inhibit B16 cells melanogenesis induced by α-MSH, and no cytotoxic effects were observed. They also inhibited cellular reactive oxygen species (ROS) generation, increased superoxide dismutase (SOD) activity and glutathione (GSH) level in α-MSH-treated B16 cells effectively. And those activities of its main constituents could reach more than 80% of PG-2. The ROS scavengers N-acetyl- L -cysteine (NAC) had a similar inhibitory effect on melanogenesis. Conclusions These results suggest that ethyl acetate extract from Panax ginseng C.A. Meyer has the highest effect on inhibiting melanogenesis, and that its main components are polyphenolic compounds , which may inhibit melanogenesis by suppressing oxidative stress. This work provides new insight into the active constituents and molecular mechanisms underlying skin-lightening effect of Panax ginseng C.A. Meyer.
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CHEMOSPHERE
·
2017
·
IF 4.208
Ying Wang,Mingxing Liang,Jiasheng Fang,Jun Fu,Xiaochun Chen
In this study, α-FeOOH on reduced graphene oxide (rGO-α-FeOOH) supported on an Al-doped MCM-41 catalyst (RFAM) was optimized for the visible-light photo-Fenton oxidation of phenol at neutral pH. The stability of the catalysts, effect of bubbling aeration, and degradation intermediates were investigated. Results indicated that RFAM with a large Brunauer-Emmett-Teller (BET) area and mesoporous structure displayed excellent catalytic activity for the visible-light-driven (VLD) photo-Fenton process. Phenol degradation was well described by a pseudo-first-order reaction kinetics model. Raman analysis demonstrated that an rGO-α-FeOOH (RF) composite is formed during the ferrous-ion-induced self-assembly process. Al-MCM-41 could uniformly disperse RF nanosheets and promote the mobility and diffusion of matter. The activity of the main catalyst α-FeOOH was enhanced after the incorporation of rGO nanosheets. The α-FeOOH crystal in RFAM showed catalytic activity superior to those of Fe 3 O 4 and Fe 2 O 3 . The RFAM catalyst, with an optimal GO-Fe 2+ mass ratio of 2.33, exhibited a larger BET area, pore size, and pore volume, and thus exhibited high performance and energy utilization efficiency in the VLD photo-Fenton reaction with remarkable stability. Bubbling N 2 inhibited catalytic performance, while bubbling O 2 or air only slightly accelerated the phenol degradation. Visible light played an important role in accelerating the formation of reactive oxygen species (·OH) for the highly efficient phenol degradation. Analysis of degradation intermediates indicated a high phenol mineralization level and the formation of low-molecular-weight organic acids. This work would be helpful in providing an insight into a new type of catalyst assembly and a possible route to a promising heterogeneous catalyst applicable in the visible light photo-Fenton process for effective wastewater remediation at neutral pH.
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MICROCHIMICA ACTA
·
2016
·Vol. 184
·期 1
·137-145
·
IF 4.831
Dai Liming,Du Xiaojiao,Jiang Ding,Chen Wei,Zhu Mingyue,Wang Kun
The authors have coupled ultrafine α-Fe 2 O 3 nanocrystals to N-doped graphene (NG) to obtain a novel material for use in a photoelectrode. The presence of NG is shown to strongly affect the morphology and size of the α-Fe 2 O 3 nanocrystals formed on the NG sheets, and to improve their photoelectrochemical (PEC) activity. Interestingly, the PEC performance of the nanocomposite is closely correlated to the size of the α-Fe 2 O 3 nanocrystals in that small nanocrystals display better PEC properties. The photocurrent of α-Fe 2 O 3 -NG is nearly 3.3-fold stronger than that of α-Fe 2 O 3 nanocrystals. Based on the remarkable PEC performance of this nanocomposite, a PEC sensor was constructed for the sensitive determination of 1,4-dihydroxybenzene (HQ). Its photocurrent increases with the HQ concentration in the range from 3.0 nM to 3.3 μM, and the detection limit is 1.0 nM (at an S/N ratio of 3). In our perception, the study presented here can serve as a basis for a better understanding of the relationship between morphologies and PEC performance of such nanomaterials. Conceivably, it may be extended to other PEC sensing system and to other fields associated with nanotechnology.
Ultrafine α-Fe 2 O 3 nanocrystals were prepared via coupling with N-doped graphene (NG) substances (α-Fe 2 O 3 -NG). They exhibit superior photoelectrochemical (PEC) performance and have been successfully utilized for PEC-based sensing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jinnan Guo,Yuanyuan Zhao,Guanqun Peng,Tong Ye,Xiaohui Zhu,Runtian Li,Jintao Shen,Lina Du,Shanshan Wang,Zhiyun Meng,Hui Gan,Ruolan Gu,Wenzhong Sun,Guifang Dou,Shuchen Liu,Yunbo Sun
Severe bleeding from deep and irregular wounds poses a significant challenge in prehospital and surgical settings. To address this issue, we developed a novel chitosan-based hemostatic dressing with a magnetic targeting mechanism using Fe 3 O 4 , termed bovine serum albumin-modified Fe 3 O 4 embedded in porous α-ketoglutaric acid/chitosan (BSA/Fe 3 O 4 @KA/CS). This dressing enhances hemostasis by magnetically guiding the agent to the wound site. In vitro, the hemostatic efficacy of BSA/Fe 3 O 4 @KA/CS is comparable to that of commercial chitosan (Celox™) and is not diminished by the modification. In vivo, BSA/Fe 3 O 4 @KA/CS demonstrated superior hemostatic performance and reduced blood loss compared to Celox™. The hemostatic mechanism of BSA/Fe 3 O 4 @KA/CS includes the concentration of solid blood components through water absorption, adherence to blood cells, and activation of the endogenous coagulation pathway. Magnetic field targeting is crucial in directing the dressing to deep hemorrhagic sites. Additionally, safety assessments have confirmed the biocompatibility and biodegradability of BSA/Fe 3 O 4 @KA/CS. In conclusion, we introduce a novel approach to modify chitosan using magnetic guidance for effective hemostasis, positioning BSA/Fe 3 O 4 @KA/CS as a promising candidate for managing various wounds.
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