ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
·
IF 4.1
Ren Jia,Guo Hao,Yang Zeyun,Yan Ruixue,Ma Jianpeng,Niu Wenting,Wang Mingyue,Yang Wu
Nitrofurazone, a commonly used nitrofuran antibiotic, is widely applied in antimicrobial therapy as well as in aquaculture and livestock farming. However, its residues can pose risks to human health and cause environmental pollution. Therefore, the development of a highly sensitive detection method for nitrofurazone is of great significance. In this study, a novel core–shell composite material, UiO@TATF COF, was prepared by in situ growing TATF COF on the UiO-66-NH 2 surface through a Schiff-base reaction using 4,4′,4″-(1,3,5-triazine-2,4,6-triyl) tris(benzaldehyde) (TFPT) and 1,3,5-tris(4-aminophenyl) benzene (TAPB) as monomers. Subsequently, by further introducing the conductive material carbon black (CB), a novel electrochemical sensor UiO@TATF COF/CB/GCE was successfully constructed. Covalently linked UiO@TATF COF achieves a robust core–shell interface and possesses a large specific surface area and abundant active functional groups. The resultant sensor system exhibits clear synergistic effects, enabling electrocatalysis and sensitive detection toward nitrofurazone in food, environmental, and ointment samples with a detection limit of 0.05 µM ( S / N = 3). Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Xuelian Wang,Hanyu Ma,Yongqiang Li,Liangfeng Chen,Caichao Ye,Yuhao Zhao,Hang Wang,Wanting Fu,Chen Yu,Fei Wang,Siwei Yang,Yuli Kang,Guqiao Ding,Zhen Li
Integrating the diagnostic and therapeutic functions of drugs poses challenges due to specific structural design requirements. However, the trial-and-error dilemma in performance-driven structural evolution of nanomaterials is unsatisfactory. Here, we propose a strategy using graphene quantum dots with sp 2 – sp 3 hybridized carbon frameworks for visualized, intelligent targeted clearance of metabolically reprogrammed senescent cells. We establish a structure-activity relationship between the complex nanostructures and photochemical reactivity. We show that property descriptor-based machine learning promotes the evolution of carbon nanostructures, endowing them with exceptionally high photodynamic efficiency. These machine-learning results also guide the design of carbon-based photo/electrocatalytic structures. By examining the interfacial transport properties of in situ carbon nanostructures in excited states, we identify changes in fluorescence and photodynamic activity of C 3 N quantum dots within metabolically reprogrammed cellular microenvironments. This allows fluorescence detection technology for senescent cells based on C 3 N quantum dots and an intelligent targeted clearance treatment plan. Designing complex carbon frameworks for specific applications often relies on trial-and-error. Here, authors integrate machine learning and interfacial mechanisms to evolve graphene quantum dot carbon frameworks, enabling selective detection and clearance of metabolically reprogrammed senescent cells.
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Natural Products and Bioprospecting
·
2026
·Vol. 16
·期 1
·73
·
IF 5.8
Li Xuan,Gu Qinghui,Hu Qile,Deng Tuo,Luo Lan,Cai Jianping,Dong Xudong,Wu Chunhua,Wu Mingyi
Bletilla striata is highly regarded in traditional Chinese medicine and has also gained widespread attention as a valuable medicinal plant resource. However, the molecular composition and bioactive potential of its polysaccharides present a significant knowledge gap. Herein, a specific glucomannan fraction, designated as BSP60, was purified from Bletilla striata tubers and subsequently subjected to structural, rheological, and biological evaluations. Comprehensive characterization via methylation-GC–MS, monosaccharide composition analysis, and 1D and 2D NMR techniques demonstrated that BSP60 possesses a β-(1 → 4)-linked backbone featuring alternating mannosyl and glucosyl units, with the mannose moieties exhibiting partial O -acetylation at their C-2 or C-3 positions (with an acetylation rate of 23.54%). Rheological studies showed that BSP60 aqueous solutions exhibit shear-thinning behavior and form an elastic-dominated viscoelastic network, with higher viscosity and storage modulus than dextran of comparable molecular weight, indicating enhanced intermolecular interactions. Biological assays revealed that the BSP60 effectively decreased the level of NO, IL-6, and TNF-α in LPS-triggered macrophages (RAW264.7). Furthermore, the scavenge ability of BSP60 to superoxide anion (O 2 •− ) and ABTS ⁺• radicals are significantly higher than that of hyaluronic acid. This study systematically characterizes the structural features of glucomannan derived from Bletilla striata , thereby establishing a robust scientific basis for its expanded utilization in the development of biomedical materials and functional cosmetic ingredients.
