BIOMEDICINE & PHARMACOTHERAPY
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2020
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IF 4.545
Ye Zhou,Meng Zhang,Zhilei Zhang,Yuming Jia,Chong Zhang,Li Peng
Hydrazinocurcumin (HZC), a curcumin analogue, serves as a tumor suppressor in breast cancer and lung cancer. In this study, we investigate the role and mechanism of HZC in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were treated with HZC and/or 5-Fu to analyze the possible synergistic effects on cell proliferation, apoptosis and cell cycle distribution in vitro using EdU staining, Hoechst staining and flow cytometry, respectively. For mechanistic investigation we used pic, a phosphatase and tensin homolog (PTEN) inhibitor, and in other studies assessed the expression pattern of PTEN and PI3K/Akt signaling pathway-related genes. Additionally, we tested in vivo effects of HZC and 5-Fu treatment on growth of HepG2 cell tumors in nude mice. We found that HZC or 5-Fu induced apoptosis and repressed proliferation of HepG2 cells by upregulating the expression of PTEN and disrupting the PI3K/Akt signaling pathway activation. Moreover, HZC had a higher pro-apoptotic effect than 5-Fu. HZC and 5-Fu induced HepG2 cell apoptosis and inhibited their tumorigenicity in vivo . Inhibition of PTEN expression activated the PI3K/Akt signaling pathway and reversed the protective effects of HZC or 5-Fu. Thus, HZC and 5-Fu increase PTEN, which blocks the PI3K/Akt signaling pathway, ultimately inducing HepG2 cell apoptosis. Importantly, the synergistic combination of HZC and 5-Fu may present promising strategy for the treatment of HCC.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Chengfeng Yi,Jingwen Li,Jiarui Li,Bingchuan Xue,Xing Lin,Zhigang Liu
The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) constitutes a pivotal pathway for biomass valorization. However, its advancement is kinetically hindered by the competitive adsorption between HMF and OH − on active sites, causing a conflict between substrate activation and oxidant supply. To circumvent this impediment, a series of Ni(OH) 2 /N,W-Ni 3 S 2 composite catalysts are designed via electrodeposition. This strategy enables the in-situ growth of amorphous Ni(OH) 2 overlayer on the nitrogen and tungsten co-modulated Ni 3 S 2 (N,W-Ni 3 S 2 ) substrate, realizing the precise construction of heterostructure. The Ni(OH) 2 component possesses strong affinity for OH − , while the Ni 3 S 2 substrate preferentially adsorbs HMF. By tuning the electrodeposition duration, the Ni(OH)₂ layer thickness can be regulated, thereby enabling the overall adsorption strengths of both HMF and OH − to be finely optimized. The superior catalyst, Ni(OH) 2 /N,W-Ni 3 S 2 –500, demonstrates exceptional catalytic activity, achieving 100 % HMF conversion, 97.2 % FDCA yield and 97.3 % Faradaic efficiency. Furthermore, it displays a wide operational potential window, maintaining FDCA yields and Faradaic efficiencies above 90 % over 1.45–1.60 V vs. RHE. This remarkable activity is attributed to an optimized adsorption behavior for HMF and OH − . Specifically, the enhanced affinity for OH − accelerates the generation of the true active species, high-valent nickel oxyhydroxide (NiOOH), and ensures a sufficient localized supply of the oxygen source. Simultaneously, the catalyst retains a moderate adsorption capacity for HMF molecules, ensuring effective substrate activation without inhibiting product desorption. This study proposes a novel and effective interfacial engineering paradigm to resolve the adsorption imbalance in biomass electrooxidation, offering a rational blueprint for superior electrocatalysts.
