CRYSTENGCOMM
·
2024
·Vol. 26
·期 38
·5431-5439
·
IF 2.6
Ting-Ting Xu,De-Sheng Wei,Shuang-Bao Li,Yu-Teng Zhang,Nan Lv
Although the fundamental configuration (tetrahedron-type and capsule-type) of Zr-MOCs is well understood, the synthesis of amino-functionalized Zr-based capsule (denoted as ZrC-1-NH2) based on 2-aminoterephthalic acid remains a considerable challenge. Fortunately, we obtained single crystals under solvothermal conditions and further achieved the rapid synthesis of ZrC-1-NH2 with pure phase and high yield using a microwave-assisted solvothermal method. In addition, ZrC-1-NH2 was utilized as a photocatalyst to perform the degradation of tetracycline (TC) in water. The degradation efficiency of 92.3% was achieved at the optimal conditions, and the main active free radical was determined as ·O2− according to the trapping agent experiment and EPR results. Furthermore, the possible degradation pathway of TC was proposed.
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Bioactive Materials
·
2024
·
IF 18
Zetao Wang,Qiyuan Dai,Huitong Luo,Xiyuan Han,Qi Feng,Xiaodong Cao
Bioactive glasses (BG) play a vital role in angiogenesis and osteogenesis through releasing functional ions. However, the rapid ion release in the early stage will cause excessive accumulation of metal ions, which in turn leads to obvious cytotoxicity, long-term inflammation, and bone repair failure. Inspired by the vibration exciter, small extracellular vesicles (sEVs) obtained by treating mesenchymal stem cells with copper-doped bioactive glass (CuBG-sEVs), is prepared as a nano-vibration exciter. The nano-vibration exciter can convert the ion signals of CuBG into biochemical factor signals through hypoxia-inducible factor 1 (HIF-1) signaling pathway and its activated autophagy, so as to better exert the osteogenic activity of BG. The results showed that CuBG extracts could significantly improve the enrichment of key miRNAs and increase the yield of CuBG-sEVs by activating HIF-1 signaling pathway and its activated autophagy. Cell experiments showed that CuBG-sEVs are favor to cell recruitment, vascularization and osteogenesis as the enrichment of key miRNAs. The animal experiments results showed that CuBG-sEVs stimulated angiogenesis mediated by CD31 and promoted bone regeneration by activating signaling pathways related to osteogenesis. These findings underscored the significant potential of sEVs as alternative strategies to better roles of BG.
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Materials
·
2024
·Vol. 17
·期 21
·5327
·
IF 3.1
Juan Li,Hao Yao,Yuting Huang,Hongxia Wang
In order to improve the microwave-absorption performance of barium ferrite and broaden its microwave-absorption band, BaFe12O19, Ba0.95Ca0.05Fe12O19, and Ba0.95Ca0.05Fe12−xCoxO19(x = 0.1, 0.2, 0.3 and 0.4, respectively) hexaferrites were synthesized by the solid-state reaction method, and the influence of Co ion substitution on the phase composition, microstructure, magnetic properties, and microwave-absorption ability of the ferrites in this system was studied. Introducing minor Co ions (x < 0.2) facilitated sintering and grain growth. At x ≥ 0.2, XRD revealed the emergence of the Co2X phase alongside the BaM phase. Increasing Co ion concentration and the secondary X-phase led to slight reductions in saturation magnetization (69 to 63.5 emu/g) and substantial decline in coercivity (2107.02 to 111.21 Oe), attributed to grain size growth and Co2X’s soft magnetic nature. Notably, Co2X incorporation significantly enhanced the microwave absorption and provided a tunable absorption band from the Ku to the C band. For a sample with a thickness of 2.0 mm and a doping level of x = 0.2, a minimum reflection loss of −59.5 dB was achieved at 8.92 GHz, with an effective absorption bandwidth of 3.31 GHz (7.07–10.38 GHz). The simple preparation method and good performance make Ba0.95Ca0.05Fe12−xCoxO19(x = 0.1, 0.2, 0.3 and 0.4, respectively) hexaferrites promising microwave-absorbing materials.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 26
