MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 4
·1-13
·
IF 5.3
Zhou Mengyan,Zhang Zhihui,Zheng Qi,Yu Mingdi,Si Mengxu,Wu Sirui,Zhang Yanan,Ding Shushu,Fu Ding-Yi
A novel ratiometric fluorescent nanohybrid probe was constructed for sensitive and selective determination of folic acid (FA) based on blue D-penicillamine-based carbon dots (CDs) and red glutathione S-transferase-Au nanoclusters (GST-AuNCs). Upon the excitation of 380 nm, the obtained CDs-NCs possessed two distinct emission peaks at 465 and 665 nm. The fluorescence intensity at 465 nm was incrementally enhanced with the addition of FA attributed to the hydrogen bonds formation, while the fluorescence intensity at 665 nm was quenched caused by the electronic interaction and the inner filter effects. The fluorescence intensity ratio ( I 465 /I 665 ) exhibited good linear correlation with FA concentrations in the range 10∼90 μM, and the limit of detection (LOD) was 0.63 μM. Notably, the corresponding fluorescent color changed from red to blue, which could be distinguished by naked eyes. On account of the excellent biocompatibility, the CDs-NCs were further successfully used for bioimaging and intracellular FA detection. Furthermore, the real sample analyses confirmed that the proposed nanoprobe could be expanded as a versatile platform for FA detection in practical applications. Graphical abstract
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高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Tianna Wu,Shuo Yang,Wei Feng,Kaiyue Li,Yanru Li,Lili Wang,Rui Chen,Xiaodong Yang,Lulu Liu,Donglai Han
Equipped with surface-enhanced Raman scattering (SERS) effect and magnetic manipulation capacity, a new paradigm of recyclable SERS substrates based on Fe 3 O 4 nanoparticles (NPs) @SiO 2 @PEI-DTC adhesive layer @Au-Ag alloy quantum dots (QDs) were successfully prepared via engineering hydrothermal and seed deposition techniques. The SERS performance and uniformity of those substrates with different gold-silver (Au-Ag) weight ratios were evaluated by 4-aminothiophenol (4-ATP) molecules, revealing that the relative standard deviations (RSDs) of all substrates were less than 12 %, with the optimal SERS substrate achieving an enhancement factor (EF) of up to 1.39 × 10 5 . This phenomenon can be attributed to the magnetic core and plasmonic resonance properties of Au-Ag alloy QDs, which result in abundant interparticle hotspots in the Fe 3 O 4 @SiO 2 @PEI-DTC@Au-Ag (FSPAA) nanocomposites. Furthermore, the optimal FSPAA nanocomposite was employed as a SERS substrate for rapid non-destructive detection of thiram on fruit surfaces. The SERS signal intensity exhibited a robust manifesting a linear association with thiram concentration within the span of 1 × 10 −4 to 1 × 10 −9 M, and the minimal detectable concentration was 1.04 × 10 −10 M. The FSPAA core–shell nanocomposites exhibit high reusability and reliability and hold great promise for the practical applications in on-site assessment of food/environmental safety, as well as in spectroscopic identification of molecules adsorbed onto fruit surfaces.
