JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Yanwei Lv,Mengni Jiang,Qiwen Jiang,Xinyuan Zhang,Yijie Xie,Yunyi Yang,Shige Wang,Lianghao Hu,Jiulong Zhao
Pyroptosis is involved in various inflammatory and fibrotic processes, but its specific role in the progression of chronic pancreatitis (CP) remains insufficiently explored. This study first investigated the dynamic expression changes of pyroptosis-related proteins during CP development and verified the regulatory effects of disulfiram (DSF) on key effector cells in CP, namely pancreatic stellate cells (PSCs) and macrophages. Building on these findings, a gut microenvironment-responsive nanoplatform, CuSe/DSF/EL nanoflowers, was designed and synthesized by integrating CuSe (as a carrier and selenium donor), DSF (as the core therapeutic agent), and Eudragit ® L100-55 (EL, a pH-sensitive polymer for intestinal targeting). Results demonstrated that the CuSe/DSF/EL nanoflowers exhibited excellent biocompatibility, robust antioxidant capacity, and efficient electrostatic targeting to inflamed pancreatic tissues via charge interactions. In vivo experiments using a mouse CP model confirmed that the nanoflowers significantly alleviated pancreatic inflammation, fibrosis, and pyroptosis, while effectively repairing pancreatic structure and restoring its function. Further RNA sequencing (RNA-seq) analysis revealed that the nanoflowers reversed CP-associated transcriptomic dysregulation, with a notable focus on correcting impaired pancreatic secretion pathways. This study clarifies the critical role of pyroptosis in CP pathogenesis and provides a novel, multi-mechanistic nanotherapeutic strategy for CP treatment by enhancing the bioavailability and targeting efficiency of DSF.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·
IF 4.4
Chen Kexin,Zhou Ronghao,Jin Zhibin,Gong Yue,Hu Yinchun,Tian Zenghui,Wei Yan,Huang Di
Flexible sensors are indispensable components in wearable electronic devices and have great potential for applications in human health monitoring, human–machine interfaces and robotics. Conductive hydrogels have emerged as key materials for flexible sensor fabrication due to their exceptional modulus, elasticity and conductivity. Polyacrylamide (PAM) and sodium alginate (SA) were employed as the base materials, while glycerin and water were used as a binary solvent, and polydopamine-modified carbon nanotubes (PDA-CNTs) acted as conductive fillers to enhance conductivity and improve the mechanical properties of the hydrogel. A sensitive, self-adhesive and super-stretchable conductive hydrogel was successfully synthesized, which was designated as glycerol–water–polyacrylamide/sodium alginate/polydopamine-modified carbon nanotubes (GW-PAM/SA/PDA@CNTs). Experimental findings demonstrate that this hydrogel exhibits excellent mechanical properties, tissue adhesion, antifreezing and heat-resistant properties, self-healing and long-term stability. Moreover, it facilitates the monitoring of human motion signals, facial micro-expressions and electrocardiographic (ECG) signals. This study proposes a novel design strategy for the development of a multifunctional conductive hydrogel.
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Biochar
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2026
·Vol. 8
·期 1
·113
·
IF 15.1
Zhang Jian,Xie Jiafang,Zhu Shuhui,Yang Jiacheng E.,Weng Bo,Zheng Yuming
Biochar optimized with oxygen-containing functional groups is believed to be beneficial for peroxymonosulfate (PMS) activation, and biochar-loaded Co 3 O 4 -based catalysts are expected to be one of the most promising PMS activators for the efficient removal of organic pollutants. Nevertheless, the real active sites on Co 3 O 4 catalysts are still in debate due to insufficient experimental evidence. Herein, Co 3 O 4 growing on the oxygen-containing functional groups optimized rice husk biochar (RHBA) was synthesized (RHBA@Co 3 O 4 ), and RHBA800@25Co 3 O 4 + PMS system achieved complete degradation (100%) of refractory levofloxacin (LFX) within 4 min. The superior catalytic performance was suggested to be attributed not only to the uniform dispersion of Co 3 O 4 , but also to the transformation of lattice oxygen in Co 3 O 4 , which was found to play an important role in the catalytic process by inducing the formation of Co 3 O 4−α –OH. Meanwhile, density functional theory (DFT) calculations indicated that the adsorption energy ( E ads ) of PMS on Co 3 O 4−α –OH was far lower than that on Co 3 O 4 . Moreover, both radical and non-radical pathways were indicated to be involved during the degradation process. Additionally, the practical application of RHBA@Co 3 O 4 was investigated using various antibiotics, actual water environments, and fixed-bed reactors. The results showed that it possessed good practical degradation performance and significantly reduced the toxicity of intermediate products. This work provides a fresh insight into the catalytic mechanism of RHBA800@25Co 3 O 4 for PMS activation and wastewater treatment, offering a new perspective on the catalytic mechanism of Co 3 O 4 -based materials. Highlights
RHBA800@25Co 3 O 4 exhibited ultrafast antibiotics degradation via peroxymonosulfate activation.
