INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Yumiao Niu,Yan Xiao,Yidan Chen,Chu Chu,Daqing Yang,Ying Wang,Bing-Bing Zhang
The disulfide dianion [S2]2–, as an important structural motif in sulfides, can incorporate isolated S2– to form homoatomic heteroleptic polyhedra [MSx(S2)y]. However, the sulfides that contain [MSx(S2)y] units have been rarely reported and have not been systematically investigated as infrared (IR) nonlinear optical (NLO) materials. It is verified in this work that the homoatomic heteroleptic coordination strategy enhances local structural asymmetry, leading to improved optical anisotropy and NLO performance. Three compounds, namely, ANb2PS10(A = K,Rb,Cs), were identified and prepared. They exhibit a large phase-matchable second-harmonic generation (SHG) response, with KNb2PS10, RbNb2PS10, and CsNb2PS10 showing the effects of 1.5, 2.2, and 1.8 (×AgGaS2@2090 nm), respectively, and large birefringence (Δn = 0.39@546 nm) with KNb2PS10 as a representative. The first-principles calculations indicate that [Nb2S4(S2)4]8– units play a dominant role in inducing strong SHG responses and large birefringence. By validating the homoatomic heteroleptic coordination strategy, this work opens avenues for the design of advanced optical materials.
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高影响因子
Journal of Biomedical Nanotechnology
·
2021
·Vol. 17
·期 4
·677-690
·
IF 4.099
Zhou Shuping,Ma Yongfang,Liu Xueke,Yu Pan,Huang Ning,Song Li,Xu Ruyue,Huo Zhen,Zhu Tao,Tang Xiaolong
The miR let-7b-5p (a kind of microRNAs) has many pathophysiological regulation effects, including human hepatocellular carcinoma (HCC) pathogenesis. This study investigated whether nanoparticle-mediated miR let-7b-5p could jointly enhance the therapeutic effect of sorafenib on HCC by
inhibiting the proliferation of HCC cells, inducing apoptosis, and reversing drug resistance. We evaluated the level of miR let-7b-5p in sorafenib-resistant HepG2 cells (HepG2R) and HepG2 HCC cells by qRT-PCR and analyzed the biological effects of hepatocellular carcinoma treated
with sorafenib with miR let-7b-5p, and further studied the toxicity of nanoparticles (Ab-miR-NPs) that deliver miR let-7b-5p mimics and target GPC3 on the surface of hepatocellular carcinoma cells. Results showed that, in HepG2 cells, the expression level of miR let-7b-5p was significantly
higher than that in HepG2R cells. Targeted nanoparticle Ab-miR-NPs mediated the delivery of miR let-7b-5p to the HCC cytoplasm and released miRNA after being broken down, down-regulating the expression of IGF1R and inhibiting AKT/mTOR and Ras/Raf signal transmission. Ab-miR-NPs
not only enhanced the proliferation of sorafenib in cultured HepG2R cells and induced cell apoptosis efficiency, but they also improved the anti-tumor activity in the mouse models. These results indicated that GPC3 antibody-modified PLGA-PLL (polylactic acid-glycolic acetic copolymer
grafted hyper-branched polylysine) loaded miR let-7b-5p polymer nanoparticles combined with sorafenib may be a new treatment strategy for HCC resistant to sorafenib.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·795
·
IF 12.6
Zhang Yuanfeng,Yang Enguang,Zhang Xinyu,Shi Yibo,Fan Guangrui,Wang Yuhan,Tian Junqiang,Wang Hanzhang,Dong Zhilong,Wang Yingru,Cheng Liang,Zhao Zhiwen,Zhang Yonghai,Wang Baodui,Wang Zhiping
Background Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity. While tumor microenvironment-responsive drug activation strategies offer a promising solution, achieving precise spatial control over the conversion of non-toxic precursors into cytotoxic agents remains a significant challenge. Methods We developed DHN@Pt/PtMBCPsNSs, a platinum (Pt)-methylene blue (MB)- based nanoscale sonosensitizer, to enable ultrasound-triggered on-demand juglone synthesis within tumors. The system was evaluated in bladder cancer models including cell lines, patient-derived organoids (PDOs) and patient-derived tumor xenograft (PDX) models, assessing tumor uptake, intracellular distribution, hypoxia modulation (“H 2 O 2 -O 2 -¹O 2 ” cascade), oxidative stress markers (SOD, GSH, MDA, GSSG), and cell death