ACS Sensors
·
2026
·Vol. 11
·期 8
·7629-7639
·
IF 10.9
He Jianwang,Zhang Rongkai,Wei Yuyu,Ji Mingwei,Meng Hu,Xu Yan
Nitrous oxide (N 2 O) is a potent greenhouse gas, but its chemical inertness hinders sensitive chemiresistive sensing. We demonstrate here that Au-decorated ZnO (Au-ZnO) dramatically enhances N 2 O detection. At an operating temperature of 260 ° C, the Au-ZnO sensor responds to 25 ppm N 2 O with a value of 7.6, which is a 3.8-fold enhancement over the ZnO sensor. It also exhibits high selectivity against common greenhouse gases, a lower theoretical limit of detection (0.24 ppm), a fast response time (10 s), and reliable stability. The previously elusive mechanism has been uncovered by integrating experimental characterizations and density functional theory calculations. A strong metal–support interaction, abundant oxygen vacancies at the Au-ZnO interface, and an electron-rich surface collectively switch N 2 O adsorption geometry from the O-end (physisorption on ZnO) to the N-end (weak chemisorption on Au-ZnO). This switch induces significant intramolecular charge rearrangement of N 2 O, which is crucial for enhancing the selective N 2 O sensing reaction. The abundance of reactive sites, the spillover effect, and the catalytic action of Au nanoparticles, as well as the narrowed band gap, promote N 2 O adsorption, surface reactions, and rapid charge transfer collectively. This work goes beyond the traditional oxygen-ionosorption model by showing that switching adsorption geometry and intramolecular polarization are crucial for activating inert molecules. This provides a detailed explanation of how to create high-performance N 2 O sensors.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·383
·
IF 5.4
Hu Rongjing,Fu Shilan,Zhang Jingwen,Zhang Jiadan,Fu Fengfu,Lin Zhenyu,Dong Yongqiang
A new method is developed to synthesize Au/Ag alloy nanoparticles (Au/Ag-NPs). The obtained Au/Ag-NPs are further dispersed in polyvinyl alcohol (PVA) solution to construct Au/Ag hydrogel surface enhanced Raman scattering (SERS) chips through a simple Ca 2+ -mediated aggregation of Au/Ag-NPs and a physical crosslinking of PVA. The formed aggregated Au/Ag-NPs (a-Au/Ag-NPs) show a strong localized surface plasmon resonance corresponding to the commonly used 532 nm laser. Therefore, under the action of 532 nm laser, the abundant nanogaps contained in the a-Au/Ag-NPs turn to high active electromagnetic “hot spots”, providing strong electromagnetic enhancement (EM). Moreover, Au/Ag-NPs provide a moderate Fermi level of -4.72 eV, which facilitates its photo-induced charge transfer with many molecules under 532 nm laser irradiation, resulting in the chemical enhancement (CM) effect. The synergistic effect of EM and CM leads to ultrahigh SERS activity. Additionally, the unique structure of hydrogel provides excellent signal uniformity and robust anti-interference ability. Thus, the obtained Au/Ag hydrogel SERS chips are ideal SERS platform for the quantitative determination of many molecules. For instance, a sensitive and reliable SERS method is established for the simultaneous detection of methyl parathion and triazophos in fruits and tea. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
ACS Nano
·
2026
·
IF 17.3
Zichen Liang,Rui Wang,Yiyang Wang,Qing Wang,Yihan Chen,Zehui Zhang,Mengyuan He,Jiajie Yang,Luchen Sun,Qing Zhang,Hongqian Guo,Pingping Shen,Nanfei Yang
Chimeric antigen receptor-T (CAR-T) adoptive transfer therapy has shown remarkable efficacy in hematologic malignancies. However, the therapeutic efficacy of CAR-T in treating solid tumors, particularly “cold tumors” such as prostate cancer, is significantly restricted by the cumbersome ex vivo manufacturing, impaired T cell fitness, and an immunosuppressive tumor microenvironment that blunts T cell function. Here, we successfully constructed a nanodelivery system based on zeolitic imidazolate framework-8 (ZIF-8). This system exhibited high CAR-gene encapsulation efficiency, reduced nonspecific hepatic accumulation, targeted delivery to tumor-associated macrophages (TAMs), and efficient intracellular gene transfection efficiency, enabling in situ construction of chimeric antigen receptor macrophage (CAR-M). Co-delivery of IFN-γ and CAR genes not only maintained the specific tumor-killing and phagocytic activity of CAR-Ms against tumor cells but also activated adaptive immunity, inducing excellent antitumor efficacy, as evidenced by the observed 95.54% inhibition of tumor growth in a prostate cancer mouse model. This strategy provides a promising approach for systematic in vivo editing of CAR-Ms.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Qianqian Yu,Jingxiao Yu,Qing Yang,Da-Wen Sun,Hongbin Pu
