Journal of Energy Storage
·
2026
·
IF 10.7
Xinyu He,Min Du,Wanqing Wu,Dedi Zhou,Yihang Zhao,Haokun Shi,Qinggong Zheng
In recent years, with the development of electric vehicles and electric vessels, the issues of battery thermal safety have garnered significant attention. Composite phase-change materials (CPCMs) hold great potential as passive cooling systems in battery thermal management systems (BTMS), but their high flammability remains an unresolved challenge. This study successfully developed a flexible composite phase-change material, CPCM/P-CSF@rGO, by encapsulating a eutectic phase-change material composed of mannitol and galactitol in a three-dimensional hydrogen-bonded network, self-polymerised by phosphated corn straw cellulose (P-CSF) and reduced graphene oxide (rGO). The study demonstrates that the strong hydrogen bonding network formed between the phosphate groups introduced by phosphoric acid modification and rGO constructs highly efficient thermal conduction pathways, achieving a thermal conductivity of 1.039 W/(m•K) and significantly accelerating thermal response rates. Simultaneously, the incorporation of the P-CSF@rGO framework endows the material with excellent flexibility and shape stability. Due to the in-situ flame-retardant modification of the framework, the phase-change material maintains a high latent heat of phase-change (194.7 J/g) and achieves superior flame retardancy through gas-phase and condensation-phase mechanisms. It exhibits a limiting oxygen index of up to 30.64% and rapidly extinguishes itself when exposed to open flame in atmospheric conditions. Thus, the flexible composite phase-change material (CPCM/P-CSF@rGO) supported by a phosphorylated cellulose framework emerges as a promising candidate for ensuring safety and high performance in thermal management applications.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Bio
·
2026
·
IF 11
Hui Zhang,Xu Zhu,Jingchun Wang,Yibo Huo,Yikai Ma,Shengzhong Rong,Yuting Lu,Yingxue Jin
To address the core issue of low clinical response rates (10%-30%) to α-PD-L1 immune checkpoint blockade therapy, this study targeted the immunosuppressive bottleneck mediated by lactate accumulation in the tumor microenvironment (TME). A targeted drug delivery system (HLC) was constructed using hyaluronic acid (HA) nanomicelles co-loaded with lactate oxidase (LOX) and copper-doped carbon dots (CuCDs). Combined with α-PD-L1, a synergistic antitumor strategy integrating lactate metabolic regulation, cuproptosis, and immune activation was established. HLC achieves targeted accumulation through specific binding between HA and CD44 receptors on tumor cells. It directionally releases LOX and CuCDs in the acidic TME via pH-responsive properties. LOX efficiently clears lactate and elevates pH, blocking the HIF-1α/PD-L1 pathway to reverse immunosuppression. It also generates H 2 O 2 in situ to provide substrates for Cu-mediated Fenton-like reactions, enhancing cuproptosis. In vitro experiments confirm that HLC promotes dendritic cell maturation and drives M2-type macrophage polarization toward the M1 phenotype. In vivo studies using CT26 tumor-bearing mouse models show that HLC combined with 808 nm laser and α-PD-L1 significantly inhibits primary and distant tumor growth. It remodels the antitumor immune microenvironment with favorable biosafety. This study elucidates the synergistic mechanism between lactate metabolic regulation and cuproptosis, establishes an association between lactate level and cuproptosis sensitivity, and provides a novel strategy and experimental basis for combined cancer immunotherapy with important clinical translation value.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Shuang Liu,Hewen Li,Yuhang Ding,Dengyi Duan,Lin Cao,Kangkang Liu,Wenyi Zhang,Shifeng Cheng,Yiming Li,Yunfei Guo,Xiang Qi,Jianmin Li,Xuening Zhang,Jing Peng,Gang Han,Yang Zhao
