EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Yao Fan,Qiaohui Lu,Wencheng Liang,Youchang Wang,Yan Zhou,Meidong Lang
In this work, polyvinyl alcohol (PVA) with antimicrobial properties (QPVD), which were modified by 2-(Dimethylamino)ethyl methacrylate (DMAEMA) and 1-bromobutane. QPVD/chitosan (CS) composite sponge dressing (QPVDC) were prepared using freeze-drying process and cross-linked with glutaraldehyde vapor. Interestingly, compared with CS wound dressing, water absorption and flexibility of QPVDC wound dressing could be significantly improved with QPVD introduced. Among them, the water absorption of QPVDC sponge was up to 2300% and the elongation at break increased by 40–113%. In addition, QPVDC sponges with more quaternary ammonium could improve higher antibacterial activity, and the highest antibacterial activity of QPVDC sponges was close to 100% against E. coli and S. aureus . The results of hemolysis and cytotoxicity in vitro indicated that QPVDC wound dressing had excellent hemocompatibility and cytocompatibility. In summary, QPVDC wound dressing could protect from bacterial infection and accelerate wound healing. Thus, QPVDC had high potential application value for wound dressing.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Shumin Wang,Xiaoguo Ji,Shumin Chen,Chunyue Zhang,Yibing Wang,Haodong Lin,Liming Zhao
Stanching severe traumatic bleeding requires hemostatic materials that can provide rapid and efficient hemostasis. However, most currently available hemostatic agents exhibit low efficiency and poor biocompatibility. In this study, a novel carboxymethyl chitosan modified with methacrylic anhydride (double-bonded carboxymethyl chitosan)/cysteamine-modified chondroitin sulfate (Me-CMC/CSS) rapid hemostatic dressing was developed using thiol-ene click chemistry. The freeze-dried Me-CMC/CSS dressings absorbed water rapidly and transformed into soft hydrogels that could seal wounds, achieving good hemostasis. The relative blood clotting index of the optimal Me-CMC/CSS dressing was decreased by 53% ( p < 0.001) and 29% compared with a pure Me-CMC dressing and a commercial hemostatic gelatin sponge, respectively. In a rat liver hemorrhage model, the Me-CMC/CSS dressing stopped bleeding rapidly, and the total blood loss was significantly decreased by 92% ( p < 0.0001) compared with the untreated group and was lower than that with gelatin sponge treatment. The Me-CMC/CSS dressing also exhibited a higher ability to adhere to platelets than the gelatin sponge. Furthermore, the Me-CMC/CSS dressing exhibited good hemocompatibility and cytocompatibility. The results indicate that the composite dressings can be potentially applied as rapid hemostatic materials.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2021
·Vol. 30
·期 3
·855-866
·
IF 3.667
Wang Zhihui,Wang Yanfei,Yao Chen
In this study, Polyethyleneimine modified magnetic chitosan (MCS-PEI) was synthesized by grafting polyethyleneimine onto chitosan and adding magnetic Fe 3 O 4 with sodium polyphosphate as crosslinking agent. The structure of the prepared material was characterized by FT-IR, SEM, EDS, XRD and XPS, which showed MCS-PEI was successfully synthesized. After a series of single factor experiments, the adsorption data fitted well with the Langmuir model ( R 2 = 0.99), being the maximum adsorption capacity equal 181.8 mg g −1 . The pseudo-second-order model ( R 2 = 0.997) and Dubinin-Radushkevich model ( R 2 = 0.9598) indicated that the adsorption process was chemical adsorption. And thermodynamic studies showed that the adsorption was spontaneous and exothermic. The adsorption rate decreased by no more than 4% after the four adsorption–desorption experiments. This work illustrates that MCS-PEI is an environmental friendly, efficient and low-cost adsorbent.
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Heliyon
·
2022
·
IF 3.776
Suwei Jiang,Hailiang Hu
In this paper, we explore the adsorption potential of catechin (CT) loaded composite microspheres and provide a new micron scale carrier of functional factor. Chitosan (CS) modified rice porous starch (RPS/CS) was used as a CT adsorption carrier to prepare bioactive CT-loaded composite microspheres (CT@RPS/CS). The adsorption kinetics, storage characteristics, and biological activity maintenance of CT@RPS/CS were studied in an aqueous solution, and the sustained-release characteristics of CT@RPS/CS were studied in vitro during simulated gastrointestinal digestion. An aqueous solution further studied the removal characteristics of adsorbed heavy metal ion Pb 2+ . RPS/CS can significantly improve the ability to adsorb CT. RPS/CS can also significantly improve CT's storage stability, antioxidant stress, and slow-release characteristics, and the sustained release effect in gastric and intestinal juice. CT@RPS/CS can be removed Pb 2+ by adsorbing in the solution, and their adsorption was physical adsorption and chemisorption, but the primary interaction is chemisorption. CT@RPS/CS can be used as a micron carrier of new food functional factors, which has potential space for improving and expanding the functional characteristics of its loaded functional factors and the endowing of new functions.
