CRYSTENGCOMM
·
2020
·Vol. 22
·期 23
·4005-4013
·
IF 3.117
Baolin Liu,Yizhao Li,Shaojun Qing,Kun Wang,Jing Xie,Yali Cao
Highly dispersed surface Cu species and oxygen vacancies are important for CuOx–CeO2 catalysts in many reactions, but it is difficult to increase the concentrations of highly dispersed Cu species and oxygen vacancies simultaneously by only adding a Cu component. Herein, CuOx–ZrO2–CeO2 (CZC) nanocatalysts with different ratios of Cu/Zr have been effectively produced by a simple solvent-free synthetic strategy. The effect of Zr doping on the structure and reactivity of the CuOx–CeO2 catalysts has been investigated with the help of carbon monoxide (CO) oxidation and 4-nitrophenol (4-NP) reduction as model reactions. It is revealed that the introduction of Zr relieved the agglomeration of surface Cu species, produced more oxygen vacancies in the interior and Cu+ species on the surface of the catalyst, and increased the reducibility of CuOx–CeO2. The CZC catalysts show remarkably enhanced catalytic activity due to the abundant surface active sites and the improved redox properties provided by the suitable doping of Zr into CuOx–CeO2. This work not only offers a practicable way to reconstruct the distribution of active metals on the metal oxide support but also provides a high-efficiency strategy to prepare oxide catalysts with excellent catalytic performance.
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 7
·1-10
·
IF 5.479
Zhang Yanshu,Hu Yufei,Li Gongke,Zhang Runkun
Core-shell nanoparticles (NPs) consisting of a gold core and a metal-organic framework shell (type MOF-74) were synthesized via one-pot synthesis. The NPs exhibit highly sensitive and stable SERS activity for the detection of 4-nitrothiophenol, with a specific band at 1337 cm −1 . The method has a linear response in 0.10–10 μmol·L −1 analyte concentration range and a lower detection limit of 69 nmol·L −1 . The potential application of this novel SERS substrate was evaluated by two model reactions involving 4-nitrothiophenol. The first involves in-situ SERS monitoring of the surface plasmon-induced nitration of aromatic rings without adding conventional acid catalyst. The second involves the photocatalytic reduction of 4-nitrothiophenol to 4-thioaminophenol in the presence of Au/MOF-74 under 785-nm laser irradiation. The plasmon-assisted dimerization of 4-nitrothiophenol to form 4,4′-dimercaptoazobenzene can also be monitored simultaneously.
Schematic presentation of a nanoparticle SERS substrate consisting of gold core and MOF-74 shell, which was applied to detection of 4-nitrothiophenol. The Au/MOF-74 was successfully used for in-situ monitoring of two model reactions involving 4-nitrothiophenol by SERS.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
·
2024
·
IF 3.9
Jiawen Cui,Zhenda Liang,Yuhao Liu,Zhiyu Hao,You Tang,Li Zhou,Xiaohua Teng
Environmental endocrine disrupting chemical 4-tert-butylphenol (4-tBP), a widely-utilized surfactant in various industries, poses potential risks to aquatic organisms. Our previous sequencing results suggested that 4-tBP-induced common carp liver injury might be associated with Ca 2+ signaling and autophagy. However, the intricate involvement of these pathways in 4-tBP-induced cytotoxic mechanisms remained unexplored. To bridge these knowledge gaps, this study focused on epithelioma papulosum cyprini (EPC) cells, a significant cell type in fish biology. Initial observations showed that 4-tBP induced a dose-dependent perturbation in Ca 2+ levels. Further investigations, with siRNA and L-type Ca 2+ channel agonist (BAY K8644), identified L-type calcium channel gene CACNA1D as a critical regulator of 4-tBP-induced Ca 2+ overload. Predictive analysis using miRanda platform suggested a potential interaction between miR-363 and CACNA1D, which was subsequently verified through dual-luciferase reporter gene assays. We then established miR-363 mimic/inhibitor models, along with miR-363 and CACNA1D co-suppression models in EPC cells. Through TEM observation, immunofluorescence assay, Ca 2+ staining, and qRT-PCR analysis, we evaluated the role of miR-363/CACNA1D axis in modulating the effects of 4-tBP on Ca 2+ signaling and autophagy. Results showed that miR-363 inhibitor exacerbated 4-tBP-induced increase in CALM2, CAMKII, Calpain2, and p62 expression and also led to decrease in ATG5, ATG7, and LC3b expression. In contrast, miR-363 mimic notably alleviated these changes. Notably, siRNA CACNA1D effectively modulating miR-363 inhibitor's effect. Our study revealed that 4-tBP induced Ca 2+ overload and subsequent autophagy impairment via miR-363/CACNA1D axis. These findings illuminated a profound understanding of molecular mechanisms underlying 4-tBP-induced cytotoxicity and spotlighted a potential therapeutic target.