Ferroptosis is triggered by iron-dependent lipid peroxidation, which shows great potential in tumor therapy. However, its biomedical applications are constrained by suboptimal therapeutic efficacy, leakage of metal ions from inducing agents, and the absence of noninvasive evaluation methods. In this study, we aimed to develop a self-reducing nano-theranostic agent (Fe@AP-SAS/RGD, FASR) for tumor-targeted ferroptosis therapy and conducted real-time magnetic resonance imaging(MRI) to monitor ferroptosis by encapsulating iron oxide particles in natural apple pectin (AP). In a weakly acidic tumor microenvironment, the strong reducing ability of AP accelerated the transformation of Fe 3+ within FASR into highly active Fe 2+ . Subsequently, the concentration of Fe 2+ increased and boosted the antitumor effect of ferroptosis. Notably, MRI of prostate cancer mouse models after intravenous injection of FASR NPs at varying doses revealed that the T 2 value decreased at the tumor sites and exhibited a linear correlation with the changes in ferroptosis hallmark markers, tumor weight, and volume after treatment. These findings demonstrate the capacity of T 2 mapping to quantitatively evaluate ferroptosis efficacy. This study not only introduced a tumor-targeted and self-reducing strategy to amplify ferroptosis but also pioneered a novel pathway for noninvasive imaging and monitoring of ferroptosis treatment processes within live tumors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Chunyu Qu,Yuanjin Sun,Kailei Liu,Ping Gan,Xichan Li,Yue Pan,Hui Zhang,Zhiqiang Wang,Guanghui Tan,Yingxue Jin
Immune checkpoint blockade (ICB) therapy often yields limited clinical efficacy due to immunosuppressive characteristics of the tumor microenvironment. Typical unfavorable factors include hypoxia, excessive accumulation of glutathione (GSH), and infiltration of M2-type tumor-associated macrophages. Single ICB treatment rarely achieves simultaneous in situ tumor eradication and systemic antitumor immune activation. This study develops a pH and glucose dual-responsive layered nanocarrier named BGHCCC to address the above challenges. The nanoplatform synergistically combines oxygen supplementation, starvation therapy, copper-amplified chemodynamic therapy (CDT), and calcium overload effects. Such combinatorial effects remodel the tumor microenvironment and improve tumor sensitivity to ICB therapy. Hollow calcium peroxide (HMCaO₂) serves as the core substrate for the in-situ immobilization of copper-doped resveratrol-derived carbon dots (CuRCDs). The final BGHCCC nanosystem is fabricated through noncovalent self-assembly of binary bovine serum albumin and glucose oxidase (BSA/GOx) protein complexes on the surface of HMCaO₂@CuRCDs. Comprehensive material characterizations confirm the tumor microenvironment-responsive controllable dissociation behavior of BGHCCC. Systematic assessments of in vitro catalytic performance, cellular biological functions, and in vivo antitumor efficacy are further conducted using tumor-bearing mouse models. Experimental results reveal that BGHCCC can consume intratumoral glucose, deplete intracellular GSH, and relieve hypoxic conditions through oxygen release. It also promotes the generation of hydroxyl radicals to activate cascaded biochemical reactions. These bioactive behaviors effectively induce tumor immunogenic cell death. In addition, BGHCCC can modulate the HIF-1α/PD-L1 signaling axis and regulate the phenotypic transformation of tumor-associated macrophages. This nanoplatform favors the polarization of macrophages from the immunosuppressive M2 phenotype to the antitumor M1 phenotype. In vivo experiments suggest that the combination of BGHCCC and αPD-L1 exhibits favorable biosafety and potent inhibitory effects on solid tumor growth. This combinatorial treatment increases the intratumoral infiltration of CD8 + effector T cells and triggers robust systemic antitumor immune responses. This study integrates multiple antitumor pathways into a single dual-responsive nanosystem and develops a synergistic therapeutic strategy to reverse tumor immunosuppression. It provides a feasible design reference for the development of combinatorial immunotherapeutic nanoplatforms with potential clinical translation value. Download: Download high-res image (229KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2026
·Vol. 9
·期 29
·13977-13986
·
IF 5.8
Lin Fan,Shao Yong,Zhang Yuanqing
Nanozyme-catalyzed reactive oxygen species (ROS) generation
has
emerged as a promising strategy for advanced ROS-based therapeutics.
