JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 3
·2535-2551
·
IF 2.993
Shen Hao,Song Jiayi,Yang Ye,Su Ping,Yang Yi
The exploration of new tactics for manufacturing artificial immobilized multi-enzyme systems based on enzyme cascades has recently attracted considerable interest because of the urgent need for multi-enzyme catalysts and the high cost of free enzymes. Because of the inevitable limitations of native enzymes such as instability and storage issues, the development of nanozyme–enzyme cascades is needed. A versatile strategy was developed for fabricating an efficient multi-catalyst system by immobilizing glucose oxidase (GO x ) on ferriferous oxide nanocomposites functionalized with nitrogen-doped graphene quantum dots (Fe 3 O 4 @N-GQDs) through DNA-directed immobilization. The Fe 3 O 4 @N-GQDs acted as a carrier for the natural enzyme and showed high peroxidase activity which enabled an enzyme cascade that included GO x to be set up. This multi-catalyst system showed great catalytic activity, reversibility and operational stability. The surfaces of GO x -targeted magnetic nanoparticles were regenerated by mild dehybridization of DNA. The Michaelis constant ( K m ) and maximum initial velocity ( V max ) of the multi-catalyst system were 1.069 mM and 11.2 × 10 −8 M s −1 , respectively, which are considerably better than the corresponding values for adsorbed and free bienzyme combinations. The increased bioactivity of the multi-catalyst system is ascribed to the satisfactory peroxidase-like activity of Fe 3 O 4 @N-GQDs, the enzyme–promoting effect of the QDs and enhancement by DNA-directed immobilization. Because of the diverse range of possible nanozyme–enzyme combinations and high efficiency of this approach, this work provides a novel pathway for the manufacturing of synthetic enzyme catalyst systems, which have great potential in the field of biotechnology.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Zi-Tao Zhong,Hai-Bo Wang,Ting Zhang,Chao-Qing Li,Bo Liu,Yuan-Di Zhao
Pregnancy test strips are one of the most mature and widely used commercial lateral flow devices used to determine pregnancy. Being a simple and rapid detection method, human chorionic gonadotropin (hCG) was used with different aptamers (hCG-apt) as probes for the detection of metal ions, small organic molecules, and proteins. Quantitative detection of target analytes was achieved using a smartphone app and a portable device developed in our laboratory. The results showed detection ranges of 1 nM−1 μM, 0.1 nM–10 μM and 32 nM–500 nM for Pb 2+ , chloramphenicol, and β-lactoglobulin, respectively, and the corresponding visual detection limits in dairy products were 5 nM, 1 nM and 50 nM, respectively. Based on these results, rapid detection of multiple analytes can be realized through aptamer modification, thereby broadening the application range of commercial lateral flow devices for analysis of food chemistry.
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PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2016
·
IF 1.733
Juan Wu,Wei Jiang,Renbing Tian,Yewen Shen,Wei Jiang
In the present study, methotrexate (MTX)-encapsulated magnetic-/pH-responsive hydrogel beads based on Fe3O4 nanoparticles and chitosan were successfully prepared through a one-step gelation process, which is a very facile, economic and environmentally friendly route. The developed hydrogel beads exhibited homogeneous porous structure and super-paramagnetic responsibility. MTX can be successfully encapsulated into magnetic chitosan hydrogel beads, and the drug encapsulation efficiency (%) and encapsulation content (%) were 93.8 and 6.28%, respectively. In addition, the drug release studies in vitro indicated that the MTX-encapsulated magnetic chitosan hydrogel beads had excellent pH-sensitivity, 90.6% MTX was released from the magnetic chitosan hydrogel beads within 48 h at pH 4.0. WST-1 assays in human liver hepatocellular carcinoma cells (HepG2) demonstrated that the MTX-encapsulated magnetic chitosan hydrogel beads had good cytocompatibility and high anti-tumor activity. Therefore, our results revealed that the MTX-encapsulated magnetic chitosan hydrogel beads would be a competitive candidate for controlled drug release in the area of targeted cancer therapy in the near future.
