CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Lin Li,Chao Feng,Haimei Xu,Ping He,Qisong Yi,Junxiang Jiang,Lu Lin,Jin Hou,Yuanshuai Liu
The catalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is an important reaction in the sustainable production of polymers from biomass resources. To advance the environmental sustainability of this process, it is crucial to develop a catalytic system that circumvents the need for liquid alkaline media, which have been conventionally employed in HMF-to-FDCA conversion. Herein, we developed an efficient catalytic system comprising Ru nanoparticles supported on Na-type zeolite Y (Ru/Na-Y) for the base-free oxidation of HMF to FDCA. Reducing the particle size of Ru significantly enhances the activity of the Ru/Na-Y catalysts. Specifically, the optimized Ru/Na-Y-300N-200H, featuring Ru nanoparticles with an average size of ∼2.5 nm, afforded nearly 100 % HMF conversion and ∼ 85 % FDCA yield under base-free aqueous-phase conditions at 100 °C and 5 MPa air pressure. Kinetic studies further evidenced that Ru/Na-Y-300N-200H could effectively catalyze the sequential oxidation of both alcohol and aldehyde groups during the HMF-to-FDCA conversion. Comprehensive characterizations and DFT calculations elucidated the enhanced interaction between Ru centers and Na sites in the Ru/Na-Y-300N-200H due to the smallest Ru particle size. The unique Ru-Na synergistic effect was thus realized, which could facilitate the activation of O 2 and the generation of O 2 •– radicals as active oxygen species, while simultaneously boosting the rate-determining step of 5-formyl-2-furancarboxylic acid (FFCA) oxidation to FDCA, resulting in a high FDCA yield. These findings unveil promising prospects for developing advanced metal-zeolite bifunctional catalysts, which could facilitate the base-free oxidation of biomass-derived HMF into FDCA.
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高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Hong Yu,Muyan Kong,Jinyi Chen,Jiyao Liu,Keyao Shan,Guiyu Zhang,Ruidi Jiang,Yinli Zheng,Qiulu Chen,Rong Zhang,Zhongqiu Liu,Jinjun Wu
Colorectal cancer (CRC), one of the primary causes of gastrointestinal malignancy-related mortality worldwide, encounters significant therapeutic challenges due to multidrug resistance. Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2, plays a crucial role in the development of drug resistance during clinical CRC treatment. This study elucidates a novel mechanism by which formononetin (FMNT), a bioactive isoflavone commonly found in food and medicinal-related plants, suppresses CRC via microRNA-490-3p (miR-490-3p)-mediated regulation of ABCC2 and synergizes with 5-fluorouracil (5-FU). HCT116 and SW480 cell lines as well as AOM/DSS-induced CRC models in wild-type and Mrp2 -/- mice were employed. The results demonstrated that FMNT markedly suppresses CRC proliferation in vitro and tumorigenesis in vivo . Transcriptomic profiling identified ABCC2 as the top target associated with FMNT’s efficacy. This finding was validated in clinical specimens, which revealed significant upregulation of MRP2 in human CRC tissues. FMNT markedly downregulated the MRP2 expression. Genetic ablation experiments further confirmed enhanced FMNT sensitivity in Mrp2 -/- mice and MRP2 silencing CRC cells. Mechanistically, FMNT upregulated tumor-suppressive miR-490-3p, which directly targets the ABCC2 3′UTR, thereby establishing a regulatory axis corroborated by gain/loss-of-function experiments. Notably, overexpression of miR-490-3p augmented FMNT’s antitumor effects, whereas inhibition of miR-490-3p diminished its efficacy. Therapeutic combination index analysis indicated robust synergy between FMNT and 5-FU, with combination therapy achieving superior tumor growth inhibition compared to monotherapies. Collectively, our findings uncover a novel miR-490-3p/ABCC2 regulatory mechanism underlying FMNT’s antitumor activity and highlight its potential for chemosensitization through ABCC2 inhibition, providing a strong rationale for flavonoid-based adjuvant therapy in CRC management.