pathways (apoptosis/pyroptosis). Transcriptome sequencing was performed to elucidate molecular mechanisms. Results DHN@Pt/PtMBCPsNSs were internalized by UMUC-3 and T24 cells and primarily accumulated within the mitochondrial compartments. The platinum-based components catalytically exhausted GSH via redox cycling. DHN@Pt/PtMBCPsNSs triggered the production of O 2 and ¹O 2 after local US irradiation, alleviating hypoxia and selectively converting dihydroxynaphthalene (DHN) to juglone in tumors, which reducing the systemic toxicity of juglone. The nanosystem further disrupted cellular redox balance by triggering depletion of antioxidant defenses (SOD and GSH) and reducing the ratio of GSH/GSSG. In vitro cell experiments and PDOs experiments demonstrated that DHN@Pt/PtMBCPsNSs combined with US irradiation can significantly inhibit bladder cancer cell proliferation, induce apoptosis, and regulate pyroptosis via the ROS-mediated caspase 3/GSDME signaling pathway. In the PDX model, DHN@Pt/PtMBCPsNSs accumulated at the tumor site and significantly inhibited tumor growth under US irradiation. Conclusions As a novel sonosensitizer and pyroptosis inducer, DHN@Pt/PtMBCPsNSs achieve a precise synergistic effect of chemotherapy and sonodynamic therapy within cells, while minimizing adverse effects on normal cells and overcoming the limitations associated with natural chemotherapeutic agents. This approach may advance clinical translation of natural anticancer agents. Graphical
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高影响因子
EXPERIMENTAL PHYSIOLOGY
·
2020
·Vol. 105
·期 11
·1827-1839
·
IF 2.431
Suwei Chen,Hong Chen,Yongliang Zhong,Yipeng Ge,Chengnan Li,Zhiyu Qiao,Junming Zhu
New Findings What is the central question of this study? Insulin-like growth factor 1 and its major binding protein insulin-like growth factor binding protein 3 (IGFBP3) are involved in collagen deregulation in several cardiovascular diseases: what is the role of IGFBP3 in thoracic aortic dissection and does it regulate aortic smooth muscle cells’ phenotypic switch? What is the main finding and its importance? IGFBP3 inhibits aortic smooth muscle cells’ phenotypic switch from a contractile to a synthetic phenotype, decreases matrix metalloproteinase 9 activation and suppresses elastin degradation. These findings provide a better understanding of the pathogenesis of thoracic aortic dissection. Thoracic aortic dissection (TAD) is characterized by aortic media degeneration and is a highly lethal disease. An aortic smooth muscle cell (AoSMC) phenotypic switch is considered a key pathophysiological change in TAD. Insulin-like growth factor binding protein 3 (IGFBP3) was found to be downregulated in aortic tissues of TAD patients. The present work aimed to study the function of IGFBP3 in AoSMCs’ phenotypic switch and matrix metalloproteinase (MMP) expression. We established a mouse model of TAD by angiotensin (Ang) II infusion to β-aminopropionitrile-administrated mice, and found decreased IGFBP3 expression accompanied by aortic dilatation and elastin degradation in vivo . Further, mouse (m)AoSMCs were isolated from mouse thoracic aorta and treated with Ang II. Ang II induced downregulation of IGFBP3 in vitro . To further study the function of IGFBP3, primary mAoSMCs were infected with adenovirus expressing IGFBP3 followed by Ang II induction. Enforced upregulation of IGFBP3 decreased MMP9 expression and activation as well as increasing tissue inhibitor of metalloproteinase (TIMP) 1 expression in Ang II-induced mAoSMCs. No difference was observed in MMP2 and TIMP3 expression. IGFBP3 suppressed subsequent Ang II-induced elastin degradation in vitro . IGFBP3 inhibited Ang II-induced mAoSMCs’ phenotypic switch as evidenced by increased smooth muscle actin α-2 (ACTA2) and myosin heavy chain 11 (MYH11) expression and decreased secreted phosphoprotein 1 (SPP1) and vimentin expression. Taken together, the present study demonstrates the role of IGFBP3 in preserving AoSMCs’ contractile state and reducing MMP9 activation and thus promoting elastic fibre synthesis, which provides a better understanding of the pathogenesis of TAD.
