CHEMICAL PAPERS
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2026
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IF 2.7
Ma Chengzhang,Tao Xin,Liu Yang,Luo Bitao,Long Qi
To develop a high-performance material for heavy metal remediation, calcium silicate hydrate (CSH) was synthesized using calcium chloride and sodium metasilicate as precursors via a constant-temperature solid-phase method. A novel ternary adsorbent, Fe 3 O 4 /CSH@MCC, was successfully constructed by coating Fe 3 O 4 -loaded CSH with microcrystalline cellulose (MCC). The surface characteristics, structural, morphological, and thermal stability were characterized using SEM, FTIR, XRD, BET, TGA and XPS analyses. The adsorption behavior was further elucidated through kinetic, thermodynamic, and isotherm modeling. The results indicated that under optimal conditions (pH = 5), the maximum adsorption capacities for Ni 2+ , Cu 2+ , Pb 2+ , and Ag + reached 792.52 mg/g, 683.45 mg/g, 750.08 mg/g, and 351.05 mg/g, respectively. Rapid adsorption equilibrium was achieved within 60 min, with corresponding removal efficiencies of 99.53%, 86.32%, 97.19%, and 48.10%. Thermodynamic and kinetic analyses demonstrated that the adsorption process follows the Langmuir isotherm model, indicating a monolayer adsorption mechanism. The pseudo-second-order kinetic model suggested that chemisorption is the dominant adsorption mechanism. These findings underscore the potential of the Fe 3 O 4 /CSH@MCC composite as an efficient material for wastewater treatment, offering a promising solution for the environmental remediation of heavy metal pollutants.
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高影响因子
Nature Energy
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2026
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IF 70.1
Ma Tianshu,Zhao Yue,Zhu Jingwei,Yin Xinxing,An Yidan,Chen Cong,Shang Minghui,Wang Huayang,Wu Zhanghao,Liu Yuhui,Chen Chen,Guan Yuxiang,Luo Jincheng,Zhang Jing,Li Minghui,Xiao Chuanxiao,Yao Fang,Lin Qianqian,Yang Zhenhai,Cao Guoyang,Wang Changlei,Zhao Dewei,Li Xiaofeng
Low-bandgap ( E g ~ 1.25 eV) tin–lead perovskite solar cells hold great potential for constructing efficient all-perovskite tandem solar cells (TSCs). However, rapid degradation of perovskite precursor solutions, owing to easy oxidation of Sn 2+ , remains a major challenge. Here we elucidate oxidation pathways in Sn–Pb perovskite precursors. We further introduce basic amino acids and basic amino acids sulfate (BAAS) as proton scavengers, which stabilize the ink for over 300 days. BAAS neutralizes excess protons to mitigate dimethyl sulfoxide-driven oxidation reactions, whereas sulfate ions coordinate Sn 2+ to passivate defects and regulate crystallization. The optimized low-bandgap perovskite solar cell achieves a power conversion efficiency of 24.06% with an open-circuit voltage of 0.905 V, enabling two-terminal all-perovskite TSCs with a power conversion efficiency of 30.24% (certified 29.56%). The BAAS-passivated TSCs retain over 85% of their initial performance after 1,000 hours of the maximum power point operation under 1-sun illumination.