Inspired formation of Co 3 O 4−α –OH by lattice oxygen induction was explored.
Ecological safety of levofloxacin degradation products was verified through antibacterial experiments.
Graphical The alternative text for this image may have been generated using AI.
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RESPIRATORY RESEARCH
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2026
·
IF 5.7
Yi Yanjun,Hu Yidu,Ren Shencheng,Wu Yingting,Chen Xinran,Lu Yang,Yu Qi,Zuo Di,Bi Guoshu,Wang Qun,Zhan Cheng,Bian Yunyi
Background KRAS G12C-targeted therapies have transformed the treatment of KRAS G12C-mutant lung adenocarcinoma. However, acquired resistance to these therapies, whose underlying molecular mechanisms are not fully understood, presents a major obstacle to achieving long-term therapeutic success. The purpose of this study was to elucidate the mechanisms of acquired resistance to KRAS G12C inhibitors and identify potential regulators of resistance in lung adenocarcinoma. Methods Two lung adenocarcinoma cell lines (H23 and H2122) were exposed to escalating doses of two novel KRAS G12C inhibitors, fulzerasib and garsorasib, to generate resistant variants. Transcriptomic profiling was conducted to identify genes consistently upregulated in resistant cells. CRISPR/Cas9-mediated knockout (MXD4-KO) and siRNA-mediated knockdown of MXD4 were performed to assess its role in drug resistance. Mechanistic investigations employed inhibitors of ferroptosis, apoptosis, and necrosis, along with assays measuring lipid peroxidation and malondialdehyde levels. Further analysis included ferroptosis-related gene expression profiling, lipidomic profiling, ChIP-Seq, ChIP-qPCR, and dual-luciferase reporter assays. The findings were validated in patient-derived organoids (PDOs) and nude mouse models. Results Transcriptomic profiling identified 11 genes consistently upregulated in resistant cells, with MXD4 emerging as a key resistance regulator. CRISPR/Cas9-mediated knockout of MXD4 restored sensitivity to fulzerasib, garsorasib, sotorasib, and adagrasib, an effect fully reversed upon MXD4 re-overexpression. Similarly, siRNA-mediated knockdown of MXD4 in resistant cells restored drug sensitivity. Mechanistic studies revealed that MXD4 specifically suppresses ferroptosis, rather than apoptotic or necrotic pathways, by repressing ACSL4 expression and blocking its catalytic synthesis of phosphatidylethanolamine-polyunsaturated fatty acids (PE-PUFAs). ACSL4 knockout or overexpression abolished MXD4’s ability to promote ferroptosis suppression and resistance to KRAS G12C inhibitors. ChIP-Seq, ChIP-qPCR, and dual-luciferase reporter assays confirmed that MXD4 directly binds to and represses the ACSL4 promoter. These findings were validated in PDOs and nude mouse models, where MXD4 knockout restored therapeutic sensitivity, while ACSL4 knockout blocked MXD4’s resistance-promoting effects. Conclusions This study uncovers a novel resistance mechanism in which MXD4 transcriptionally silences ACSL4 to suppress ferroptosis, enabling cancer cells to evade KRAS G12C inhibitors. Targeting the MXD4-ACSL4 axis represents a promising strategy to overcome therapeutic resistance in KRAS G12C-mutant lung cancer, potentially improving long-term treatment outcomes.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Luo Jiawei,Liu Yuhang,Zhang Jingchao,Liu Zhedong,Guo Zhaoxin,Qian Kunyan,Li Zekun,Huang Pengfei,Wang Chunying,Zeng Jianrong,Liu Rui,Chen Yanan,Ding Jia,Hu Wenbin