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PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2012
·
IF 5.625
Hongying Zhao,Yujing Wang,Yanbin Wang,Tongcheng Cao,Guohua Zhao
A novel electro-Fenton (E-Fenton) system with the Fe 3 O 4 @Fe 2 O 3 /activated carbon aerogel (ACA) composite cathode was firstly constructed in this study. Its application on degrading imidacloprid exhibited highly catalytic efficiency over a wide applicable pH range from 3 to 9. The removal of imidacloprid and TOC achieved to 90% within 30 and 60 min, respectively. The nature of composite cathode was examined by BJH, XRD, SEM, TEM, XPS and FTIR techniques. ACA with high surface area of 2410 m 2 g −1 and multiplicated porosities composed of micropores and mesopores worked not only as cathode but also as Fenton catalyst support, enhancing oxidation activity. We proposed reasonable E-Fenton oxidation mechanisms with Fe 3 O 4 @Fe 2 O 3 /ACA cathode at acidic and basic conditions. At pH 3, it followed a Haber–Weiss mechanism that the dissolved iron ions and surface Fe(II) sites catalyzed the decomposition of H 2 O 2 to generate hydroxyl radicals ( OH). While at pH 9, it was expected the formation and deactivation of H 2 O 2 complex as well as the catalytic decomposition of H 2 O 2 with surface Fe(III) and Fe(II) sites to produce both superoxide anion ( O 2 − /HO 2 ) and hydroxyl radicals ( OH), involving an in situ recycling of iron oxide (FeO·Fe 2 O 3 → Fe 2 O 3 ).
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Menglu Wang,Bolong Liang,Shumin Lin,Zhe Zhao,Hongbin He,Xiliang Li,Shu-xuan Liang
The magnetic Fe 3 O 4 @ZIF-8 with high adsorption properties and easy separation were embedded in BiOX (X = Cl, Br, I) to synthesize Fe 3 O 4 @ZIF-8@BiOX using a simple one-pot solvothermal strategy. The crystal structure, surface morphology, photoelectric properties, thermal stability and magnetic response of the three materials were compared and analyzed, and the effect on the removal of OTC and Cr(VI) from single and coexisting systems by adsorption-photocatalysis is discussed. The results show Fe 3 O 4 @ZIF-8@BiOI has the highest separation efficiency of photogenerated carriers upon photoexcitation and stronger light absorption capacity, and exhibits better adsorption-photocatalytic activity than the other two materials in the photocatalytic reduction of Cr(VI) (68 % and 65 % removal for single and coexisting systems) and degradation of OTC (86 % and 59 % removal for single and coexisting systems). It is noteworthy that in the coexistence of Cr(VI) and OTC, a slight decrease of removal occurred, which could be due to a competitive effect between two pollutants being greater than the synergistic effect. ∙O 2 - is the main active substances in the adsorption-photocatalysis process. Finally, this work demonstrates the excellent adsorption and photocatalytic ability of Fe 3 O 4 @ZIF-8@BiOI for the simultaneous removal of Cr(VI) and OTC, which has great potential for practical wastewater treatment.
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Catalysis Science & Technology
·
2016
·Vol. 6
·期 17
·6513-6524
·
IF 5.287
Ziyang Lu,Xiaoxu Zhao,Zhi Zhu,Minshan Song,Nailing Gao,Youshan Wang,Zhongfei Ma,Weidong Shi,Yongsheng Yan,Hongjun Dong
A novel hollow capsule-like recyclable functional ZnO/C/Fe3O4 was synthesized by employing the convenient and mild sol–gel method combined with the surface imprinting technique, which possessed good light response ability, superior magnetic separation performance and excellent reproducibility. This as-prepared functional ZnO/C/Fe3O4 was proved to not only exhibit high photocatalytic activity but also possess a strong three-dimensional oriented ability to selectively recognize and photodegrade danofloxacin mesylate. Through getting insight into the mechanism, we can confirm that in this photocatalytic reaction, h+ and ˙OH play major roles compared with ˙O2−. This work not only puts forward a novel design idea of functional semiconductor materials but also is expected to be widely applied to the oriented recognition and removal of a target substance according to the practical requirement.
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高影响因子
Journal of Physical Chemistry C
·
2011
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IF 4.524
Maiyong Zhu,Guowang Diao
An efficient magnetic carbon nanocomposite supported Pd nanoparticle catalyst has been prepared by a three-step process in this report. The morphology, inner structure, and magnetic properties of all products were studied with transmission electron microscopy, X-ray powder diffraction, Fourier translation infrared spectroscopy, X-ray photoelectron spectroscopy, and vibrating sample magnetometer. The Suzuki and Heck coupling reactions were used to demonstrate the catalytic efficiency of the as-prepared Pd/Fe3O4@C (Pd/MFC) nanocomposite catalyst. The results showed that the catalyst is completely recoverable with the simple application of an external magnetic field and the catalytic efficiency shows no obvious loss for Suzuki and Heck coupling reactions even after five repeated cycles.
