ACS Nano
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2026
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IF 17.3
Ya Wang,Yuan Wang,Yan Sun,Xianbin Sun,Yuanming Li,Haijun Chen,Yu Gao
Ferrocene derivatives possess a typical “sandwich” structure that facilitates the formation of two-dimensional nanosheets (2D NSs), while their ferrous ions can effectively mediate chemodynamic therapy (CDT). However, conventional bottom-up synthesis methods for nanosheets often involve complex processes and stringent preparation conditions, limiting their therapeutic applications. In this study, we developed a simple yet efficient premix-dropwise-stir synthetic strategy to fabricate ultrathin oleanolic acid/perfluorocarbon-ferrocene (O/F-Fc) 2D NSs with considerable antitumor properties. The incorporation of oleanolic acid (OA) effectively inhibited F-Fc self-aggregation and facilitated the formation of ultrathin nanosheets (∼1.5 nm), while simultaneously enhancing the CDT efficacy of F-Fc through synergistic effects. Comprehensive in vitro and in vivo studies demonstrated that these carrier-free 2D NSs possess multifunctional capabilities, including oxygen self-supply to alleviate tumor hypoxia, generation of multiple reactive oxygen/nitrogen species to amplify oxidative stress and enhance CDT, antifibrotic activity, promotion of macrophage M1 polarization to activate immune responses, and enhanced deep tumor penetration, collectively enabling effective tumor microenvironment (TME) remodeling. This study not only presents an approach for preparing ultrathin ferrocene-based carrier-free 2D NSs, but also offers mechanistic insights into developing carrier-free organic 2D nanosystems for synergistic TME remodeling and enhanced CDT efficacy in cancer therapy.
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Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 3
·349-364
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IF 7.5
Jiaying Wang,Yangfan Zhang,Haoqian Wu,Siqi Yu,Xiaoying Cai,Youying Zhang,Jian Chen,Zixing Chen,Xiao Zheng,Haiping Hao
Huperzine A (HupA) is a highly selective, reversible acetylcholinesterase (AChE) inhibitor that exhibits neuroprotective effects and is clinically used to manage benign memory decline. However, the specific relationship between the pharmacokinetic (PK) profile of HupA and cerebral acetylcholine (ACh) dynamics remains poorly characterized. Here, we characterize the PK-pharmacodynamic (PD) properties of HupA in rats under both physiological and pathological conditions. Following a single intramuscular injection, HupA exhibits a short half-life but rapid brain penetration, while multiple dosing significantly enhances its brain exposure. In a middle cerebral artery occlusion (MCAO) rat model, HupA demonstrates increased brain distribution. Furthermore, HupA elevates ACh concentrations across multiple brain regions, concurrently modulating several monoamine neurotransmitters. Using a minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) modeling approach, cerebral ACh dynamics were accurately predicted based on the pharmacokinetics of HupA in systemic circulation. The developed mPBPK-PD model exhibits robust predictive performance and holds potential for guiding the optimization of clinical dosing regimens and improving the therapeutic efficacy of HupA.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Hongyan Sun,Huasen Lin,Jianmin Shi,Hongyu Li,Ruyuan Jiao,Yunan Gao
There have been numerous studies on floc formation between coagulants and natural organic matter (NOM). However, research on floc aging remains relatively scarce. This study systematically investigated the influence of NOM types and hydraulic conditions on the morphology, structure and stability of flocs during the aging process. Results indicated that flocs underwent hydroxyl-bridging reactions and crystallization during aging, leading to a decrease in floc activity. Humic acid (HA) exhibited a significant release phenomenon during aging, because its adsorption and complexation with aluminum could promote the aluminum dissolution-precipitation process. In contrast, bovine serum albumin (BSA) remained relatively stable during aging, which was attributed to the steric hindrance effect and hydrogen bonding interactions. Based on the two dimensional correlation spectroscopy analysis, high-intensity rapid agitation could inhibit hydroxyl-bridging reactions by reducing the number of η-OH 2 active sites on floc surfaces. Low-intensity slow agitation was conductive to floc formation. Compared with Al-HA flocs, Al-BSA flocs possessed higher shear resistance due to sweep flocculation. Consequently, the hydraulic parameters of the coagulation process need to be adjusted according to the specific water quality characteristics. Specifically, for water matrices with high loads of HA-like substances, it is recommended to either shorten the hydraulic retention time or implement the hydraulic conditions defined for the S-20 group. This study provided new insights into the interaction between NOM and coagulants during aging, which laid a theoretical foundation for the optimization of technical parameters in drinking water treatment and the reuse of flocs.