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高影响因子
Nature Communications
·
2026
·Vol. 17
·期 1
·4773
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IF 18.1
Ren Lingling,Ma Guoxuan,Wang Zheng,Liu Shuang,Cheng Haoran,Weitz David A.,Zhang Liyuan
Hydrogels typically deteriorate under high-salinity conditions because electrostatic screening and reduced polymer-solvent affinity suppress swelling and weaken load-bearing network connectivity. Here, we report a double-network hydrogel that strengthens while swelling in brine. Compared with its behavior in water, the network undergoes an ion-triggered topological reconfiguration upon salt exposure. The intrachain zwitterionic ion pairs open and reform as inter-network SBVI + -AMPS − bridges, increasing effective bridge density at lower polymer fraction. The hydrogel exhibits 1.63-fold tensile strength and 1.21-fold swelling ratio in 200 g/L NaCl compared to deionized water. SAXS and XPS confirm salt-induced structural homogenization and charge redistribution. Density functional theory calculations support strengthened ionic association under saline conditions between SBVI and AMPS. Free energy analysis reveals that reduced loop fraction and increased connectivity enable associative stabilization to compensate for elastic swelling penalties. Core-flooding demonstrates robust injectability in high-salinity porous rock. This mechanism provides design rules for salt-adaptive hydrogels.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 3
·820-827
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IF 1.4
Zhou Rui,Ding Jie,Wu Tengfei,Lu Xiaodie,Chen Jingyu,Li Zhiqiang
In order to investigate the effects of oxide particles on the high-temperature resistance and ablation performance of ceramicizable phenolic resin composites, three types of quartz fiber-reinforced ceramicizable phenolic resin composites were prepared using MgO particles or Al 2 O 3 particles as the second-phase oxides and ZrB 2 particles as the high-temperature ceramic filler, through a mold pressing process. The enhancement effects and mechanisms of the added second-phase oxides on the high-temperature resistance and ablation performance of the composites were discussed and analyzed through high-temperature testing, phase characterization, oxyacetylene testing, and microstructure characterization. The results show that ZrB 2 particles oxidize to form ZrO 2 and B 2 O 3 in an oxygen-rich high-temperature environment. The added second-phase oxide particles can react with B 2 O 3 to form corresponding borates, thereby strengthening the matrix. After treatment at 800 °C, the flexural strength of the ZrB 2 -MgO quartz fiber-reinforced phenolic resin composite (QFPR/ZM) increased by 55.3% compared to the ZrB 2 quartz fiber-reinforced phenolic resin composite (QFPR/Z). The oxyacetylene ablation performance of the composites with added oxide particles was significantly influenced by the generated borates. Mg 3 B 2 O 6 has a higher high-temperature viscosity than Al 18 B 4 O 33 at high temperatures, resulting in a lower linear ablation rate for QFPR/ZM compared to the ZrB 2 -Al 2 O 3 quartz fiber-reinforced phenolic resin composite (QFPR/ZA).
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高影响因子
CELL RESEARCH
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2026
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IF 31.1
Li Xiaojing,Li Renjie,Wei Yiqing,Chen Jiexin,Zhao Jiaojiao,Zhao Jun,Wang Wei,Li Na,Wang Lili,Hu Tuo,Dong Yanli,Zhu Yongping,Wei Chao,Li Long,Zhang Wei,Huang Zhuo,Zhao Yan
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission throughout the central nervous system. Calcium-permeable AMPARs and GluA4-containing receptors are critical for cerebellar functions, such as motor learning, associative memory, auditory processing, and synaptic plasticity. In contrast to the well-characterized, predominantly GluA2-containing AMPARs of the hippocampus and cortex, cerebellar AMPARs contain a higher proportion of GluA4 and remain poorly understood. Here, we generated a highly GluA4-specific antibody. Using this antibody in combination with antibodies specifically recognizing GluA1 and GluA2, we purified native AMPARs and determined the subunit compositions of both calcium-impermeable and calcium-permeable native AMPARs in the cerebellum. The isolated cerebellar AMPARs that contained both GluA1 and GluA4 were calcium-permeable, with GluA4 occupying mainly the B/D positions, GluA1 occupying the A/C positions, and the complex associated primarily with cornichon 3 (CNIH3). We determined the structures of the complex in distinct functional states, including the resting, active, and desensitized states, and characterized the conformational transitions that underlie its activity. During desensitization, the receptor adopts a pseudo-4-fold configuration of the ligand-binding domain layer, which may be important for its functional properties. This study provides a blueprint for the subunit compositions of AMPARs in the cerebellum and clarifies the gating mechanism of the calcium-permeable native AMPAR A1A4 –CNIH3 complex, providing significant insight into AMPAR-mediated synaptic transmission in the cerebellum.