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PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2025
·
IF 4.3
Fengxue Liu,Xuefei Yu,Yanmei Wu,Ting Zhu,Ning Chen,Hao Chen,Wei Shen,Wei Zheng
5-fluorouracil (5-FU) is one of the most effective chemotherapeutic drugs for various solid tumors. However, its low water solubility and limited absorption rates in the stomach are crucial limitations that prevent it from being effectively applied in clinical practice. To address these issues, we first encapsulated 5-FU in β-cyclodextrin (5-FU–β-CD) to enhance its solubility, and the resulting 5-FU–β-CD was then loaded into a PLA film to prepare a novel gastro-retentive drug delivery system (GRDDS) based on shape-memory properties. The excipients, such as tributyl citrate (TBC), hydroxyethyl cellulose (HEC), citric acid (CA), and sodium bicarbonate (NaHCO 3 ), were incorporated into the PLA matrix at an optimized ratio. This was done to enhance the performance of PLA as an ideal matrix material in GRDDS, including improvements in drug release, floating behavior, shape recovery, gastric retention, and in vivo anti-tumor activity. The results suggested that the solubility of the 5-FU–β-CD inclusion complex was significantly enhanced, which was 1.88-fold higher than that of pure 5-FU. The optimal shape-memory drug delivery formulation, 5-FU–β-CD–PLA/TBC (86/14), prepared in this study consists of PLA/TBC (86/14) incorporating 3 % HEC, 3 % NaHCO 3 , 1 % CA, and 3 % 5-FU. Its gastric retention time was notably prolonged to approximately 8 h following oral administration in mice, whereas the residual amount of 5-FU–β-CD at this time point was much lower than the initial loading. The oral bioavailability of the 5-FU–β-CD–PLA/TBC (86/14) was 269 % higher than that of pure 5-FU. Additionally, the mean tumor size and weight in the mouse model of gastric carcinoma administered with 5-FU–β-CD–PLA/TBC (86/14) were 215.3 mm 3 and 241.4 mg respectively, significantly smaller than those in the 5-FU group. This indicates that the novel PLA-based drug delivery system has significantly enhanced anti-tumor effects. Its excellent therapeutic effects were further confirmed through HE, Ki67, and TUNEL staining. Taken together, 5-FU–β-CD–PLA/TBC (86/14) can be retained in the stomach to improve relative bioavailability. This system represents a promising carrier not only for 5-FU but also for other poorly soluble drugs that require prolonged retention in the stomach.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Chengfeng Yi,Jingwen Li,Jiarui Li,Bingchuan Xue,Xing Lin,Zhigang Liu
The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) constitutes a pivotal pathway for biomass valorization. However, its advancement is kinetically hindered by the competitive adsorption between HMF and OH − on active sites, causing a conflict between substrate activation and oxidant supply. To circumvent this impediment, a series of Ni(OH) 2 /N,W-Ni 3 S 2 composite catalysts are designed via electrodeposition. This strategy enables the in-situ growth of amorphous Ni(OH) 2 overlayer on the nitrogen and tungsten co-modulated Ni 3 S 2 (N,W-Ni 3 S 2 ) substrate, realizing the precise construction of heterostructure. The Ni(OH) 2 component possesses strong affinity for OH − , while the Ni 3 S 2 substrate preferentially adsorbs HMF. By tuning the electrodeposition duration, the Ni(OH)₂ layer thickness can be regulated, thereby enabling the overall adsorption strengths of both HMF and OH − to be finely optimized. The superior catalyst, Ni(OH) 2 /N,W-Ni 3 S 2 –500, demonstrates exceptional catalytic activity, achieving 100 % HMF conversion, 97.2 % FDCA yield and 97.3 % Faradaic efficiency. Furthermore, it displays a wide operational potential window, maintaining FDCA yields and Faradaic efficiencies above 90 % over 1.45–1.60 V vs. RHE. This remarkable activity is attributed to an optimized adsorption behavior for HMF and OH − . Specifically, the enhanced affinity for OH − accelerates the generation of the true active species, high-valent nickel oxyhydroxide (NiOOH), and ensures a sufficient localized supply of the oxygen source. Simultaneously, the catalyst retains a moderate adsorption capacity for HMF molecules, ensuring effective substrate activation without inhibiting product desorption. This study proposes a novel and effective interfacial engineering paradigm to resolve the adsorption imbalance in biomass electrooxidation, offering a rational blueprint for superior electrocatalysts.