✓ 已验证
DOI
PubMed
高影响因子
American Journal of Translational Research
·
2016
·
IF 3.146
Junhui Yuan,Kuang Ge,Junhuan Mu,Jiang Rong,Li Zhang,Bin Wang,Jingyuan Wan,Gong Xia
Ferulic acid (FA), a phenolic acid which is abundant in vegetables and fruits, has been reported to exert anti-oxidative and anti-inflammatory activities. In the present study, the pharmacological effects and the underlying mechanisms of FA in mice with acetaminophen-induced hepatotoxicity were investigated. Our results revealed that FA pretreatment inhibited the augments of serum aminotransferases in a dose-dependent manner and attenuated the hepatic histopathological abnormalities and hepatocellular apoptosis in acetaminophen (APAP) exposed mice. Moreover, FA inhibited the expression of cytochrome P450 2E1 (CYP2E1), enhanced the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the contents of glutathione (GSH). Furthermore, FA markedly attenuated acetaminophen-induced serum tumor necrosis factor (TNF)-α and interleukin (IL)-1β production, suppressed Toll-like receptor (TLR) 4 expression and dampened p38 mitogen-activated (MAPK) and nuclear factor kappa (NF-κB) activation. These data suggested that FA could effectively protect against APAP-induced liver injury by down-regulated expression of CYP 2E1 and the suppression of TLR4-mediated inflammatory responses.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Chendong Yang,Entao Li,Xiaoping Guo,Wenyu Xie,Yuanzhan Wang,Xuefei Huang,Sandra Chiu,Xuanjun Wu
Over the past 3 years, SARS-CoV-2 Omicron has been circulating globally with the emergence of multiple subvariants, including BA.5, BA.5.2, XBB, XBB.1, EG.5.1, HK.3, BA.2.86, JN.1, and KP.2. To combat these Omicron subvariants, several vaccines based on receptor-binding domain (RBD) dimers have been developed; however, RBD dimer vaccines require frequent updates to cope with the emergence of new variants. In contrast, the development of a safe, effective, and broad-spectrum vaccine against multiple Omicron subvariants, including the latest JN.1 and KP.2, would be a one-size-fits-all solution. Here, we designed BA.4/5 RBD-PC7A conjugate micelles by displaying the BA.4/5 RBD in PC7A micelles. Remarkably, the micelles elicited potent neutralizing antibodies (NAbs) in rabbits, effectively neutralizing BA.5.2, XBB.1.18, and HK.3 infections. Moreover, the micelles alone were able to induce NAbs in mice against the BA.5 variant. When a cytosine-phosphate-guanine (CpG) adjuvant was added and electrostatically adsorbed to the micelles, there was a significant increase in the antibody titers of IgG1, IgG2b, and IgG2c. This enhancement facilitated the broad neutralization of various strains, including BA.5.2, XBB.1.18, HK.3, JN.1, and KP.2. Furthermore, the micelles adsorbed with CpG protected golden hamsters from infection with the BA.5.2 strain. This study presents a potent and broadly neutralizing nanovaccine that includes the BA.4/5 RBD antigen and a CpG adjuvant. It demonstrates efficacy against multiple Omicron subvariants, including BA.5, BA.5.2, XBB.1.18, HK.3, JN.1, and KP.2, highlighting its potential for clinical translation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2012
·
IF 4.555
Tao Li,Haoyue Xie,Zhifeng Fu
A facile, sensitive and universal method was established for analysis of biogenic amines using micellar electrokinetic chromatography coupled with chemiluminescent (CL) detection. It was found that diperiodatocuprate (III) (K 5 [Cu(HIO 6 ) 2 ], DPC), a transition metal chelate at unstable high oxidation state, could effectively enhance the reaction between luminol-type compound and hydrogen peroxide, to produce very strong CL signal. In addition, triethylamine was found to be able to effectively improve the yield of the derivatization reaction between biogenic amines and a luminol-type derivatization reagent, N -(4-aminobutyl)- N -ethylisoluminol (ABEI). Based on these facts, three biogenic amines were pre-column derivatized with ABEI, and post-column detected using high sensitive luminol-hydrogen peroxide-DPC CL system. Since the background was quite low, and the signal was quite strong, a considerable improved sensitivity was obtained. The presented method had been successfully applied to simultaneously analyze glycine, proline and phenylalanine with the detection limits (S/N = 3) of 0.030 μmol L −1 , 0.23 μmol L −1 and 0.21 μmol L −1 , respectively. To evaluate its potential application value, glycine in saliva and urine samples was detected using this method, and satisfied results were obtained. This approach can be further extended to detection of many other compounds such as peptides and drugs by using luminol-type derivatization reagent.
