MOLECULES
·
2025
·Vol. 30
·期 6
·1254
·
IF 4.6
Yuexia Qin,Zhuyu Zheng,Di Liu,Shuhua Sun,Xiaolei Zhao,Lei Lv,Dengyu Xie,Zhonghui Han,Jinxing He
The effects of furfural and 5-methyl-2-furfural produced by the Maillard reaction on PhIP formation were investigated in chemical models and roasted pork patties. In the chemical models, the results indicated that increasing levels of furfural (r = −0.7338, R2= 0.9557) and 5-methyl-2-furfural (r = −0.7959, R2= 0.9864) significantly reduced PhIP formation, displaying a strong linear correlation. The effects of furfural and 5-methyl-2-furfural on the precursors of phenylalanine (Phe) and phenylacetaldehyde showed a significant reduction in the Phe level, while the level of phenylacetaldehyde was not increased. In addition, neither furfural nor 5-methyl-2-furfural could significantly reduce creatinine or PhIP. Further mechanism studies showed that furfural (5-methyl-2-furfural) directly captured Phe to form the corresponding Schiff base compounds a (2-((furan-2-ylmethylene) amino)-3-phenylpropanoic acid) and b (2-(((5-methylfuran-2-yl)methylene)amino)-3-phenylpropanoic acid). This process reduced the production of phenylacetaldehyde, thereby inhibiting the PhIP formation pathway. More importantly, these two compounds were detected in roasted pork patties to which glucose was added. The above pathway was finally confirmed in roasted pork patties. These results revealed that furfural and 5-methyl-2-furfural, formed during the Maillard reaction, play a significant role in inhibiting the formation of PhIP by reacting with Phe.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Binxia Zhao,Nan Shao,Xingliang Chen,Jixian Ma,Yijia Gao,Xiaoqian Chen
As a novel photocatalyst with visible light responsiveness, Bi 2 WO 6 has excellent activity in treating wastewater containing organic pollutants and noble metals. However, its photocatalytic action is limited due to the rapid recombination of photogenerated electrons and holes. Based on the study of Bi 2 WO 6 , a type Ⅱ heterojunction photocatalyst (WO 3 /Bi 2 WO 6 ) and a Z-scheme heterojunction photocatalyst (CdS/Bi 2 WO 6 ) were constructed. Composites exhibited higher catalytic activity than pure Bi 2 WO 6 . The degradation efficiency of RhB(50 mg/L) and reduction efficiency of Cr(VI) (50 mg/L) by 5%WO 3 /Bi 2 WO 6 catalyst within 60 min of photocatalytic reaction was 98.82% and 53.82%, respectively. The degradation efficiency of RhB and reduction efficiency of Cr(VI) by 15%CdS/Bi 2 WO 6 catalyst was 99.52% and 69.52%, respectively. By studying the structural composition , microscopic morphology, photoelectrochemical performance, and light absorption performance of the catalysts of the two different systems. These mechanisms may help to explain the reasons for the enhanced activity of the composite photocatalysts. In addition, mixed wastewater containing organic pollutants (RhB) and heavy metal ions (Cr(VI)) was used to simulate real and complex wastewater, which provided more ideas for wastewater treatment problems.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Asthma and Allergy
·
2022
·
IF 3.027
Yang Sun,Tiancong Liu,Weiliang Bai
Purpose This work aimed to investigate the effects of MAF bZIP transcription factor B (MAFB) on the progression of allergic rhinitis (AR). Patients and Methods Nasal mucosa was isolated from AR patients and healthy individuals from Shengjing Hospital of China Medical University. The experimental procedures were approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University (2019PS341K) in accordance with the Declaration of Helsinki. Informed consents were signed by participants or a parent/legal guardian of the participants under 18 years old of age. Then, an AR mouse model with MAFB overexpression was established with 25 μg ovalbumin (OVA) sensitization on day 0, 7, 14, followed by an injection with 1×10 7 TU/mL lentivirus MAFB on day 19 and a nasal challenge with 500 μg OVA from day 21 to 27. Results The results revealed that MAFB was down-regulated in the nasal mucosa of AR patients. The up-regulation of MAFB protected the AR mice against the OVA-induced allergic symptoms (sneezing and nasal rubbing) by alleviating the OVA-induced epithelial thicknesses, goblet cell hyperplasia, and inflammation including the eosinophil and mast cell infiltration. Moreover, MAFB facilitated the T helper (Th) 1 response and inhibited the Th2 and Th17 responses by the down-regulation of T-box transcription factor 21 and the up-regulation of GATA binding protein-3 as well as retinoid-related orphan receptor-γt in the splenocytes of AR mice. MAFB was found to repress the differentiation of naive CD4 + T cells into Th2 cells. Subsequently, MAFB overexpression reversed the OVA-induced enhancement of epithelial permeability, downregulation of tight junctions, and upregulation of cadherin-26, indicating the protective role of MAFB on epithelial barrier integrity. Conclusion MAFB protected against OVA-induced AR via the alleviation of inflammation by restoring the Th1/Th2/Th17 imbalance and epithelial barrier dysfunction.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2020
