IMMUNITY
·
2023
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IF 32.4
Qiong Luo,Yijun Liu,Ke Shi,Xuecheng Shen,Yaqi Yang,Xuejiao Liang,Liangliang Lu,Wenxuan Qiao,Airu Chen,Dongmei Hong,Yang Sun,Qiang Xu
Anti-interleukin-17 (IL-17) therapy has been used in various autoimmune diseases. However, the efficacy is unexpectedly limited in several IL-17-associated diseases, and the mechanism of limited efficacy remains unclear. Here, we show that a molecular complex containing the adaptor molecule Act1 and tyrosine phosphatase SHP2 mediated autonomous IL-17R signaling that accelerated and sustained inflammation. SHP2, aberrantly augmented in various autoimmune diseases, was induced by IL-17A itself in astrocytes and keratinocytes, sustaining chemokine production even upon anti-IL-17 therapies. Mechanistically, SHP2 directly interacted with and dephosphorylated Act1, which replaced Act1-TRAF5 complexes and induced IL-17-independent activation of IL-17R signaling. Genetic or pharmacologic inactivation of SHP2, or blocking Act1-SHP2 interaction, paralyzed both IL-17-induced and IL-17-independent signaling and attenuated primary or relapsing experimental autoimmune encephalomyelitis. Therefore, Act1-SHP2 complexes mediate an alternative pathway for autonomous activation of IL-17R signaling, targeting which could be a therapeutic option for IL-17-related diseases in addition to current antibody therapies.
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2023
·Vol. 98
·期 10
·2597-2609
·
IF 3.4
Jun Chen,Xiaohong Yang,Shangqing Xia,Xue Li,Yutong Wang,Zongsheng Zhan,Mingxia Du,Dongliang Shao
BACKGROUND Persulfate (PS) has the capability to yield free radicals via activators, thereby shaping an advanced oxidation process that can significantly contribute to effective sterilization. Central to this technology is the pursuit of appropriate activators. RESULTS In our research, we successfully synthesized an economical and efficient PS activator, namely a pyrrhotite-loaded sludge carbon (Pyr-SC) composite. This was achieved via a straightforward procedure utilizing two environmentally friendly and cost-efficient raw materials: pyrite and sludge. Pyr-SC exhibited a specific surface area of 60.4 m 2 g −1 and rich functional groups such as carbon–sulfur and sulfur–oxygen. The magnetic and graphitic carbon structures were formed at high temperatures during the preparation process, and the sludge carbon (SC) exhibited porous defects, which allowed the effective insertion of iron/sulfur into SC to form the stable Pyr-SC structure. Pyr-SC activated PS, which further sterilized Escherichia coli in the wastewater at a sterilization rate of 7.00 lg E. coli at 10 7 cfu mL −1 in 80 min. The sterilization rate was less affected by temperature and pH. We verified sulfate, hydroxyl and oxygen free radicals produced by the Pyr-SC-activated PS. The Pyr-SC composite, thanks to its expedited electron transfer, could activate PS to engender free radicals. Furthermore, the oscillatory transformation of iron ions caused by the monosulfide ion on the Pyr-SC surface augmented the production of free radicals. An assessment of Pyr-SC's stability was conducted, adhering to the principles of magnetic separation. After five cycles in the Pyr-SC/PS reaction system, the sterilization rate reached 3.29 lg, whereas the leaching rate of iron in Pyr-SC decreased. The Pyr-SC/PS reaction system also had a broad spectrum of wastewater. CONCLUSION The economically prepared Pyr-SC composite provided an effective technology for activating PS and sterilizing microorganisms in wastewater. © 2023 Society of Chemical Industry.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Li Guoqing,Liu Su,Chen Yixiao,Zhao Jin,Xu Huihui,Weng Jian,Yu Fei,Xiong Ao,Udduttula Anjaneyulu,Wang Deli,Liu Peng,Chen Yingqi,Zeng Hui
Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development of a biofunctional hydrogel for improved delivery is required. In this study, we introduce a liposome-anchored teriparatide (PTH (1–34)) incorporated into a gallic acid-grafted gelatin injectable hydrogel (GLP hydrogel). We show that the GLP hydrogel can form in situ and without affecting knee motion after intra-articular injection in mice. We demonstrate controlled, sustained release of PTH (1–34) from the GLP hydrogel. We find that the GLP hydrogel promotes ATDC5 cell proliferation and protects the IL-1β-induced ATDC5 cells from further OA progression by regulating the PI3K/AKT signaling pathway. Further, we show that intra-articular injection of hydrogels into an OA-induced mouse model promotes glycosaminoglycans synthesis and protects the cartilage from degradation, supporting the potential of this biomaterial for OA treatment.