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高影响因子
JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Yilin Ge,Yushan Li,Feng Wang,Xiaoqin Tan,Peng Liu,Dianhui Wang,Wentong Zhou,Qingrong Yao,M.-Sadeeq Balogun (Jie Tang),Dan Huang,Jianqiu Deng
The development of low-cost and eco-friendly electrode materials is crucial for the next-generation rechargeable lithium-ion batteries (LIBs). Herein, the single-phase Na 1.2 Fe 4 (PO 4 ) 3 (NFP) with a monoclinic NaCo 4 (PO 4 ) 3 -type structure is demonstrated to be a suitable anode material for LIBs. The NFP anode exhibits superior high-rate performance, releasing an initial charge capacity of 128.6 mAh g −1 at 10C and a high-capacity retention rate of 86.7% over 1500 cycles. The prominent rate performance and cycling stability of the NFP anode are attributed to the stable single-phase crystal structure and fast Li-ion diffusion verified by galvanostatic intermittent titration technique (GITT). Furthermore, the structure evolution and Li-ion diffusion pathway of the NFP anode are clarified by ex-situ X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and first-principles calculations.
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高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Zijing Zhou,Anlin Zhang,Li Zhou,Ziyue Hu,Yixuan Zhao,Jiexin Chen,Yanyan Li,Lei Zhao,Bin Deng,Ruijin Yu
In the present work, a series of zincate CaY 2 Sb 2 (ZnO 4 ) 3 :Eu 3+ phosphors were successfully obtained via the conventional solid-state method at high temperature. The phase purity, morphology, element mapping, photoluminescence excitation/emission (PLE/PL), and decay time of the obtained phosphors were investigated systematically. Results show that the synthesized samples demonstrate the strongest red-emitting peak at 610 nm under the n-ultraviolet (n-UV) 395 nm excitation. The Judd-Ofelt parameters (Ω 2 , Ω 4 ), radiative transition rates, and branching ratios ( β 0 J, J = 2, 4) of CaY 2 Sb 2 (ZnO 4 ) 3 :Eu 3+ to explore the Eu 3+ -coordinated environment in the host matrix. The concentration quenching of CaY 2 Sb 2 (ZnO 4 ) 3 :2 x Eu 3+ phosphors happened until at high doping concentration of x = 50 mol%. CaY 2 Sb 2 (ZnO 4 ) 3 :100 mol%Eu 3+ sample presented the excellent thermal stability with abnormal thermal quenching behavior. Compared with the commercial Y 2 O 3 :Eu 3+ red phosphor , the luminescent intensity of the prepared phosphor is 1.14 times stronger. The high internal quantum efficiency (IQE) of CaY 2 Sb 2 (ZnO 4 ) 3 :100 mol%Eu 3+ phosphor is 79.20%. In addition, the fabricated red and white light-emitting diodes (w-LEDs) both emit bright light. The w-LED demonstrates a high color rendering index ( R a = 96) and a low correlated color temperature (CCT = 5249 K). Therefore, the prepared red-emitting phosphor has a promising application in w-LEDs.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ruiting Fan,Li Song,Yongsheng Hu,Xiaoyang Guo,Xingyuan Liu,Lishuang Wang,Chong Geng,Shu Xu,Yonghui Zhang,Zihui Zhang,Nannan Luan,Wengang Bi
Properties of the underlying hole transport layer (HTL) in perovskite light-emitting devices (PeLEDs) play a critical role in determining the optoelectronic performance through influencing both the charge transport and the quality of the active perovskite emission layer (EML). This work focuses on manipulating the carrier transport behavior and obtaining a high-quality EML film by tailoring the poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) HTL with previously unused amino alcohol 3-amino-1-propanol (3AP). The modified PEDOT:PSS rendered a deeper work function that is more suitable for