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2015
·
IF 6.409
Yulan Wang,Hongmin Ma,Xiaodong Wang,Xuehui Pang,Dan Wu,Bin Du,Qin Wei
An ultrasensitive sandwich-type electrochemical immunosensor based on a novel signal amplification strategy was developed for the quantitative determination of human immunoglobulin G (IgG). Pd nanocubes functionalized magnetic graphene sheet (Pd–Fe 3 O 4 -GS) was employed as the matrix to immobilize the primary antibodies (Ab 1 ). Owing to the synergetic effect between Pd nanocubes and magnetic graphene sheet (Fe 3 O 4 -GS), Pd–Fe 3 O 4 -GS can provide an obviously increasing electrochemical signal by electrochemical catalysis towards hydrogen peroxide (H 2 O 2 ). Silicon dioxide (SiO 2 ) was functionalized as the label to conjugate with the secondary antibodies (Ab 2 ). Due to the larger steric hindrance of the obtained conjugate (SiO 2 @Ab 2 ), the sensitive decrease of the electrochemical signal can be achieved after the specific recognition between antibodies and antigens. In this sense, this proposed immunosensor can achieve a high sensitivity, especially in the presence of low concentrations of IgG. Under optimum conditions, the proposed immunosensor offered an ultrasensitive and specific determination of IgG down to 3.2 fg/mL. This immunoassay method would open up a new promising platform to detect various tumor markers at ultralow levels for early diagnoses of different cancers.
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 34
·期 3
·e5415
·
IF 3.259
Yao Zhu,Jian Rong,Kaili Mao,Dongya Yang,Tao Zhang,Fengxian Qiu,Jianming Pan
Recently, shikimic acid (SA) has aroused great concern as the starting raw material for the synthesis of antiviral drug (Tamiflu) against the spread of influenza virus in the body. In this work, magnetic chitosan composite modified with boric acid and its application in SA recognition and separation was described. Chitosan (CT) with plenty of hydroxyl and amino groups was first coated on the surface of magnetic core Fe 3 O 4 , then carboxylic groups were grafted to the surface of Fe 3 O 4 @CT via anhydride modification, followed by the introduction of 3-aminophenylboronic acid (APBA). The uniform morphology and composition analysis of the adsorbent (Fe 3 O 4 @CT-COOH-BA) were characterized by FT-IR, XRD, XPS, SEM, TEM and UV–visible spectroscopy. The adsorption capacity of as-prepared material was explored in detail by batch mode experiments. The adsorption kinetics fitted well with a pseudo-second order model, and the adsorption isotherms was well described by the Langmuir model with a maximum adsorption capacity of 23.8 mg g −1 at 25 °C. Solution pH plays a crucial role in adsorption process and the optimized pH was 8.0. In addition, Fe 3 O 4 @CT-COOH-BA could be easily reused through an external magnet and the adsorption capacity reduced by only 4% after five adsorption–desorption cycles. These results prove that boric acid modified magnetic chitosan composite is an effective and practical adsorbent for specific recognition and selective adsorption of cis-diol-containing compounds.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Jianan Cui,Tingting Liu,Qian Zhang,Ting Wang,Xiaohong Hou
Various metal-based heterogeneous catalysts activated peroxymonosulfate for organic pollutants degradation are increasingly recognized as an environmentally important sewage treatment technology. In this study, polyvinyl pyrrolidone (PVP) modified Fe 3 O 4 loaded ZIF-67 magnetic catalyst with transition metal cobalt ion was prepared for the first time by microwave-assisted solvothermal (MS) method within 30 min to activate peroxymonosulfate. The microwave synthesis process changed the time-consuming shortcoming of conventional method. The catalytic activity of the synthesized Fe 3 O 4 -PVP@ZIF-67 was assessed on bisphenol F (BPF) removal. The result showed 99.8% BPF was removed under the conditions of catalyst content of 0.15 g·L −1 , PMS content of 0.3 mM, and pH without adjustment in 60 min. And the Fe 3 O 4 -PVP@ZIF-67/PMS