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高影响因子
Advanced Composites and Hybrid Materials
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2026
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IF 15.5
He Chenglong,Hao Yue,Cao Lei,Ning Lei,Sun Ningning,Han Pei,Wang Yufei,Yang Junlin,Hao Xihong,Li Yong
Ferroelectrics hold great promise for electromagnetic (EM) absorption owing to intrinsic spontaneous polarization. However, high‑efficiency absorption in thin‑layer configurations is severely limited by a single dominant relaxation mechanism. Herein, a microcapacitor-network strategy is developed to synergistically unlock multiple relaxation pathways in ferroelectrics, enabling high‑efficiency EM absorption at ultrathin thicknesses. A “jujube-cake”-architected ferroelectric composite ceramic is presented, featuring an integrated La 0.7 Sr 0.3 MnO 3 -BiFeO 3 -La 0.7 Sr 0.3 MnO 3 (LSMO‑BFO‑LSMO) microcapacitor network. The microcapacitor orchestrates dynamic accumulation‑compensation of interfacial polar charges under EM excitation, thereby generating transient dipoles that significantly intensify interfacial polarization. Meanwhile, BFO ferroelectric domains tailored by interfacial ion diffusion enhance their intrinsic polarization response to EM waves, further reinforcing the microcapacitor-driven interfacial polarization. Empowered by LSMO-tuned continuous microcapacitor networks that amplify this synergy, the optimized BFO/LSMO2 composite delivers robust absorption over an ultrathin 1.2–1.6 mm thickness, with an average RL of -33.9 dB and a minimum RL of -65.8 dB at 1.3 mm. Furthermore, the EM metamaterial designed from this composite exhibits full-band absorption across the entire X-band. Notably, leveraging its pronounced thickness sensitivity, an intelligent pressure-sensing array is validated for rapid battery safety monitoring and response. This study establishes a novel paradigm to high-performance integrated multifunctional EM materials and devices. Graphical A microcapacitor-guided paradigm is established in BFO/LSMO ceramics. Synergistic coupling of interfacial charge accumulation with domain-engineered ferroelectricity transcends the single-relaxation bottleneck, enabling high-performance ultrathin electromagnetic absorption and intelligent pressure sensing. The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
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IF 18.1
Zhu Shilu,Shen Shuwei,Ye Min,Zhang Yang,Zheng Zhiyuan,Gao Jie,Zhang Ru,Lang Zhongliang,Yao Peng,Sun Mingzhai,Lee Luke P.,Xu Ronald X.
Biological systems dynamically grow high-aspect-ratio architectures from a site, enabling traversal of phase boundaries and functional execution. Emulating this growth strategy in synthetic systems could yield functional microsystems for operation across interfaces. However, engineering such bio-inspired growth to proceed out of plane from a substrate in synthetic colloidal assemblies remains challenging, as it requires overcoming gravitational collapse while maintaining structural coherence during extension. Here, we present a field-driven particle system that achieves gravity-resisting growth of high-aspect-ratio structures via frequency-modulated magnetic and hydrodynamic interactions. This growth is enabled by combining static and oscillating magnetic fields, which guide the assembly of magnetic particles into dynamic structures exhibiting a distinct segmented, seaweed-like morphology. These architectures are reconfigurable, stabilizable, programmably actuatable, and capable of penetrating a perfluorohexane–water interface. When functionalized with enzymes, the growing structures act as micro-transporters, delivering catalytic activity across the interface and triggering detectable reactions in both bulk two-phase and microfluidic chip systems. This work establishes a field-driven assembly-to-function approach that integrates structural growth, phase-boundary penetration, and triggered functionality, enabling active microsystems capable of interfacial transport and functional execution.