Polyanionic positive electrodes with XO 4 (X = P, S, Si etc.) tetrahedra exhibit beneficial properties, making them crucial for energy storage systems. However, strong covalent X-O bonds cause electron localization, reducing intrinsic electronic conductivity and limiting rate performance. Here we show a strategy to directional design the covalency of X-O bonds for enhanced intrinsic electronic conductivity of polyanionic positive electrodes. We developed a non-equilibrium fast calcination technique to synthesize polyanionic positive electrodes inheriting weak covalent (WC) X-O bond characteristics from screened precursor. In as-synthesized NASICON-Na 3 V 2 O 1.6 (PO 4 ) 2 F 1.4 as proof-of-concept positive electrode, the WC P-O bonds effectively activate electron delocalization, thereby increasing electrons transport capability along V-O-P-O-V pathway. The intrinsic electronic conductivity of optimised material achieves 3.57 times enhancement, leading to 3.70 times and 3.86 times improvement in specific capacity and specific energy at 50 C. Meanwhile, the optimised material exhibits capacity retention of 85.9% after 3000 cycles at 1 C. This study potentially opens up a broad space for improving the intrinsic conductivity of polyanionic materials (such as phosphates, sulfates, silicates, etc.), with the potential to promote the development of next-generation high-power positive electrode.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Jiachen Chen,Zihao Tao,Chenyu Qiu,Rui Wu,Zihao Huang,Xinyu Jiang,Pingyi Zhu,Yifan Wang,Longfa Kou,Xiujun Cai
Liver fibrosis is a major contributor to global mortality due to its progressive disruption of hepatic architecture and function, and it remains a critical unmet medical need. Hepatic stellate cells (HSCs) are considered a key therapeutic target owing to their central role in fibrosis progression, primarily mediated through the TGF-β1/Smad2/3 signaling pathway. Pirfenidone (PFD), a clinically approved broad-spectrum antifibrotic agent, shows potential for repurposing in liver fibrosis therapy. However, its clinical translation is limited by poor aqueous solubility and a lack of cellular targeting specificity. To address these limitations, we developed a vitamin A-conjugated liposomal delivery system (P@GB-Lipo-VA) to enhance the liver-specific accumulation of PFD. In vitro studies demonstrated that P@GB-Lipo-VA significantly increased cellular uptake in TGF-β1-stimulated LX-2 cells and reduced oxidative stress. In a bile duct ligation (BDL)-induced mouse model of liver fibrosis, P@GB-Lipo-VA effectively alleviated collagen deposition, improved liver function, and suppressed activation of the TGF-β1/Smad signaling pathway. These findings support P@GB-Lipo-VA as a promising targeted nanotherapeutic platform for enhancing the efficacy and safety of PFD in the treatment of liver fibrosis.
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高影响因子
Nature Nanotechnology
·
2026
·
IF 37.5
Wang Qin,Zeng Cici,Chen Ziqi,Hu Lei,Dou Jiaxiang,Ye Chengkun,Zhu Lianbang,Liang Qirui,Pan Huimin,Jiang Wei,Wang Yucai
Considering that 90% of cancer-related deaths are due to metastasis, treating micrometastases in their infancy is critical. Targeting micrometastases with nanoparticles has shown therapeutic potential, but a limited understanding of the delivery mechanisms has slowed material optimization. Here, using real-time intravital imaging, we discover that nanoparticles can gather around avascular micrometastases through the enhanced permeability of vessels in adjacent non-malignant tissues, defined as the enhanced permeability of adjacent vessels effect. We show that micrometastases have altered mechanical properties and imposed compressive stress on adjacent vessels, activating β1 integrins and subsequent cytoskeletal organization, which leads to the disruption of endothelial integrity and increased vascular permeability. Ultimately, this enhanced-permeability-of-adjacent-vessels-enabled nanoparticle enrichment substantially amplifies the therapeutic outcomes for metastatic interventions. These findings elucidate the mechanisms of nanoparticle delivery to micrometastases, offering promising avenues for nanoparticle-based diagnostics and therapies for metastatic cancer.
