CNS Neuroscience & Therapeutics
·
2025
·Vol. 31
·期 12
·e70682
·
IF 5
Haitao Zhang,Ning Zhang,Xiaotong Yang,Jiejie Zhang,Xiaoli Ge,Lei Wang,Shan Wang,Ya Wen
This study provides a novel insight into the molecular mechanism whereby NBP protects mitochondria against ischemia/hypoxia damage, offering a promising drug for mitochondria‐targeting therapeutics for ischemic stroke.
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DOI
PubMed
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Weijun Chen,Hui Hou,Jiaxin Han,Xinhui Wang,Yuncheng Li,Fanbing Meng,Donghong Liu,Xiaoying Guo
A ternary covalent complex was prepared by conjugating whey protein isolate (WPI)-(−)-epigallocatechin-3-gallate (EGCG) covalent complex with gum acacia (GA). A blue shift in the amide A band and decreased intensity of amide bands in the Fourier transform infrared spectroscopy spectra, and an increase in molecular size confirmed the covalent linkage. It was utilized to stabilize β-carotene emulsion. The freeze–thaw, ionic strength, thermal and pH stability of emulsions were enhanced by conjugation with GA. Compared with WPI, the WPI-EGCG covalent complex and its mixture with GA, the ternary covalent complex used as an emulsifier more effectively inhibited the degradation of encapsulated β-carotene under ultraviolet light irradiation and thermal treatment. The stability of the emulsion during simulated gastrointestinal digestion and the in vitro bioaccessibility of BC also significantly ( p < 0.05) increased after conjugation with GA. These findings could provide insights into the design of promising and effective food-grade emulsion delivery systems.
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DOI
PubMed
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Dongxing Dong,Zhiqiang Cheng,Jingjing Zhang,Zhengyi Gu,Zhaolian Han,Wenli Hou,Xiaoli Lv
Pressure ulcer dressings with different functions can enhance wound healing ability to varying degrees; however, pressure ulcer dressings that integrate various functions and break the resistance of bacteria to traditional antibiotics have not been widely studied. We proposed a self-pumping/super-absorbent/transportable drug dressing (PLD-SLD), polycaprolactone (PCL)/sodium alginate (SA) was used to load platelet-derived growth factor (PDGF) and lidocaine hydrochloride (LID) by Janus electrospinning and self-assembly technology, and Ɛ-polylysine was used as a biological bacteriostatic agent to prepare a multi-layer dressing. SEM showed that the dressing had a fluffy structure. The dressing can pump the exudate to the SA layer away from the skin. The swelling ratio reached 1378.667 ± 44.752 %. Coagulate blood in 5 min. On the 8th day, the unclosed area rate of the PLD-SLD dressing group was 16.112 ± 0.088 % lower than that of the model group. Importantly, the dressing can induce the expression of CD31, VEGF, α-SMA, and reduce the expression of CD68, thereby giving priority to wound healing. There was no scar formation after healing. In this study, a new dressing preparation method was proposed for the problems of exudate management, infection control, pain relief and healing promotion of stage 3–4 pressure ulcer healing.