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高影响因子
Food Science & Nutrition
·
2024
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IF 3.5
Jialing Lin,Chuanhui Zeng,Xueli Li,Qin Tang,Jing Liao,Yan Jiang,Xianchun Zeng
Heterocyclic amines (HAs) are a group of mutagenic and carcinogenic compounds produced from the processing of high-protein foods, which include 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) showing the strongest carcinogenic effect. Camels are able to digest HAs in foods, which provide rich microbial resources for the study. Thus, camel rumen and intestinal microbiota were used to degrade IQ, and the dominant microorganisms and their degradation characteristics were investigated. After three generations of culture with IQ as the sole carbon source, the highest abundance in rumen and intestinal microbes was found in the Proteobacteria phylum. The strains of third generation of the rumen contents were mainly attributed to the genera Brevundimonas and Pseudomonas , and the dominant genera in intestine were Ochrobactrum , Bacillus , and Pseudomonas . Microorganisms were further isolated and purified from the third generation cultures. These 27 strains from the rumen (L1–L27) and 23 strains from the intestine (C1–C23) were obtained. Among them, four strains with the most effective degrading abilities were as follows: L6 (28.55% of IQ degrading rate) and C1 (25.19%) belonged to the genus Ochrobactrum , L15 (23.41%) belonged to the genus Pseudomonas , and C16 (20.89%) were of the genus Bacillus . This study suggested the application of abundant microbial resources from camels' digestive tract to biodegrade foodborne toxins.
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 75
·47435-47447
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IF 3.108
Donglin He,Huiping Zhang,Ying Yan
CuO over ZSM-5 zeolite membrane was prepared by chemical vapor deposition (CVD) for catalytic wet peroxide oxidation (CWPO) of phenol in a fixed bed reactor. Firstly, Cu-ZSM-5/PSSFs catalysts with Cu loading of 2 wt%, 4 wt% and 6 wt% were prepared and characterized by XRD, XPS, SEM, EDS, N2 adsorption–desorption and TPR (H2), respectively. Compared with CuO deposited directly onto PSSFs, the CuO supported on ZSM-5/PSSFs tended to be more regular with smaller crystal size. Then, several parameters affecting H2O2 consumption and phenol oxidation such as reaction temperature, Cu loading, and different supports were investigated in the CWPO of phenol with a high concentration (1 g L−1 phenol and 5.1 g L−1 H2O2). Experimental results revealed that Cu-ZSM-5/PSSFs (6%) showed better activity for the oxidation of phenol than Cu-ZSM-5/PSSFs catalysts with lower Cu loading and CuO/PSSFs with same theoretical loading. A complete reduction of phenol and a high TOC removal around 60% had been achieved over Cu-ZSM-5/PSSFs (6%) at the temperature of 80 °C, feed flow rate of 2 mL min−1 and catalyst bed height of 2 cm. Finally, the possible oxidation pathway of phenol was studied based on the by-products detected by high-performance liquid chromatography (HPLC).
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高影响因子
ENERGY & FUELS
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2020
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IF 3.421
Yonghou Xiao,Qiangqiang Xue,Kerun Zhu,Gaohong He
High-efficiency adsorbents are essential for ultradeep desulfurization through selective adsorption, which features low energy consumption without causing secondary pollution. Aluminum oxide is always added as a binder to form physically bound pellets, which weakens the adsorptive desulfurization performance. In this work, a novel micro–mesoporous binderless ZSM-5 (BL-ZSM-5) was successfully prepared through in situ crystallization, which could efficiently remove thiophene from model fuel. Desulfurization ability was investigated by static and fixed bed adsorption. The breakthrough adsorption capacity of thiophene on BL-ZSM-5 reaches 0.38 mg/g, which is twice as high as that of ZSM-5 with alumina binders (Al-ZSM-5). The improvement is attributed to the conversion of alumina into molecular sieves, which could increase the adsorption sites and provide appropriate mesoporous channels for thiophene transfer. The thermal stability of BL-ZSM-5 is superior to that of Al-ZSM-5. The adsorption performance of BL-ZSM-5 is maintained well after 6 cycles of regeneration. The results demonstrate that the attractive prospect of BL-ZSM-5 in highly efficient desulfurization of transport fuels through selective adsorption.