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ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Li Tan,Wenyi Zhang,Ziqi Lian,Yu Wang,Wenjing Gao,Tao Zeng,Yun Chen,Meng Yu,Benlin Hong,Rongkai Ye,Ying Ma,Yuchan Liu,Jianqiang Hu,Jiaju Mo,Aiqing Li
ABSTRACT MicroRNAs (miRNAs) are important biomarkers for tracking occurrence and development of many diseases, therefore, the reliable, sensitive, fast and accurate detection of miRNAs plays an extremely critical role in clinic diagnosis and treatment of early stage diseases. Herein, we developed ultrasensitive electrochemiluminescence (ECL) biosensor constructed by luminol-diazonium ion functionalized Au/MXene nanocomposites for early stage detection of kidney disease in human. The synergistic effect of MXene and Au nanoparticles significantly enhanced the ECL emission of luminol up to 6.9-fold due to their shortened electron transfer distance and excellent catalytic performance. The loading efficiency of luminol on MXene could be as high as ∼7%, enabling the enrichment of luminol on MXene nanosheets. The enhanced ECL signal and excessive loading of luminol allowed the Au-MXene-luminol as an excellent ECL labeling agent, which was further developed for the determination of miRNA-377 according to the sandwich-like assay. The as-developed miRNA-377 biosensor had ultrahigh sensitivity, wide linear range (from ∼50 aM to ∼1 nM), low limit of detection (∼13.2 aM) and high selectivity (∼82.6%) for highly homologous miRNA with mismatched single-bases. The ultrasensitive ECL biosensor was successfully applied to determine miRNA-377 in the serum samples of early stage kidney patients, which were well consistent with the clinic standard of quantitative real-time polymerase chain reaction method. The ultrasensitive ECL-labeling biosensor with high selectivity is very promising for universally screening any kinds of biomarkers with corresponding specific targets.
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RARE METALS
·
2025
·
IF 11
Guo Jing,Mu Zhi-Mei,Yu Jing,Sun Guan-Liang,Hou Lin-Rui,Qiao Xue-Zhi,Yang Shi-Kuan,Zhang Xing-Shuang,Xu Guan-Chen,Liu Guo-An,Yang Fan,Yuan Chang-Zhou,Liang Xiu
Metal–organic framework materials exhibit considerable potential as molecularly selective surface-enhanced Raman spectroscopy (SERS) substrates because of their microporous structures, which enrich small molecules while excluding larger ones. In this study, we develop a template-assisted chemical-etching strategy to prepare layered tuneable SERS substrates based on hierarchical porous zeolitic imidazolate framework-67 (HP-ZIF-67) with a rhombic dodecahedral structure. The synergistic SERS enhancement mechanisms of HP-ZIF-67, which combine electromagnetic (EM) and chemical (CM) effects, were systematically studied through numerical simulations and experiments. Calculations revealed that under 633-nm laser excitation, the contributions of the EM and CM effects to the total SERS enhancement factor of HP-ZIF-67 were 60% and 40%, respectively. The hierarchical porous structure enhanced the fluid-flow flux over the microporous ZIF-67 because the increased pore radius reduced the viscous resistance and facilitated rapid molecular transport through the interconnected macro-meso-channels. Precise modulation of the CM and EM effects, combined with enhanced mass transfer, facilitated the development of HP-ZIF-67 and HP-ZIF-67@Au as efficient SERS sensors. An investigation of the relationship between pore-size distribution and EM effects revealed the pivotal role of light confinement by whispering-gallery-mode microcavities in enhancing the SERS performance. The optimised HP-ZIF-67@Au composites functioned as flexible and highly sensitive in situ SERS sensors for gases and liquids, including volatile organic-compound gas and liquid-pesticide residues. This study introduces a novel design concept and provides a robust theoretical foundation for the future development of exhaled-breath point-of-care diagnostic devices and sweat-based wearable biomedical sensors. Graphical abstract
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 45
·19206-19219
·
IF 2.7
Li Cui,Fei Wang,Xiaoli Zhang,Yuewen Chen,Hai Liu,Yihu Ke,Yimin Wang,Xiya Zhang