·Vol. 16
·期 13
·1906880
·
IF 11.459
Weikang Wang,Hongjian Zhou,Yanyan Liu,Shengbo Zhang,Yunxia Zhang,Guozhong Wang,Haimin Zhang,Huijun Zhao
It is an important issue that exposed active nitrogen atoms (e.g., edge or amino N atoms) in graphitic carbon nitride (g-C 3 N 4 ) could participate in ammonia (NH 3 ) synthesis during the photocatalytic nitrogen reduction reaction (NRR). Herein, the experimental results in this work demonstrate that the exposed active N atoms in g-C 3 N 4 nanosheets can indeed be hydrogenated and contribute to NH 3 synthesis during the visible-light photocatalytic NRR. However, these exposed N atoms can be firmly stabilized through forming B N C coordination by means of B-doping in g-C 3 N 4 nanosheets (BCN) with a B-doping content of 13.8 wt%. Moreover, the formed B N C coordination in g-C 3 N 4 not only effectively enhances the visible-light harvesting and suppresses the recombination of photogenerated carriers in g-C 3 N 4 , but also acts as the catalytic active site for N 2 adsorption, activation, and hydrogenation. Consequently, the as-synthesized BCN exhibits high visible-light-driven photocatalytic NRR activity, affording an NH 3 yield rate of 313.9 µmol g −1 h −1 , nearly 10 times of that for pristine g-C 3 N 4 . This work would be helpful for designing and developing high-efficiency metal-free NRR catalysts for visible-light-driven photocatalytic NH 3 synthesis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Rui Gao,Shen Zhang,Hailong Liu,Zhizhou Yang,Yue Wu,Sheng Gao,Mei Li,Hanlin Shao,Mingjie Wu
Disposal of dye-contaminated wastewater has become an imperative issue. Synthesis of novel materials for larger-capacity removal of those contaminants assisting by special interaction is a significant challenge. In this paper, a series of hyper-crosslinked poly 9-bromophenanthrene hybrids (HCPs) were synthesized by combination of 9-bromophenanthrene (9BP) and octavinylsilsesquioxane (OVS) via Friedel-Crafts alkylation reaction. The synthesized HCPs were well characterized. The results illustrated that HCPs were porous polymer hybrids consisting of micropores and mesopores with the apparent surface areas ( S BET ) in range of 980.0–1010.6 m 2 g −1 , and the micropore and mesopore widths located at 1.42 and 4 nm. Dye adsorption disclosed that the adsorbed amounts of rhodamine B (RB) and Congo red (CR) on HCP-2 respectively arrived at 2646.0 ± 37.4 and 1550.0 ± 38.5 mg g −1 , ascribing to the interactions of pore filling, hydrogen bonds, π π stacking, electrostatic attraction, especially the C Br⋯π interaction between the resulting polymers and the dye molecules of RB and CR. Moreover, HCP-2 exhibited larger adsorbed amount of iodine vapor arriving at 179.9 ± 2.6 wt%. This work provided an innovative strategy to design new adsorbents for larger-amount removal of contaminants from the environment.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
·
2023
·Vol. 78
·期 2
·213-221
·
IF 1.1
Suo Lili,Hu Meihua
Abstract A new specific sorbent entitled molecularly imprinted polymer (Fe 3 O 4 @PDA MIP) was fabricated on the surface of ferroferric oxide nanoparticles with the dummy template of 5,7-dimethoxycoumarin through self-assembly of dopamine which is efficient for recognition and determination of aflatoxin B in food samples coupled with UPLC-FLD with a large volume flow cell. The prepared MIPs were characterized, and the adsorption properties were evaluated. The maximum adsorption capacities were 0.46 mg/g for aflatoxin B1 and 0.047 mg/g for aflatoxin B2. Under optimized conditions, the calibration plots are linear in the range of 0.005–0.5 and 0.001–0.1 ng/mL with LODs of 0.0024 and 0.0004 ng/mL for aflatoxin B1 and aflatoxin B2, respectively. The recoveries from spiked samples are 89.0–105.0% with RSDs of 5.6–7.7% in case of corn, peanut and edible oil. And after 7 cycles, the adsorption capacity of the MIPs did not decrease significantly.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Qili Liu,Qing Xu,Wei Sun
