Acta Biomaterialia
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2026
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IF 10.4
Canyu Wang,Tao Yu,Hongxia Pu,Zhizhuo Zhou,Gaocan Li,Qinsheng Hu,Yunbing Wang
Heart valve disease poses a significant threat to human health, and the limitations of pharmacological interventions have led to heart valve replacement as an increasingly important therapeutic approach. However, the widely used glutaraldehyde cross-linked bioprosthetic heart valves are associated with several clinical problems, including thrombosis, chronic inflammation, calcification, and endothelial dysfunction, which seriously compromise their long-term efficacy. To overcome these issues, we develop an innovative functional surface engineering strategy performed sequentially at the molecular level. The proposed approach leverages the synergistic integration of a hyaluronic acid (HA) hydrogel coating and polyethyleneimine-dextran sulfate nanoparticles (PD NPs) to construct a bionic cascade functional interface. The HA hydrogel coating provides a hydrophilic barrier to decrease the risk of thrombosis and inflammation, while also mimicking the structure of the vascular endothelial glycocalyx to promote endothelial regeneration and block calcium ion deposition physically. PD NPs offer immediate anticoagulation and are chemically linked with hyaluronic acid to create a durable anti-inflammatory and slow-release network. By utilizing only three fundamental components (polyethyleneimine, dextran sulfate, and hyaluronic acid), this method integrates anticoagulant, anti-inflammatory, anti-calcification, and pro-endothelialization functions via a single surface modification. The topological coupling of the nanocarrier-hydrogel structure overcomes the constraints of traditional multi-step modifications and functional antagonism. It is worth noting that this functional system exhibits long-term stability, retaining structural integrity for over 2 years at room temperature, and is readily scalable for industrial application, presenting a promising solution to enhance the clinical performance of bioprosthetic heart valves. Statement of significance Heart valve disease poses a significant threat to human health, and the limitations of pharmacological interventions have led to heart valve replacement as an increasingly important therapeutic approach. However, the widely used glutaraldehyde cross-linked bioprosthetic heart valves (BHVs) are associated with several clinical problems, including thrombosis, chronic inflammation, calcification, and endothelial dysfunction, which seriously compromise their long-term efficacy. To overcome these issues, an innovative functional surface engineering strategy performed sequentially at the molecular level has been developed. The proposed approach leverages the synergistic integration of a hyaluronic acid hydrogel coating and polyethyleneimine-dextran sulfate nanoparticles to construct a bionic cascade functional interface, enhancing the antithrombotic and anti-inflammatory properties and enabling comprehensive regulation of acute and chronic inflammation for BHV materials. Download: Download high-res image (253KB) Download: Download full-size image
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Siwei Sun,Xinxin Zhang,Haitao Yu,Ying Xie
NiFe alloy is regarded as a promising electrocatalyst for water splitting owing to its superior conductivity, tunable electronic structure, and abundant active sites. Nevertheless, its practical application is hindered by slow water dissociation kinetics and unfavorable adsorption of hydrogen intermediates. Herein, we develop a composite catalyst, denoted as Co/Ni 3 Fe@NC-3 through a coordination-pyrolysis route, where ZIF-67-derived Co nanoparticles are anchored on Ni 3 Fe@NC porous nanosheets. In 1 M KOH, the catalyst exhibits remarkable bifunctional activity, requiring overpotentials of 67 mV for HER and 240 mV for OER at 10 mA cm −2 . Notably, a symmetric electrolyzer based on this catalyst (Co/Ni 3 Fe@NC-3) (+||−) achieves overall water splitting at a low voltage of 1.499 V (10 mA cm −2 ), superior to the commercial Pt/C||RuO 2 benchmark (1.592 V), and sustains stable operation for 100 h at 100 mA cm −2 . In-situ electrochemical impedance spectroscopy (EIS) indicates that Co incorporation optimizes the interfacial electronic structure, leading to faster charge transfer and reduced impedance. Density functional theory (DFT) calculations and experimental results further demonstrate that Co-induced interfacial electron redistribution upshifts the d-band centers ( E d ) of Ni/Fe sites, strengthens the adsorption of H* and H 2 O, and thus synergistically enhances both HER and OER performance. This study highlights the effectiveness of interface engineering and electronic structure modulation, providing a viable strategy for designing advanced NiFe-based water-splitting catalysts.