the hole injection from the HTL to EML. More importantly, the 3AP-modified PEDOT:PSS film can induce a low-dimensional perovskite phase that can passivate the defects in the EML, resulting in a significantly improved light emission. Such ameliorations consequently result in a dramatical enhancement in performance of PeLED with a low turn-on voltage of 2.54 V, a maximum luminance of 23033 cd/m2, a highest current efficiency of 29.38 cd/A, a corresponding maximum external quantum efficiency of 9.4%, and a prolonged lifetime of 6.1 h at a proper Cs/Pb ratio.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2023
·Vol. 106
·期 11
·6577-6585
·
IF 3.9
Yuting Zhang,Huan Tu,Guoying Zhao,Jingshan Hou,Yufeng Liu,Xin Qiao,Zhongzhi Wang,Bo Li,Ji-Guang Li,Feng Wang,Yongzheng Fang
Compared with other fluorescent crystal phases, garnet has better structural stability in a glass matrix and renders precisely controllable emissions due to the abundant lattice control positions. In this work, we regulate the coordination field of Ce 3+ ion based on the co-substitution method and achieve the spectra regulation in the yellow–green range. We used Ba 2+ –Si 4+ cations to replace Y 3+ –Al 3+ cations in Y 3 Al 5 O 12 (YAG) matrix to obtain blue-shift of the emission peak from 552 to 539 nm. The centroid shift and crystal field splitting decrease with the decreasing covalency of the bond between the Ce 3+ ion and the surrounding anions owing to the higher electronegativity of Si 4+ ions than Al 3+ ions. The corresponding fluorescent films were prepared by a low-temperature co-sintering process based on the as-made Ba 2+ –Si 4+ co-substituted phosphor. X-ray powder diffractometer and scanning electron microscopy images showed that the fluorescence crystals were less eroded and evenly dispersed in the glass matrix. Spectral analysis showed that the garnet phase was protected by using lead-free borosilicate glass with a low melting point, and the quantum efficiency of phosphor-in-glass (PiG) retains 98% of the corresponding phosphor. By adjusting the ratio of garnet phosphor to commercial red nitride phosphors, a warm white fluorescence with a color rendering index of 80.3 and color temperature of 3899 K was obtained. The prepared warm white film has potential application value in the whole spectra field.
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 15
·B1426
·
IF 3.12
Haiyun Zhai,Shiqiao Wang,Jianfeng Zhou,Jianbin Pan,Yanli Tong,Qinghua Mei,Qing Zhou
A sensitive and facile electrochemical sensor based on glassy carbon electrode (GCE) receiving electrochemical anodic pretreatment for signal amplification was developed for the determination of 3-nitrotyrosine (3-NT) (an oxidative stress biomarker). Adding sodium hexadecyl sulfate (SDS) to 0.1 M HNO3 solution was conducive to adsorption onto the surface of modified electrode, which promoted electron exchange and enhanced electrochemical behaviors by significantly increasing the hydrophobicity of electrode surface. Scanning electron microscopy showed that the surface of modified GCE had a remarkably thin layer composed of dense nanoparticles owing to surface layer oxidation, growth of graphite oxide thin layer and microscopic mechanical destruction of electrode surface during cyclic voltammetry by anodization oxidation. Under optimal conditions, the current change of 3-NT in square wave stripping voltammetry (SWV) was linearly related to its concentration in the range of 0.05∼30.0 μM, with a detection limit (S/N = 3) of 17.0 nM, acceptable stability and reproducibility. Additionally, this sensor was successfully applied to detect 3-NT in human serum samples.