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高影响因子
Molecular Catalysis
·
2017
·
IF 0
Shuang Chu,Li’na Yang,Xingcui Guo,Linlin Dong,Xiufang Chen,Yaru Li,Xindong Mu
The catalytic behavior of a series of MFI catalysts with different Si/Al ratio (25–300) in the direct aqueous-phase hydrolysis of α-cellulose was studied. The effects ultrasonic pretreatment time, ZnCl 2 content, zeolite pore structure and acid-basic properties on catalyst activity and products distribution were systematically investigated. The results indicated that HZSM-5 with lower Si/Al ratio was beneficial for production of glucose and LA from α-cellulose. Ultrasonic pretreatment could decrease the degree of crystallinity and polymerization of α-cellulose, enhance the accessibility of acid sites and ZnCl 2 to the loosened amorphous regions of α-cellulose in water, and improve the hydrolysis efficiency of α-cellulose. The desilicated ZSM-5 (HZSM-5-DS(0.2)) showed much higher catalytic activities as compared to commercial ZSM-5 and α-cellulose conversion reached 76.5% over HZSM-5-DS(0.2) at 200 °C. Catalytic conversion of α-cellulose consisted of at least three important parallel reactions under the present hydrothermal conditions and a plausible pathway was proposed. Effective control of these reactions would be helpful to further maximize the target product yield during the catalytic conversion of α-cellulose.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Li Wang,Liyuan Li,Penggang Lv,Xin Gao,Yang Gao,Lu Han,Xuedong Zhu,Kake Zhu
A hierarchically structured ZSM-11/ZSM-5 intergrowth zeolite was generated using a polycationic organic structure-directing agent (OSDA), [-N+(CH2CH2CH2CH3)2-(CH2)8-]n[OH–]n, which is conceptually equivalent to bond-linked tetrabutylammonium (TBA), the frequently used OSDA for ZSM-11 synthesis. The produced ellipsoidal crystals have a major axis length of 130–240 nm and a minor axis length of 75–120 nm, made up of aligned nanocrystals of 44 to 83 nm, to construct an auxiliary macro- to mesopore network ranging from 45 to 80 nm. The Si/Al ratio can be manipulated from 50 to ∞, and the intergrowth exhibits acidity comparable to that of ZSM-5, which is distinct from previous reports that formation of hierarchical porosity or intergrowth often compromises the inherent acidity of zeolitic crystals. Such hierarchical architecture also endows the material with enhanced transport properties, as validated by 2-methylhexane adsorption measurements. In the catalytic methylation of meta-xylene with methanol, the hierarchical ZSM-11/ZSM-5 zeolite exhibited superior performance to that of ZSM-5, with enhanced activity and total trimethylbenzene and tetramethylbenzene selectivity, which was elevated from 28% to 39%. These catalytic merits stem from the combined effects of preserved acid strength, optimized pore connectivity, and alleviated diffusion limitations.