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Applied Nanoscience
·
2026
·Vol. 16
·期 3
·38
·
IF 3.869
Shi Yu
The application of magnetic nanoprobes based on nuclear magnetic resonance (NMR) technology offers a rapid and highly sensitive approach for detecting foodborne pathogenic microorganisms. To enhance the detection efficiency of nuclear magnetic resonance technology for Salmonella and similar pathogenic microorganisms in food, a new detection method was proposed. Firstly, Bio-PEG-MNPs with high water solubility and biocompatibility were obtained by modifying magnetic nanoparticles with chain shaped polyethylene glycol and biotin. Secondly, by analyzing its particle size distribution through dynamic light scattering, a dual antibody sandwich NMR detection system for salmonella was optimized and constructed. Finally, the lateral relaxation time of salmonella was rapidly measured using low field NMR, with a focus on optimizing the key parameters of the detection system. The experiments revealed that Bio-PEG-MNPs had monodisperse and stable properties at MNPs/PEG of 1:15 and MNPs/Bio of 1:21. The experimental parameters for optimal detection of signals were a biotinylated antibody concentration of 1 µg/mL, incubation time of 60 min for both salmonella and probe, and SA dosage of 1 µg/mL. The NMR sensor was able to specifically detect salmonella in PBS with a lower limit of detection of 100 CFU/mL, including a wide range of detections from 10 2 to 10 7 CFU/mL. The sensor was effective in detecting salmonella in milk and pork samples in the range of 10 2 ~ 10 7 CFU/mL and CFU/g. This suggests that the NMR biosensor is a practical and accurate method for identifying salmonella in food. The technique can be used to identify salmonella in actual samples, which will encourage the use of low-field magnetic resonance imaging.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
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2026
·Vol. 48
·期 6
·250
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IF 4.3
Ma Chuang,Liu XueMei
Lead (Pb) and cadmium (Cd) in soil threaten agroecosystem safety and human health. Due to the high bioavailability and mobility of heavy metals in red soil, the risk is further increased. Biochar is widely used for heavy metal immobilization, but original biochar suffers from inherent limitations. Most existing studies of iron (Fe)–manganese (Mn) modified biochar have not focused on red soil, and the relationship with soil–plant responses remains unclear. This study aimed to evaluate and compare the efficacy of sugarcane bagasse biochar (BC) and Fe–Mn modified sugarcane bagasse biochar (FMBC) for Pb and Cd immobilization in red soil, and clarify their effect on plant uptake. BC and FMBC were applied to Pb and Cd contaminated red soil for pot experiments with pak choi ( Brassica rapa chinensis ) as an indicator plant. The results showed that both BC and FMBC elevated soil pH, organic matter (SOM), enzyme activities, reduced Pb and Cd bioavailability, and transformed Pb and Cd to stable fractions. FMBC outperformed BC, and the 5% FMBC treatment achieved the optimal remediation efficacy. The 5% FMBC decreased the acid-extractable Pb and Cd by 9.33 and 34.40% compared to control. The plant biomass was significantly increased, Pb and Cd content in edible shoots met the limit standards, and bioconcentration (BCF) and translocation factors (TF) were lowered. Overall, this study establishes theoretical foundations and empirical bases for the application of FMBC to immobilize Pb and Cd in red soils, thereby providing a feasible and eco-friendly approach to support sustainable agriculture and the recycling of agricultural waste.
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Journal of Food Measurement and Characterization
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2026
·
IF 3.6
Peng Xinyue,Xiang Zhongda,Ma Zheng,Zhao Chuchu,Li Xiaodie,Yuan Ya,Liu Shan,Liu Yao,Zhang Ting,Dai Juan
Pomelo flower essential oil (PFEO) has been reported to possess various pharmacological activities; however, differences among cultivars remain unclear. In this study, PFEO was extracted from four pomelo cultivars (Xindu, Tai, Honey, and Longan), and differences in their volatile components were analyzed using GC×GC-MS. In addition, the DPPH•, ABTS•⁺, and NaNO₂ scavenging activities of Xindu PFEO, which showed the highest extraction yield, were evaluated. Furthermore, the anti-inflammatory activities of Xindu PFEO and its major component, farnesol were also assessed. In the results, a total of 184 volatile compounds, mainly terpenoids and their derivatives, were identified in the four PFEOs, with significant varietal differences in both composition and relative abundance. Xindu PFEO showed maximum scavenging rates of 62.33%, 92.33%, and 37.33% against DPPH•, ABTS•⁺, and NaNO₂, respectively. Both Xindu PFEO and its major component, farnesol, exhibited inhibitory activity against 5-LOX. Furthermore, 40 µM farnesol significantly suppressed the expression of IL-1β, IL-6, and TNF-α in LPS-induced RAW 264.7 cells. These findings improve the understanding of varietal differences and bioactivities of PFEO and provide a basis for the development of PFEO-based functional foods.