system exhibited a quality catalytic performance when the solution pH of BPF varied from 3 to 11. Compared with humic acid (HA), inorganic anions (Cl − , H 2 PO 4 − , SO 4 2− , HCO 3 − , and CO 3 2− ) showed slight effect to the degradation system. The quenching experiment verified that the main active substance in this system was SO 4 − •. Based on the degradation intermediates identified by gas chromatography-mass spectrometer (GC–MS), the main degradation pathways were proposed for the degradation of BPF. Overall, Fe 3 O 4 -PVP@ZIF-67 as PMS activator is promising catalyst for sulfate radical-based wastewater treatment.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Feng Gao,Xinlei Wu,Die Wu,Jianxing Yu,Jun Yao,Qi Qi,Zhihai Cao,Qinmin Cui,Yifang Mi
This work reports the synthesis of novel degradable magnetic temperature- and redox-responsive polymer/Fe 3 O 4 nanocomposite nanogels (NCGs) through inverse miniemulsion polymerization and their potential application as nanocarriers for controlled drug delivery. Surface of Fe 3 O 4 magnetic nanoparticles (MNPs) were vinyl-modified with 2-isocyanatoethyl methacrylate . Poly( N -vinylcaprolactam) (PNVCL)/Fe 3 O 4 NCGs were prepared via inverse miniemulsion polymerization by using a disulfide-containing cross-linker. The Fe 3 O 4 MNPs were chemically attached to the polymer matrix of NCGs, offering a good structural integrity of NCGs in aqueous systems. The PNVCL/Fe 3 O 4 NCGs not only inherited the good superparamagnetism of Fe 3 O 4 MNPs, but also displayed a reversible temperature-responsiveness as well as marked redox-responsiveness. The release behavior of a model anticancer drug 5-fluorouracil from the PNVCL/Fe 3 O 4 NCGs could be conveniently tuned by the external temperature, redox condition of media, or their combination. The prepared PNVCL/Fe 3 O 4 NCGs displayed a low cytotoxicity, holding a great potential in functioning as magnetic guiding nanocarriers for controlled drug delivery.
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高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Le-Yi Weng,Yu-Fei Wang,Hao-Yu Shen,Mei-Qin Hu
Ethylenediamine (EDA)-functionalized nano-Fe 3 O 4 magnetic particle (EDA@nFe 3 O 4 ) was first synthesized by solvothermal method, followed by condensation with 3 kinds of salicylaldehydes, and coordinated with Fe(III) ion to obtain 3 kinds of Fe(III)-Salen (salicylaldehydoethylenediamine)-grafted Fe 3 O 4 magnetic composites (nFe 3 O 4 @Fe(III)Salen). The nFe 3 O 4 @Fe(III)Salen composites were characterized by elementary analyzer, X-ray diffractometer, FTIR, ultraviolet Vis DRS, XPS, transmission electron microscopy, and vibrating sample magnetometer. The results showed that the nFe 3 O 4 @ Fe(III)Salen composites had an average size of ~200 nm, with the saturation magnetization intensity of 20.3–24.8 emu/g. The nFe 3 O 4 @Fe(III)Salen can be used as heterogeneous catalyst for the degradation of 2,4,6-trichlorophenol (2,4,6-TCP) via Fenton-like reaction under visible light. Radical-trapping experimental results indicated that the • OH radicals were the dominant active oxidizing species in the photoreaction process. The results showed that the highest degradation efficiency to 2,4,6- TCP was found when the nonsubstituted Fe(III)-Salen-grafted composite, nFe 3 O 4 @Fe(III)Salen, was used as catalyst. Further degradation studies indicated that at pH 4.0–7.0, with the usage amount of nFe 3 O 4 @Fe(III)Salen above 0.8 g/L and hydrogen peroxide (H 2 O 2 ) concentration at 8.16–40.8 mmol/L, the degradation of 2,4,6-TCP with initial concentration less than 50.0 mg/L (253.2 mg/L) can reach almost 100% under the nFe 3 O 4 @Fe(III)Salen/H 2 O 2 /vis system within 5 min, which showed a wider pH range than that of normal Fenton system. nFe 3 O 4 @Fe(III)Salencan be reused after regeneration for at least 5 times (with degradation percentage of 2,4,6-TCP over 95%). It is a potential effective and reusable material for catalytic degradation of 2,4,6-TCP.
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