The monomer of two-in-one molecular design strategy (i.e., A 2 B 2 type monomer) 1,6-bis(4-formylphenyl)-3,8-bis((4-aminophenyl) ethynyl)) pyrene (BFBAEPy) was self-polymerized and coated on the modified Fe 3 O 4 surface to synthesize a magnetic covalent organic framework (Fe 3 O 4 @COF) nanocomposite with a core-shell structure. Before high-performance liquid chromatography with ultraviolet detection (HPLC-UV) determination, Fe 3 O 4 @COF was used as a magnetic solid-phase extraction (MSPE) adsorbent to enrich Rhodamine B (RhB) illegally added to Chili powder and Chinese prickly ash. It had a large specific surface area and suitable pore size, which promoted the efficient adsorption of RhB dye and eliminated the interference of the matrix. Several key parameters affecting the extraction recovery rate were investigated, including adsorption capacity, adsorption time, pH, ionic strength, elution solvent, elution volume and elution time. Under the best optimized conditions, within the linear detection range of 0.05–5 µg/mL for RhB with the limit of detection (LOD) was 0.0038 µg/mL, excellent linearity (correlation coefficient R 2 =0.9997), and good repeatability (relative standard deviations RSD%< 3.8%), satisfactory extraction recovery rate (91.7%-97.5%). Therefore, the application of the established method to the detection of RhB in food samples has bright prospects.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Peiqing Luo,Xiaocui Huang,Fang Luo,Zhonghui Chen,Yu Chen,Cuiying Lin,Jian Wang,Bin Qiu,Zhenyu Lin
In this work, combined with the high amplification efficiency of hybridization chain reaction (HCR), high specificity of the CRISPR/Cas12a system, and convenience of the homogeneous electrochemiluminescence (ECL) assay based on the regulation of negative charge on the reporting probes, a sensitive ECL biosensor for hepatitis B virus DNA (chosen as a model target) had been developed. The initiator chain trigger DNA that can induce HCR amplification is modified on the surface of ruthenium bipyridine-doped silica nanoparticles (Ru@SiO2 NPs) first, and large amounts of negative charges modified on the particles were achieved through the HCR amplification reaction. The efficiency of the nanoparticles reaching the negatively charged working electrode can be regulated and realize the change of the ECL signal. In addition, long DNA on the surface of the luminescent body may prevent the coreactant from entering the pore to react with ruthenium bipyridine. These factors combine to produce a low-background system. The presence of the target can activate the CRISPR/Cas12a system and make trigger DNA disappear from the nanoparticle surface, and strong ECL can be detected. The sensor does not require a complex electrode modification; therefore, it has better reproducibility. Additionally, due to dual signal amplification, the sensor has a high sensitivity. In the range of 10 fM to 10 nM, the ECL intensity exhibits a strong linear relationship with the logarithm of the target concentration, and the detection limit is 7.41 fM. This sensor has shown high accuracy in detecting clinical samples, which holds significant potential for application in clinical testing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Zhe-Xuan Yu,Yang-Yang Zhang,Xi-Xi Zhao,Li Yu,Xiao-Bo Chen,Hai-Tong Wan,Yu He,Wei-Feng Jin
Dried roots and rhizomes of Salvia miltiorrhiza Bge. (Danshen in Chinese) are widely used in Chinese herbal medicine. These components from Danshen have significant anti-oxidation properties owing to high levels of tanshinone IIA (TIIA) and salvianolic acid B (Sal B). To make the best use of this natural resource, response surface methodology (RSM) and artificial neural network (ANN) were used for the modeling and optimization of ultrasound-assisted extraction (UAE) of TIIA and Sal B together to determine the antioxidant activity of the extracts obtained from Danshen. In this study, the Box-Behnken design (BBD) was used to improve extraction time ( X 1 ), solvent-to-material ratio ( X 2 ), extraction temperature ( X 3 ), and ethanol concentration ( X 4 ) for the optimal combination of the comprehensive yield of TIIA and Sal B ( Y 1 ) and the antioxidant activity ( Y 2 ). The optimal process parameters were determined to be as follows: extraction time, 73 min; solvent-to-material ratio, 11 mL/g; extraction temperature, 76℃; and ethanol concentration, 80 %. Using these conditions, the predictive optimal combination revealed a comprehensive evaluation value of 16.2281 and an antioxidant activity of 1.1453 mM FeSO 4 /5 g, while the experimental average values for these parameters were determined to be 16.1826 and 1.1415 mM FeSO 4 /5 g, respectively. It was clear that the ANN model had higher accuracy in predictive and optimization capabilities, with higher R 2 and lower RMSE, MAE, and relative deviations values, than did RSM. Hence, the ANN model proved to be more effective for the analysis and improvement of the extraction process.