However, achieving efficient ROS production with favorable catalytic
kinetics in a confined microenvironment remains challenging. Herein,
a cancer-targeting heterogeneous Janus nanozyme (JN, Cu 2– x Se–Au-TLS11a) was rationally fabricated via
a facile modular synthesis and assembly. Upon near-infrared II (NIR-II)
light irradiation, the well-designed JN realized multimodal synergistic
anticancer effects via three coordinated mechanisms: (i) efficient
photothermal conversion with a high efficiency of 61.9% for photothermal
therapy (PTT); (ii) NIR-II-triggered hot-electron transfer from the
Au domain to Cu 2– x Se promoted the
generation of Cu + , which accelerated Fenton-like reactions
to produce hydroxyl radicals (•OH); and (iii) NIR-II photoexcitation
induced the formation of electron–hole (e – -h + ) pairs on the Janus nanostructure, enabling additional
photocatalytic •OH generation. Under NIR-II light activation,
the JNs, integrating photothermal, photoenhanced chemodynamic, and
photocatalytic effects, demonstrated highly specific and potent in
vitro anticancer efficacy, achieving an IC 50 value of approximately
12.5 μg mL –1 against HepG2 cells and reducing
cell viability to 13.8%, thereby providing an innovative paradigm
for designing spatiotemporally controlled, ROS-amplifying nanoplatforms
toward precision cancer therapy.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·11602-11617
·
IF 5.2
Xu Yue,Du Yanwei,Liang Jingshi,Ding Xiaochu,Zhang Chunling,Zhang Zhihui,Liu Bo
Endogenous signaling molecules are essential for coordinated
wound
healing, yet current donor-based dressings typically provide only
single-mediator delivery with limited release duration. Here, a multifunctional
hydrogel dressing, HEVCTM, is developed by free radical copolymerization
of N -hydroxyethyl acrylamide (HEAA) with a hydrogen
peroxide (H 2 O 2 ) releasing donor (VIM-CAT) and
a hydrogen sulfide (H 2 S) releasing donor (TBA-MA). The
hydrogel enables temporally programmed release, with rapid H 2 O 2 delivery within 24 h for early stage antibacterial
action and sustained H 2 S release for up to 7 days to alleviate
inflammation and promote angiogenesis during later healing stages.
HEVCTM exhibits potent antibacterial activity against Escherichia coli (99.6%) and Staphylococcus aureus (99.97%), significantly enhances macrophage
M2 polarization (52.4%), and shows favorable antioxidant, hemostatic,
adhesive, and pro-angiogenic properties. Moreover, in an infected
mouse wound model, HEVCTM significantly accelerated wound healing
and promoted tissue regeneration. This work provides a bioactive hydrogel
platform that matches the dynamic requirements of wound healing and
effectively accelerates tissue repair.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Pharmaceutical Analysis
·
2026
·
IF 11.2
Guifeng Zhang,Hongjiang Li,Wei Zhang,Dan Pu,Longxing Wang,Xiaofei Han,Ju Wu
Mannan-oligosaccharides (MOS), as indigestible functional prebiotic, support intestinal health. Here, we engineered MOS to undergo linoleic acid (LA)-mediated self-assembly with quercetin, forming lipid bilayer nanoparticles (MOS-LA/LA-Q NPs). These nanoparticles achieved a high quercetin encapsulation efficiency (92.4%) and demonstrated superior stability in aqueous solution at 4 °C. The MOS outer layer effectively protected the quercetin core from gastrointestinal stress. Triggered by microbial enzymes, the system enabled a sustained quercetin release, up to 60% over 48 h, representing a novel microbe-specific delivery mechanism. In an Alzheimer’s disease (AD) mice models induced by AlCl 3 /D-galactose, MOS-LA/LA-Q NPs significantly enhanced gut microbiota diversity, restored gut microbiota balance, suppressed pathogenic bacteria, and regulated metabolites short-chain fatty acid (SCFA) and lactic acid levels. Compared with free quercetin, these nanoparticles (NPs) alleviated cognitive deficits, reduced inflammation and oxidative stress in both the colon and brain, improved gut-brain barrier integrity, and restored gut-brain function more significantly. Mechanistically, these effects were associated with modulation of the kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathways, reducing tau phosphorylation and Aβ amyloid levels, thus demonstrating superior neuroprotection. This study proposes a novel strategy for addressing the complex pathology of AD through multi-target intervention, highlighting the potential of MOS-based NPs to enhance quercetin’s therapeutic efficacy.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2026
·
IF 4.7
Zhang Pan,Sun Xuelin,Liu Longteng,Zhang Yatong,Bo Jiaqi,Huang Wenli,Na Yifan,Zhang Jingyi,Qin Xiaoyun,Luo Qingfeng
Gastric precancerous lesions (GPLs) are a pivotal stage in the gastritis-gastric cancer sequence, and the absence of effective treatments presents a clinical challenge. Veratramine is a natural anti-inflammatory and analgesic steroid alkaloid; however, its effects on GPLs and the mechanisms have remained unexplored. This study investigated the effects of veratramine on GPLs using 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced GES-1 cells and rat models, utilizing RNA-seq to elucidate the underlying mechanisms. In vitro, veratramine inhibited malignant cells (MC) proliferation, induced apoptosis, and triggered G0/G1 cell cycle arrest. It also suppressed epithelial-mesenchymal transition (EMT), migration, and invasion by upregulating E‑cadherin and downregulating Slug and vimentin. Transcriptomic and molecular docking analyses highlighted the Wnt/β-catenin pathway as a key target, regulated via DDX60, MUC1, APOL1, and MSH5. Veratramine reduced Wnt10B, β-catenin, and cyclin D1 expression and blocked β‑catenin nuclear