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高影响因子
Nature Communications
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2026
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IF 18.1
Zheng Xueying,Yu Dongpeng,Tian Fei,Lei Danni,Wang Chengxin
The initially anode-free sodium metal batteries represent promising candidates for high specific energy and safe battery systems, relying solely on cathodic sodium reservoirs. However, the irreversible accumulation of electrochemically inactive “dead” Na and unstable solid electrolyte interphases fundamentally constrains cyclability through rapid active Na depletion. Here, we utilize a grain-boundary gallium-rich polycrystalline aluminum current collector to trigger controlled dissolution of aluminum ions. The dissolved aluminum ions modify the local coordination environment of the electrolyte, thereby perturbing the solvation equilibrium of sodium ions and facilitating sodium ions migration toward the positive electrode for charge compensation. The gallium-rich aluminum current collector enables stable Na plating/stripping for over 2500 cycles. The pouch cell with Na 3 V 2 (PO 4 ) 3 delivers 88.7% capacity retention after 100 cycles at 35.1 mA g −1 in 1 M NaPF 6 in diglyme, based on a nominal capacity of 117 mAh g −1 . In addition, the full cell with a high positive electrode loading (47.4 mg cm −2 ) achieves a high specific energy of 201.5 Wh kg −1 , calculated based on all cell components (positive electrode, negative electrode, separator and electrolyte). This work proposes a viable current collector design concept that can be extended to other initially anode-free battery systems.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Ma Tianyu,Li Qiang,Chen Xingwu,Dong Jixiang,Jiang Yuqing,Li Shanshan
Bioactive peptides are promising candidates for hair regeneration, but their topical application is often limited by poor skin delivery and the need for frequent dosing. To overcome these challenges, we designed a palmitoylated peptide, Pal-MPAPO, and incorporated it into a hyaluronic acid-based hydrogel microneedle (MN) system for localized transdermal delivery. The fabricated MNs showed adequate mechanical strength for skin insertion and provided a time-dependent, prolonged release of Pal-MPAPO. In human dermal papilla cells (DPCs), Pal-MPAPO activated the Wnt/β-catenin pathway and increased intracellular cyclic adenosine monophosphate (cAMP) levels in a predominantly VPAC1-dependent manner. Additional VPAC2 validation did not reveal a significant contribution to cAMP signaling under the tested conditions. Functional interactions between Pal-MPAPO and VPAC1 were supported by molecular docking, molecular dynamics simulations, receptor knockdown, and fluorescence imaging. In a C57BL/6 mouse model, Pal-MPAPO-loaded MNs significantly promoted hair regrowth, achieving efficacy comparable to minoxidil but at a reduced application frequency. These findings identify Pal-MPAPO as a potential peptide candidate for hair regeneration and suggest that hydrogel MN-assisted delivery provides a localized peptide administration strategy. Graphical The alternative text for this image may have been generated using AI.
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产品关联
DOI
PubMed
高影响因子
Journal of Animal Science and Biotechnology
·
2026
·Vol. 17
·期 1
·109
·
IF 7.9
Zhang Jiaqi,Shi Xiaohan,Peng Siyi,Zhang Chi,Qiao Shiyan,Yu Haitao
Background While the livestock industry actively seeks alternatives to antibiotics, residual low-dose exposures continue to drive the spread of antibiotic resistance genes (ARGs). Icariin, a plant-derived compound, is recognized for improving poultry growth and immunity. However, it remains unclear how this compound influences the environmental persistence of ARGs, mobile genetic elements (MGEs), and horizontal gene transfer (HGT) during the vulnerable recovery phase after antibiotic withdrawal. Results We designed a two-phase feeding trial with laying hens, using longitudinal metagenomic sequencing to track post-withdrawal resistance dynamics. Following initial exposure to a low-dose antibiotic mixture that established a baseline of elevated resistance, hens received either a basal diet, an icariin-supplemented diet, or a copper sulfate-supplemented diet. The data indicate that icariin supplementation consistently reduced the burdens of both ARGs and MGEs. It also suppressed the potential for HGT and restricted the diversity of microbial hosts harboring these resistance elements. Conversely, copper sulfate—a traditional metal-based additive—exacerbated resistance risks by expanding both the abundance and the host range of ARGs and MGEs. Across all treatments, the population of Escherichia and the prevalent ARG subtype bacA correlated strongly with total resistance loads, tracking the overall resistome burden. Conclusions Compared to conventional copper sulfate treatments, icariin facilitates a safer ecological recovery in the poultry gut by actively lowering ARG and MGE reservoirs after antibiotic withdrawal. These genomic insights, combined with its known physiological benefits, support icariin as a sustainable feed additive. Furthermore, the Escherichia - bacA correlation provides a reliable, streamlined indicator for monitoring resistance risks in farm environments. However, as these findings rely on short-term fecal metagenomic tracking, further validation through multi-environment studies is warranted. Graphical
The alternative text for this image may have been generated using AI.