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Yan Zhang,Lingqian Kong,Hongmei Du,Jinsheng Zhao,Yu Xie
Three novel donor-accept type electrochromic polymers with very low band gap, namely PMFTTP, PMFBTTP and PMFMOTTP, were prepared via electrochemical polymerization , employing 2,3-bis(5-methylfuran-2-yl)thieno[3,4- b ]pyrazine as the acceptor units and thiophene , butylthiophen and methoxythiophen as the donor units, respectively. All the polymers were comparatively studied by cyclic voltammetry (CV), scanning electron micrographs (SEM), UV–vis-NIR spectroscopy and colorimetry . The results revealed that PMFTTP and PMFBTTP showed obvious color change from green color to brown in the oxidation process , while PMFMOTTP exhibited color change from brick red to dark gray. And the three polymers possessed very low optical band gaps in the following order: PMFTTP (1.23 eV) > PMFBTTP (0.88 eV) > PMFMOTTP (0.74 eV), which demonstrated the different election-donating ability of thiophene or its derivatives. The electrochromic kinetic investigations manifested that the polymers presented satisfactory optical contrasts (ΔT%) in the near infrared region (NIR), which were 35%, 67% and 60% for PMFTTP, PMFBTTP and PMFMOTTP, respectively. Moreover, the polymers also displayed short switching times (lower than 1 s at any wavelengths), high coloration efficiencies (around about 200 cm 2 /C) and outstanding robust stabilities, suggesting the probability of being the promising candidates for the electrochromic devices. In summary, the above positive results, especially the neutral green color and the very low band gap, had important theoretical significance for the application and development of electrochromic polymers.
✓ 已验证
产品关联
DOI
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Mantong Zhao,Zhongyuan Liu,Mengyin Zha,Ying Sun,Haohao Shi,Xueying Zhang,Chuan Li,Guanghua Xia
The effect of aldehydes from lipid oxidation on the generation of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) during pan-frying of golden pompano fillets was investigated. It was observed the aldehydes that contribute to thiobarbituric acid reactive substances (TBARS) value significantly promoted PhIP generation ( p < 0.05). The defat treatment of fresh fish tissue significantly reduced the PhIP formation in pan-fried products ( p < 0.05). During pan-frying, massive aldehydes were generated in a time-dependent manner with acrolein, propanal, hexanal, 4-hydroxy-nonenal (HNE), and 2,4-decadienal (DDE) as the abundant species. In the established chemical model, these aldehydes congruously promoted PhIP formation with the increased concentration, especially acrolein, HNE and DDE. Therefore, aldehydes could significantly enhance the PhIP generation under processing. However, except for propanal and hexanal, the promoting effect was slightly decreased with high levels of aldehydes addition due to the strong electrophilic properties and participation of reaction with the amino group of phenylacetaldehyde, creatinine, even PhIP.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2016
·
IF 4.32
Lingling Ding,Jiawei Li,Rui Huang,Zhidong Liu,Chunhua Li,Shaozi Yao,Jinyan Wang,Dongli Qi,Nan Li,Jiaxin Pi
Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO 2 nanocarrier. Then, an FA-PEG-TiO 2 nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO 2 nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO 2 NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）