A novel chiral hierarchical porous ZIF-8/Au@Ag bipyramids SERS substrate (HPZA) was constructed. • Developing a dual-chiral synergistic enhancement strategy. • Pioneering the integration of deep learning algorithm with this chiral SERS platform. The widespread use of combined pesticides has led to increasing concerns over mixed pesticide residues in food, posing significant challenges for rapid and reliable detection. Herein, we develop an intelligent surface-enhanced Raman spectroscopy (SERS) platform by integrating a bichiral nanostructured substrate with deep learning for multiplex pesticide analysis. A hierarchical porous chiral ZIF-8 (HPZ) was engineered using L-histidine as a pore-expanding agent and assembled with L-cysteine-directed Au@Ag bipyramids to form the HPZA substrate, enabling synergistic adsorption enrichment and electromagnetic enhancement. The resulting platform exhibits high sensitivity and stability, achieving a detection limit of 9.54 ng/mL for quinalphos in citrus samples. Moreover, when coupled with a fully connected neural network (FCNN), it enables accurate discrimination of multiple pesticides and their mixtures, reaching an identification accuracy of 93.33%. This work presents an integrated material–algorithm strategy for rapid and intelligent detection of pesticide residues, offering a promising approach for food safety monitoring. Download: Download high-res image (105KB) Download: Download full-size image
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LANGMUIR
·
2026
·
IF 4.4
Zhenyu Wen,Wenjie Zhu,Huanhuan Sun,Yongxue Chen,Yuling Yang,Wutao Yang,Yanping Song,Wei Xie
Flexible and application-oriented surface-enhanced Raman spectroscopy (SERS) substrates are in high demand for trace-level molecular detection in complex environmental matrices. Herein, we report the development of a flexible hybrid SERS substrate supported on polydimethylsiloxane (PDMS), integrating phase-engineered 1T/2H-MoS2 nanoclusters decorated with Au nanoparticles (denoted as PDMS@1T/2H-MoS2@Au). Benefiting from the synergistic coupling between localized surface plasmon resonance (LSPR) of Au nanoparticles and charge-transfer-induced chemical enhancement from 1T/2H mixed-phase MoS2, the as-fabricated substrate exhibits strong and tunable SERS responses under multiwavelength excitation. Systematic SERS performance evaluations demonstrate that the substrate achieves high sensitivity with a detection limit down to 10–10 M for methylene blue (MB), excellent signal uniformity with a relative standard deviation (RSD) of 6.57%, and long-term stability with negligible signal degradation over 2 months, outperforming most flexible SERS substrates. Notably, multivariate analysis based on principal component analysis (PCA) reveals selective signal amplification toward MB in multicomponent dye systems, where the first principal component shows a strong correlation with the Raman fingerprint of MB. After spectral normalization, the PCA score plots further confirm the reliable molecular discrimination capability among multiple dye molecules. Importantly, the practical applicability of the flexible PDMS@1T/2H-MoS2@Au substrate is validated by the trace-level detection of the pesticide thiram on real apple surfaces through conformal contact, achieving a detection limit as low as 10–9 M. This work presents an application-focused sensing workflow, from the elucidation of the enhancement mechanism to real-sample analysis, highlighting the great potential of flexible MoS2–Au hybrid SERS substrates for advanced environmental and food safety molecular sensing.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Huilun Zhang,Wenhui Wang,Shanshan Xue,Limei Yin,Lijin Wang,Heera Jayan,Xiaobo Zou,Zhiming Guo
Background Rapid screening of pesticide residues directly on fruit surfaces is essential for food safety monitoring. However, conventional analytical methods usually require complicated sample pretreatment. This limitation restricts their practical use in in-situ residue analysis. Moreover, the non-planar morphology of fruit surfaces requires sensing platforms with good conformability. Results In this study, a low-cost flexible surface-enhanced Raman scattering (SERS) sensor was developed for thiabendazole (TBZ) residue detection on apple. Bimetallic Au@Ag core-shell nanocubes (Au@AgNCs) were immobilized onto inexpensive cellulose filter paper (CFP) through a simple polyelectrolyte-mediated layer-by-layer self-assembly strategy. The sharp corners of Au@AgNCs provided abundant plasmonic hotspots and strong Raman enhancement. The polyelectrolyte layers improved nanoparticle loading uniformity and substrate stability. The optimized sensor achieved an enhancement factor of 5.72 × 10 5 and showed good signal reproducibility. For in-situ detection of TBZ residues on apple, the sensor exhibited a linear response over 0.5–50 mg/L, with a correlation coefficient of 0.993 and a detection limit of 0.30 mg/L. The quantitative results were further validated by high-performance liquid chromatography (HPLC), confirming the reliability of the proposed sensor for real-sample analysis. Significance and novelty Overall, the Au@AgNCs/CFP/PSS flexible SERS sensor provides a low-cost and sensitive platform for in-situ detection of pesticide residues on irregular fruit samples.