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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
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2026
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IF 6.6
Yuan-yuan Wang,Meng-na Ma,Bo Han,Hong-liang Zhang,Ling Ran,Ke-jia Qiang
Nanofluids are increasingly replacing conventional cooling media, such as deionized water, in CPU heat pipe cooling systems due to their superior thermophysical properties. However, screening and optimizing nanofluids for heat pipes remain highly complex and critical, and experimental and macroscopic simulations alone cannot fully reveal the underlying nanofluid heat transfer mechanisms. This study experimentally optimized nanofluid formulations and innovatively constructed a mesoscopic model of the porous wick structures in heat pipes based on Nano-CT reconstruction, providing in-depth insights into nanofluid heat transfer within porous wicks. Experiments evaluated the dispersion stability, thermal performance, and long-term stability of single-component Al₂O₃ and MgO nanofluids, Al₂O₃-MgO hybrid nanofluids, and surfactant-enhanced hybrid nanofluids, revealing the effects of nanoparticle concentration as well as surfactant type and concentration on heat pipe performance. The optimized SDS-enhanced Al₂O₃-MgO hybrid nanofluid exhibited a 36.55% reduction in thermal resistance compared with deionized water and a 33.51% reduction compared with the Al₂O₃ nanofluid, while maintaining stable performance over 100 days. Mesoscopic simulations further indicated that the optimal nanofluid achieved a 35.81% increase in heat transfer coefficient and a 16.25% enhancement in inlet-to-outlet temperature difference, effectively balancing low flow resistance with an adequate heat transfer coefficient. This study establishes design principles for heat pipe working fluids, providing theoretical guidance for the optimized matching of nanofluid formulations and porous wick structures in heat pipes and other nanofluid-enabled electronic cooling systems.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Xinglei Cui,Zhonglian Li,Long Li,Lei Zhu,Honghua Xu,Xi Zhu,Zhi Fang
Plasma polymerization is induced above and within the cellulose insulating paper. • Electrical, waterproof, and mechanical performances are enhanced simultaneously. • Surface and bulk insulation strength is improved for oil-paper insulation system. • Silicone crosslinking networks are constructed between cellulose porous structures. The oil-paper insulation system is widely used in power transmission devices such as the transformer and bushing, and the cellulose paper, immersed in oil serving as the primary insulation dielectric material, plays the pivotal role in ensuring reliable operation of the devices. However, it remains a challenge for the cellulose paper to possess long-term sufficient insulation performance in high-voltage, oil-immersed and water-contained complex environments due to its high dielectric constant and hydrophilicity compared with the oil, prone to absorb charge and moisture from the oil-paper interface to the bulk, making it vulnerable to breakdown failure. Herein, we propose to initiate polymerization on the surface and within the bulk of the cellulose insulating paper enabled by atmospheric low-temperature plasma treatment, constructing low-polarity crosslinking network between its intrinsic porous structures, thereby comprehensively enhancing versatile properties, specifically oil-paper dielectric constant adaptation, mechanical and insulation strength improvement, and moisture absorption suppression. The relative dielectric constant of the insulating paper is decreased by 44.4%, enabling its adaptation with the insulating oil. The wetting performance is changed from hydrophilic to superhydrophobic, reducing water absorption by 37.2%, inhibiting the transportation of water from the surface to the bulk. The insulation strength of the oil-paper system is enhanced by more than 22.9% by introducing deep traps, which inhibit the charge transportation and partial electric field distortion. The plasma-enhanced insulating paper and its improvements of comprehensive performances provide potential application for safe and stable power transmission. Download: Download high-res image (423KB) Download: Download full-size image
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CERAMICS INTERNATIONAL
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2026
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IF 6
Yujie Li,Jing Li,Jie Chen,Hui Lin,Yang Tang,Ruijin Hong,Zhaoxia Han,Dawei Zhang
Ceramic phosphors offer extremely high brightness and are well-suited for low-etendue optical systems. However, efficient heat dissipation under high-power-density excitation remains a key challenge. In this work, the influence of Al 2 O 3 addition on the densification, photoluminescence performance, and laser-induced damage behavior of YAG:Ce ceramic phosphors is systematically investigated. The main contribution of this study is to reveal the trade-off between low etendue and effective thermal management. The results show that a suitable amount of Al 2 O 3 addition can promote grain growth and reduce porosity. Under low power density, the emission intensity is maximized at moderate Al 2 O 3 content. As the power density increases, samples with higher Al 2 O 3 content exhibit more stable emission due to enhanced thermal conductivity and improved heat dissipation. The 20 wt% sample achieves balanced performance, exhibiting a relatively small emission spot that ensures low etendue while maintaining a comparably higher damage threshold, representing a key trade-off between low etendue and efficient thermal management.