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ENERGY
·
2023
·
IF 9
Xingxing Zhao,Yudong Ding,Lijiao Ma,Xun Zhu,Hong Wang,Min Cheng,Qiang Liao
Porous liquids (PLs) is a new material with two seemingly unrelated characteristics: porosity and liquidity. In this study, an amine functionalized strategy was proposed to enhance the CO 2 absorption of Type III Porous Liquids. 2-Methylimidazole zinc salt (ZIF-8) modified by tetraethylenepentamine (TEPA) was chosen for providing porosities and the 1-Ethyl-3-methylimidazolium Bis(trifluoro-methanesulfonyl)-imide ([EMlm][NTf 2 ]) was chosen as sterically hindered solvent, an amine-functionalized type Ⅲ porous liquids were reported. First, amine groups were successfully loaded on the ZIF-8. Then, the effect of amine loading on ZIF-8 was investigated. It was found the 30 TEPA@ZIF-8 nanoparticles were the optimum candidates based on CO 2 absorption capacity and micropore analysis. Subsequently, the CO 2 absorption capacity of absorbent was studied. 5-30TEPA@ZIF-8/[EMlm][NTf 2 ] had a CO 2 absorption capacity of 0.124 mmol g −1 , which was 4.43 times higher than 5-0TEPA@ZIF-8/[EMlm][NTf 2 ]. And the corresponding absorption rate increased by 745%. Three kinetics models were used for describing the absorption process, and the result showed the fractional-order kinetic model was the most accurate. Finally, the absorbent had a low heat absorption with a value of −1.38 kJ/mol. The CO 2 absorption capacity lost just 4.3% after five cycles. All the results indicate the prepared porous liquids had an application potential in CO 2 capture.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-7
·
IF 16.6
Wang Zhi-Da,Liang Song,Yang Yuqing,Liu Zhen-Ning,Duan Xiao-Zheng,Li Xinpei,Liu Tianbo,Zang Hong-Ying
Inorganic salts usually demonstrate simple phasal behaviors in dilute aqueous solution mainly involving soluble (homogeneous) and insoluble (macrophase separation) scenarios. Herein, we report the discovery of complex phase behavior involving multiple phase transitions of clear solution – macrophase separation – gelation – solution – macrophase separation in the dilute aqueous solutions of a structurally well-defined molecular cluster [Mo 7 O 24 ] 6− macroanions with the continuous addition of Fe 3+ . No chemical reaction was involved. The transitions are closely related to the strong electrostatic interaction between [Mo 7 O 24 ] 6− and their Fe 3+ counterions, the counterion-mediated attraction and the consequent charge inversion, leading to the formation of linear/branched supramolecular structures, as confirmed by experimental results and molecular dynamics simulations. The rich phase behavior demonstrated by the inorganic cluster [Mo 7 O 24 ] 6− expands our understanding of nanoscale ions in solution.
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Guo-chang Song,Xing-yu Yang,Zhong-wei Li,Qiang Song
Arsenic (As) pollutants are highly toxic and using Ca-based minerals to adsorb As 2 O 3 is effective for emission control. In this study, a fixed-bed experimental system was used to study the adsorption of As 2 O 3 by the mixture of CaO, SiO 2 , and Al 2 O 3 at 1200 °C. The amount of As adsorbed by multiple minerals was higher than that by single minerals, indicating enhanced adsorption of As 2 O 3 under the coupling effects of Ca, Si, and Al. The adsorption amount of As first increased and then decreased with an increase in the CaO:(SiO 2 +Al 2 O 3 ) and SiO 2 :Al 2 O 3 ratios. Adsorbed As was mainly enriched in Ca-Si-Al mineral, including Ca 2 Al 2 SiO 7 . Density Functional Theory calculation was conducted to study the As 2 O 3 adsorption on the Ca 2 Al 2 SiO 7 (0 0 1) surface. The analysis of Mulliken charge and density of states showed that As 2 O 3 molecules formed Al-O, O-As, and Ca-O bonds with the Al, O, and Ca sites. Si and Al in Ca 2 Al 2 SiO 7 enhanced the adsorption ability of Ca sites by promoting electron transfer . Si/Al ratio close to 1:1 is conducive to the formation of Si-O-Al structures, thus further enhancing the adsorption. The results can help optimize coal blending strategies and modify adsorbents to further reduce As emissions during coal combustion .
