ChemistrySelect
·
2024
·Vol. 9
·期 11
·e202400114
·
IF 1.9
Jin Liang,Xiaoxin Wang,Dongsheng Yu,XiTao Luo,Xiangfeng Liang,Zhongliang Su,Qinghui Shou
Graphical Self-supported osmotic membranes were prepared by blending PIM-1-mPEG, which was obtained by modifying PIM-1 with polyethylene glycol monomethyl ether (mPEG), and hydrophilic Tröger's base polymer (DMBP-TB). The membranes utilized microporous molecular sieves and the differences in solute-membrane interactions to achieve high pentose/hexose selectivity in aqueous solutions. Monosaccharides are vital building blocks in bioengineering applications; however, their extraction from intricate mixtures is challenging and uses substantial amounts of energy. Polymers of intrinsic microporosity (PIMs) offer an innovative avenue for separating monosaccharides. We modified PIM-1membranes to improve the glucose/xylose separation by incorporating polyethylene glycol monomethyl ether (mPEG). The optimal mPEG (molecular weight: 1000 Da; mass fraction: 2.5 %; solvent: methanol) delivered a xylose separation coefficient of 2.62. With the hybrid membrane of PIM-1-mPEG (50 w.t.%) and hydrophilic Tröger's base polymerer (DMBP-TB, 50 w.t.%), the separation factor for xylose/glucose in an aqueous solution was 2.51 for single-stage running and 11.32 after five-stage running. There are large fractions of micropores for PIM-1-mPEG, and there is difference on solute-membrane interactions for pentose/hexose, which are regarded to be the main driving force for the high pentose/hexose selectivity in methanol. The blending of PIM-1-mPEG and DMBP-TB, integrates the microporosity and hydrophilicity, finally endues the high pentose/hexose selectivity in aqueous solution. These microporous membranes are promising materials for efficiently separating monosaccharides and jnl> small organic molecules while minimizing energy consumption. We established a solid foundation for further exploring microporous membranes for various applications, notably in bioengineering.
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INFLAMMATION RESEARCH
·
2024
·
IF 4.8
Tan Min,Mao Jing,Zheng Jianxiong,Meng Yu,Li Jun,Hao Jiayao,Shen Haili
Background Mammalian STE20-like kinase 1 (MST1) is involved in the occurrence of cancer and autoimmune diseases by regulating cell proliferation, differentiation, apoptosis and other functions. However, its role and downstream targets in rheumatoid arthritis (RA) remain unclear. Methods The model of RA fibroblast-like synoviocytes (RA-FLSs) overexpressing MST1 was constructed by lentiviral transfection in vitro and analyzed the effects of MST1 on apoptosis, migration, invasion, and inflammation of RA-FLSs. The effect of MST1 on joint synovial membrane inflammation and bone destruction was observed in vivo by establishing a rat model of arthritis with complete Freund’s adjuvant. Results MST1 is down-regulated in RA-FLSs, and up-regulation of MST1 inhibits the survival, migration, invasion and inflammation of RA-FLSs. Mechanistically, MST1 inhibits SIRT3/mTOR-signaling pathway, inducing decreased mitochondrial autophagy and increased mitochondrial fission, resulting in mitochondrial morphological abnormalities and dysfunction, and ultimately increased apoptosis. We have observed that activation of MST1 alleviates synovial inflammation and bone erosion in vivo. Conclusions MST1 reduces the survival, migration, invasion and inflammation of FLSs by inhibiting the SIRT3/mTOR axis to reduce mitochondrial autophagy and promote mitochondrial division, thereby achieving the potential role of relieving rheumatoid arthritis.
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ACS Nano
·
2024
·
IF 15.8
Xirui Xin,Junjun Liu,Xinchan Liu,Yu Xin,Yubo Hou,Xingchen Xiang,Yu Deng,Bai Yang,Weixian Yu
Periodontitis is a chronic inflammatory disease closely associated with reactive oxygen species (ROS) involvement. Eliminating ROS to control the periodontal microenvironment and alleviate the inflammatory response could potentially serve as an efficacious therapy for periodontitis. Melatonin (MT), renowned for its potent antioxidant and anti-inflammatory characteristics, is frequently employed as an ROS scavenger in inflammatory diseases. However, the therapeutic efficacy of MT remains unsatisfactory due to the low water solubility and poor bioavailability. Carbon dots have emerged as a promising and innovative nanomaterial with facile synthesis, environmental friendliness, and low cost. In this study, melatonin-derived carbon dots (MT-CDs) were successfully synthesized via the hydrothermal method. The MT-CDs have good water solubility and biocompatibility and feature excellent ROS-scavenging capacity without additional modification. The in vitro experiments proved that MT-CDs efficiently regulated intracellular ROS, which maintained mitochondrial homeostasis and suppressed the production of inflammatory mediators. Furthermore, findings from the mouse model of periodontitis indicated that MT-CDs significantly inhibited the deterioration of alveolar bone and reduced osteoclast activation and inflammation, thereby contributing to the regeneration of damaged tissue. In terms of the mechanism, MT-CDs may scavenge ROS, thereby preventing cellular damage and the production of inflammatory factors by regulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. The findings will offer a vital understanding of the advancement of secure and effective ROS-scavenging platforms for more biomedical applications.