·1-13
·
IF 2.8
Gao Qin,Zhao Nianshun,Wu Jiale,Yu Qi,Wang Li,Hu Juan,Lu Sha,Zheng Xiaofan
The solid-state reaction method was employed to synthesize (1− x )[0.90NaNbO 3 –0.10Bi(Mg 0.5 Ta 0.5 )O 3 ]– x (Bi 0.5 Na 0.5 ) 0.7 (Sr 0.7 La 0.2 ) 0.3 Ti 0.9 Zr 0.1 O 3 , denoted as (1− x )(NN–BMT)– x BNSLTZ ( x BNSLTZ). XRD analysis of x BNSLTZ confirmed that all samples possessed a pure perovskite structure. SEM micrographs demonstrated homogeneous grain distribution and minimal porosity. With an increasing concentration of BNSLTZ, there was a gradual reduction in average grain size. Impedance spectroscopy was utilized to investigate the electrical properties of x BNSLTZ across a frequency sweep of 10 Hz–1 MHz and over a temperature range of 420–560 °C. The complex impedance and modulus spectra reveal non-Debye-type dielectric relaxation, indicative of two contributing mechanisms: grain and grain boundary effects on conduction. Electric modulus analysis indicated that the low-frequency relaxation process was temperature independent. The dc conductivity variation with temperature follows the Arrhenius equation. The ac conductivity was found to adhere to Jonscher power law. The E a (the relaxation activation energy) and E c (conductance activation energy) confirmed the relaxation mechanism of 0.3BNSLTZ is dipolar conduction. The dielectric properties showed a significant dependence on both frequency and temperature. A dielectric anomaly pointed to the presence of a single relaxation behavior. It was observed that an increase in BNSLTZ concentration led to a decrease in the maximum dielectric constant. Optimum performance was obtained with the 0.3BNSLTZ ceramics, which has the smallest average grain size (1.54 μm), considerable resistance value ( R ~ 1000 K \({\Omega }cm\) ), and moderate dielectric constant ( ε r ~ 600), superior to the pure NN-BMT ceramic. These results demonstrate that the electrical property of the x BNSLTZ ceramics have some potential value in the application of electrical materials.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Mufan Wang,Shiying Fan,Xinyong Li,Jugong Shi,Yan Mao,Yaqi Yang,Gao Li
Efficiently upgrading 5-hydroxymethylfurfural (HMF) into high-value-added products, such as 2,5-diformylfuran (DFF) and 2,5-furan dicarboxylic acid (FDCA), through a photocatalytic process by using solar energy has been incessantly pursued worldwide. Herein, a series of transition-metal (TM = Ni, Fe, Co, Cu) single atoms were supported on Ti4+αTi3+1-αO2−δ nanofibers (NFs) with certain defects (Ov), denoted as TM SAC-Ti4+αTi3+1-αO2−δ NFs (TM = Ni, Fe, Co, Cu), aiming to enhance the photocatalytic conversion of HMF. A super HMF conversion rate of 57% and a total yield of 1718.66 μmol g–1 h–1 (DFF and FDCA) surpassing that of the Ti4+αTi3+1-αO2−δ NFs by 1.6 and 2.1 times, respectively, are realized when TM is Co (Co SAC-Ti4+αTi3+1-αO2−δ NFs). Experiments combined with density functional theory calculation (DFT) demonstrate that the TM single atoms occupy the Ti site of Ti4+αTi3+1-αO2−δ NFs, which plays a dominant role in the photo-oxidation of HMF. Raman, X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) characterizations confirm the strong electron local exchange interaction in TM SAC-Ti4+αTi3+1-αO2−δ NFs and demonstrate the substitution of Ti by the TM SACs. The projected density of states and charge density difference reveal that the strong interaction between metal-3d and O-2p orbitals forms Ti–O–TM bonds. The bonds are identified as the adsorption site, where TM single atoms on the surface of Ti4+αTi3+1-αO2−δ NFs reduce HMF molecule adsorption energy (Eads). Furthermore, the TM single atom modulates the electronic structure of TM SAC-Ti4+αTi3+1-αO2−δ NFs through electron transfer, leading to narrow band gaps of the photocatalysts and enhancing their photocatalytic performance. This study has uncovered a newer strategy for enhancing the photocatalytic attributes of semiconducting materials.