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高影响因子
Regenerative Biomaterials
·
2020
·Vol. 7
·期 4
·381-390
·
IF 4.882
Liu Zhu,Ye Weilong,Zheng Jingchuan,Wang Qindong,Ma Guowu,Liu Huiying,Wang Xiumei
Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration, which usually demands appropriate carriers like microspheres (MS) to control drugs releases. Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate. In this study, we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres, with smaller poly(lactic-co-glycolic acid) MS (∼8–10 μm in diameter) embedded in a larger chitosan MS (∼250–300 μm in diameter). The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or voltage. Two kinds of model drugs, bovine serum albumin and chlorhexidine acetate, were encapsulated in the microspheres. The fluorescence-labeled rhodamine-fluoresceine isothiocyanate (Rho-FITC) and ultraviolet (UV) spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres, as well as sustained, slow release in vitro. In addition, far-UV circular dichroism and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) results indicated original secondary structure and molecular weight of drugs after electrospraying. Generally speaking, our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded, which could be applied in sequential, multi-modality therapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2019
·
IF 6.361
Jun-Shuai Zhang,Wei-De Zhang
Developing earth-abundant H 2 -production heterogeneous photocatalysts with robust activity and stability has attracted great interests. Herein, a low-cost photocatalyst was prepared by binding nickel complex covalently from primary amines of chitosan (NiL) onto photosensitive carbon nitride nanosheets (CN) through electrostatic interaction. Introduction of NiL results in more efficient utilization of solar energy, photogenerated electrons’ direct transfer and lower overpotential for water reduction. The optimized NiL3-CN photocatalyst shows the highest H 2 evolution rate of 346 μmol g −1 h −1 under visible light irradiation and exhibits high stability during test. This work presents great potentials for sustainable conversion of solar energy, and sheds positive light on the development of heterogeneous photocatalysts via anchoring H 2 -evolving molecule catalysts confined by inexpensive macromolecules onto a semiconductor photosensitizer through a facile and valid method.
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CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Qing Wan,Meiying Liu,Dazhuang Xu,Liucheng Mao,Jianwen Tian,Hongye Huang,Peng Gao,Fengjie Deng,Xiaoyong Zhang,Yen Wei
Chitosan based nanomaterials have been extensively examined for biomedical applications for their biodegradability, low toxicity, biological activity and low cost. In this work, a novel strategy for fabrication of luminescent polymeric nanoparticles (LPNs) based on aggregation induced emission (AIE) dye and water soluble chitosan (WS-Chitosan) were firstly developed via a highly efficient mercaptoacetic acid (MA) locking imine reaction. In this multicomponent reaction (MCR), MA serves as “lock” to connect 9,10-Bis(aldehydephenl)anthracene dye (An-CHO) and amino-containing WS-Chitosan under mild reaction conditions. The obtained WS-Chitosan@An-CHO LPNs show strong yellow emission and great water dispersibility. Biological evaluation results demonstrated that synthetic luminescent polymeric nanoparticles possess desirable cytocompatibility and distinct imaging properties. Therefore, we have developed a facile and useful method to fabricate AIE active nanoprobes with desirable properties for various biomedical applications. This strategy should be a general and easy handling tool to fabricate many other AIE dye based materials.
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CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Yurui Xu,Sajid Asghar,Liu Yang,Hongying Li,Zhilin Wang,Qineng Ping,Yanyu Xiao
Curcuminoid (Cur) loaded polysaccharide nanoformulations with blood-brain barrier (BBB) penetration and brain targeting properties, based on hyaluronic acid (HA) and chitosan hydrochloride (CSH) (Lf-Cur-PSNPs) were developed as a novel delivery system for malignant glioma. Formulations were investigated for physicochemical characteristics, cytotoxicity, uptake, and BBB penetration. The results showed that Lf M -Cur-PSNPs (concentration of Lf was 0.5 mg/mL) were preferentially taken up by brain capillary endothelial cells than Cur-PSNPs at any time. After crossing the BBB, Lf M -Cur-PSNPs remained largely intact and were more effective in targeting glioma cells (C6). In vivo imaging studies in mice exposed Lf M -PSNPs could effectively permeate BBB and preferentially accumulate in the brain (2.39 times greater than PSNPs). Moreover, PSNPs were detected in brain up to 72 h. This data indicates that Lf-Cur-PSNPs could effectively target and accumulate within the gliomas after enhanced permeation through BBB, thus should be further explored for their potential in CNS maliganancies.