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American Journal of Translational Research
·
2021
·Vol. 13
·期 4
·2111-2126
·
IF 4.06
Chao Shi,Chongwen Shen,Ge Liu,Shaofeng Yang,Fenglin Ye,Jinjin Meng,Youmin Pan
Purpose To clarify the regulatory effect of Nuclear-enriched abundant transcript 1 (NEAT1) on abdominal aortic aneurysm (AAA) model rats and isolated endothelial progenitor cells (EPCs). Methods The AAA rat model was established by CaCl 2 stimulation, and overexpressed NEAT1 was injected into rats through tail vein. Abdominal aorta lesions and numbers of EPCs in tissues and peripheral blood were examined by hematoxylin-eosin, immunofluorescence and flow cytometry. The extracted EPCs were identified by microscopy, DiI-ac-LDL staining and flow cytometry. Effect of overexpressed/silencing NEAT1 on the viability, migration, tube formation and VEGF content of EPCs was investigated by MTT-, wound-healing, tube formation assays and ELISA, respectively. The expressions of NEAT1, miR-204-5p, Angiopoietin-1 (Ang-1)/ERK pathway were determined by qRT-PCR and Western blot as needed. The targeting relationships between NEAT1 and miR-204-5p, and miR-204-5p and Ang-1 were predicted on starBase, TargetScan and confirmed by dual-luciferase experiments. The mutual regulation effect was studied through rescue experiments. Results Overexpressed NEAT1 not only reduced inflammatory infiltration and increased the number of EPCs in abdominal aorta and peripheral blood, but also promoted the viability, migration, tube formation of EPCs, increased VEGF content and upregulated the expression of the Ang-1/ERK pathway in EPCs. However, silencing NEAT1 produced opposite results. NEAT1 targeting miR-204-5p inhibited the functional effects of miR-204-5p on of EPCs. Overexpressed/silencing Ang-1 partially reversed the effects of NEAT1 or miR-204-5p on the characteristics of EPCs. Conclusion NEAT1 competitively binds with miR-204-5p and up-regulates Ang-1 expression in EPCs to effectively improve the proliferation, migration and angiogenesis of EPCs.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Lichen Zhang,Xing Su,Shuo Wang,Xiaodong Li,Meishuai Zou
Fluoride coating can reduce the ignition temperature, enhance the burning rate and inhibit the agglomeration of aluminum powder. However, the addition of non-energetic fluoride can reduce the energy of aluminum powder. In this study, for the first time, 3-Perfluorohexyl-1,2-epoxypropane (PFHP) was coated on the surface of aluminum powder, which reacted with glycidyl azide polymer (GAP) in situ to form core–shell Al@PFHP@GAP. Compared with raw aluminum powder, Al@PFHP@GAP not only significantly reduced ignition temperature (about 150 °C), but also greatly improved the combustion efficiency (from 87.7% to 97.6%). Besides, the heat of combustion was also greatly increased by 6.3%, compared with that of raw aluminum powder. Such performances were outstanding among the existing coated Al. In addition, the formation of coating shell effectively improved the hydrophobicity and corrosion resistance of the aluminum powder. In a word, our derived Al@PFHP@GAP provided a novel rationale for aluminum powder with greatly enhanced combustion performance.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Yu Wu,Lingchi Zeng,Yancheng Zheng,Fuchang You,Xuejin Liu
In this study, nitrogen-doped carbon dots (N-CDs) were synthesized via a one-step hydrothermal method using pectin polysaccharide as the carbon source, with 1-hexylamine, 1,2-diaminocyclohexane, and diethylenetriamine as individual nitrogen sources. The chemical composition, fluorescence properties, and morphology of the synthesized N-CDs were characterized. Their corrosion inhibition performance on N80 steel in 1 M H 2 SO 4 was evaluated using electrochemical analyses and weight loss experiments. Tafel and EIS analyses demonstrated that at a concentration of 200 mg/L, the maximum inhibition efficiencies of PHA-CDs, PCA-CDs, and PDA-CDs, synthesized using monoamine, diamine, and triamine as nitrogen sources, were 75.3 %, 90.1 %, and 95.4 %, respectively. The inhibition efficiency increased with the total nitrogen and pyrrolic N content in the N-CDs, corresponding to the choice of nitrogen source. Weight loss experiments further confirmed these trends. Additionally, the N-CDs were found to act as mixed-type inhibitors with a predominant anodic inhibition effect and are classified as predominantly chemisorptive. The adsorption behavior adhered to the Langmuir adsorption model, where coordination complexes formed between pyrrolic N and metal Fe increase the surface coverage of the adsorption film, thereby enhancing corrosion resistance.