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ChemistrySelect
·
2024
·Vol. 9
·期 11
·e202400114
·
IF 1.9
Jin Liang,Xiaoxin Wang,Dongsheng Yu,XiTao Luo,Xiangfeng Liang,Zhongliang Su,Qinghui Shou
Graphical Self-supported osmotic membranes were prepared by blending PIM-1-mPEG, which was obtained by modifying PIM-1 with polyethylene glycol monomethyl ether (mPEG), and hydrophilic Tröger's base polymer (DMBP-TB). The membranes utilized microporous molecular sieves and the differences in solute-membrane interactions to achieve high pentose/hexose selectivity in aqueous solutions. Monosaccharides are vital building blocks in bioengineering applications; however, their extraction from intricate mixtures is challenging and uses substantial amounts of energy. Polymers of intrinsic microporosity (PIMs) offer an innovative avenue for separating monosaccharides. We modified PIM-1membranes to improve the glucose/xylose separation by incorporating polyethylene glycol monomethyl ether (mPEG). The optimal mPEG (molecular weight: 1000 Da; mass fraction: 2.5 %; solvent: methanol) delivered a xylose separation coefficient of 2.62. With the hybrid membrane of PIM-1-mPEG (50 w.t.%) and hydrophilic Tröger's base polymerer (DMBP-TB, 50 w.t.%), the separation factor for xylose/glucose in an aqueous solution was 2.51 for single-stage running and 11.32 after five-stage running. There are large fractions of micropores for PIM-1-mPEG, and there is difference on solute-membrane interactions for pentose/hexose, which are regarded to be the main driving force for the high pentose/hexose selectivity in methanol. The blending of PIM-1-mPEG and DMBP-TB, integrates the microporosity and hydrophilicity, finally endues the high pentose/hexose selectivity in aqueous solution. These microporous membranes are promising materials for efficiently separating monosaccharides and jnl> small organic molecules while minimizing energy consumption. We established a solid foundation for further exploring microporous membranes for various applications, notably in bioengineering.
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
·
2025
·
IF 2.5
Zhuoqi Chen,Chaochao Gong,Shaowei Wang,Han Lu,Yang Zhu,Ren-shan Ge,Yunbing Tang,Yingfen Ying
Benzophenone (BP) UV-filters have been extensively used for the prevention of UV-induced adverse effects in personal care products. Their potential to interfere with steroidogenesis in the female reproductive system remains uncertain. 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) facilitates the conversion of estrone to estradiol, playing a key role in estrogen activation. This study delves into the effects of eleven BPs on human and rat 17β-HSD1, while also analysing the 3D-quntitative structure-activity relationship (3D-QSAR) and the underlying mechanisms. The inhibitory potency of inhibiting human placental 17β-HSD1 was found to be in the order of BP-2 (IC 50 , 11.42 μM) > BP-1 (14.17 μM) > BP-4 (49.05 μM) > BP-6 (63.49 μM) = BP-8 (63.46 μM) > others. BP-1 and BP-2 markedly inhibited estradiol secretion by human placental BeWo cells at ≥ 1 μM. In contrast, the inhibitory strength of suppressing rat ovarian 17β-HSD1 activity was found to be in the order of BP-2 (IC 50 , 13.33 μM) > BP-1 (15.09 μM) > BP-4 (22.68 μM) > BP-12 (31.12 μM) > BP (119.99 μM) > others. Mode action analysis revealed that these BP compounds acted as mixed inhibitors of both human and rat 17β-HSD1. The introduction of a 4-hydroxyl substitution in the benzene ring was found to markedly increase the inhibitory potency against human and rat 17β-HSD1. BP-1 and BP-2 demonstrated the ability to penetrate human BeWo cells and inhibit estradiol secretion at ≥ 1 μM. Docking analysis revealed that the 2-hydroxyl group of BP-1 and BP-2 forms a hydrogen bond with catalytic residue Ser142 of human 17β-HSD1. 3D-QSAR pharmacophore analysis showed that there are hydrophobic regions and hydrogen bond donor can interact with BPs. In conclusion, this study establishes that BP-2 is the most potent inhibitors of human 17β-HSD1 among the BPs under investigation, highlighting a significant difference in the structure-activity relationship.
