MOLECULES
·
2024
·Vol. 29
·期 12
·2778
·
IF 4.2
Xi Zhu,Yong Guo,Baozhan Zheng
Efficient recovery of gallium (Ga) from vanadium slag processing residue (VSPR) solution is of great significance for environmental protection and resource utilization, but improving its selective adsorption against the coexisting Sc3+and In3+is still challenging. Herein, a novel adsorbent consisting of 4-amino-3-hydrazino-1,2,4-triazol-5-thiol (AHTZT)-modified graphene oxide (GO-AHTZT) was successfully synthesized that exhibits a higher adsorption selectivity for Ga3+in VSPR solution with coexisting Sc3+and In3+. Under optimal conditions, the adsorption capacity of GO-AHTZT for Ga3+can reach 23.92 mg g−1, which is 4.9 and 12.6 times higher than that for Sc3+(4.87 mg g−1) and In3+(1.90 mg g−1) adsorption, indicating the excellent anti-interference ability of GO-AHTZT against Sc3+and In3+. The process and mechanism of Ga3+adsorption onto GO-AHTZT was also studied and discussed in detail. By measuring the adsorption process and by characterizing the adsorbent before and after adsorption, we demonstrate that the selective interaction between the Ga3+- and N-containing groups in AHTZT is the main reason for the improved adsorption selectivity. This work opens up an avenue for the design and synthesis of highly selective adsorbents for Ga3+in complex VSPR solutions.
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PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Wenhao Zhang,Meiyan Cui,Zhiying Zhao,Tianyu Zhu,Zhangzhen He
Based on the crystal structure of A2Cu5(TeO3)(SO4)3(OH)4 (A = Na, K), two new compounds ACo5(SeO3)4(OH)2F (A = Rb, Cs) have been synthesized by introducing F− ions, achieving the extension from a one-dimensional kagomé strip lattice to a distorted 2-uniform lattice (T29). Magnetic measurements indicate that RbCo5 exhibits antiferromagnetic order at low temperatures, while CsCo5 shows canted antiferromagnetic behavior. Both compounds display a field-induced magnetic transition at their respective critical fields. To the best of our knowledge, this is the first reported synthesis of compounds with a distorted 2-uniform lattice (T29).
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Animal Nutrition
·
2025
·
IF 7.5
Li Dong,Yangshu Zhou,Mengxuan Wang,Qingqing Yuan,Guangzhi Qiu,Jun Liu,Hongrong Wang,Aimin Wu,Lihuai Yu,Daiwen Chen
This study aims to elucidate intestinal injury from the perspective of intestinal epithelial cell homeostasis and to explore the modulatory roles of terpine-4-ol (a major bioactive component of tea tree oil). Forty 28-day-old piglets (7.82 ± 0.43 kg) were randomly divided into 5 groups with 8 pigs per group. Piglets in the control (CON) and lipopolysaccharide (LPS) groups were fed a basal diet, while those in the remaining 3 groups were fed the basal diet supplemented with 30 (LTP), 60 (MTP), or 90 mg/kg terpine-4-ol (HTP), respectively. Piglets in the LPS and terpine-4-ol supplementation groups were intraperitoneally injected with 100 μg/kg BW of LPS at the end of the 21-day growth period. Six hours after injection, 6 piglets from each group were randomly selected and slaughtered to detect intestinal cell homeostasis. The results showed that the average daily weight gain (ADG) and average daily feed intake (ADFI) of piglets in MTP and HTP groups were higher than those in the CON group ( P < 0.05), whereas the feed conversion ratio (FCR) of piglets in LTP group were lower as compared to the CON group ( P < 0.05). Terpine-4-ol supplementation also decreased the diarrhea rate of piglets. Lipopolysaccharide challenge decreased the villus length and the ratio of villus length to crypt depth (V/C) in the jejunum ( P < 0.05), decreased the V/C ratio and increased the crypt depth in the ileum ( P < 0.05). In contrast, terpine-4-ol supplementation led to increased villus length and V/C ratio in the jejunum, raised the V/C ratio in the HTP group, and decreased crypt depth in the LTP and MTP groups in the ileum ( P < 0.05). Lipopolysaccharide reduced the number of Ki67 + cells and increased the number of caspase 3 + cells ( P < 0.05) in both the jejunum and ileum, whereas terpine-4-ol increased the number of Ki67 + cells in the crypts of the jejunum and ileum, while decreasing the number of caspase 3 + cells of the the ileum and in the jejunum of MTP and HTP groups ( P < 0.05). Lipopolysaccharide down-regulated the expression of the intestinal stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) ( P < 0.05, execpt for Lgr5 gene in the jejunum), while terpine-4-ol supplementation alleviated the effect. Lipopolysaccharide decreased the number of goblet cells and mucin 2 (Muc2) secretion ( P < 0.05), whereas the number of goblet cells and Muc2 secretion in the small intestine of MTP group was increased ( P < 0.05). In addition, LPS injection led to a reduction in the expression of endocrine cell marker chromogranin A and absorption cell marker villin ( P < 0.05). Conversely, terpine-4-ol increased the abundance of endocrine cells and absorption cells in the small intestine ( P <0.05). Moreover, LPS inhibited the expression of genes and proteins of wingless-type MMTV integration site family (Wnt)/β-catenin signaling pathway ( P < 0.05), whereas terpine-4-ol reversed this effect. In conclusion, terpine-4-ol supplementation improved growth performance, decreased diarrhea in piglets and alleviated the damage to the intestinal epithelial cell homeostasis under LPS challenge, probably via Wnt/β-catenin signaling activation. A dose of 60 mg terpine-4-ol per kilogram diet was recommended based on the present study.
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ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Fangyuan Dong,Xiao Chen,Ziming Ye,Xiangyu Deng,Shaoyang Hu,Chunguang Liu
Phenolic halogenated DBPs are an emerging class of highly toxic DBPs in drinking water. However, the underlying mechanisms for isomer-specific cytotoxicity of phenolic disinfection byproducts are still largely veiled. In this work, comparative cytotoxicity of 3,5-dichloro-2-hydroxybenzoic acid (3,5-DC-2-HBA) and 3,5-dichloro-4-hydroxybenzoic acid (3,5-DC-4-HBA) in diverse mammalian cell lines was investigated, SOD activity in Chinese hamster ovary cells treated by 3,5-DC-2-HBA and 3,5-DC-4-HBA was compared, and their binding interactions with Cu/Zn-superoxide dismutase (Cu/Zn-SOD) were analyzed. Results indicated that 3,5-DC-2-HBA commonly presented significantly higher cytotoxicity compared to 3,5-DC-4-HBA. Exposure to 3,5-DC-2-HBA and 3,5-DC-4-HBA caused a dose-dependent increase in intracellular SOD activity, with the trend paralleling the cytotoxicity of the two isomeric compounds. In addition, this rank order was consistently observed in the conformational changes, secondary structure alterations, as well as enzymatic activity modulation of Cu/Zn-SOD induced by these isomeric compounds. Molecular docking simulations further elucidated the binding mechanisms, demonstrating that van der Waals interactions and hydrogen bonding energies predominantly drive complex formation between these two halogenated phenolic DBPs and Cu/Zn-SOD. Notably, the interaction with Cu/Zn-SOD may be generally applied to explain the isomeric structure-derived cytotoxic pattern of various groups of phenolic DBPs. This systematic investigation advances our mechanistic understanding of isomer-specific cytotoxicity in phenolic DBPs, providing valuable insights for risk assessment and mitigation strategies in drinking water treatment processes.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Yi-Heng Wang,Yang Liu,Jin Tong,Shu-Yan Yu