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高影响因子
BMC MICROBIOLOGY
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2026
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IF 5.4
Hao Danrui,Huang Yuhang,Zhao Tianzhu,Wang Runyu,Jiang Wei,Yuan Xiangting,Wang Xinrong,Chu Yiwen,Zhao Kelei,Huang Ting,Wang Zhenxing
Background Acinetobacter baumannii is a notorious clinical pathogen that predominantly causes nosocomial infections. The multidrug resistant Acinetobacter baumannii clinical isolates are becoming more prevalent on a global scale. In this study, we aimed to determine the potential synergistic antibacterial activity of contezolid in combination with polymyxin B nonapeptide (PBNP) against various A. baumannii strains. Results Contezolid, a commonly-used agents targeting Gram-positive bacteria, in combination with PBNP (CP) was used to explore the potential synergistic antibacterial activity against A. baumannii in vitro and Caenorhabditis elegans models. We found that CP treatment exhibited a strong synergistic effect on A. baumannii or multidrug resistant A. baumannii . CP also inhibited the biofilm formation and alter morphology of A. baumannii compared to the control group. Moreover, the residual bacteria were significantly decreased in the CP-treated murine alveolar macrophages (MH-S). Importantly, CP treatment improved the survival of C. elegans compared to the control or monotherapy group. Conclusions This strategy improved antibacterial activity spectrum of agents targeting Gram-positive bacteria like contezolid. Nevertheless, CP combination therapy requires further validation in mammalian infection models.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Yao Jing,Li Yanyan,Meng Yiling,Wang Tao,Meng Jie,Liu Jian,Wen Tao,Xu Haiyan
Acute myeloid leukemia (AML) is characterized by differentiation arrest and apoptosis resistance, frequently with mitochondrial dysfunction and aberrant heat shock protein 60 (HSP60) overexpression as key drivers of malignant progression. Platinum-based nanozymes exhibit multi-enzymatic activity but lack organelle specificity, limiting their therapy efficacy. Based on that there are abundant HSP60 in mitochondrial, we constructed a peptide-conjugated nanozyme PtNPs-P17 by conjugation platinum nanoparticle (PtNPs) and HSP60-targeting peptide P17. It was shown that PtNPs-P17 retained intrinsic oxidase (OXD), peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT)-like activities while acquiring the targeting ability. In the myeloperoxidase (MPO)-positive AML cell line MOLM-13, PtNPs-P17 specifically localized to mitochondria in cells, significantly increasing the production of reactive oxygen species (ROS), oxygen and especially singlet oxygen due to its multi-enzymatic redox regulatory function, which disrupted mitochondrial membrane potential and triggered mitophagy evidenced by the elevated LC3BII/actin ratio and LC3B-mitochondria co-localization. Moreover, PtNPs-P17 induced dual inhibition of mitochondrial respiration and glycolysis, leading to total NAD levels reduced. These metabolic perturbations together resulted in the differentiation of the AML cells, with up-regulated levels of CD235a, CD11b, and CD41a, and enhanced apoptosis. In a refractory AML mouse model, PtNPs-P17 significantly down-regulated the HSP60 expression while reduced spleen GFP + leukemia cells, suggesting significantly enhanced anti-leukemia effects compared to PtNPs. In conclusion, it was demonstrated that PtNPs-P17 targeted mitochondrial HSP60 to induce mitophagy by orchestrating multi-enzymatic redox regulation and mitochondrial reprogramming, thereby overcoming AML differentiation block and apoptosis resistance. This study provides a novel AML therapy option via precise mitochondrial targeting and metabolic intervention, highlighting the translational potential of HSP60-targeted multi-enzyme nanozymes. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
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