The oxidation of glycerol to dihydroxyacetone (DHA) represents an efficient and economical process route. Although preparing Au/CuO catalysts from plant constituents has emerged as a novel approach for synthesizing biocompatible products, the complexity of plant constituents means that the active components still need to be clarified, making it challenging to control catalytic activity. In this study, we effectively separated and identified the active components of Syringa oblata Lindl. (SoL) leaf using column chromatography, and synthesized a series of Au/CuO catalysts from the different separated samples. Glycerol catalytic evaluation experiments showed that the S3 fraction, mainly consisting of phenolic substances, exhibited the highest catalytic activity, with a glycerol conversion rate of 86.6% and DHA selectivity of 82.0%, exceeding the activity of most current catalysts. A series of experiments and characterizations demonstrated the differences in reducibility and protective ability among the separated samples, and the preparation and glycerol reaction conditions for optimal performance are systematically optimized. This work provides in-depth insights into the preparation of catalysts using plant-based methods.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-15
·
IF 5.3
Yang Rong,Wang Qian,Zhu Ling,Shen Xiaodong,Cao Yang,Wang Yifeng,Xin Wenbo
A facile, one-pot synthesis method is proposed for the in situ growth of multibranched gold (Au) mesocrystals on polydopamine (PDA)-modified three-dimensional (3D) carbon nanotube (CNT) foams using cetyltrimethylammonium bromide (CTAB) and silver nitrate (AgNO 3 ) as shape-directing agents. The synthesized Au mesocrystals exhibit complex 3D architectures composed of ultra-long branches (exceeding 1 μm) with sharp tips and serrated edges. Their morphology can be precisely tuned on CNT foams by adjusting the concentrations of CTAB and AgNO 3 in the growth solutions. The resulting CNT foam-multibranched Au mesocrystal hybrids exhibit high surface-enhanced Raman scattering (SERS) sensitivity, enabling the detection of rhodamine 6G and thiram at concentrations as low as 1 × 10 –11 M and 1 × 10 –10 M, respectively. Additionally, the 3D SERS substrates exhibit excellent uniformity, reproducibility, and long-term stability, maintaining high SERS activity after 10 weeks of storage. Importantly, the SERS substrates achieve sensitive detection of thiram on apple peels down to 2.4 ng/cm 2 . This work provides a promising strategy for the efficient fabrication of high-performance 3D SERS platforms for practical sensing applications. Graphical
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-10
·
IF 5.3
Dong Huahua,Qv Kaige,Zhu Qunyan,Li Jinshuo,Liu Chang,Zhang Lin,Yang Wensheng
A closed bipolar electrode-based electrochemiluminescence (cBPE-ECL) sensor was developed for wireless uric acid (UA) detection. In the cBPE-ECL sensor design, a cobalt-based metal–organic framework (Co-MOF)-derived Au/CoO-modified carbon cloth (Au/CoO-C/CC) electrode served as a polarized anode for UA oxidation, where the generated faradaic current triggered the cathodic ECL of [Ru(bpy) 3 ] 2+ -[S 2 O 8 ] 2− at the polarized cathode electrode, enabling both quantitative and visual UA detection. The polarized anode was fabricated by incorporating Au nanoparticles into a Co-MOF structure on carbon cloth (CC), yielding an open architecture with enhanced charge transfer capabilities that significantly improved electrocatalytic activity toward UA. The as-prepared cBPE-ECL sensor exhibited excellent analytical performance, featuring a wide linear range (10–1000 µM), low detection limit (6 µM), high stability, good reproducibility, and strong anti-interference capabilities. The practical utility of this cBPE-ECL sensing platform was validated through successful UA detection in fetal bovine serum and artificial serum samples, achieving recoveries between 96.4 and 103.4%, demonstrating its potential for UA detection in clinical and biomedical applications. Graphical abstract
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Quanhong Ou,Yehao Zuo,Yunhua Li,Xuan He,Lun Li,Gang Liu,Junqi Tang,Weibin Zhang
The integration of noble metals onto semiconductor surfaces has become a key focus in advancing surface-enhanced Raman spectroscopy (SERS) research. Two-dimensional materials such as MoS 2 are valued for their exceptional thermal and chemical stability, making them promising candidates for advanced SERS sensor development. In this study, we synthesized flower-like MoS 2 microspheres (~380 nm in diameter) through a facile hydrothermal method and functionalized their surfaces with gold nanoparticles (AuNPs) to produce MoS 2 @Au composites. Rhodamine 6G, used as a Raman probe, revealed that the enhancement factor of the MoS 2 @Au system increased substantially from 2.78 × 10 5 to 3.79 × 10 7 , and the detection limit improved to an impressive 3.13 × 10 −10 mol/L—exhibiting a two-order-of-magnitude improvement in sensitivity compared with