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Advanced Science
·
2024
·
IF 14.3
Tianliang Li,Dan Xu,Zhao Ruan,Jie Zhou,Wenbo Sun,Bo Rao,Haibo Xu
Intrinsic immunosuppressive tumor microenvironment (ITM) and insufficient tumor infiltration of T cells severely impede the progress of glioblastoma (GBM) immunotherapy. In this study, it is identify that inhibiting the expression of glucose transporter 1 (GLUT1) can facilitate the prevention of lactate excretion from tumor glycolysis, which significantly alleviates the lactate-driven ITM by reducing immunosuppressive tumor-associated macrophages (TAMs) and regulatory T cells (Tregs). Simultaneously, the findings show that the generated inflammatory cytokine IFN-γ during immune activation aggravates the immune escape by upregulating immune checkpoint programmed death-ligand 1 (PD-L1) in tumor cells and TAMs. Therefore, an injectable thermogel loaded with a GLUT1 inhibitor BAY-876 and a PD-1/PD-L1 blocker BMS-1 (Gel@B-B) for dual-regulation of metabolism and immunity of GBM is developed. Consequently, in situ injection of Gel@B-B significantly delays tumor growth and prolongs the survival of the orthotopic GBM mouse model. By actively exposing tumor antigens to antigen-presenting cells, the GBM vaccine combined with Gel@B-B is found to significantly increase the fraction of effector T cells (Th1/CTLs) in the tumor microenvironment, thereby remarkably mitigating tumor recurrence long-term. This study may provide a promising strategy for GBM immunotherapy.
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Materials
·
2024
·Vol. 17
·期 21
·5327
·
IF 3.1
Juan Li,Hao Yao,Yuting Huang,Hongxia Wang
In order to improve the microwave-absorption performance of barium ferrite and broaden its microwave-absorption band, BaFe12O19, Ba0.95Ca0.05Fe12O19, and Ba0.95Ca0.05Fe12−xCoxO19(x = 0.1, 0.2, 0.3 and 0.4, respectively) hexaferrites were synthesized by the solid-state reaction method, and the influence of Co ion substitution on the phase composition, microstructure, magnetic properties, and microwave-absorption ability of the ferrites in this system was studied. Introducing minor Co ions (x < 0.2) facilitated sintering and grain growth. At x ≥ 0.2, XRD revealed the emergence of the Co2X phase alongside the BaM phase. Increasing Co ion concentration and the secondary X-phase led to slight reductions in saturation magnetization (69 to 63.5 emu/g) and substantial decline in coercivity (2107.02 to 111.21 Oe), attributed to grain size growth and Co2X’s soft magnetic nature. Notably, Co2X incorporation significantly enhanced the microwave absorption and provided a tunable absorption band from the Ku to the C band. For a sample with a thickness of 2.0 mm and a doping level of x = 0.2, a minimum reflection loss of −59.5 dB was achieved at 8.92 GHz, with an effective absorption bandwidth of 3.31 GHz (7.07–10.38 GHz). The simple preparation method and good performance make Ba0.95Ca0.05Fe12−xCoxO19(x = 0.1, 0.2, 0.3 and 0.4, respectively) hexaferrites promising microwave-absorbing materials.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaoyue Zhou,Zhenjie Li,Yingxi Shi,Yingqi Miao,Yunying Liu,Renli Yin,Wanqian Guo,Junhao Qin,Huashou Li,Adela Jing Li,Rongliang Qiu
Bisphenol A (BPA) has raised worldwide concern owing to its ecological risks, highlighting the urgent need to develop efficient removal strategies in wastewater treatment. A metal–organic framework (Bio-MOF-1) piezoelectrically activating peroxymonosulfate (PMS) process (Bio-MOF-1/PMS/US) was developed to remove BPA at 98.5%, which was 3.5 times higher than the Bio-MOF-1/US process. Further analysis confirmed that the piezoelectric field initiated by Bio-MOF-1 could reduce the activation energy of PMS and then promote the reaction of PMS with holes and electrons to convert into 1 O 2 and OH. The steady-state concentration of 1 O 2 was 4 orders of magnitude higher than OH, indicating the dominant contribution of 1 O 2 for BPA removal, which resulted in the efficient BPA removal from a variety of anions, organics, and municipal wastewater through a low-risk manner. This work provides new perspectives for the application of MOF-based materials in the field of piezoelectric catalysis and promising applications in wastewater remediation.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