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Bioactive Materials
·
2026
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IF 23.6
Jing Zhang,Kunpeng Duan,Qianyue Liu,Shurong Chen,Hongshuai Zheng,Yan Liu,Jing Qian,Mingjing Yin,Jing Liu,Jiaxiao Li,Zhijian Li,Min Chen,Ximei Huang,Faquan Lin,Ming Gao,Lin Liao
Mitophagy is a self-protection mechanism for cells to eliminate dysfunctional mitochondria, and maintain mitochondrial homeostasis. Thus, precisely inducing mitophagy represents a promising strategy for acute lung injury (ALI) immunotherapy. Here, the mitochondrial targeted palladium loaded siraitia grosvenorii derived carbon dots (CPs@SS31) were engineered designed to integrate PTT, mitophagy induction, and immunoregulation for synergistic enhanced ALI therapy. CPs@SS31 combining with near infrared (NIR) irradiation not only directly scavenged reactive oxygen species to achieve antioxidant and anti-inflammation, but also amplified mitophagy via activating PINK1/Parkin pathway. Furthermore, it specifically targeted mitochondria to increase ATP production and mitochondrial membrane potential, thereby repairing the mitochondrial function of lipopolysaccharide induced cells. Meanwhile, it also demonstrated that CPs@SS31+NIR efficiently induced macrophage M2 polarization, and upregulated CD4 + T cells number and CD4 + /CD8 + ratio, thereby activating immunoregulation, and achieving ALI repair therapy. In vitro and in vivo studies both demonstrated the robust alleviated lung inflammation, and accelerated lung tissue repair in ALI rats models. This work proposed an innovative “mitophagy induction-immunoregulation” paradigm, offering a promising strategy for ALI therapy, and being extended to the treatment of other inflammation related diseases.
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.9
Haoran Li,Yongsheng Ni,Yumeng Li,Baocai Xu
Photodynamic inactivation (PDI) is a promising non-thermal antimicrobial technology. However, its practical application is constrained by the low-light utilization efficiency and poor adhesion of photosensitizers. To address these limitations, we developed a curcumin/octyl gallate/chitosan (COS) coating. COS was prepared via a two-stage self-assembly process by incorporating a curcumin/octyl gallate (CUR/OG) assembly into a chitosan (CS) matrix. The CUR/OG, characterized by a band gap of 2.3 eV, imparted visible-light activity to the COS. Furthermore, the COS exhibited good adhesion, storage stability, and photostability. Compared to pristine CS, the COS exhibited a 1.3-fold enhancement in adhesion strength. Upon visible-light irradiation, it achieved up to a 6.5-log CFU reduction in the population of four representative foodborne bacteria ( Pseudomonas fragi , Brochothrix thermosphacta , Escherichia coli O157:H7, and Staphylococcus aureus ). Biochemical analyses indicated that COS-mediated PDI was associated with the disruption of bacterial cell membrane integrity, impairment of energy metabolism, and induction of oxidative stress. Under visible light, the COS extended the refrigerated shelf-life of prepared mutton to 1.5 times that of the untreated control. Moreover, the COS-mediated PDI maintained approximately 99.99% reduction in bacterial counts after three consecutive reuse cycles on food contact surfaces. This study provided an effective approach for enhancing the bactericidal activity and adhesion of photodynamic coatings, offering a promising solution for preservation of prepared mutton.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Chunyu Wang,Yixin Zheng,Qingwen Cui,Yuxin Jiang,Jinhe Wang,Tianyu Zhang,Yuxin Song,Xiao Guo,Manli Wang,Liping An
Portulaca oleracea acidic polysaccharide (POPW-A) demonstrates significant efficacy in anti-inflammatory and immune-enhancing properties. Intervention with POPW-A reduced blood uric acid levels and significantly up-regulated uric acid transporter expression in hyperuricemic (HUA) model mice. Additionally, it suppressed the activation of the NLRP3 inflammasome by down-regulating AIF-1 and CMPK2 protein expression, thereby alleviating renal inflammation. The polysaccharide components of POPW-A were screened after purifying. Among them, the POPW-Ab component effectively enhanced the expression of uric acid transport proteins and suppressed the activation of the NLRP3 inflammasome. Structural analysis confirmed that POPW-Ab is a pectin polysaccharide composed primarily of a homogalacturonan (HG) domain with a backbone of →4)-α-D-GalpA-(1→, along with a minor rhamnogalacturonan-I (RG-I) domain containing side chains of →5)-α-L-Araf-(1→. After silencing the CMPK2 gene in model cells, the protective effects of POPW-Ab were counteracted. Conversely, overexpression of the CMPK2 gene restored the intervention efficacy of POPW-Ab. Therefore, POPW-Ab is likely the fundamental material basis for the bioactivity of Portulaca oleracea polysaccharides. The underlying mechanism involves targeted down-regulation of CMPK2 gene expression, thereby inhibiting NLRP3 inflammasome activation and subsequent release of pro-inflammatory cytokines. These findings suggest that POPW-Ab holds promise as a potential therapeutic agent for HUA and its associated renal complications.