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Nature Communications
·
2026
·
IF 18.1
Xu Rongfu,Chen Ningxin,Yuan Zichan,Guo Zihan,Deng Jie,Chen En,Yan Yinglin,Wang Xianhui,Chen Chaoji,Wang Zhaohui
Aqueous batteries offer inherent safety and low cost, but the inherently fixed physicochemical functionality and poor interfacial compatibility of existing binders limit their ability to boost positive electrode performance. Here we present a hydroxyl-chemistry regulation strategy that transforms cellulose, an abundant biopolymer on Earth, into a high-affinity, interfacially compatible binder that stabilizes high-capacity, shuttling-prone positive electrodes. By selectively opening the rigid cellulose ring structure within its molecular chains, we enhance dipole polarity, chain flexibility, and intermolecular hydrogen-bond density, thereby increasing functional-group accessibility and interfacial adhesion. These molecular-level modifications drive the formation of a dense nanofibrous network that conformally encapsulates active particles and anchors polyiodides, accelerating redox kinetics and reinforcing electrode stability. Iodine positive electrode incorporating the engineered binder deliver a reversible capacity of 150.9 mAh g −1 at 20 A g −1 , with pouch cells retaining 98.07% capacity after 3000 h at 0.2 A g −1 . The binder also enables layer-by-layer fabrication of high mass loading electrodes, and benefits other dissolution-prone positive electrodes such as V 2 O 5 . Overall, this work establishes a general and sustainable route for the molecular engineering of biopolymer binders, expanding their role in the design of advanced aqueous batteries.
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JOURNAL OF SOLUTION CHEMISTRY
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2025
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IF 1.3
Cai Weibin,Meng Hui,Zhou Qibo,Zeng Minzhi,Gai Hengjun
This study experimentally measured the liquid–liquid equilibrium (LLE) data for the cyclohexanol + phenol + water system at three specific temperatures (298.15 K, 308.15 K, and 318.15 K) under standard atmospheric conditions, and these data were subsequently utilized to compute the distribution coefficients ( D ) and separation factors ( S ), which served as critical indicators for evaluating cyclohexanol's performance in extracting phenol. Quantitative analysis indicates that for systems with phenol concentrations above 0.0015, cyclohexanol is not only a significantly better extractant than cyclohexanone, but also has stronger temperature adaptability. Additionally, the non-random two liquid model and the universal quasi-chemical model were employed for correlation analysis of the experimental data, yielding binary interaction parameters and root-mean-square deviation (RMSD) values, with the RMSD consistently remaining below 0.32 across all tested temperatures, thereby validating the strong agreement between the model predictions and the experimental data.
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ECOTOXICOLOGY
·
2026
·Vol. 35
·期 5
·122
·
IF 2.7
Li Wenyu,Ouyang Tian
Microplastics (MPs) are ubiquitous contaminants in aquatic ecosystems and frequently co-occur with plasticizers such as phthalate esters (PAEs). While the combined toxicity of pristine MPs and pollutants has been increasingly reported, the role of environmentally relevant aged MPs in modulating co-contaminant toxicity remains critically understudied. Here, zebrafish ( Danio rerio ) embryos were exposed for 7 days to diisobutyl phthalate (DIBP), pristine polyethylene MPs (PE-MPs; ~0.3 μm), artificially aged PE-MPs (via UV treatment), and their binary mixtures. Results showed that DIBP exposure induced developmental inhibition, oxidative stress, and disruption of thyroid hormone homeostasis, with the severity of these effects generally increasing with concentration over the tested range (1, 10 and 100 µg/L). Both pristine and aged PE-MPs independently triggered oxidative and endocrine disturbances, with aged particles exhibiting greater intrinsic toxicity. Crucially, co-exposure outcomes diverged dramatically based on MP aging status: pristine PE-MPs partially alleviated DIBP toxicity, an effect we infer to be associated with reduced contaminant bioavailability, a process commonly attributed to adsorption by pristine MPs; conversely, aged PE-MPs significantly exacerbated DIBP-induced adverse effects, particularly on thyroid hormones. These findings highlight that microplastics not only act as contaminants in their own right but also serve as dynamic vectors whose capacity to modulate the bioavailability and toxicity of coexisting pollutants is critically shaped by environmental aging. Rather than functioning as passive carriers, aged MPs become active toxicological participants, thereby amplifying the ecological risks of MP–pollutant mixtures in aquatic environments.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2026
·
IF 3.1
He Shuangyi,Zhao Weiwei,Zhang Shuai,Li Tianbao,Luo Jujie
Cu − Bi bimetallic material with excellent electrochemical performance was successfully fabricated on iron foam via a one-stop microwave method. Under the optimal microwave power, heating time, and metal molar ratio, metallic Bi presents a needle-like morphology, interconnects to form a network, and is coated with Bi. This unique structure endows the Cu − Bi bimetal with the best electrochemical performance. Meanwhile, metallic Fe undergoes redox reactions in the alkaline electrolyte, which further enhances the capacitance value. The electrode prepared under the optimal synthesis conditions achieves an impressive areal capacitance value of 7.55 F cm −2 when tested at 1 A cm −2 , and it maintains 77.47% of its initially measured capacitance even after undergoing 15,000 long-term charge–discharge cycles, demonstrating excellent electrochemical stability. The assembled asymmetric supercapacitor device retains 84.1% of its original capacitance after 20,000 cycles. A power density value of 1185 μW cm −2 is realized when the energy density reaches 766.96 μWh cm −2 .