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Journal of Hazardous Materials Advances
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2026
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IF 9.1
Wenqi Li,Ying Cao,Quanzhen Yang,He Liu,Stefanos Giannkis,Jin Jiang
UVA-driven iron-mediated sulfite advanced oxidation processes have demonstrated high efficiency in degrading organic pollutants, yet their potential for microbial inactivation remains underexplored. This study systematically investigates the disinfection performance and mechanism of a UVA/Fe(III)/sulfite system using Escherichia coli ( E. coli ) as a model bacterium. The ternary system exhibited synergistic bactericidal activity, achieving complete inactivation of 10 6 CFU/mL E. coli within 45 min at pH 5.6, significantly outperforming individual or binary controls. Radical quenching and electron paramagnetic resonance (EPR) analyses identified sulfate radicals ( SO 4 • − ) , hydroxyl radicals ( • OH ) , superoxide ( O 2 • − ) , and peroxymonosulfate radicals ( SO 5 • − ) as the primary reactive species, generated via a sustained photochemical Fe(II)/Fe(III) redox cycle. Mechanistic investigations revealed a multi-target oxidative cascade: initial disruption of cell envelope integrity and lipid peroxidation facilitated intracellular radical influx, leading to rapid adenosine triphosphate (ATP) depletion, inactivation of antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)), and oxidative deoxyribonucleic acid (DNA) lesions. Disinfection efficiency increased with decreasing pH, and was promoted by elevated dissolved oxygen. While chloride and nitrate exhibited moderate interference, phosphate and humic acid severely inhibited inactivation through Fe(III) precipitation and radical scavenging/light screening, respectively. These findings elucidate the inactivation pathways of the UVA/Fe(III)/sulfite system, establishing a theoretical foundation for its application as a cost-effective, solar-driven water disinfection strategy.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Wang Kai Tong,Chaomeng Dai,Jiajun Hu,Han Tang,Hong Cheng Zhang,Jia Jie Zou,Min-tian Gao,Jixiang Li,Zhi Li,Xihua Wang,Yalei Zhang,Kah Hon Leong,Swee Pin Yeap,Lang Zhou,Zhe Zhou
Surfactant-modified nanobubbles (S-NBs) are promising carriers for subsurface remediation, yet their transport in porous media remains insufficiently understood. In this study, the mobility of anionic sodium dodecyl sulfate (SDS)-, cationic cetyltrimethylammonium bromide (CTAB)-, and nonionic Triton X-100 (TX100)-stabilized nanobubbles was systematically evaluated in sand columns under varying groundwater chemistries and media conditions. The transport capacity followed the order SDS-NBs > CTAB-NBs > TX100-NBs > pure NBs. Adsorption of free surfactants on sand altered the interfacial electrical properties and shifted S-NB–collector interactions toward electrostatic repulsion. However, classical Derjaguin-Landau-Verwey-Overbeek (DLVO) theory could not explain the lower mobility of CTAB-NBs despite their higher predicted energy barrier relative to SDS-NBs. Straining and surface roughness effects were excluded. Kelvin probe force microscopy and microfluidic visualization showed that surfactant adsorption dynamically remodels nanoscale charge heterogeneity on sand surfaces. SDS preferentially shields positively charged impurity sites, reduces surface heterogeneity, and suppresses localized energy traps, resulting in an effective repulsive barrier stronger than that predicted by DLVO theory. In contrast, CTAB forms hydrophobic hemimicelles that enhance charge heterogeneity and lower the effective barrier to retention. These results identify adsorption-induced remodeling of nanoscale heterogeneity as a key mechanism governing S-NB transport in porous media and provide a basis for screening surfactant formulations for site-specific subsurface delivery.
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Stem Cell Reports
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2026
·Vol. 21
·期 9
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IF 5.6
Li Wenjing,Feng Yiting,Han Dongbo,Ao Yanxiao,Michael W. Chen,Li Ning,Jin Yuhong,Liang Haiwei,Liu Wen,Zhu Xiaoyu,Du Yanan
Understanding the regulation of hematopoietic stem and progenitor cell (HSPC) fate and translating it into effective culture strategies remains a significant challenge. Asymmetric lysosomal inheritance during HSPC division has been shown to predict variations in daughter cell activity and fate, yet the underlying regulators remain unclear. Through cell-cell communication analysis of bone marrow single-cell sequencing data, we identified the Notch ligand Delta-like protein 1 (DLL1) as a potential regulator in HSPC asymmetric division (ACD). Interactions between DLL1-presenting microparticles (MP-Ds) and HSPCs were observed in addressable microwell arrays, simulating cellular responses to localized niche signals. Long-term single-cell tracking revealed that MP-D interactions polarized HSPC lysosomes toward the contact site, directing division orientation and consequent asymmetric lysosomal inheritance in paired daughter cells. Furthermore, this co-culture system enhanced long-term hematopoietic reconstitution capacity of HSPCs in serial transplantations. Our findings support an association between HSPC ACD and the presentation mode of DLL1 signals, which enhances the ex vivo maintenance of HSPCs.