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高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2025
·
IF 4.3
Fengxue Liu,Xuefei Yu,Yanmei Wu,Ting Zhu,Ning Chen,Hao Chen,Wei Shen,Wei Zheng
5-fluorouracil (5-FU) is one of the most effective chemotherapeutic drugs for various solid tumors. However, its low water solubility and limited absorption rates in the stomach are crucial limitations that prevent it from being effectively applied in clinical practice. To address these issues, we first encapsulated 5-FU in β-cyclodextrin (5-FU–β-CD) to enhance its solubility, and the resulting 5-FU–β-CD was then loaded into a PLA film to prepare a novel gastro-retentive drug delivery system (GRDDS) based on shape-memory properties. The excipients, such as tributyl citrate (TBC), hydroxyethyl cellulose (HEC), citric acid (CA), and sodium bicarbonate (NaHCO 3 ), were incorporated into the PLA matrix at an optimized ratio. This was done to enhance the performance of PLA as an ideal matrix material in GRDDS, including improvements in drug release, floating behavior, shape recovery, gastric retention, and in vivo anti-tumor activity. The results suggested that the solubility of the 5-FU–β-CD inclusion complex was significantly enhanced, which was 1.88-fold higher than that of pure 5-FU. The optimal shape-memory drug delivery formulation, 5-FU–β-CD–PLA/TBC (86/14), prepared in this study consists of PLA/TBC (86/14) incorporating 3 % HEC, 3 % NaHCO 3 , 1 % CA, and 3 % 5-FU. Its gastric retention time was notably prolonged to approximately 8 h following oral administration in mice, whereas the residual amount of 5-FU–β-CD at this time point was much lower than the initial loading. The oral bioavailability of the 5-FU–β-CD–PLA/TBC (86/14) was 269 % higher than that of pure 5-FU. Additionally, the mean tumor size and weight in the mouse model of gastric carcinoma administered with 5-FU–β-CD–PLA/TBC (86/14) were 215.3 mm 3 and 241.4 mg respectively, significantly smaller than those in the 5-FU group. This indicates that the novel PLA-based drug delivery system has significantly enhanced anti-tumor effects. Its excellent therapeutic effects were further confirmed through HE, Ki67, and TUNEL staining. Taken together, 5-FU–β-CD–PLA/TBC (86/14) can be retained in the stomach to improve relative bioavailability. This system represents a promising carrier not only for 5-FU but also for other poorly soluble drugs that require prolonged retention in the stomach.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Lin Li,Chao Feng,Haimei Xu,Ping He,Qisong Yi,Junxiang Jiang,Lu Lin,Jin Hou,Yuanshuai Liu
The catalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is an important reaction in the sustainable production of polymers from biomass resources. To advance the environmental sustainability of this process, it is crucial to develop a catalytic system that circumvents the need for liquid alkaline media, which have been conventionally employed in HMF-to-FDCA conversion. Herein, we developed an efficient catalytic system comprising Ru nanoparticles supported on Na-type zeolite Y (Ru/Na-Y) for the base-free oxidation of HMF to FDCA. Reducing the particle size of Ru significantly enhances the activity of the Ru/Na-Y catalysts. Specifically, the optimized Ru/Na-Y-300N-200H, featuring Ru nanoparticles with an average size of ∼2.5 nm, afforded nearly 100 % HMF conversion and ∼ 85 % FDCA yield under base-free aqueous-phase conditions at 100 °C and 5 MPa air pressure. Kinetic studies further evidenced that Ru/Na-Y-300N-200H could effectively catalyze the sequential oxidation of both alcohol and aldehyde groups during the HMF-to-FDCA conversion. Comprehensive characterizations and DFT calculations elucidated the enhanced interaction between Ru centers and Na sites in the Ru/Na-Y-300N-200H due to the smallest Ru particle size. The unique Ru-Na synergistic effect was thus realized, which could facilitate the activation of O 2 and the generation of O 2 •– radicals as active oxygen species, while simultaneously boosting the rate-determining step of 5-formyl-2-furancarboxylic acid (FFCA) oxidation to FDCA, resulting in a high FDCA yield. These findings unveil promising prospects for developing advanced metal-zeolite bifunctional catalysts, which could facilitate the base-free oxidation of biomass-derived HMF into FDCA.