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2026
·Vol. 34
·期 7
·164
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IF 5.6
Zhao Zhenxiao,Jia Jun,Zhang Ning,Hu Jing,Qi Chao,Feng Jingyuan,Li Haiyang,Qin Yi,Wang Guoqiang
To improve the ductility of polylactic acid (PLA) and broaden its application, we synthesized poly(butylene glutarate-co-2,5-furandicarboxylate) (PBGF) via melt polycondensation from 2,5-furandicarboxylic acid (FDCA), glutaric acid (GA) and 1,4-butanediol (BDO). We prepared PLA/PBGF blends from PLA and PBGF at mass ratios of 90/10, 80/20, and 70/30. The chemical structure and molecular weight of PBGF were characterized. The thermal properties, mechanical properties, microstructure, crystal structure and processability of the blends were studied by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), tensile test, dynamic thermal mechanical analysis (DMA), scanning electron microscopy (SEM), X-ray diffraction (XRD) and rheological analysis. The results showed that the random copolyester PBGF was successfully synthesized. Its number-average molecular weight ( M n ) was 36,200 g/mol, weight-average molecular weight ( M w ) was 84,900 g/mol, and polydispersity index ( D ) was 2.3. PBGF is a crystalline material, while PLA/PBGF blends have an approximate amorphous structure. With the increase of the PBGF content from 0 wt% to 30 wt%, the elongation at break increased significantly from 10.3% to 255.2%, the glass transition temperature ( T g ) decreased from 61.18 ℃ to 57.59 ℃, and the fracture mode changed from brittle fracture to ductile fracture. SEM and DMA confirmed PLA and PBGF had partial compatibility, island structure was formed in the blend, and shear bands appeared after stretching, which effectively improved the energy absorption capacity. Rheological tests showed that PBGF improved the processing stability of PLA. In this study, the ductility of PLA was improved by PBGF, which provides a new way to prepare high-performance biodegradable polymer.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Zhang Wei,Shu Jia,Gong Chonghai,Zhou Song,Wang Hanting,Feng Kunyang,Liu Dongmei,Chen Rui,Li Juan,Zhang Zhengwei,Li Siqiao
Multi-enzyme cascade reactions offer powerful amplification and accelerated biotransformation, yet their implementation in free-solution systems is limited by enzyme instability, diffusion losses, and low coupling efficiency. Here, we reported a spatially confined multi-enzyme cascade nanoreactor (AChE/CHO/HRP@MSN) constructed by co-immobilizing acetylcholinesterase (AChE), choline oxidase (CHO), and horseradish peroxidase (HRP) within amino-functionalized mesoporous silica nanoparticles (MSN-NH 2 ). The ordered mesoporous architecture provides high loading capacity, efficient substrate channeling, and enhanced structural stability, enabling tightly coupled multi-step biocatalysis even in complex environments. The AChE/CHO/HRP@MSN platform supports dual-mode colorimetric and fluorescent sensing of organophosphorus pesticides (OPs) and enables real-time monitoring of pesticide degradation in plants. By coupling with a smartphone-readable hydrogel matrix, the system enables portable signal output and on-site visual monitoring of OP residues. This spatially organized, cascade-driven strategy not only addresses longstanding limitations in multi-enzyme system design but also provides a versatile framework for programmable biosensing in complex environments. Graphical The alternative text for this image may have been generated using AI.
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