The cyclometalated Ir(III) complex, Ir(ppy) 2 (phen-dipzH 2 ) ( Ir-1 ), was synthesized using the ligand 3,8-di(1H-pyrazol-4-yl)-1,10-phenanthroline (phen-dipzH 2 ) and the auxiliary ligand 2-phenylpyridine (ppy). Crystal structure analysis reveals that each {Ir(ppy) 2 } + unit is coordinated by a neutral phen-dipzH 2 ligand in Ir-1 . The packing arrangement of Ir-1 displays aromatic stacking interactions and [C–H…N] hydrogen bonding interactions between the [Ir(ppy) 2 (phen-dipzH 2 )] + cations. In solution, Ir-1 exhibits emission switching induced by acid/base changes, with the emission wavelength shifting from 562 nm (yellow color) in the neutral state to 618 nm (pink color) under acidic conditions and to 528 nm (gray color) under basic conditions. These shifts are attributed to the protonation and deprotonation of the pyrazole units, which is confirmed by 1 H NMR spectra. Additionally, Ir-1 demonstrates high selectivity and sensitivity toward Cu 2+ ions, with a detection limit as low as 9.47 μM compared to other metal ions. The acid/base-responsive phosphorescence of Ir-1 has also been successfully utilized in the development of paper strip-based devices for urea detection.
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Acta Biomaterialia
·
2022
·
IF 10.633
Kailei Ding,Cheng Zheng,Xueyu Huang,Shumang Zhang,Meiling Li,Yang Lei,Yunbing Wang
With the development of diagnostic techniques, the incidence of bioprosthetic heart valve thrombosis (BHVT) is found to be seriously underestimated. Developing bioprosthetic heart valves (BHVs) that have good hemocompatibility without sacrificing other properties such as hydrodynamics and durability will be an effective strategy to alleviate BHVT. In this study, we developed a PEGylation method by co-crosslinking and subsequent radical polymerization . 2-amino-4-pentenoic acid was used to introduce carbon-carbon double bonds for glutaraldehyde crosslinked pericardia. Then poly (ethylene glycol) diacrylate (PEGDA) was immobilized on pericardia by radical polymerization. A comprehensive evaluation of the modified pericardia was performed including structural characterization, hemocompatibility, cytocompatibility, mechanical properties , component stability, hydrodynamic performance and durability of the BHVs. The modified pericardia significantly reduced platelet adhesion by more than 75% compared with traditional glutaraldehyde crosslinked pericardia. Cell viability in the modified pericardia group was nearly 5-fold higher than that in glutaraldehyde crosslinked pericardia. The hydrodynamic performance met the requirements of ISO 5840–3 under physiological aortic valve conditions and its durability was proved after 200 million cycles of accelerated fatigue test. In conclusion, PEGDA modified pericardia exhibited improved antithrombogenicity and cytocompatibility properties compared with glutaraldehyde crosslinked pericardia. Statement of significance Bioprosthetic valve (BHV) implantation requires BHV to be structurally stable as well as biocompatible in vivo . Traditional glutaraldehyde crosslinking method prepared BHV suffers from severe cytotoxicity, thrombosis, and calcification. BHV modification methods that have simultaneously improved structural stability and biocompatibility were rarely reported. Here, we proposed a PEGylation method for BHV based on co-crosslinking strategy that could improve its structural stability as well as hemocompatibility. We take the advantage of high efficiency of glutaraldehyde crosslinking and demonstrate the feasibility and superiority of the PEGylated strategy, offering a promising option in glutaraldehyde-based BHV fabrication in the future.