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高影响因子
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
·
2026
·
IF 2.5
Gu Wenhui,Wu Lingyu,Yang Zhiguo,Cheng Zhongbin,Liu Wenwen,Huang Yi-You,Liu Dan,An Faliang,Li Jian,Zhou Qian,Li Baoli,Luo Hai-Bin
Wendlandia uvariifolia subsp. chinensis (Merr.) Cowan is a traditional medicinal plant used by the Li ethnic group in Hainan Province, China, for the treatment of herpes zoster. However, its pharmacological properties remain unclear. This study aimed to evaluate its phosphodiesterase type 5 inhibitory activity, identify the active components, and explore its therapeutic potential for erectile dysfunction. Through high-throughput screening of 1200 traditional Chinese herbal medicines, this plant was identified as a potential phosphodiesterase type 5 inhibitor. Bioactivity-guided fractionation and gas chromatography–mass spectrometry analysis identified the petroleum ether fraction as the most active fraction, while phytol, one of its identified constituents, inhibited phosphodiesterase type 5 in vitro with an IC₅₀ value of 2.5 ± 0.1 μmol/L. In H₂O₂-injured endothelial cells, petroleum ether fraction significantly restored nitric oxide production. In a paroxetine-induced erectile dysfunction rat model, the fraction improved sexual behavior parameters, restored NO/cGMP signaling, and alleviated pathological remodeling and fibrosis in the corpus cavernosum. In a diabetes mellitus-associated erectile dysfunction rat model, the fraction also improved corpus cavernosum architecture, increased smooth muscle content, and reduced fibrosis, although the increase in the intracavernous pressure/mean arterial pressure ratio did not reach statistical significance. Overall, the results suggest the preclinical anti-erectile dysfunction potential of petroleum ether fraction and support its further mechanistic, pharmacokinetic, safety, and translational evaluation.
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高影响因子
Green Energy & Environment
·
2025
·
IF 14.6
Peiya Chen,Xinghao Li,Yuhan Liu,Huai Liu,Rui Zhang,Wenlong Jia,Junhua Zhang,Yong Sun,Lincai Peng
Concurrent activation of lattice oxygen (O L ) and molecular oxygen (O 2 ) is crucial for the efficient catalytic oxidation of biomass-derived molecules over metal oxides. Herein, we report that the introduction of ultralow-loading of Ru single atoms (0.42 wt%) into Mn 2 O 3 matrix (0.4%Ru-Mn 2 O 3 ) greatly boosts its catalytic activity for the aerobic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA). The FDCA productivity over the 0.4%Ru-Mn 2 O 3 (5.4 mmol FDCA ‧g cat -1 ‧h -1 ) is 4.9 times higher than the Mn 2 O 3 . Especially, this FDCA productivity is also significantly higher than that of existing Ru and Mn-based catalysts. Experimental and theoretical investigations discovered that the Ru single atom facilitated the formation of oxygen vacancy (O v ) in the catalyst, which synergistically weakened the Mn-O bond and promoted the activation of O L . The co-presence of Ru single atoms and O v also promote the adsorption and activation of both O 2 and HMF. Consequently, the dehydrogenation reaction energy barrier of the rate-determining step was reduced via both the O L and chemisorbed O 2 dehydrogenation pathways, thus boosting the catalytic oxidation reactions.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Beiling Liang,Yongxin Liang,Jiashuo Chen,Ying Zhu,Fuzheng Fu,Tao Gan,Zuqiang Huang,Huayu Hu,Yanjuan Zhang
To achieve the goal of “no waste” in circular bioeconomy on the basis of waste-to-energy conversion, the development of efficient technology for sustainable treatment and utilization of lignocellulosic biomass is significant yet challenging. In this study, a stepwise processing strategy based on enzymatic hydrolysis and catalytic conversion was proposed for comprehensive utilization of sugarcane bagasse (SCB) to produce value-added products. Mechanical activation (MA) pretreatment was adopted to disrupt the recalcitrant structure of SCB for improving enzymatic hydrolysis of polysaccharides to produce reducing sugars, obtaining a high yield (392 mg/g SCB) of target sugars (TS; i.e., cellobiose and glucose). The enzymolysis residue and Al(NO 3 ) 3 ·9 H 2 O were treated by MA and then calcinated to construct the biochar (BC)-based catalyst (denoted as MA-Al/BC) with Brønsted–Lewis dual-acidic sites, which effectively catalyzed the conversion of TS to produce 5-hydroxymethylfurfural (5-HMF). A TS conversion of 94.5% and a 5-HMF yield of 77.6% were achieved at 190 °C for 4 h in the biphasic system. MA-Al/BC exhibited excellent universality for efficient catalytic conversion of various carbohydrates. This study offers a promising approach for value-added exploitation of agricultural wastes within circular bioeconomy principles.
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高影响因子
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