translocation; these effects were reversed by the Wnt activator BML-284. In vivo, treatment with veratramine ameliorated the GPLs-induced pathological changes in rats. It restored body weight and preserved gastric mucosal integrity, as evidenced by intact glandular and cellular morphology, reduced hyperplasia, and attenuated intestinal metaplasia. These improvements were associated with a modulation of key molecular markers, specifically a decrease in the expression of N-cadherin, Wnt10B, and β-catenin, alongside an increase in E-cadherin expression in gastric tissues. These results collectively indicate that veratramine exerts its therapeutic effects against GPLs primarily by suppressing the Wnt/β-catenin signaling pathway. Taken together, our findings suggest that veratramine is a promising candidate small-molecule drug for the treatment of GPLs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
Ziwei Li,Qiuying Wu,Rui Ni,Jingjing Wang,Meiyang Yang,Wenyuan Zhang,Jiaming Li,Dan Peng,Lin Song,Yao Liu
Qu@NPs/ADSCs@CS-gel integrates anti-inflammatory, antibacterial, immunomodulatory properties for infected wound healing. • Hydrogel with genipin-crosslinked chitosan/silk sericin, encapsulated ADSCs, and surface-attached ROS-responsive Qu@NPs. • Qu@NPs release quercetin in response to ROS, effectively scavenging ROS and reducing inflammation while preserving SOD activity. • Hydrogel inhibits M1 polarization & inflammatory cytokines, promotes M2 transition & creates regenerative microenvironment. • Enhances antibacterial, proliferation, re-epithelialization, angiogenesis, collagen deposition, accelerates wound repair. Chronic infected wounds face healing challenges due to the interplay of persistent infection, excessive inflammation, and impaired angiogenesis. Conventional dressings often address only one pathological aspect, resulting in limited therapeutic effects. To overcome these barriers, we developed a multifunctional hydrogel Qu@NPs/ADSCs@CS-gel that integrates anti-inflammatory, antibacterial, and immunomodulatory activities. The system was fabricated from genipin-crosslinked chitosan and silk sericin into a biocompatible hydrogel (CS-gel) that exhibits antibacterial activity and permits cellular matrix permeability. Adipose-derived stem cells (ADSCs) were encapsulated within this hydrogel, while reactive oxygen species (ROS)-responsive quercetin-loaded nanoparticles (Qu@NPs), based on poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG), were attached to its surface. Upon wound contact, Qu@NPs are released from Qu@NPs/ADSCs@CS-gel, and PPS-PEG breaks down in response to ROS to release quercetin, effectively eliminating ROS and alleviating the inflammatory response, thereby establishing a regenerative microenvironment for ADSC-mediated repair. Qu@NPs/ADSCs@CS-gel exhibited potent antibacterial activity, reduced ROS accumulation in macrophages while preserving superoxide dismutase (SOD) activity. Furthermore, it inhibited M1 macrophage polarization and pro-inflammatory cytokine secretion, while promoting transition to the M2 phenotype. These effects collectively improved cell proliferation, re-epithelialization, angiogenesis, and collagen deposition, accelerating the three phases of wound repair. Our findings support Qu@NPs/ADSCs@CS-gel as an advanced dressing for infected wounds.
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2026
·
IF 9.9
Qiang Xian,Xingrui Tang,Shibing Zuo,Di Wu,Lei Xie,Hao Li,Jun Wen
Adsorbents with same grafting ratio but varied chain densities were obtained. • Different grafting densities yield distinct conformations and uptake abilities. • High-density, short-chain materials show better salt tolerance; • High-density adsorbent reaches 9.6 mg/g in seawater-twice that of low-density one. Polymers with distinct chain conformations exhibit pronounced performance differences across various applications, and the grafting density as a critical parameter that governs both chain conformation and the overall performance of polymeric materials. However, existing seawater uranium extraction materials rely exclusively on grafting ratio as the sole criterion for functionalization, but neglecting the critical role of grafting density, resulting in insufficiently extended chain conformations and limited accessibility of adsorption sites, which ultimately constrains uranium extraction efficiency. Herein, a series of materials with identical degrees of functionalization but varying grafting densities and chain lengths of the polymers were obtained, and their uranium adsorption behavior were systematically investigated. In aqueous systems, the adsorption capacities of these adsorbents are comparable. However, in saline environments (including simulated, U-spiked and natural seawater) the adsorbent with high grafting density and short chains architecture exhibits the highest uranium adsorption performances. To gain deeper insight into the underlying mechanisms, the conformational behaviors of polymer chains were monitored by Quartz Crystal Microbalance with Dissipation (QCM-D). The results reveal that high grafting density and short chains display a significantly stronger anti-polyelectrolyte effect compared to that low grafting density and long chains. Consequently, the high grafting density and short of polymer chain adsorbent demonstrates superior resistance to salt-shrinkage and achieves higher uranium extraction capacity (9.6 mg/g) in natural seawater, substantially outperforming the low grafting density long chain (4.9 mg/g). This study provides critical design principles for developing polymeric adsorbents tailored for high-salinity environment applications, such as uranium extraction from seawater.