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高影响因子
Frontiers in Pharmacology
·
2019
·
IF 3.845
Zhu Mingfei,Wang Hong,Wang Chenglin,Fang Yanfen,Zhu Tong,Zhao Weili,Dong Xiaochun,Zhang Xiongwen
Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However, the adverse effects and drug resistance restricted the use of Hh inhibitors. In the present study, 61 synthesized compounds containing central backbone of phthalazine or dimethylpyridazine were screened as candidates of new Hh signaling inhibitors by performing dual luciferase reporter assay. Among the compounds, L-4 exhibited an IC50 value of 2.33 nM in the Shh-Light II assay. L-4 strongly inhibited the Hh pathway in vitro and blocked the Hh pathway by antagonizing the smoothened receptor (Smo). Remarkably, L-4 could significantly suppress the Hh pathway activity provoked by Smo mutant (D473H) which showed strong resistant properties to existing drugs such as Vismodegib. Orally administered L-4 exhibited prominent dose-dependent anti-tumor efficacy in vivo in Ptch+/-; p53-/- MB allograft model. Furthermore, L-4 showed good tolerance in acute toxicity test using ICR mice. These evidences indicated that L-4 was a potent, well-tolerated, orally active inhibitor of Hedgehog pathway, and might be a promising candidate in development of Hh-targeted anti-cancer drugs.
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高影响因子
Oncotarget
·
2017
·
IF 5.168
Ting Tao,Caimei He,Jun Deng,Yanjun Huang,Qiongli Su,Mei Peng,Meiling Yi,Kwame Oteng Darko,Hui Zou,Xiaoping Yang
Quercetin is a naturally existing compound and shows attractive anticancer properties for a variety of solid tumors including glioma, bladder cancer, hepatocellular carcinoma, breast cancer, hematological malignancies and prostate carcinoma. However, these anticancer properties have not been clinically approved due to unclear mechanistic information and its low bioactivity. In our previous study, we elucidated that quercetin activates AMPK pathway which is the major mechanism for its unique anticancer effect in bladder cancer. In the present study, we are trying to enhance its bioactivity by chemical modification using fluorination approach to prepare novel chemical entities, based on the principle of intermediate derivative method (IDM). The compound we obtained is named 8-trifluoromethyl-3,5,7,3′,4′-O-pentamethyl- quercetin (TFQ), characterized by NMR spectra and mass spectrum (MS). The results from MTT and cologenic assay in two human and one murine bladder cancer cell lines showed that TFQ exhibits more potent inhibition on the three bladder cancer cell lines than quercetin (Que) although this enhanced effects is not very dramatic. Furthermore, we found that the survival of normal bladder cells PEBC was not significantly suppressed by TFQ compared with Que. Western blot analysis showed that TFQ possess more potent AMPK activation than Que. The downstream of AMPK was further examined by western blot. TFQ treatment is able to inactivate mTOR signaling pathway with the regulation of mTOR, 4EBP1 and P70S6K. These results demonstrated that the fluorinated quercetin derivative TFQ inhibits bladder cancer cell growth through the AMPK/mTOR pathway. Altogether, our findings suggest that TFQ could serve as a new potential therapeutic agent for bladder cancer more effective than Que.
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PubMed
高影响因子
Bioresource Technology Reports
·
2018
·
IF 0
Bing-Qian Wang,Bo Peng,Jian-Fei Sun,Chu Wang,Ke Jiang,Jing-Hao Ma,Peng-Qi Zhang,Yu-Cai He
An effecti v e combination pretreatment of bamboo shoot shell (BSS) using Emulsifier OP-10 (0.5%, w/v) in the acidified media (pH 4.0) by autoclaving (120 °C, 40 min) was conducted. After BSS slurry without detoxification was enzymatically hydrolyzed for 96 h, glucose (25.2 g/L) and xylose (7.5 g/L) were obtained from 50 g/L BSS at high yields. HPLC results showed that no potential inhibitors (furfural and 5-hydroxymethylfurfural) formed. In the hydrolysates , an effective biocatalytic synthesis of ethyl ( S )-4-chloro-3-hydroxybutanoate (100% yield; >99% e.e. ) from 1000 mM ethyl 4-chloro-3-oxobutanoate was developed without the extra addition of cofactors within 24 h. In summary, this combination strategy involving biomass pretreatment, enzymatic saccharification , and bioreduction can be developed for producing chiral alcohols.