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高影响因子
JOURNAL OF SEPARATION SCIENCE
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2013
·Vol. 36
·期 7
·1283-1290
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IF 2.591
Shaolei Yang,Chunyan Chen,Zhihong Yan,Qingyun Cai,Shouzhuo Yao
Metal-organic frameworks, a new class of materials with high surface area and great porosity, have been widely applied in gas sorption. It is generally known that metal-organic framework 5 cannot be applied in aqueous phase since it is water sensitive. However, this work reveals that the derived material of metal-organic framework 5 is a good SPE sorbent that can be applied to aqueous phases. Metal-organic framework 5 was prepared and used as a SPE sorbent for the determination of polycyclic aromatic hydrocarbons in environmental matrices coupling with HPLC. The water treatment induced changes in the properties were investigated in detail. Even though metal-organic framework 5 is conversed to a second phase after water treatment, it still shows high extraction ability. Under the optimized experimental conditions, good sensitivity levels were achieved with low LODs ranging from 0.4 to 4.0 ng L −1 and a linearity of 0.004–20 μg L −1 ( R 2 > 0.996) for the investigated polycyclic aromatic hydrocarbons. The method has been validated in the analysis of real water samples with recoveries in the range of 80.2–120.2% and RSDs in the range of 0.5–11.7%.
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JOURNAL OF HAZARDOUS MATERIALS
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2019
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IF 7.65
Weicheng Xu,Bingxu Chen,Xueding Jiang,Feng Xu,Xin Chen,Limin Chen,Junliang Wu,Mingli Fu,Daiqi Ye
The effect of Ca modification on the Ni/ZSM-5 catalyst for efficient toluene oxidation was studied in a plasma-catalytic system. The Ni/ZSM-5 and Ca-Ni/ZSM-5 catalysts were prepared by a wet impregnation method and characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), Pyridine-FTIR spectroscopy and temperature programmed desorption of ammonia (NH 3 -TPD). Among the catalysts tested, the Ca-Ni/ZSM-5 sample showed the best potential for toluene conversion (90.2%) and CO 2 selectivity (70.7%). Pyridine-FTIR spectra and NH 3 -TPD results proved that the introduction of Ca and Ni onto ZSM-5 caused a decrease in the strong and weak acidic sites. In addition, gas chromatography/mass spectrometry (GC-MS) result showed that the Ca-Ni/ZSM-5 catalyst reduced the production of undesirable byproducts (such as p-nitrotoluene and methyl benzoate). Calcium in the Ni/ZSM-5 system influenced the acidity and other surface characteristic of the catalyst, as well as directly impacting the reactive plasma species and the intermediates. Finally, possible reaction mechanisms in the plasma catalysis of toluene were also proposed.
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高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Shihong Zhang,Dongyan Li,Jie Huang,Wenjie Liu,Guoxing Jing,Wen Liu,Jianna Yu,Tiejun Song,Wenshan Li
Lead ion (Pb 2+ ) is a highly toxic heavy metal with strong bioaccumulation potential, posing serious risks to environmental and food safety. In this work, we developed a dual-trigger enhanced catalytic hairpin assembly (CHA) strategy for rapid and sensitive colorimetric detection of Pb 2+ using a GR–5 DNAzyme-mediated cascade reaction. A dumbbell-shaped hairpin probe was designed to form a dimeric complex through complementary palindrome sequences of H1, with its loop region containing a ribonucleotide adenosine (rA) site. In the presence of Pb 2+ , the GR–5 DNAzyme catalyzed cleavage at the rA site, generating a new dimeric complex that efficiently initiated the CHA reaction. This dual-trigger design significantly accelerated the CHA process through the localized high-concentration trigger sequence. Consequently, an intact G-quadruplex sequence was exposed, which produced a distinct colorimetric signal. The biosensor enables accurate quantification of Pb 2+ over the linear range of 0.5–100 nM, with a detection limit as low as 51.25 pM. Spiked recovery rates in drinking water and fish samples range from 96.61 % to 109.77 %, demonstrating the biosensor's accuracy and practical applicability. These results highlight the potential of this biosensor for real-time monitoring of Pb 2+ contamination in environmental and food samples, contributing to improved public health and safety.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.9