✓ 已验证
产品关联
DOI
高影响因子
Current Research in Food Science
·
2026
·
IF 7.7
Ruya Guo,Zhuorui Li,Jingjiang Qiu,Zhongwei Guo,Wuzhen Qi,Li Xue,Xiangyang Gao,Ronghan Wei,Jianhan Lin
Colorimetric immunoassays based on nanozyme labelling offer promising solution to rapid detect pathogenic bacteria for ensuring food safety. However, sluggish electron transfer kinetics and finite active sites of nanozyme result in unsatisfactory catalytic activity, achieving sensitive detection remains a challenge. Here, we report a Cu 2 O@CeO 2 heterostructure nanozyme with synergistic amplification effect integrating rapid charge transfer kinetics and abundant active sites to enhance the colorimetric immunoassay for sensitive detection of pathogenic bacteria. Highly active CeO 2 nanoparticles (NPs) are uniformly and firmly anchored onto stable Cu 2 O nanocubes to form Cu 2 O@CeO 2 core-shell heterostructure, which effectively alleviates the aggregation of NPs and achieves extremely exposure of catalytic active sites. Density functional theory (DFT) calculations reveal that electron transfer at the heterointerface induces a strong built-in electric field, along with abundant density and high affinity for H 2 O 2 , thus enhancing the reaction kinetics and catalytic activity of the nanozyme. Benefiting from these advantages, the Cu 2 O@CeO 2 heterostructure nanozyme exhibits excellent peroxidase-like activity, which could effectively catalyze the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) to generate blue oxidized TMB. More importantly, the colorimetric immunoassay utilizing Cu 2 O@CeO 2 nanozyme as labeling probe achieves sensitive detection of Salmonella with a low limit of detection (LOD) of 26 CFU/mL and presents high specificity and stable applicability in spiked food samples. This work provides scientific insights for developing high-activity heterostructure nanozyme and advancing the exploitation of fast bacteria detection technologies to ensure food safety.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Cheng Han,Zhe Zhang,Yin Wei,Lanlan Liang,Xinao Zhao,Danna Yang,Zhongze Cui,Chuanliang Zhao,Liwei Yang
PVP-assisted synthesis enabled in-situ δ-MnO 2 -to-MnOOH reconstruction. • MnOOH/δ-MnO 2 interfaces enhanced PMS adsorption and electron transfer. • Surface-bound PMS* species enabled selective ETP-dominated TC oxidation. • The system maintained high TC removal in real lake water and groundwater. • The catalytic membrane achieved stable TC removal at low PMS dosage. Developing non-radical peroxymonosulfate (PMS) activation pathways that resist interference from complex water matrices remains challenging for the treatment of emerging contaminants in practical applications. A polyvinyl pyrrolidone-assisted hydrothermal strategy was therefore developed to induce the partial in - situ reconstruction of δ-MnO 2 into MnOOH. The resulting MnOOH/δ-MnO 2 interface directed PMS activation toward an electron transfer process (ETP) for tetracycline (TC) removal. The catalyst achieved nearly complete TC removal within 30 min and maintained high activity under complex water matrix conditions. Experimental results and density functional theory (DFT) analysis revealed that the MnOOH/δ-MnO 2 composite interface strengthened PMS adsorption and promoted interfacial charge redistribution. These effects facilitated electron transfer during TC oxidation. Surface-bound PMS* species on the MnOOH/δ-MnO 2 interface acted as electron-accepting centers, steering TC oxidation toward an ETP-dominated non-radical pathway. The MnOOH/δ-MnO 2 catalytic membrane maintained above 98% TC removal in real water matrices under continuous-flow conditions at only 0.2 mM PMS. These results demonstrate the promising practical applicability of the system. Life cycle assessment further indicated a comparatively low environmental burden for the MnOOH/δ-MnO 2 /PMS system. These findings provide a mechanistic basis for designing manganese oxide/oxyhydroxide catalysts through polymer-induced interfacial reconstruction and offer a practical strategy for ETP-dominated PMS activation in complex water treatment Download: Download high-res image (222KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）