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JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Jun Guo,Ruixin Chen,Wei Gan,Zifeng Wang,Xiaofen Xu,Deshuo Meng,Miao Zhang,Zhaoqi Sun
Antibiotics have garnered significant interests because of their harmful effects on non-target aquatic organisms, photocatalysis is an important technique for their removal. However, the photodegradation pathways, the toxicity of intermediates and the photodegradation mechanism of antibiotics are still unclear. In this study, Gatifloxacin was picked as the antibiotics’ representative via theoretical calculations and experiments to gain a comprehensive understanding of its decomposition pathways, the toxicity of intermediates, and the photodegradation mechanism on the Au-Black-TiO 2 nanorod arrays system. The highest photodegradation rate of Gatifloxacin is up to 92.6 %, with a reaction rate constant value of 0.00437. Moreover, three potential photodegradation pathways for Gatifloxacin were proposed based on density functional theory (DFT) and LC-MS experiments. Additionally, the toxicity of intermediates produced during the photodegradation of Gatifloxacin was assessed using quantitative structure-activity relationship (QSAR), revealing a decreased level of toxicity. Furthermore, the superior photodegradation mechanism and possible charger transfer pathways were also investigated. In conclusion, this research suggests a potential approach to understand the pathways, toxicity assessment, and mechanism insight during the antibiotics’ photodegradation process.
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ADVANCED FUNCTIONAL MATERIALS
·
2017
·Vol. 27
·期 18
·1700371
·
IF 12.124
Dan Yang,Guixin Yang,Piaoping Yang,Ruichan Lv,Shili Gai,Chunxia Li,Fei He,Jun Lin
Photodynamic therapy (PDT), as a minimally invasive and high-efficiency anticancer approach, has received extensive research attention recently. Despite plenty of effort devoted to exploring various types of photodynamic agents with strong near-infrared (NIR) absorbance for PDT and many encouraging progresses achieved in the area, effective and safe photodynamic photosensitizers with good biodegradability and biocompatibility are still highly expected. In this work, a novel nanocomposite has been developed by assembly of iron oxide (Fe 3 O 4 ) nanoparticles (NPs) and Au nanoparticles on black phosphorus sheets (BPs@Au@Fe 3 O 4 ), which shows a broad light absorption band and a photodegradable character. In vitro and in vivo assay indicates that BPs@Au@Fe 3 O 4 nanoparticles are highly biocompatible and exhibit excellent tumor inhibition efficacy owing to a synergistic photothermal and photodynamic therapy mediated by a low-power NIR laser. Importantly, BPs@Au@Fe 3 O 4 can anticipatorily suppress tumor growth by visualized synergistic therapy with the help of magnetic resonance imaging (MRI). This work presents the first combination application of the photodynamic and photothermal effect deriving from black phosphorus nanosheets and plasmonic photothermal effect from Au nanoparticles together with MRI from Fe 3 O 4 NPs, which may open the new utilization of black phosphorus nanosheets in biomedicine, optoelectronic devices, and photocatalysis.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Ziyin Yang,Xiao Bai
In this study, we described the facile synthesis of Au core flower surrounding with thin Co 3 O 4 shell for enhanced electrochemical sensing of H 2 O 2 . Such core-shell structure was obtained by employing Au 3+ to oxidize Co 2+ under alkaline conditions for triggering the redox assembly process. The experiment results revealed that conductive Au core flower was surrounded by thin Co 3 O 4 shell, and such structure not only accelerates electron transfer rate but also provides more effective active sites for H 2 O 2 reaction, therefore making the sensor based on Au@Co 3 O 4 exhibit an excellent performance for H 2 O 2 analysis with a linear range of 0.2 μM-7.1 mM, a high sensitivity of 722.4 μA mM −1 cm -2 and a low detection limit of 0.06 μM. The excellent experimental results implied that Au@Co 3 O 4 nanocomposite was a promising sensing material for electrochemical detection of H 2 O 2 .