Yongxin Liang,Jinlong Liang,Wenhong Lei,Huamin He,Zuqiang Huang,Huayu Hu,Tao Gan,Yanjuan Zhang
Photocatalytic oxidation of 5-hydroxymethylfurfural (HMF) to 2,5-diformylfuran (DFF) represents a promising pathway for the valorization of biomass. However, this process still encounters challenges including low conversion efficiency and limited selectivity. To address these issues, a MnO 2 /potassium-doped carbon nitride (MnO 2 /K-CN) heterojunction photocatalyst, featuring abundant oxygen vacancies and intercalation structure, was synthesized for highly efficient and selective photocatalytic oxidation of HMF to DFF. Characterizations reveal that MnO 2 /K-CN with a large specific surface area facilitates the exposure of active sites and the mass transfer of reactants. Concurrently, the S-scheme heterojunction not only broadened the visible-light absorption range but also increased the density of oxygen vacancies in MnO 2 , effectively promoting the separation of photogenerated electron‒hole pairs. MnO 2 /K-CN induced the selective generation of superoxide radicals (•O 2 − ) and singlet oxygen ( 1 O 2 ) while suppressing the formation of hydroxyl radical (•OH), achieving high selectivity toward DFF. MnO 2 /K-CN achieved a HMF conversion of 98.6% and a DFF yield of 94.4%, while maintaining excellent catalytic stability. Theoretical calculations further reveal that MnO 2 /K-CN significantly reduced the energy barrier for the oxidation reaction of HMF, accelerating the oxidation kinetics. This study provides new insights for developing highly efficient and stable photocatalytic systems to achieve high-value-added utilization of biomass resources.
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高影响因子
DYES AND PIGMENTS
·
2014
·
IF 3.468
Kun Zhou,Chao Qin,Li-Kai Yan,Wen-E Li,Xin-Long Wang,Hai-Ning Wang,Kui-Zhan Shao,Zhong-Min Su
Three silver(Ι) alkynyl compounds, [Ag 5 (C C t Bu)(CF 3 COO) 7 ( n Bu 4 N) 3 ·H 2 O] ( 1 ), [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 (Et 3 N) 4 ] ( 2 ), and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ( n Bu 4 N) 2 (Et 3 N) 2 (CF 3 COO) 2 ] ( 3 ), have been obtained. Concomitantly, isolated [Ag 5 (C C t Bu)(CF 3 COO) 7 ] 3– , [Ag 8 (C C t Bu) 2 (CF 3 COO) 10 ] 4– and [Ag 12 (C C t Bu) 6 (CF 3 COO) 8 ] 2– clusters ( Ag 5 , Ag 8 and Ag 12 for short) appear in 1 – 3 , respectively. The synthesis of 1 – 3 demonstrates silver(I) alkynyls are better systems for the study of the template effect. ESI-MS analysis indicates compounds 1 – 3 can stably exist in methanol, and they have been proved to be potential wide gap semiconductor materials by the reflectance spectra. Notably, the second hyperpolarizabilities ( γ values) of Ag 5 , Ag 8 and Ag 12 have been studied by using time-dependent density functional theory (TDDFT) calculations and the finite filed (FF) approach combining CAM-B3LYP. The calculated results show that they can be applied as potential third-order nonlinear optical (NLO) materials owing to their second hyperpolarizabilities rising from 39.1 × 10 −36 , 60.3 × 10 −36 to 97.7 × 10 −36 esu with the growth of the number of Ag atoms and C C groups.
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高影响因子
Journal of Nanomaterials
·
2018
·Vol. 2018
·期 1
·1634814
·
IF 2.207
Lianbing Zhong,Guihong Geng,Yujin Wang,Feng Ye,Limeng Liu
A fully dense TaC ceramic was prepared by hot pressing using 10 mol% ZrC plus 5 mol% Cu as a sintering aid. Formation of (Ta, Zr)C solid solution (ss) by reaction between TaC and ZrC facilitated densification. Addition of Cu refined the microstructure and consequently improved flexural strength of the TaC ceramics. TEM investigation found ubiquitous precipitation of nanocrystallites at multigrain conjunctions. The nanocrystallites were (Ta, Zr)C solid solution with uniform dispersion in an oxygen-rich glassy matrix. Although formation of nanoprecipitates may not much affect the mechanical properties of the TaC ceramic, the structure suggested a new type of nanoceramic worth further research.