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Molecular Biomedicine
·
2025
·Vol. 6
·期 1
·1-14
·
IF 10.1
Ao Danyi,Peng Dandan,He Cai,Ye Chunjun,Hong Weiqi,Huang Xiya,Lu Yishan,Shi Jie,Zhang Yu,Liu Jian,Wei Xiawei,Wei Yuquan
Despite the declared end of the COVID-19 pandemic, SARS-CoV-2 continues to evolve, with emerging JN.1-derived subvariants (e.g., KP.2, KP.3) compromising the efficacy of current XBB.1.5-based vaccines. To address this, we developed an mRNA vaccine encoding the full-length spike protein of JN.1, incorporating GSAS and 2P mutations and encapsulated in lipid nanoparticles (LNPs). The JN.1-mRNA vaccine elicited robust humoral and cellular immune responses in mice, including high JN.1-specific IgG titers, cross-neutralizing antibodies, and increased T follicular helper (Tfh) cells, germinal center (GC) B cells, and T cell cytokines. Importantly, immunity persisted for up to six months and induced RBD-specific long-lived plasma cells. We also compared the immune responses induced by homologous and heterologous vaccination regimens, and our results demonstrated that the heterologous regimen—combining JN.1-mRNA with a recombinant protein vaccine (RBD JN.1 -HR)—induced stronger responses. These findings highlight the JN.1-mRNA vaccine constitutes an effective prophylactic approach against JN.1-related variants, as it induces potent neutralizing antibody responses across all tested lineages. This enhanced immunogenicity is expected to significantly reduce hospitalization rates and mitigate post-COVID complications associated with JN.1 and KP.3 infections. This study emphasizes the need for timely vaccine updates and the adaptability of mRNA vaccines in addressing emerging pathogens, providing a framework for combating future infectious diseases. Collectively, these results offer critical insights for vaccine design and public health strategies in response to emerging SARS-CoV-2 variants.
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ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Shouchun Xiao,Jingna Cui,Yue Cao,Yaru Zhang,Jiaxing Yang,Li Zheng,Fanrong Zhao,Xueke Liu,Zhiqiang Zhou,Donghui Liu,Peng Wang
Chemical-caused reproductive dysfunction has emerged as a global public health concern. This study investigated the adverse effects of the organophosphorus pesticide malathion on reproductive function in adolescent male mice at environmentally relevant concentrations. The results indicated that eight-week malathion exposure reduced testis weight, caused sex and thyroid hormone disorders, and induced testicular spermatogenic epithelium damage and oxidative stress. Testicular RNA sequencing indicated that malathion significantly affected testicular energy metabolism, hypoxia-inducible factor 1 (HIF-1) signaling, and steroid hormone biosynthesis pathways. Malathion significantly increased the gene and protein expression of HIF-1α by upregulating key genes in the mitogen-activated protein kinase (MAPK) pathway ( Map2k2 , Mapk3 , and Eif4e2 ) and the phosphatidylinositol 3-kinase (PI3K) pathway ( Pik3r2 and Akt1 ). Furthermore, malathion downregulated HIF-1α degradation-regulating genes while upregulating anaerobic metabolism and inflammation-related genes, thereby inhibiting normoxia and promoting hypoxia processes. Testicular hypoxia subsequently induced steroid hormone biosynthesis disorders and spermatogenesis dysfunction. Molecular docking verified that malathion interfered with HIF-1α and steroid hormone synthases (CYP11A1, CYP17A1 and CYP19A1) by forming hydrogen bonds and hydrophobic interactions with these proteins. This study presents the first evidence that malathion triggers spermatogenesis dysfunction in mice through activating the HIF-1/MAPK/PI3K pathway, providing a comprehensive understanding of the reproductive toxicity risks associated with organophosphorus pesticides.