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PubMed
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Mingwei Zhao,Mengjiao Cao,Yong Hu,Qianru Yang,Yining Wu,Zhongzhong Chu,Xuewen Hu,Caili Dai
Polymer as non-Newtonian fluids is widely used in oilfield flooding for enhanced oil recovery (EOR). The study on the oil droplet behaviors in polymer solution has a remarkable influence for clarifying the EOR mechanism of polymer flooding. In this paper, factors influencing the oil droplet breakup process, including polymer concentration, pore throat structure, elasticity as well as flow rate, were investigated. It was found that the oil droplets were liable to breakup and the average size of daughter droplet decreased by about a quarter as the polymer concentration increased (from 0.01% to 0.5%). A prediction model for the effect of polymer concentration on the length of the first daughter droplet was established. Furthermore, the relationship between polymer concentration and the length of the first daughter droplet was fitted to an exponential function. After excluding the influence of viscosity, it was found that the elastic property of polymer fluid made the oil droplets more likely to breakup when passing through pore throat.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Jinhong Song,Chen Zhang,Zejian Zheng,Shizhe Huo,Yihan Lin,Fei Yang,Lei Liu
SnO 2 layer between Li 1.5 Al 0.5 Ge 1.5 (PO 4 ) 3 (LAGP) and lithium anode was prepared through simple scratch-coating process to improve interface properties. The physical phase, morphology, and electrochemical properties of Li/SnO 2 /LAGP structure were characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and electrochemical analytical methods. It was found that SnO 2 layer effectively improved the interface stability of LAGP and lithium anode. The prepared Li/SnO 2 /LAGP/SnO 2 /Li symmetric cell exhibited a large critical current density of 1.8 mA cm −2 and demonstrated excellent cycling characteristics. The polarization voltages of symmetric cell were 0.1 V and 0.8 V after 1000 h of cycling at current densities of 0.04 mA cm −2 and 0.5 mA cm −2 , respectively. Li/SnO 2 @LAGP/LiFePO 4 solid-state full cells were also assembled, exhibiting a discharge specific capacity of 150 mAh g −1 after 200 cycles at 0.1C with capacity retention rate of 96 %. The good interface properties of Li/SnO 2 /LAGP structure are attributed to the transformation of SnO 2 layer into a buffer layer containing Li 2 O, Sn 0 , and Li x Sn y alloy during cycling process, which effectively inhibits the reduction reaction between LAGP and lithium anode.
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JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Yilin Ge,Yushan Li,Feng Wang,Xiaoqin Tan,Peng Liu,Dianhui Wang,Wentong Zhou,Qingrong Yao,M.-Sadeeq Balogun (Jie Tang),Dan Huang,Jianqiu Deng
The development of low-cost and eco-friendly electrode materials is crucial for the next-generation rechargeable lithium-ion batteries (LIBs). Herein, the single-phase Na 1.2 Fe 4 (PO 4 ) 3 (NFP) with a monoclinic NaCo 4 (PO 4 ) 3 -type structure is demonstrated to be a suitable anode material for LIBs. The NFP anode exhibits superior high-rate performance, releasing an initial charge capacity of 128.6 mAh g −1 at 10C and a high-capacity retention rate of 86.7% over 1500 cycles. The prominent rate performance and cycling stability of the NFP anode are attributed to the stable single-phase crystal structure and fast Li-ion diffusion verified by galvanostatic intermittent titration technique (GITT). Furthermore, the structure evolution and Li-ion diffusion pathway of the NFP anode are clarified by ex-situ X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and first-principles calculations.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ruiting Fan,Li Song,Yongsheng Hu,Xiaoyang Guo,Xingyuan Liu,Lishuang Wang,Chong Geng,Shu Xu,Yonghui Zhang,Zihui Zhang,Nannan Luan,Wengang Bi
Properties of the underlying hole transport layer (HTL) in perovskite light-emitting devices (PeLEDs) play a critical role in determining the optoelectronic performance through influencing both the charge transport and the quality of the active perovskite emission layer (EML). This work focuses on manipulating the carrier transport behavior and obtaining a high-quality EML film by tailoring the poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) HTL with previously unused amino alcohol 3-amino-1-propanol (3AP). The modified PEDOT:PSS rendered a deeper work function that is more suitable for the hole injection from the HTL to EML. More importantly, the 3AP-modified PEDOT:PSS film can induce a low-dimensional perovskite phase that can passivate the defects in the EML, resulting in a significantly improved light emission. Such ameliorations consequently result in a dramatical enhancement in performance of PeLED with a low turn-on voltage of 2.54 V, a maximum luminance of 23033 cd/m2, a highest current efficiency of 29.38 cd/A, a corresponding maximum external quantum efficiency of 9.4%, and a prolonged lifetime of 6.1 h at a proper Cs/Pb ratio.