研究领域:
材料科学
·
电化学
·
纳米技术
·
传感器与生物传感器
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Tianhang Liu,Kaisheng Yao,Shuaibo Li,Hang Li,Qi Wang,Tianhang Han,Aozhou Wang,Haili Zhao
Concave nanomaterials possess superior properties, but their synthesis usually requires complicated steps, specific conditions and additional reagents (surfactants, capping agents, seeds, etc.). Herein, the well-defined Au@Pd concave nanocubes (CNCs) is facile one-step fabricated in a deep eutectic solvent (DES, named reline) composed of choline chloride (ChCl) and urea. It is found that the reline is crucial to the formation of Au@Pd CNCs. Owing to the concave core-shell structures, and electronic effects between Au core and Pd shell, Au@Pd CNCs exhibited excellent catalytic performance, and recovery convenience in the selective hydrogenation of 4-nitrostyrene. Specifically, under normal temperature and pressure conditions (25°C, 0.1 MPa), 4-nitrostyrene can be completely hydrogenated to 4-nitroethylbenzene within 7.0 min. After five cycles, Au@Pd CNCs still maintain the highly catalytic activity and 100 % selectivity toward 4-nitroethylbenzene. It is expected that well-constructed Au@Pd CNCs also display advanced potentials in other applications.
研究领域:
纳米材料
·
催化化学
·
绿色化学
·
无机合成
·
加氢反应
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 3.8
Yin Yanjun,Shen Hailin,Wang Mengyao,Suo Zhiguang,Liu Yong,Wei Min
A self-calibrated ratiometric electrochemical aptasensor was developed for the detection of ochratoxin A. This sensor is based on DNA-mediated gold/prussian blue nanoflowers (Au/PB NFs), methylene blue/platinum/zinc-cobalt metal-organic framework (MB/Pt/ZnCo MOF), and an exonuclease III (Exo III)–driven bipedal DNA walker cyclic amplification strategy. The self-calibration mechanism of this sensor relies on the ratio between the response signal of MB/Pt/ZnCo MOF (I MB ) and the internal reference signal of Au/PB NFs (I PB ). This ratio can effectively resist external interference factors. DNA-mediated Au/PB NFs with a flower-like structure provide stable internal reference signals and promote electron transfer. MB/Pt/ZnCo MOF, leveraging ZnCo MOF with a porous structure and bimetallic synergistic effects, and Pt with electrocatalytic activity, serve as response signals. An Exo III–driven biped DNA walker was used to realize the cyclic amplification strategy. The sensor showed a wide linear range of 0.001~500 ng/mL, with a low limit of detection of 0.17 pg/mL. The detection capability of spiked corn flour, wine, and coffee powder samples was satisfactory, and the detection results for the quality control samples of coarse rice flour and wheat flour were not significantly different from those of high-performance liquid chromatography (HPLC), showing the potential for practical application.
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高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Jiajie Yu,Muzhong Shen,Siyu Liu,Feng Li,Dongping Sun,Tianhe Wang
In this paper, we describe a simple technique for direct growth of gold nanoparticles (GNPs) into a nanostructured porous alumina layer on conductive glass slide (PAOCG). PAOCG was attached firmly with a small piece of steel and was then immersed in a HAuCl 4 solution. Electro-induced electrons from steel were employed to reduce AuCl 4 − on PAOCG. The galvanic replacement reaction (GRR) was adopted as the fundamental mechanism for reducing metal precursors. This mechanism was further studied by open circuit potential-time (OCP-t) experiment and the result demonstrated that steel induced the continuous proceeding of this reaction. This strategy presents a simple and general protocol for preparation of metal nanoparticles (MNPs) on conductive glass substrates. The SERS properties of Au/PAOCG were investigated using aqueous crystal violet (CV) and 4-mercaptopyridine (4-Mpy) as probe molecules. Au/PAOCG allowed as low as 10 −9 M CV and 10 −8 M 4-Mpy to be detected. The reusability of this substrate was achieved by measuring the SERS spectrum of the probe molecules followed with a 400 °C heat treatment for 10 min to remove the residuals. This substrate could be reused for at least ten cycles without any significantly reduced SERS performance. Therefore, this surface can serve as a portable, durable and reusable SERS substrate and has a potential for commercial applications.
研究领域:
材料科学
·
分析化学
·
纳米技术
·
生物传感
·
表面科学
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