pristine MoS 2 . Detecting trace tramadol hydrochloride holds immense significance. It enables the precise identification of minuscule drug quantities, facilitating early detection of abuse. This provides crucial support for clinical treatment, rehabilitation interventions, and holds vital importance in judicial appraisal and related fields. The composite demonstrated exceptional proficiency in detecting tramadol hydrochloride, achieving an unprecedented detection limit of 10 −10 mol/L, well below clinically relevant thresholds. Finite-difference time-domain simulations revealed the spatial distribution of the electromagnetic field, while density functional theory calculations elucidated the intricacies of charge transfer and bandgap modulation upon tramadol adsorption. These theoretical insights uncovered the fundamental mechanisms driving the observed SERS enhancement. Experimental validation confirmed that AuNP modification substantially enhanced charge transfer efficiency, highlighting the synergistic contributions of electromagnetic and chemical enhancement effects in improving SERS sensitivity. This work not only deepens our understanding of SERS phenomena but also broadens its potential applications in biomedical sensing.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zixuan Wang,Wei Ran,Juan Shen,Yuanyuan Cao,Zhongzhong Wang,Simeng Zhang,Rongzhang Hao
The detection of volatile organic compounds (VOCs) markers in exhaled breath based on surface-enhanced Raman scattering (SERS) technology is expected to become a non-invasive diagnosis method for lung cancer patients. However, the inherently low Raman scattering efficiency of trace VOCs in exhaled breath, coupled with the inadequate stability and uniformity of conventional Raman substrates, has hampered the practical application of SERS technologies for lung cancer biomarker detection. Additionally, the development of nanomaterials that simultaneously exhibit superior electromagnetic enhancement capabilities and efficient molecular enrichment functions remains a significant challenge. Herein, we have reported a size-effect-driven strategy for constructing Au nanocube (Au NC) @ zeolite imidazolate framework-8 (ZIF-8) core-shell nanoparticles. Tunability of Au NC@ZIF-8 shell thickness from 3 nm to 40 nm was achieved through cetyltrimethylammonium bromide (CTAB) concentration gradient control (0.5–2 mL) and ice bath kinetics control. This method requires no harsh conditions, featuring simple operation, mild reaction, and short synthesis time, successfully fabricating thin ZIF-8 shell layers with controllable structural properties. This unique architecture integrates the strong localized surface plasmon resonance (LSPR) effect of Au NCs with the porous adsorption capability of ZIF-8, realizing ultrasensitive detection of benzaldehyde (BA) with a limit of detection (LOD) of 2.5 ppb. As a straightforward approach for synthesizing homogeneous and controllable core-shell SERS-active nanoparticles, this method not only offers valuable insights for the preparation of analogous core-shell materials but also provides a robust material foundation and technical support for the non-invasive screening of lung cancer.
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高影响因子
TALANTA
·
2017
·
IF 4.162
Kangning Zhang,Xiaoling Chen,Zhuang Li,Yan Wang,Sen Sun,Li’na Wang,Tong Guo,Dongxia Zhang,Zhonghua Xue,Xibin Zhou,Xiaoquan Lu
In this work, a novel nanohybrid (AuPtNPs/S-NS-GR) of well-defined Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on sulfonated nitrogen sulfur co-doped graphene (S-NS-GR) was developed. Firstly, nitrogen sulfur co-doped graphene (NS-GR) was synthesized by one-step thermal annealing method. Secondly, phenyl SO 3 H- group was introduced onto the surface of NS-GR via diazotization reaction, which could provide more binding sites for the formation of metal nanoparticles . Finally, Au-Pt bimetallic nanoparticles were anchored on the surface of S-NS-GR by using electrochemical deposition . The prepared material was characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDS), Raman spectroscopy and electrochemical impedance spectra (EIS). In addition, the electrocatalytic activity towards dopamine (DA) and uric acid (UA) was systematically studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Under optimum conditions, the linear ranges for the detection of DA and UA were 1.0 × 10 −8 – 4.0 × 10 −4 M and 1.0 × 10 −6 – 1.0 × 10 −3 M with the limits of detection (LOD, S/N = 3) of 0.006 μM and 0.038 μM, respectively. Furthermore, the modified electrode was applied to real sample analysis.