研究领域:
材料科学
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陶瓷学
·
固态化学
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显微结构分析
·
复合材料
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高影响因子
FUEL
·
2026
·
IF 7.5
Yuejin Zhan,Bi Luo,Jiaying Chen,Vasilevich Sergey Vladimirovich,Bilainu Oboirien,Qingang Xiong,Yefeng Zhou
During plastic catalytic pyrolysis, HZSM-5 faces challenges such as limited mass transfer and low active site utilization, resulting in poor aromatization and anti-deactivation performance. To address these challenges, a hollow HZSM-5 catalyst with a hierarchical micro- meso -macroporous structure was designed in this work. The structure–activity relationship of hollow HZSM-5 was then systematically explored, focusing on the influence of pore structure and acidic sites on catalytic performance. The hollow HZSM-5 catalyst without metal loading exhibited outstanding catalytic performance in the catalytic pyrolysis of plastics, with high selectivity of 95.79% for aromatic hydrocarbons (AHs) and 83.08% for monocyclic aromatic hydrocarbons (MAHs). More importantly, hollow HZSM-5 delivered outstanding stability with an initial performance retention of 95.75% after five cycles and achieved selectivity of AHs exceeding 86% for various polyolefin plastics. The excellent catalytic performance was attributed to the synergistic optimization of pore structure and acidic sites. On the one hand, the hierarchical porous structure significantly enhanced mass transfer, thereby improving the anti-deactivation performance and active site utilization of the catalyst. On the other hand, acidity enhanced by desilication efficiently promoted the aromatization of plastics. This work highlighted the importance of rational catalyst design in achieving efficient and stable catalytic pyrolysis of plastics toward valuable chemical products.
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高影响因子
PLANT AND SOIL
·
2026
·
IF 4.8
Chen Ji,Wang Yazhuo,Fan Zhongdi,Wang Conghu,Zhang Zihan,Liu Yuting,He Yanhui,Wu Zhansheng
Introduction Plant growth-promoting rhizobacteria (PGPR) colonize the rhizosphere and enhance plant growth, stress tolerance, and soil properties. To better harness these benefits, this study investigates the synergistic interaction between two PGPR strains— Bacillus subtilis SL-44 and Klebsiella oxytoca RS-5—and evaluates their combined effects on rapeseed growth through integrated direct and indirect mechanisms. Methods The plant growth-promoting traits (e.g., phosphate solubilization, siderophore and indole-3-acetic acid (IAA) production) and biofilm-forming capacity of individual strains and their consortium were characterized in vitro. Subsequently, pot experiments were conducted to evaluate their effects on rapeseed growth parameters and rhizosphere soil quality. Finally, the rhizosphere microbial communities were analyzed via high-throughput sequencing on the Illumina NextSeq platform. Results The co-culture consortium (SR) demonstrated synergistic enhancements in key plant growth-promoting traits and biofilm stability in vitro. Pot experiments confirmed that SR treatment most effectively promoted rapeseed biomass accumulation, improved physiological status, and elevated antioxidant capacity. It also optimally enhanced rhizosphere soil nutrient availability, enzyme activities, and selectively reshaped the microbial community by enriching beneficial taxa and increasing ecological network complexity. Ultimately, plant growth promotion was achieved through an integrated mechanism combining direct stimulation and microbiome-mediated soil improvement. Conclusion In summary, this study demonstrates that functional complementarity between PGPR strains drives synergistic growth promotion through combined direct stimulation and rhizosphere microbiome engineering, offering a framework for developing effective microbial consortia for sustainable agriculture. Graphical
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