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULES
·
2017
·
IF 5.835
Qiliao Wang,Shanshan Chen,Yongjiu Liang,Dewen Dong,Ning Zhang
A general and efficient method for the preparation of bottle-brush brushes is presented via the combination of self-initiated photografting and photopolymerization (SIPGP) and rare earth metal mediated group transfer polymerization (REM-GTP). This strategy involves the creation of poly(3-((2,6-dimethylpyridin-4-yl)oxy)propyl methacrylate) (PDMPPMA) brushes and the successive conversion to surface-grafted macroinitiator brushes through the C–H bond activation by Cp2YCH2TMS(THF) complex. The surface-bound macroinitiator exhibits high activity and no initiation period in the polymerization of monomers following a group-transfer polymerization mechanism, resulting in the formation of side chains along the PDMPPMA backbone. The versatile approach is not only applicable to the polymerization of conventional MMA, but also active for the polymerization of heteroatom containing monomers, e.g., vinylphosphonate, 2-vinylpyridine and 2-isopropenyl-2-oxazoline, thus affording bottle-brush brushes which cannot be efficiently realized by conventional polymerization techniques.
✓ 已验证
DOI
高影响因子
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
·
2019
·Vol. 74
·期 3
·261-265
·
IF 0.961
Gao-Feng Wang,Shu-Wen Sun,Wei-Bing Wang,Hong Sun,Shao-Fei Song
Two coordination polymers, {[Co(bipmo)(tbip)]·3H 2 O} n ( 1 ) and {[Cd(bipmo)(tbip)]·3H 2 O} n ( 2 ) (bipmo=bis(4-(1 H -imidazol-1-yl)phenyl)methanone, H 2 tbip=5- tert -butylisophthalic acid), were synthesized by solvothermal methods and structurally characterized by elemental analyses, infrared spectroscopy, and single-crystal X-ray diffraction. The results from single-crystal X-ray diffraction data indicate that the solid state structures of 1 and 2 consist of metal-aromatic carboxylate layers, which are pillared by weak interactions to generate a three-dimensional network. The topological structures of 1 and 2 are uninodal nets based on 3-connected nodes with the Schläfli symbol of {6 3 }.
✓ 已验证
DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2020
·Vol. 27
·期 1
·77-86
·
IF 0
Zhai Yuanyuan,Qu Hongmei,Li Zhongxuan,Zhang Bo,Cheng Jinxi,Zhang Jiaji
In this study, we modified microcrystalline cellulose by cross-linking it with epichlorohydrin to obtain a rapid and efficient adsorbent for the removal of Reactive Blue 4 dye from aqueous solution. Evidences of the cross-linking of the microcrystalline cellulose were obtained by Fourier transform infrared spectroscopy, X-ray diffraction, Brunauer–Emmett–Teller analysis, thermogravimetric analysis, and scanning electron microscopy. We investigated the effects of adsorbent dosage, pH, initial dye concentration, temperature, and contact time on the dye adsorption capacity. The results showed that the adsorption equilibrium time was just 20 min and the maximum adsorption capacity was 69.79 mg/g. The adsorption isotherm data fitted the Langmuir isotherm model well, and the adsorption kinetics data followed the pseudo-second-order kinetic model. The results of the thermodynamic analysis suggest that the adsorption process was spontaneous and exothermic. Recyclability experiments demonstrated the good reusability of this adsorbent. Electrostatic interaction was found to dominate the adsorption process.