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CHEMICAL PAPERS
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2026
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IF 2.7
Ma Chengzhang,Tao Xin,Liu Yang,Luo Bitao,Long Qi
To develop a high-performance material for heavy metal remediation, calcium silicate hydrate (CSH) was synthesized using calcium chloride and sodium metasilicate as precursors via a constant-temperature solid-phase method. A novel ternary adsorbent, Fe 3 O 4 /CSH@MCC, was successfully constructed by coating Fe 3 O 4 -loaded CSH with microcrystalline cellulose (MCC). The surface characteristics, structural, morphological, and thermal stability were characterized using SEM, FTIR, XRD, BET, TGA and XPS analyses. The adsorption behavior was further elucidated through kinetic, thermodynamic, and isotherm modeling. The results indicated that under optimal conditions (pH = 5), the maximum adsorption capacities for Ni 2+ , Cu 2+ , Pb 2+ , and Ag + reached 792.52 mg/g, 683.45 mg/g, 750.08 mg/g, and 351.05 mg/g, respectively. Rapid adsorption equilibrium was achieved within 60 min, with corresponding removal efficiencies of 99.53%, 86.32%, 97.19%, and 48.10%. Thermodynamic and kinetic analyses demonstrated that the adsorption process follows the Langmuir isotherm model, indicating a monolayer adsorption mechanism. The pseudo-second-order kinetic model suggested that chemisorption is the dominant adsorption mechanism. These findings underscore the potential of the Fe 3 O 4 /CSH@MCC composite as an efficient material for wastewater treatment, offering a promising solution for the environmental remediation of heavy metal pollutants.
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高影响因子
Nature Energy
·
2026
·
IF 70.1
Ma Tianshu,Zhao Yue,Zhu Jingwei,Yin Xinxing,An Yidan,Chen Cong,Shang Minghui,Wang Huayang,Wu Zhanghao,Liu Yuhui,Chen Chen,Guan Yuxiang,Luo Jincheng,Zhang Jing,Li Minghui,Xiao Chuanxiao,Yao Fang,Lin Qianqian,Yang Zhenhai,Cao Guoyang,Wang Changlei,Zhao Dewei,Li Xiaofeng
Low-bandgap ( E g ~ 1.25 eV) tin–lead perovskite solar cells hold great potential for constructing efficient all-perovskite tandem solar cells (TSCs). However, rapid degradation of perovskite precursor solutions, owing to easy oxidation of Sn 2+ , remains a major challenge. Here we elucidate oxidation pathways in Sn–Pb perovskite precursors. We further introduce basic amino acids and basic amino acids sulfate (BAAS) as proton scavengers, which stabilize the ink for over 300 days. BAAS neutralizes excess protons to mitigate dimethyl sulfoxide-driven oxidation reactions, whereas sulfate ions coordinate Sn 2+ to passivate defects and regulate crystallization. The optimized low-bandgap perovskite solar cell achieves a power conversion efficiency of 24.06% with an open-circuit voltage of 0.905 V, enabling two-terminal all-perovskite TSCs with a power conversion efficiency of 30.24% (certified 29.56%). The BAAS-passivated TSCs retain over 85% of their initial performance after 1,000 hours of the maximum power point operation under 1-sun illumination.