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ENZYME AND MICROBIAL TECHNOLOGY
·
2024
·
IF 3.4
Dingyu Guo,Zhengchao Wang,Wanqing Wei,Wei Song,Jing Wu,Jian Wen,Guipeng Hu,Xiaomin Li,Cong Gao,Xiulai Chen,Liming Liu
D-allulose is a naturally occurring rare sugar and beneficial to human health. However, the efficient biosynthesis of D-allulose remains a challenge. Here, we mined a new D-tagatose 3-epimerase from Kroppenstedtia eburnean (KeDt3e) with high catalytic efficiency . Initially, crucial factors contributing to the low conversion of KeDt3e were identified through crystal structure analysis, density functional theory calculations (DFT), and molecular dynamics (MD) simulations. Subsequently, based on the mechanism, combining restructuring the flexible region, proline substitution based onconsensus sequence analysis, introducing disulfide bonds , and grafting properties, and reshaping the active center, the optimal mutant M5 of KeDt3e was obtained with enhanced thermostability and activity. The optimal mutant M5 exhibited an enzyme activity of 130.8 U/mg, representing a 1.2-fold increase; T m value increased from 52.7 °C to 71.2 °C; and half-life at 55 °C extended to 273.7 min, representing a 58.2-fold improvement, and the detailed mechanism of performance improvement was analyzed. Finally, by screening the ribosome-binding site (RBS) of the optimal mutant M5 recombinant bacterium (G01), the engineered strain G08 with higher expression levels was obtained. The engineered strain G08 catalyzed 500 g/L D-fructose to produce 172.4 g/L D-allulose, with a conversion of 34.4% in 0.5 h and productivity of 344.8 g/L/h on a 1 L scale. This study presents a promising approach for industrial-scale production of D-allulose.
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DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 15
·B1426
·
IF 3.12
Haiyun Zhai,Shiqiao Wang,Jianfeng Zhou,Jianbin Pan,Yanli Tong,Qinghua Mei,Qing Zhou
A sensitive and facile electrochemical sensor based on glassy carbon electrode (GCE) receiving electrochemical anodic pretreatment for signal amplification was developed for the determination of 3-nitrotyrosine (3-NT) (an oxidative stress biomarker). Adding sodium hexadecyl sulfate (SDS) to 0.1 M HNO3 solution was conducive to adsorption onto the surface of modified electrode, which promoted electron exchange and enhanced electrochemical behaviors by significantly increasing the hydrophobicity of electrode surface. Scanning electron microscopy showed that the surface of modified GCE had a remarkably thin layer composed of dense nanoparticles owing to surface layer oxidation, growth of graphite oxide thin layer and microscopic mechanical destruction of electrode surface during cyclic voltammetry by anodization oxidation. Under optimal conditions, the current change of 3-NT in square wave stripping voltammetry (SWV) was linearly related to its concentration in the range of 0.05∼30.0 μM, with a detection limit (S/N = 3) of 17.0 nM, acceptable stability and reproducibility. Additionally, this sensor was successfully applied to detect 3-NT in human serum samples.
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Arthropod-Plant Interactions
·
2020
·Vol. 14
·期 2
·169-179
·
IF 1.466
Sun Ya-Lan,Dong Jun-Feng,Huang Ling-Qiao,Wang Chen-Zhu
Campoletis chlorideae Uchida (Hymenoptera: Ichneumonidae) is an important larval endoparasitoid of the cotton bollworm Helicoverpa armigera (Hübner). A better understanding of herbivore-induced plant volatiles (HIPVs) employed by C. chlorideae to locate hosts will contribute towards the biological control of this notorious crop pest. In this study, we first investigated the electrophysiological and behavioral responses of C. chlorideae to 19 volatile compounds emitted by herbivore-infested plants. Eleven odorants induced EAG responses of C. chlorideae , while only two compounds, cis -jasmone and cis -3-hexenyl acetate, were attractive to the parasitoid in Y-tube olfactometer assays. Next, we used two- and four-choice tests in cage settings to investigate the parasitism rate of H. armigera larvae by C. chlorideae on tobacco plants treated with different doses of cis -jasmone, cis -3-hexenyl acetate, and their mixtures. Results showed that the parasitism rate of H. armigera was significantly higher on the plants treated with cis -jasmone or cis -3-hexenyl acetate, and their optimal dose for both compounds was 1 mg. However, the mixtures of cis -jasmone and cis -3-hexenyl acetate did not increase H. armigera parasitism rate by C. chlorideae when compared with control groups. Our results indicate that the single compounds cis -jasmone and cis -3-hexenyl acetate, at certain doses, enhance parasitic efficiency of C. chlorideae , but their mixtures negate this effect. These results will help us in the exploitation of C. chlorideae as biological control agent to reduce the populations of H. armigera .