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CHEMOSPHERE
·
2023
·
IF 8.8
Qipeng Shi,Huaran Yang,Yanan Zheng,Na Zheng,Lei Lei,Xiaoyu Li,Weikai Ding
Resorcinol bis(diphenyl phosphate) (RDP), an emerging organophosphorus flame retardant and alternative to triphenyl phosphate (TPHP), is a widespread environmental pollutant. The neurotoxicity of RDP has attracted much attention, as RDP exhibits a similar structure to TPHP, a neurotoxin. In this study, the neurotoxicity of RDP was investigated by using a zebrafish ( Danio rerio ) model. Zebrafish embryos were exposed to RDP (0, 0.3, 3, 90, 300 and 900 nM) from 2 to 144 h postfertilization. After this exposure, the decreased heart rates and body lengths and the increased malformation rates were observed. RDP exposure significantly reduced the locomotor behavior under light-dark transition stimulation and the flash stimulus response of larvae. Molecular docking results showed that RDP could bind to the active site of zebrafish AChE and that RDP and AChE exhibit potent binding affinity. RDP exposure also significantly inhibited AChE activity in larvae. The content of neurotransmitters (γ-aminobutyric, glutamate, acetylcholine , choline and epinephrine) was altered after RDP exposure. Key genes ( α1-tubulin , mbp , syn2a , gfap , shhα , manf , neurogenin , gap - 43 and ache ) as well as proteins (α1-tubulin and syn2a) related to the development of the central nervous system (CNS) were downregulated. Taken together, our results showed that RDP can affect different parameters related to CNS development, eventually leading to neurotoxicity. This study indicated that more attention should be paid to the toxicity and environmental risk of emerging organophosphorus flame retardants.
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Journal of Cleaner Production
·
2023
·
IF 11.1
Huiping Wang,Qixiang Wang,Qiwei Wang,Wenjuan Dong,Yang Liu,Qin Hu,Xiuli Song,Shaomin Shuang,Chuan Dong,Xiaojuan Gong
Bacterial infections have become a considerable obstacle to public health due to the emergence of antibiotic resistance. Herein, we rationally developed a novel and attractive nitrogen-doped carbon nanodots (N-CNDs) as efficient metal-free artificial nanozymes that synergistically and efficiently inhibit bacterial survival by inheriting the bacteriostatic ability of tea polyphenols and light-triggered oxidase-like catalytic activity . The excellent oxidase-mimicking activity exhibited by N-CNDs in the light was mediated by superoxide radicals (•O 2 − ) with a high maximum reaction rate (1.59 μM⋅s −1 ) and a low Michaelis constant (0.421 mM). Furthermore, the constructed N-CNDs-based nanozyme was demonstrated to serve as a complex biomaterial platform for efficient sterilization by light-driven oxygen molecule generation of •O 2 − . Remarkably, the inherent antibacterial ability of N-CNDs can effectively inhibit both Gram-positive and Gram-negative bacteria, particularly against Gram-positive S. aureus at a minimum inhibitory concentration (MIC 90 ) of 375 μg⋅mL −1 . The inactivation rates of N-CNDs alone agsinst E. coli and S. aureus were 59.72% and 37.15%, respectively. However, the inactivation rates of E. coli and S. aureus by N-CNDs achieved by light were as high as 97.91% and 80.02%, respectively. Encouragingly, a two-way ANOVA revealed that the concentration of N-CNDs and the duration of light exposure had a synergistic effect on antibacterial behavior, which provided favorable conditions for the sustained eradication of exposed bacteria. This synergistic strategy for bacterial eradication based on a novel metal-free carbon-based nanozyme provides a powerful and feasible approach for bacterial contamination management in food safety and environmental protection.