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Materials Research Express
·
2023
·Vol. 10
·期 5
·055003
·
IF 2.3
Yuheng Zhang,Yanan Wang,Shuai Yang,Fangyu He,Jun Yan,Zhengwen Yang,Dacheng Zhou,Qi Wang,Jianbei Qiu
The construction of metal/semiconductor heterostructures is a useful technique for improving the electron-hole separation of Semiconductor Photocatalysts. However, there only are a few studies on the mechanism of electron transfer between metal/semiconductor heterostructures. Therefore, through the intelligent design of the material structure, two metal/semiconductor heterostructures (Au/W18O49 heterostructure) were fabricated with identical composition but different structures by different preparation methods: (1) The heterostructure of Au nanoparticles at the tip of sea urchin W18O49 was achieved through photoreduction method; (2) the heterostructure of Au nanoparticles at the root of sea urchin W18O49 was achieved via chemical reduction method, and their electron transfer paths were studied. The results demonstrated that the two materials went through completely different electron transfer paths, and these different electron transfer path also leads to an opposite set of photocatalytic properties. The heterostructure achieved through photoreduction has the best photocatalytic performance. Nevertheless, the photocatalytic performance of the heterostructure prepared by chemical reduction is far inferior to that of the heterostructure prepared by photoreduction, and even inferior to the original W18O49 sample. Therefore, we believe that the structural characteristics of metal/semiconductor heterostructure have a great influence on the electron transfer path. Our work renders useful information that may facilitate the design of heterostructure photocatalyst based on metal/semiconductors.
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Zhengtao Li,Lingjun Geng,Jiashuai Sun,Jingcheng Huang,Rui Xu,Zhen Guo,Shouyi Dou,Liying Zhang,Fangling Du,Yemin Guo,Xia Sun,Nortoji A. Khujamshukurov
Au@PtNPs displayed superiority in antibody binding efficiency and signal intensity. • Multifunctional Au@PtNPs were employed to construct dual-signal ICTS. • Au@PtNPs-ICTS demonstrated excellent performance in thiamethoxam detection. • Au@PtNPs-ICTS could change identification components to detect different targets. Immunochromatographic test strip (ICTS) is a rapid analytical technique widely used in environmental and food detection owing to its merits of simple operation and short analysis time. Herein, three-dimensional nanoflower-structured gold‑platinum nanoparticles (Au@PtNPs) were synthesized via a seed-growth method. Compared with conventional gold nanoparticles (AuNPs), Au@PtNPs exhibited stronger signal intensity, excellent catalytic performance, and efficient antibody binding efficiency. Colorimetric Au@PtNPs-ICTS and catalytic colorimetric Au@PtNPs-ICTS were developed for the sensitive detection of thiamethoxam (THI) in vegetables. The limits of detection (LODs) for colorimetric Au@PtNPs-ICTS and catalytic colorimetric Au@PtNPs-ICTS quantitative analysis were 0.18 ng/mL and 0.093 ng/mL, respectively, representing approximately 3-fold and 6-fold improvement compared to AuNPs-ICTS (0.56 ng/mL). Furthermore, highly sensitive detection of multiple pesticide residues (chlorpyrifos, acetamiprid, and imidacloprid) was achieved by replacing the corresponding target antigens and antibodies, which further verified the universality of this immunochromatographic strategy. Fig. 1. (A) Schematic of the preparation process of AuNPs and Au@PtNPs; (B) Schematic of the preparation process of Au@PtNPs-mAb and AuNPs-mAb probes; (C) Schematic diagram of ICTS structure; (D) Schematic diagram of the detection process of Au@PtNPs-ICTS. Download: Download high-res image (151KB) Download: Download full-size image
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高影响因子
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