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Nature Nanotechnology
·
2025
·
IF 34.9
Xu Jianchang,Zhang Yang,Zhao Sheng,Zhang Juan,Wang Yanfang,Liu Wei,Ji Kangfan,Xu Guangzheng,Wen Ping,Wei Xinwei,Mei Shaoqian,Lu Leihao,Yao Yuejun,Liu Feng,Ma Yufei,You Jiahuan,Gao Jianqing,Buse John B.,Wang Jinqiang,Gu Zhen
The nuclear envelope serves as a highly regulated gateway for macromolecule exchange between the nucleus and cytoplasm in eukaryotes. Here we have developed a cell nucleus-mimicking polymeric membrane-enclosed system for long and self-regulated therapy. A polymeric nano-membrane with nanopores is conformally synthesized in situ on the surface of each insulin crystal, ensuring sustained, adjustable and zero-order drug release kinetics. Glucose- and β-hydroxybutyrate-dually sensitive microdomains are integrated into the nano-membranes. Under a normal state, the microdomains are uncharged and the channel is narrow enough to block insulin outflow. Under hyperglycaemia and ketonaemia, microdomains convert the high glucose and β-hydroxybutyrate concentration signals to the negative electric potential of membranes, widening the nanopores with rapid insulin outflow. In type 1 diabetic mice and minipigs, this system can maintain normoglycaemia for longer than 1 month and 3 weeks, respectively, with validated glucose- and β-hydroxybutyrate-triggered insulin release. Such membrane-enclosed drug crystal/powder formulation provides a broad platform for long-acting controlled release.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Hua Xu,Liling Cao,Yi Yu,Yuan Li,Xiangming Liu,Chengliang Mao,Lizhi Zhang
1 O 2 generation over (0 0 1) or (0 1 0) facet exposed BiOCl (B001 or B010) with/without phosphate modification were studied from the aspects of excitons involved energy transfer route, the O 2 − oxidation based charge transfer route and the H 2 O 2 oxidation by HClO. Phosphate modification not only enhance charge separation thus result in H 2 O 2 oxidation by HClO to release 1 O 2 but also weaken excitonic effect in the confined layer of BiOCl accordingly affect 1 O 2 generation via energy transfer. Considering [0 0 1] orientation favors the formation of excitons than that of [0 1 0] direction over BiOCl, excitons loss was hardly compensated by the H 2 O 2 oxidation by HClO for 1 O 2 generation over phosphate modified B001. Nevertheless, limited excitonic effect makes the O 2 − oxidation by h + via charge transfer as dominant route for 1 O 2 yielding over B010, the extra H 2 O 2 oxidation with HClO after phosphate modification significantly enhance 1 O 2 generation over B010 followed with 2.2 times higher carbamazepine photodegradation activity. The initial attack of C C bond via 1 O 2 to form epoxide played important roles on carbamazepine degradation. This study demonstrated that the facet-specific phosphate modification of photocatalysts can finely tune reactive 1 O 2 species for superior pharmaceuticals degradations.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaoyue Zhou,Zhenjie Li,Yingxi Shi,Yingqi Miao,Yunying Liu,Renli Yin,Wanqian Guo,Junhao Qin,Huashou Li,Adela Jing Li,Rongliang Qiu
Bisphenol A (BPA) has raised worldwide concern owing to its ecological risks, highlighting the urgent need to develop efficient removal strategies in wastewater treatment. A metal–organic framework (Bio-MOF-1) piezoelectrically activating peroxymonosulfate (PMS) process (Bio-MOF-1/PMS/US) was developed to remove BPA at 98.5%, which was 3.5 times higher than the Bio-MOF-1/US process. Further analysis confirmed that the piezoelectric field initiated by Bio-MOF-1 could reduce the activation energy of PMS and then promote the reaction of PMS with holes and electrons to convert into 1 O 2 and OH. The steady-state concentration of 1 O 2 was 4 orders of magnitude higher than OH, indicating the dominant contribution of 1 O 2 for BPA removal, which resulted in the efficient BPA removal from a variety of anions, organics, and municipal wastewater through a low-risk manner. This work provides new perspectives for the application of MOF-based materials in the field of piezoelectric catalysis and promising applications in wastewater remediation.
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危险品化学品经营许可证（带存储）