He Zhu,Chentao Ding,Yunbing Tang,Jingyi Zheng,Shaowei Wang,Zhongyao Ji,Yang Zhu,Ren-shan Ge,Huitao Li
Parabens are preservatives used in personal care products, cosmetics, and pharmaceuticals. Steroid 5α-reductase 1 (SRD5A1) catalyzes the conversion of testosterone to dihydrotestosterone and is present in the brain, contributing to neurosteroid production. This study aimed to assess the effects of nine paraben preservatives on SRD5A1 in human SF126 glioblastoma cell and rat brain microsomes, particularly focusing on dihydrotestosterone production in SF126 cells. The results showed that methyl, ethyl, propyl, butyl, hexyl, heptyl, nonyl, phenyl, and benzyl paraben inhibited human SRD5A1, with nonylparaben having the strongest effect (7.59 μM). Additionally, kinetic analysis indicated that parabens acted as mixed/noncompetitive inhibitors, leading to a significant decrease in dihydrotestosterone production in SF126 cells. While rat SRD5A1 exhibited lower sensitivity to parabens, docking analysis revealed that parabens bind to the NADPH-binding site of both human and rat SRD5A1. In conclusion, these results highlight the inhibitory effects of paraben preservatives on SRD5A1 and elucidate their binding mechanisms, underscoring their role in hormone production.
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CRYSTENGCOMM
·
2024
·Vol. 26
·期 38
·5431-5439
·
IF 2.6
Ting-Ting Xu,De-Sheng Wei,Shuang-Bao Li,Yu-Teng Zhang,Nan Lv
Although the fundamental configuration (tetrahedron-type and capsule-type) of Zr-MOCs is well understood, the synthesis of amino-functionalized Zr-based capsule (denoted as ZrC-1-NH2) based on 2-aminoterephthalic acid remains a considerable challenge. Fortunately, we obtained single crystals under solvothermal conditions and further achieved the rapid synthesis of ZrC-1-NH2 with pure phase and high yield using a microwave-assisted solvothermal method. In addition, ZrC-1-NH2 was utilized as a photocatalyst to perform the degradation of tetracycline (TC) in water. The degradation efficiency of 92.3% was achieved at the optimal conditions, and the main active free radical was determined as ·O2− according to the trapping agent experiment and EPR results. Furthermore, the possible degradation pathway of TC was proposed.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Hua Xu,Liling Cao,Yi Yu,Yuan Li,Xiangming Liu,Chengliang Mao,Lizhi Zhang
1 O 2 generation over (0 0 1) or (0 1 0) facet exposed BiOCl (B001 or B010) with/without phosphate modification were studied from the aspects of excitons involved energy transfer route, the O 2 − oxidation based charge transfer route and the H 2 O 2 oxidation by HClO. Phosphate modification not only enhance charge separation thus result in H 2 O 2 oxidation by HClO to release 1 O 2 but also weaken excitonic effect in the confined layer of BiOCl accordingly affect 1 O 2 generation via energy transfer. Considering [0 0 1] orientation favors the formation of excitons than that of [0 1 0] direction over BiOCl, excitons loss was hardly compensated by the H 2 O 2 oxidation by HClO for 1 O 2 generation over phosphate modified B001. Nevertheless, limited excitonic effect makes the O 2 − oxidation by h + via charge transfer as dominant route for 1 O 2 yielding over B010, the extra H 2 O 2 oxidation with HClO after phosphate modification significantly enhance 1 O 2 generation over B010 followed with 2.2 times higher carbamazepine photodegradation activity. The initial attack of C C bond via 1 O 2 to form epoxide played important roles on carbamazepine degradation. This study demonstrated that the facet-specific phosphate modification of photocatalysts can finely tune reactive 1 O 2 species for superior pharmaceuticals degradations.
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