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高影响因子
Nature Communications
·
2026
·Vol. 17
·期 1
·4773
·
IF 18.1
Ren Lingling,Ma Guoxuan,Wang Zheng,Liu Shuang,Cheng Haoran,Weitz David A.,Zhang Liyuan
Hydrogels typically deteriorate under high-salinity conditions because electrostatic screening and reduced polymer-solvent affinity suppress swelling and weaken load-bearing network connectivity. Here, we report a double-network hydrogel that strengthens while swelling in brine. Compared with its behavior in water, the network undergoes an ion-triggered topological reconfiguration upon salt exposure. The intrachain zwitterionic ion pairs open and reform as inter-network SBVI + -AMPS − bridges, increasing effective bridge density at lower polymer fraction. The hydrogel exhibits 1.63-fold tensile strength and 1.21-fold swelling ratio in 200 g/L NaCl compared to deionized water. SAXS and XPS confirm salt-induced structural homogenization and charge redistribution. Density functional theory calculations support strengthened ionic association under saline conditions between SBVI and AMPS. Free energy analysis reveals that reduced loop fraction and increased connectivity enable associative stabilization to compensate for elastic swelling penalties. Core-flooding demonstrates robust injectability in high-salinity porous rock. This mechanism provides design rules for salt-adaptive hydrogels.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 3
·820-827
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IF 1.4
Zhou Rui,Ding Jie,Wu Tengfei,Lu Xiaodie,Chen Jingyu,Li Zhiqiang
In order to investigate the effects of oxide particles on the high-temperature resistance and ablation performance of ceramicizable phenolic resin composites, three types of quartz fiber-reinforced ceramicizable phenolic resin composites were prepared using MgO particles or Al 2 O 3 particles as the second-phase oxides and ZrB 2 particles as the high-temperature ceramic filler, through a mold pressing process. The enhancement effects and mechanisms of the added second-phase oxides on the high-temperature resistance and ablation performance of the composites were discussed and analyzed through high-temperature testing, phase characterization, oxyacetylene testing, and microstructure characterization. The results show that ZrB 2 particles oxidize to form ZrO 2 and B 2 O 3 in an oxygen-rich high-temperature environment. The added second-phase oxide particles can react with B 2 O 3 to form corresponding borates, thereby strengthening the matrix. After treatment at 800 °C, the flexural strength of the ZrB 2 -MgO quartz fiber-reinforced phenolic resin composite (QFPR/ZM) increased by 55.3% compared to the ZrB 2 quartz fiber-reinforced phenolic resin composite (QFPR/Z). The oxyacetylene ablation performance of the composites with added oxide particles was significantly influenced by the generated borates. Mg 3 B 2 O 6 has a higher high-temperature viscosity than Al 18 B 4 O 33 at high temperatures, resulting in a lower linear ablation rate for QFPR/ZM compared to the ZrB 2 -Al 2 O 3 quartz fiber-reinforced phenolic resin composite (QFPR/ZA).
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CELL RESEARCH
·
2026
·
IF 31.1
Li Xiaojing,Li Renjie,Wei Yiqing,Chen Jiexin,Zhao Jiaojiao,Zhao Jun,Wang Wei,Li Na,Wang Lili,Hu Tuo,Dong Yanli,Zhu Yongping,Wei Chao,Li Long,Zhang Wei,Huang Zhuo,Zhao Yan
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission throughout the central nervous system. Calcium-permeable AMPARs and GluA4-containing receptors are critical for cerebellar functions, such as motor learning, associative memory, auditory processing, and synaptic plasticity. In contrast to the well-characterized, predominantly GluA2-containing AMPARs of the hippocampus and cortex, cerebellar AMPARs contain a higher proportion of GluA4 and remain poorly understood. Here, we generated a highly GluA4-specific antibody. Using this antibody in combination with antibodies specifically recognizing GluA1 and GluA2, we purified native AMPARs and determined the subunit compositions of both calcium-impermeable and calcium-permeable native AMPARs in the cerebellum. The isolated cerebellar AMPARs that contained both GluA1 and GluA4 were calcium-permeable, with GluA4 occupying mainly the B/D positions, GluA1 occupying the A/C positions, and the complex associated primarily with cornichon 3 (CNIH3). We determined the structures of the complex in distinct functional states, including the resting, active, and desensitized states, and characterized the conformational transitions that underlie its activity. During desensitization, the receptor adopts a pseudo-4-fold configuration of the ligand-binding domain layer, which may be important for its functional properties. This study provides a blueprint for the subunit compositions of AMPARs in the cerebellum and clarifies the gating mechanism of the calcium-permeable native AMPAR A1A4 –CNIH3 complex, providing significant insight into AMPAR-mediated synaptic transmission in the cerebellum.
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