✓ 已验证
DOI
FOOD AND CHEMICAL TOXICOLOGY
·
2019
·
IF 3.775
Congyong Sun,Wenjing Li,Yingkun Liu,Wenwen Deng,Michael Adu-Frimpong,Huiyun Zhang,Qilong Wang,Jiangnan Yu,Ximing Xu
1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside (MPG) is a phenolic glycoside that exists in Moringa oleifera seeds with various health benefits, whereas its hepatoprotective effect is lacking clarification. Herein, MPG was isolated from Moringa oleifera seeds, and its hepatoprotection against CCl 4 -induced hepatotoxicity in L02 cells and ICR mice was investigated. Toxicity studies showed that MPG did not induce significant changes in organ coefficients and histological analysis, as well as exhibited no cytotoxicity. In vitro studies indicated that MPG substantially increased cell viability and intracellular SOD activities, and significantly inhibited LDH leakage in CCl 4 -treated cells. In vivo studies demonstrated that MPG significantly alleviated CCl 4 -induced hepatotoxicity in mice, as indicated by diagnostic indicators of hepatic injury, as well as the histopathological analysis. Moreover, MPG reduced the lipid peroxidation levels and regulated the inflammatory cytokines. Notably, MPG substantially suppressed the significant elevation of ROS production in hepatocytes of mice intoxicated with CCl 4 . Moreover, TUNEL assay demonstrated that MPG obviously inhibited hepatic apoptosis induced by CCl 4 . Altogether, these results suggested that MPG has excellent liver-protecting effects against hepatocytotoxicity induced by CCl 4 in mice and L02 cells, which can be further developed as a valuable functional food additive or drug for the treatment of hepatic injury.
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Xuehua Zhang,Lin Lin,Dan Qu,Jiangong Yang,Yuxiang Weng,Zhuan Wang,Zaicheng Sun,Yong Chen,Tao He
Developing highly efficient photocatalysts for solar-fuels production under visible-light irradiation is of great promise, but still remains a big challenge. In this work, we use g-C 3 N 4 incorporated with carbon dots as the photosensitizer to couple with tetra(4-carboxyphenyl)porphyrin iron(III) chloride (FeTCPP) molecular catalyst. The obtained g-C 3 N 4 -C 0.05 /FeTCPP hybrid photocatalyst exhibits high activity for the solar-fuels production of CO and H 2 under visible-light irradiation, with CO yield of 23.1 mmol/g and H 2 yield of 71.1 mmol/g in 6 h. The enhanced mechanism has been studied by various techniques like photocurrent response, photoluminescence and mid-infrared femtosecond transient absorption. The presence of trace amount of carbon dots in the system can provide an alternative channel for the electron transfer, i.e., from g-C 3 N 4 to FeTCPP via the CDs. Accordingly, the interfacial charge separation and electron transfer can be promoted, leading to enhanced photocatalytic performance of the g-C 3 N 4 -C x /FeTCPP hybrid photocatalysts.
✓ 已验证
DOI
高影响因子
Environmental Science-Nano
·
2023
·Vol. 10
·期 12
·3317-3328
·
IF 7.3
Baoyu Li,Wengui Duan,Guishan Lin,Yucheng Cui,Rongzhu Wen,Chuwen Liu,Yulu Xie
Natural product-based nanopesticide is an effective and sustainable approach for solving the environmental issues caused by the application of current commercial herbicides. In this study, 21 novel L-carvone-derived 4-methyl-1,2,4-triazole-thioether derivatives 5a–5u were rationally designed by transketolase-based in silicon virtual screening, synthesized, and structurally characterized using FT-IR spectroscopy, 1H/13C NMR spectroscopy, and HRMS technique. Besides, the herbicidal activity of the target compounds against Brassica campestris and Echinochloa crusgalli L. was evaluated, and the bioassay results revealed that compound 5a with the most significant herbicidal and TK-inhibition activities could serve as a potential TK inhibitor and could serve as a leading compound for further study of green herbicides. Subsequently, the molecular skeletons of chitosan and L-carvone were incorporated for developing high-efficiency nanopesticide carriers, and thus samples 7a–7d were synthesized by N-alkylation of chitosan and characterized using various methods. Compared with unmodified chitosan, L-carvone-derived nanochitosan carrier 7b with the micro-morphologies of nubby lumps and porous surfaces exhibited higher dispersibility and similar thermostability. Finally, L-carvone-derived 4-methyl-1,2,4-triazole-thioether/nanochitosan complexes 7b/5a, 7c/5a, and 7d/5a with better 5a-loading capacities and multi-stage sustained releasing performances were constructed, and the herbicidal activities of 7b/5a and 7d/5a against Brassica campestris were evaluated in the petri dish and greenhouse. It was found that 7b/5a and 7d/5a exhibited significant herbicidal activities. Among them, 7b/5a had great potential as a green and eco-friendly nanopesticide for weed control.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）