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INORGANICA CHIMICA ACTA
·
2021
·
IF 2.545
Xingliang Li,Juncai Lu,Wanjun Mu,Baihua Chen,Daibing Luo,Bijun Liu,Yanqiu Yang,Hongyuan Wei,Shuming Peng
Nitrilotri–3–propanoic Acid (NTPA) and Tris(2–carboxyethyl) phosphine (TCEP) possess similar skeleton. This pair of isostructural ligands is a perfect set to assess the differences of uranyl (UO 2 2+ ) complexes with N–tricarboxylate versus P–tricarboxylate. The protonation reactions of NTPA and TCEP were investigated by potentiometry and calorimetry. Complexation of uranyl with the both ligands was studied by potentiometry and structural analysis. The results indicate that central trialkylamine in NTPA has a higher affinity for the proton than trialkylphosphine in TCEP. Crystal structures and NMR analyses indicate that central amine of NTPA and central phosphine of TCEP are not involved in the bonding. NTPA/UO 2 2+ complex is more stable than TCEP/UO 2 2+ complex. This difference cannot be explained by electronic effect of central N and P atoms because of nonbonding interactions. The higher stability of UO 2 2+ /NTPA versus UO 2 2+ /TCEP may be due to the fact that the central N atom of NTPA has a lower steric hindrance than the central P atom of TCEP. Another possible reason is that UO 2 2+ /TCEP complexes have different coordination modes from UO 2 2+ /NTPA complexes.
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JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Zijing Zhou,Anlin Zhang,Li Zhou,Ziyue Hu,Yixuan Zhao,Jiexin Chen,Yanyan Li,Lei Zhao,Bin Deng,Ruijin Yu
In the present work, a series of zincate CaY 2 Sb 2 (ZnO 4 ) 3 :Eu 3+ phosphors were successfully obtained via the conventional solid-state method at high temperature. The phase purity, morphology, element mapping, photoluminescence excitation/emission (PLE/PL), and decay time of the obtained phosphors were investigated systematically. Results show that the synthesized samples demonstrate the strongest red-emitting peak at 610 nm under the n-ultraviolet (n-UV) 395 nm excitation. The Judd-Ofelt parameters (Ω 2 , Ω 4 ), radiative transition rates, and branching ratios ( β 0 J, J = 2, 4) of CaY 2 Sb 2 (ZnO 4 ) 3 :Eu 3+ to explore the Eu 3+ -coordinated environment in the host matrix. The concentration quenching of CaY 2 Sb 2 (ZnO 4 ) 3 :2 x Eu 3+ phosphors happened until at high doping concentration of x = 50 mol%. CaY 2 Sb 2 (ZnO 4 ) 3 :100 mol%Eu 3+ sample presented the excellent thermal stability with abnormal thermal quenching behavior. Compared with the commercial Y 2 O 3 :Eu 3+ red phosphor , the luminescent intensity of the prepared phosphor is 1.14 times stronger. The high internal quantum efficiency (IQE) of CaY 2 Sb 2 (ZnO 4 ) 3 :100 mol%Eu 3+ phosphor is 79.20%. In addition, the fabricated red and white light-emitting diodes (w-LEDs) both emit bright light. The w-LED demonstrates a high color rendering index ( R a = 96) and a low correlated color temperature (CCT = 5249 K). Therefore, the prepared red-emitting phosphor has a promising application in w-LEDs.
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