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ChemCatChem
·
2024
·Vol. 16
·期 21
·e202401010
·
IF 3.8
Ziwei Wu,Han Sun,Quanzheng Deng,Lu Han,Penggang Lv,Haijun Chen,Hongchang Duan,Kake Zhu
Graphical Mono-quaternary 1-(1-methylpropyl)-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide is proposed to direct the Faujasite-to-Chabazite inter-zeolite conversion to generate 35–258 nm CHA crystals with Si/Al ratio of 7.2. The Cu-CHA zeolite exhibits superior hydrothermal stability and catalytic performance in standard NH 3 -SCR process. Cu-exchanged chabazite zeolite is the state-of-the-art used on-board catalyst for NO x selective reduction by ammonium (NH 3 -SCR), and the zeolite is currently generated in the presence of N , N , N -trimethyl-1-adamantylammonium hydroxide, serving as organic structure-directing agent (OSDA). The expensiveness of this OSDA increases the catalyst production cost, while its low degradability brings about environmental concerns in post treatment of waste water. Here, a new type OSDA, 1-(1-methylpropyl)-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide, is proposed to direct Faujasite-to-Chabazite inter-zeolite conversion and generate chabazite with Si/Al ratio up to 7.2. The obtained zeolite possesses high hydrothermal stability for the high crystallinity, siliceous framework and low concentrations of Si(2Si, 2Al) sites. The Cu-form catalyst exhibits better catalytic performance in standard NH 3 -SCR process for the tiny crystallite size (35–258 nm) and formation of highly dispersed copper sites. The synthesis offers a new type of OSDA to fabricate zeolites and expands the toolkit to regulate their physicochemical properties.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Ling Tang,Qin Yang,Jianfang Zhang,Guisheng Deng
A regioselective reverse strategy for the construction of eight-membered sulfur-containing heterocycle-fused γ-pyrones and 2-(1,4-dithianyl)-4-pyrones starting from 2-diazo-γ-pyrones and dithioacetals was achieved for the first time. The process combines C–S bond formation via sulfur ylides and C–C bond formation via electron transfer to afford the target molecules in a facile manner with 100% regioselectivity and in excellent isolated yields (up to 90%).
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高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Zhuangpeng Huang,Zhiping Chen,Yuancai Chen,Yongyou Hu
Iron-copper bimetal supported on mesoporous γ-Al 2 O 3 with different Fe/Cu ratios was prepared via a modified evaporation-induced self-assembly method and employed to degrade 4-chlorophenol (4-CP) in a Fenton-like process. The X-ray photoelectron spectroscopy, X-ray diffraction spectrum and UV–vis diffuse reflectance spectroscopy results confirmed the co-doping of Fe 2+ /Fe 3+ and Cu + /Cu 2+ into the lattice of γ-Al 2 O 3 through the bonds of Al O Fe and Al O Cu. With the iron and copper co-doped in γ-Al 2 O 3 , three-fold oxygen vacancies (V 0 ) could be achieved compared with that of non-metal catalysts, which was favorable for the reduction of iron and copper species. The 1Fe3Cu-γ-Al 2 O 3 with a Fe/Cu mass ratio of 1:3 exhibited the highest activity on Fenton-like degradation of 4-CP due to the synergistic effects of Fe and Cu by facilitating the electron transfer in the recycles of Cu + /Cu 2+ and Fe 2+ /Fe 3+ based on the results of X-ray photoelectron spectroscopy, cyclic voltammetry and electro paramagnetic resonance analysis. The utilization efficiency of H 2 O 2 was as high as 86.0% when 4-CP almost disappeared (i.e., 99.7 percent of 0.78 mM 4-CP) at 240 min and pH 7.0, additionally, their dechlorination and TOC removal efficiencies were 92.0% and 81.6%, respectively. The catalyst also displayed a good performance after 5th cycles. Furthermore, a possible mechanism for activation of OH on the catalyst surface was also proposed.
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