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FOOD CHEMISTRY
·
2026
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IF 10.4
Yina Yang,Wenxuan Zhu,Huijun Liu,Jiaying Wang,Xin Jia,Yuchun Tao,Jing Meng,Qingyu Meng,Jing Dai,Lijia Yu,Chunguang Ding
Paraquat (PQ), a highly toxic and persistent herbicide, poses severe risks to environmental and public health. Herein, we developed a supramolecular indicator displacement assay (IDA) for PQ detection using a squaraine dye (J3-Ad) and cucurbit[7]uril (CB7). PQ displaces J3-Ad monomers from the J3-Ad&CB7 (J3&CB) complex, inducing J3-Ad self-assembly into H-aggregates. This process was characterized by Ultraviolet–visible (UV–vis) absorption and fluorescence spectroscopy, proton nuclear magnetic resonance ( 1 H NMR) spectroscopy, and density functional theory (DFT) calculations. The assay achieved a detection limit of 1.86 μM with a linear range of 0–30 μM, and exhibited excellent anti-interference ability. It was successfully applied to visually detect PQ in soil and fruit samples, with recovery rates of 96.21–104.66%. This method provides a simple, rapid, and reliable approach for monitoring PQ residues in environmental and food safety applications.
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ANALYST
·
2026
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IF 3.6
Huiqi Zhu,Ying Chen,Weiqing Yang,Zunxiang Zeng,Yuling Hu,Ji Zhang
The inherently weak Raman signals from molecules with small scattering cross-sections pose a significant challenge for surface-enhanced Raman scattering (SERS), a technique that is further limited by its reliance on costly precious metal substrates and exogenous labeling strategies. To address these limitations, this study constructs a Ti3C2–CoFe2O4 heterostructure by anchoring oxidase (OXD)-like CoFe2O4 nanoparticles (NPs) on two-dimensional (2D) conductive Ti3C2 MXene nanosheets. The resulting interface forms a Mott–Schottky junction, which facilitates rapid charge transfer and synergistically enhances both catalytic and SERS performance. Structurally, the 2D Ti3C2 framework provides abundant anchoring sites for the uniform dispersion of CoFe2O4 NPs. This effectively prevents particle aggregation and maximizes the exposure of catalytic active sites, thereby enhancing both stability and catalytic activity. Additionally, the Ti3C2–CoFe2O4 heterojunction effectively suppresses the recombination of charge carriers and promotes the separation of photogenerated charges, generating abundant superoxide anion radicals that oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) for catalytic signal amplification. Therefore, the ingenious combination of nanozymes and SERS technology enables the generation of SERS-active reporters via nanozyme-catalyzed reactions, thus avoiding the need for external labeling modifications. The strategy simultaneously enhances Raman signals through the synergistic effect of photoinduced charge transfer and localized surface plasmon resonance. This Ti3C2–CoFe2O4 heterojunction exhibits integrated OXD-like activity and SERS enhancement, enabling sensitive glutathione (GSH) detection in human serum samples. Through catalytic oxidation of TMB to oxidized TMB, a distinct Raman peak emerges at 1615 cm−1, with its intensity reduction quantitatively correlating with GSH concentration via competitive reactive oxygen species scavenging. Quantitative analysis demonstrates a linear response range of 0.50–200 μmol L−1 and a detection limit of 0.073 μmol L−1, with serum sample recoveries ranging from 94.7%–115%. This study provides a paradigm for designing non-precious metal nanozyme materials with integrated catalytic and SERS capabilities, demonstrating significant potential for practical applications in clinical diagnostics and biosensing.
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Nature Communications
·
2026
·
IF 18.1
Xu Yinhan,Tian Meirong,Zhang Mengmeng,Hu Dengwen,Han Guoqiang,Zhu Jintao,Xu Jiangping,Kim Shin-Hyun
Responsive optical materials offer real-time visual feedback to external stimuli by converting them into visible light signals, holding great promise in display, sensing, and information encryption. Typically, heterogeneous Janus droplets can exhibit vivid coloration induced by total internal reflection and interference (TIRI) at concave liquid–liquid interfaces. Yet, achieving stimuli-responsive TIRI-based structural colors remains a challenge due to the difficulty in controlling interface curvature and reflective behavior under external stimuli. Here, we report the fabrication of Janus droplets with tunable TIRI structural colors that respond to both surfactant composition and temperature. By tailoring surfactant formulation, the droplet morphology and interface curvature can be adjusted, enabling reversible modulation of structural color appearance, including both iridescent and non-iridescent modes depending on incident light conditions. Furthermore, the structural color can be reversibly or irreversibly switched on/off in response to temperature changes, due to phase transitions that alter light reflection at the concave interface. Owing to their temperature-dependent optical response and real-time visual signaling, these droplets can serve as single-use security labels for monitoring freeze history of freeze-sensitive pharmaceuticals, providing reliable indication of product integrity.