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高影响因子
Journal of the Iranian Chemical Society
·
2015
·Vol. 12
·期 12
·2149-2159
·
IF 1.087
Wu Kai-Fei,Jiang Fen,Bai Xian-Li,Mo Shao-Yin,Qin Gui-Fang,Feng Yu
The reactions of a semirigid carboxylic ligand 5-(Pyridin-3-yl)isophthalic acid(H 2 pyip) with Mn(CH 3 COO) 2 /Zn(NO 3 ) 2 /Pb(NO 3 ) 2 afforded three new complexes: [Mn(pyip)(H 2 O) 2 ] n ( 1 ), [Zn(pyip)(H 2 O) 2 ] n ( 2 ), and [Pb(pyip)] n ( 3 ). Their structures have been determined by single-crystal X-ray diffraction analyses and further characterized by elemental analyses, IR spectra, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. X-ray structure analysis reveals that complexes 1-2 showed identical 3D supramolecular architecture that just connect different metal centers. They all crystallize in hexagonal space group P6(5) and exhibit the same coordination mode. One of the H 2 pyip adopts bidentate chelate coordination mode, and the other coordinate carboxylate oxygen atom adopts the single dentate-bridging mode. Complex 3 adopts different coordination modes crystallized in monoclinic space group P2(1)/c compared to 1-2, combined bidentate chelate and chelating–bridging tetradentate coordination modes. A noticeable point in this paper is that compounds 1-3 exhibit preferable catalytic properties on degradation of Rhodamine B (RhB). Moreover, the luminescent properties were investigated.
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高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2020
·Vol. 132
·期 1
·1-7
·
IF 1.406
DU ZHONGLIN,LI FENRUI,LI LI,LI RAN
Abstract Microwave-assisted one-pot quick synthesis to 1-monosubstituted 1,2,3-triazoles was achieved with good to excellent yields using the widely available arylboronic acids, sodium azide and 3-butyn-2-ols within 15 min. This method features high efficient and facile as organic azides, acetylene gas and harsh conditions were avoided. Graphic abstract Microwave-assisted one-pot quick synthesis to 1-monosubstituted 1,2,3-triazoles was achieved with good to excellent yields using the widely available arylboronic acids, sodium azide and 3-butyn-2-ols within 15 min.
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高影响因子
Arthropod-Plant Interactions
·
2020
·Vol. 14
·期 2
·169-179
·
IF 1.466
Sun Ya-Lan,Dong Jun-Feng,Huang Ling-Qiao,Wang Chen-Zhu
Campoletis chlorideae Uchida (Hymenoptera: Ichneumonidae) is an important larval endoparasitoid of the cotton bollworm Helicoverpa armigera (Hübner). A better understanding of herbivore-induced plant volatiles (HIPVs) employed by C. chlorideae to locate hosts will contribute towards the biological control of this notorious crop pest. In this study, we first investigated the electrophysiological and behavioral responses of C. chlorideae to 19 volatile compounds emitted by herbivore-infested plants. Eleven odorants induced EAG responses of C. chlorideae , while only two compounds, cis -jasmone and cis -3-hexenyl acetate, were attractive to the parasitoid in Y-tube olfactometer assays. Next, we used two- and four-choice tests in cage settings to investigate the parasitism rate of H. armigera larvae by C. chlorideae on tobacco plants treated with different doses of cis -jasmone, cis -3-hexenyl acetate, and their mixtures. Results showed that the parasitism rate of H. armigera was significantly higher on the plants treated with cis -jasmone or cis -3-hexenyl acetate, and their optimal dose for both compounds was 1 mg. However, the mixtures of cis -jasmone and cis -3-hexenyl acetate did not increase H. armigera parasitism rate by C. chlorideae when compared with control groups. Our results indicate that the single compounds cis -jasmone and cis -3-hexenyl acetate, at certain doses, enhance parasitic efficiency of C. chlorideae , but their mixtures negate this effect. These results will help us in the exploitation of C. chlorideae as biological control agent to reduce the populations of H. armigera .
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高影响因子
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