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JOURNAL OF MATERIALS CHEMISTRY
·
2012
·Vol. 22
·期 11
·4861-4873
·
IF 5.968
Sisi Cui,Haiyan Chen,Hongyan Zhu,Junmei Tian,Xuemei Chi,Zhiyu Qian,Samuel Achilefu,Yueqing Gu
Upconversion nanoparticles (UCNPs) have attracted much attention as potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this study, hydrophilic UCNPs were prepared by coating amphiphilic chitosan (N-succinyl-N′-octyl chitosan, SOC) on the surface of hydrophobic oleic acid-capped NaYF4 UCNPs (OA-UCNPs). Water-insoluble photosensitizer zinc(II) phthalocyanine (ZnPc) was loaded into the SOC-coated UCNPs (SOC-UCNPs) via hydrophobic interactions to form a novel drug delivery system for in vivo deep tissue PDT triggered by near-infrared (NIR) light. The ZnPc-loaded SOC-UCNPs exhibited good dispersibility, excellent optical properties and good photostability. Under NIR light irradiation, the measurement of singlet oxygen production indicated that ZnPc effectively generated singlet oxygen induced by the emission from the UCNPs. Cell viability assays showed the low cytotoxicity of the UCNPs after surface modification. In vitro and in vivo therapeutic investigation evidenced the prominent PDT effects of ZnPc-loaded SOC-UCNPs upon NIR light irradiation. Furthermore, NIR imaging of ICG derivative-loaded SOC-UCNPs after intra-tumoral injection indicated the high retention of SOC-UCNPs only in the tumor site. Histological examination confirmed the negligible toxicity of ZnPc-loaded SOC-UCNPs on other organs. All the results demonstrate the promising potential of using SOC-UCNPs as new photosensitizer carriers for PDT of cancer and other diseases in deep tissues.
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Journal of Materials Chemistry B
·
2021
·Vol. 10
·期 4
·598-606
·
IF 6.331
Shuai Wu,Xiaoyang Cheng,Xiaomu Xu,Jiacheng Wu,Zhiqiang Huang,Zhenzhao Guo,Ping He,Changren Zhou,Hong Li
In this work, the role of chitosan (CS) in improving the properties of bioactive glass (BG) paste for wound healing was studied. Based on in vitro evaluation, it was found that the addition of CS neutralizes the pH value from 11.0 to 7.5, which did not lead to decreasing the bioactivity of BG paste in vitro. The rheological properties showed that the composite paste had higher bio-adhesion and better affinity with the skin surface than either CS or the BG paste. The antibacterial property evaluation showed that the composite paste had stronger antibacterial activity than either CS or BG paste and promoted the proliferation of HUVECs (human umbilical vein endothelial cells) and HaCat (human immortalized keratinocyte cells). Comparatively, the effect of promoting the proliferation of HUVECs is more significant than that of HaCat. The burn-wound model of rat was developed for evaluating in vivo activity, and the addition of CS effectively promoted wound healing without obvious inflammation according to the IL-1β and IL-6 staining. This novel paste is expected to provide a promising alternative for wound healing.
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JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Canhong Zhu,Jiani Wu,Xueting Jin,Yinghua Yan,Chuan-Fan Ding,Keqi Tang,Di Zhang
Chemical modification of biological materials is indispensable for enrichment of phosphorylated peptides. In this work, we synthesized a biomimetic honeycombed affinity chromatography (IMAC) adsorbent by preparing Crosslinked Chitosan, chelating aminomethyl phosphate decorated with Ti (IV) cation. The as-prepared CTSM@AMPA-Ti 4+ composites with stable structure, low steric hindrance, and high Ti 4+ loading amount were used as a promising adsorbent for enrichment of phosphopeptides. CTSM@AMPA-Ti 4+ showed extremely high sensitivity (0.4 fmol) and selectivity at a low composition molar ratio of β-casein/BSA (1:1000). What's more, it can keep its performance in the case that used to capture phosphorylated peptides from standard protein ten times or soaking in the acid/base solution for a long time. In addition, CTSM@AMPA-Ti 4+ successfully captured 35 phosphorylated peptides from human saliva. This study offers a way about diversiform functionalization of CTSM in phosphoproteome analysis and disease research.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Rui Wang,Xin Song,Tao Xiang,Qiang Liu,Baihai Su,Weifeng Zhao,Changsheng Zhao
A straightforward mussel-inspired approach was proposed to construct chitosan-polyurethane coatings and load Ag nanoparticles (AgNPs) to endow polyethersulfone (PES) membranes with dual-antibacterial and antifouling properties. The macromolecule O -carboxymethyl chitosan (CMC) was directly reacted with catechol in the absence of carbodiimide chemistry to form the coating and load AgNPs via in situ reduction; while lysine (Lys) was used as a representative small molecule for comparison. Then, PEG-based polyurethane (PU) was used for constructing Lys-Ag-PU and CMC-Ag-PU composite coatings, which substantially improved the protein antifouling property of the membranes. Furthermore, the CMC-Ag-PU coating exhibited superior broad-spectrum antibacterial property towards E. coli and S. aureus than Lys-Ag-PU coating. Meanwhile, the CMC-Ag-PU coating showed sustained antifouling property against bacteria and could reload AgNPs to be regenerated as antibacterial and antifouling coating. This approach is believed to have potential to fabricate reusable antifouling and antibacterial coatings on materials surfaces for aquatic industries.
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危险品化学品经营许可证（带存储）