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Food Bioscience
·
2026
·
IF 6.2
Hang Si,Qinggele Borjihan,Xin Li,Hairihan Li,Changming Zhang,Yongfu Chen
Ready-to-use probiotics have shown promising safety and patient acceptability in inflammatory bowel disease (IBD), yet their efficacy is limited by poor tolerance and inadequate targeting. Here, we developed a dual-precisely engineered prebiotic coating for the robust probiotic Lacticaseibacillus rhamnosus Probio-M9. The coating features an inner tannic acid–iron (Fe/TA) network for reactive oxygen species (ROS) scavenging and an outer hyaluronic acid (HA) layer that enables targeted binding to inflamed mucosa and enhances epithelial adhesion. This synergistic design alleviates inflammation, repairs the epithelial barrier, modulates gut microbiota, and ultimately achieves superior therapeutic outcomes in IBD. This strategy provides a new perspective and a feasible path for probiotic-based IBD intervention research.
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Materials Today Bio
·
2026
·
IF 11
Lanbing Zou,Baixue Fu,Dianyu Wang,Yanbin Chen,Han Gui,Ganen Mu,Xinyi Li,Yumin Zhang,Jianfeng Liu,Cuihong Yang
Sepsis is a critical global health challenge, characterized by dysregulated host responses and high mortality rates. Current treatment therapies inadequately address persistent immunoparalysis and adverse reactions, leaving survivors susceptible to recurrent infections. Herein, we developed the first β-glucan (BG) delivery system using self-assembling peptide hydrogels to combat immuneparalysis associated with sepsis. This hydrogel combines oxidized BG (BGA) and tuftsin-functionalized self-assembling peptides (t-RADA16) to create an injectable glycopeptide hydrogel (BGA@t-RADA16). Upon subcutaneous injection, the hydrogel forms a dual-functional platform consisting of a "sustained-release depot" of BGA and a local "trained immunity center", where the three-dimensional network of peptide nanofibers actively recruits and the BGA educates macrophages in-situ. This endows the macrophages with an immune memory function, generating a rapid and powerful defense against secondary infection, and achieving a "targeted-sustained-response" cascade treatment system. The results demonstrate that the glycopeptide hydrogel reduces organ damage, lowers sepsis mortality and confers protection against secondary infections by coordinating the activation of both innate and adaptive immune pathways. Furthermore, BGA-P@t-RADA16 simultaneously clears acute-phase pathogens and provides long-term immune training by loading polymyxin B within a single system, which truly addresses the dynamic nature of "immune imbalance" in the pathological process of sepsis. BGA@t-RADA16 provides a new tool for sepsis immunotherapy, pioneering an integrated strategy of "immune training, acute intervention and long-term defense". This strategy is expected to be an important breakthrough in the treatment of sepsis and related immune disorders.
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Nature Communications
·
2026
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IF 18.1
Mao Congyang,Jin Wanyu,Dou Limeng,Guo Tong,Huang Jin,Wang Yi,Liu Xiangmei,Wu Shuilin,Qiao Wei,Xiang Yiming,Zhu Yizhou,Wu Jun,Yeung Kelvin Wai Kwok
The pandemic-scale progression of type 2 diabetes mellitus (T2DM) necessitates innovative interventions targeting the pathogenic triad of insulin resistance, dysregulation of lipid metabolism, and gut microbiome dysbiosis. Here, we report a synthetically bioengineered probiotic consortium (REcN-F/Ca) developed through directed metabolic adaptations of Escherichia coli Nissle 1917 (EcN) under iterative hydrogen peroxide selection, subsequently functionalized with fructooligosaccharide-calcium carbonate composites. REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability. In high-fat diet-induced obese male mice, REcN-F/Ca restores gut microbiota diversity, enriches butyrogenic taxa (Lachnospiraceae and Blautia ), and rescues short-chain fatty acids depletion. Transcriptomic profiling reveals PPAR signaling activation, driving lipid metabolism and suppressing adipose inflammation. These effects translate to systemic metabolic improvements with attenuated weight gain (−25.4%), restored glucose homeostasis, and reduced insulin resistance (HOMA-IR: −73.2%) in the obesity and T2DM murine model. Our findings establish REcN-F/Ca as a synthetically engineered probiotic that simultaneously corrects intestinal ecological perturbations and reverses host metabolic dysfunction, proposing a paradigm for metabolic syndrome management.
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