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Materials
·
2023
·Vol. 16
·期 8
·3195
·
IF 3.4
Tingting Pei,Yaxian Chen,Huiting Wang,Lixin Xia
A new type of catalyst was synthesized by immobilizing heteropolyacid on ionic liquid-modified mesostructured cellular silica foam (denoted as MCF) and applied to the oxidative desulfurization of fuel. The surface morphology and structure of the catalyst were characterized by XRD, TEM, N2adsorption–desorption, FT-IR, EDS and XPS analysis. The catalyst exhibited good stability and desulfurization for various sulfur-containing compounds in oxidative desulfurization. Heteropolyacid ionic liquid-based MCF solved the shortage of the amount of ionic liquid and difficult separation in the process of oxidative desulfurization. Meanwhile, MCF had a special three-dimensional structure that was not only highly conducive to mass transfer but also greatly increased catalytic active sites and significantly improved catalytic efficiency. Accordingly, the prepared catalyst of 1-butyl-3-methyl imidazolium phosphomolybdic acid-based MCF (denoted as [BMIM]3PMo12O40-based MCF) exhibited high desulfurization activity in an oxidative desulfurization system. The removal of dibenzothiophene could achieve levels of 100% in 90 min. Additionally, four sulfur-containing compounds could be removed completely under mild conditions. Due to the stability of the structure, sulfur removal efficiency still reached 99.8% after the catalyst was recycled six times.Keywords:heteropolyacids;ionic liquids;mesostructured cellular silica foam;oxidative desulfurization
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Shudi Zhang,Juan Xi,Jiajia Wu,Peng Wang,Feng Lin,Dun Zhang
Underwater optical instruments are subjecting marine biofouling, which leads to inaccuracy of data acquisition. In order to solve the biofouling of the optical instrument, a specific electrochemical chlorination device with highly efficient chlorine evolution reaction (CER) catalyst prepared by potentiostatic electrodeposition was designed and utilized. The catalytic activity, CER selectivity , and durability of the as-prepared CER catalyst are better than the noble metal catalysts in near-neutral seawater . Compared with the common optical glass , the application of the chlorination instrument effectively inhibits the bacterial settlement, and helps to maintain high light transmittance of the optical window. This work offers a useful strategy for the antifouling of marine optical equipment .
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CHEMOSPHERE
·
2021
·
IF 7.086
Yifan Liu,Zuxue Liang,Chunxiang Lin,Xiaoxia Ye,Yuancai Lv,Pingfan Xu,Minghua Liu
An amphiphilic cellulose aerogel (HCNC-TPB/TMC) was fabricated by grafting 1,3,5-Tris (4-aminophenyl)benzene (TPB) and trimesoyl chloride (TMC) onto the aldehyde nanocellulose through Schiff alkali and substitution reaction. The obtained HCNC-TPB/TMC exhibited good morphology with cellulose fiber and owned abundant hydrophilic amino and carboxyl groups and hydrophobic aromatic groups. The batch adsorption experiments demonstrated that HCNC-TPB/TMC showed excellent adsorption performance ( Q max = 526.32 mg g −1 ) for sodium diclofenac (DCF), wide pH applicability (4–10) and outstanding stability and reusability. The DCF adsorption obeyed the pseudo-second-order kinetic model and the Langmuir isotherm, and underwent a spontaneous exothermic process. The main adsorption mechanisms involved electrostatic interaction, hydrogen bonds , π-π stacking interaction and hydrophobic effect. Importantly, the introduced carboxyl aromatic groups on TMC could effectively strengthen the hydrogen bonds and the π-π stacking between HCNC-TPB/TMC and DCF.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yuechao Yang,Danxia Xu,Baolong Zhang,Zhimin Xue,Tiancheng Mu
Electrochemical oxidation of alcohol and aldehyde to carboxylic acids is one of the most important classes of catalytic reaction. The key point for such reactions lies in the fine tailoring the catalysts to improve the reaction and energy efficiency. For such a destination, identifying descriptors which are highly related to the catalytic efficiency is a prerequisite for designing electrocatalysts. In this work, taking 5-hydroxymethylfurfural (HMF), a biomass derived platform molecule containing alcohol and aldehyde, as the main research object, we revealed for the first time that the adsorption energy of substrate molecule is an activity descriptor for electrochemical alcohol and aldehyde oxidation. Too weak substrate adsorption is not favorable to C–H/O–H bond activation and dissociation, while too strong substrate adsorption hinders the formation of enough OH ads (an important intermediate) due to the competitive adsorption of substrate molecules and OH – at limited reaction sites. The optimal catalytic activity can be achieved by adjusting the adsorption energy of substrate molecules to make them properly adsorbed on the catalyst surface. This work not only offers a guideline for the design of advanced catalysts towards the electrochemical alcohol and aldehyde oxidation (e.g., methanol, ethanol, benzyl alcohol, glycerol, glucose, furfural and HMF) for the utilization and production of renewable resources, but also benefits the design of other electrochemical catalysts.
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