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Advanced Science
·
2026
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IF 14.1
Tianhua Xiao,Zunlei Gong,Chuke Chen,Hui Yu,Yu Cai,Can Liu,Hongkai Huang,Ying Li,Jinyuan Guan,Le Wang,Chengyun Ning,Guoxin Tan,Lei Zhou
Radiotherapy (RT) is widely used as an adjuvant treatment after surgical resection for osteosarcoma, but its efficacy is often limited by insufficient radiosensitization and an immunosuppressive tumor microenvironment that restricts systemic antitumor immunity and promotes recurrence and metastasis. Here we report an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. The condensate forms through coordination‐driven liquid‐liquid phase separation between Hf 4+ ions and alendronate, enabling local retention within postoperative bone defects and sustained therapeutic release. Upon X‐ray irradiation, the Hf component amplifies radiation energy deposition and reactive oxygen species generation, thereby enhancing radiation‐induced DNA damage and immunogenic cell death. Meanwhile, the acidic tumor microenvironment triggers responsive release of CXB and ALN; CXB inhibits the COX‐2/PGE 2 immunosuppressive pathway, while ALN promotes macrophage repolarization toward the M1 phenotype, collectively remodeling the tumor immune microenvironment. This strategy enhances dendritic cell maturation, activates cytotoxic CD8 + T cells, and reduces regulatory T‐cell infiltration. In orthotopic osteosarcoma models, CXB@Hf‐ALN combined with RT suppresses tumor recurrence, preserves bone integrity, inhibits pulmonary metastasis, and prolongs survival with minimal systemic toxicity, offering a promising strategy to improve postsurgical RT outcomes in osteosarcoma. This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage, while CXB blocks COX‐2/PGE 2 and ALN repolarizes M1 macrophages, remodeling immune microenvironment to inhibit recurrence/metastasis and preserve bone integrity.
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Laser & Photonics Reviews
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2026
·
IF 9.7
Qiming Huang,Jialiang Jiang,Hui Fu,Xi Chen,Hui Peng,Kanybek Osmonaliev,Samat Toktogonov,Jinju Zheng,Jialong Zhao,Weiyou Yang
Multimodal imaging that integrates x-ray, white light, and near-infrared (NIR) information offers enhanced diagnostic accuracy. However, the absence of material that can efficiently respond to all three types of signals requires the use of separate hardware for each modality, inevitably causing pixel misalignment and complicating system integration. To address this, we develop a Te 4+ /Mo 4+ co-doped Cs 2 HfCl 6 perovskite microcrystals (MCs) platform. Rational dopant engineering yields an optimized composition (3%Te 4+ , 5%Mo 4+ ) that simultaneously emits in the visible (570 nm, PLQY = 17.6%, from Te 4+ self-trapped excitons) and NIR (910 nm, PLQY = 41.7%, from Mo 4+ d-d transitions) regions. The high-Z host also ensures strong x-ray absorption, leading to exceptional x-ray scintillation performance with a light yield of 35 073 photons/MeV, a detection limit of 81.43 nGy air /s, and a spatial resolution of 13.6 lp/mm. The resulting flexible PDMS composite films function concurrently as white-light and NIR-emitting diodes, as well as high-resolution x-ray screens. Using a single detector with switchable excitation (450 nm LED or x-rays), we demonstrated pixel-registered trimodal imaging of a screw-ink-capsule phantom without the need for post-processing alignment. This rare-earth-free, all-in-one material strategy provides a compact and scalable route toward next-generation multimodal medical diagnostics.
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Small
·
2026
·
IF 11.8
Sihang Liu,Xin Jiang,Shuai Yin,Lian Xiao,Xiaopeng Shang,Hua Yang,Yuan Cao,Haiwang Li,Yi Huang
Triggered rupture in core–shell capsules is particularly attractive for applications that require rapid response, irreversible operation, or high instantaneous output, such as burst release and catalytic processes. In most existing designs, however, both rupture activation and threshold tuning rely on stimuli-responsive materials, which increases fabrication complexity and makes the triggering temperature largely dependent on the intrinsic thermal response of the chosen material. Here, we show that the thermal rupture threshold of sealed liquid-core capsules can be programmed through capsule geometry without incorporating thermoresponsive additives. Pentaerythritol triacrylate (PETA)-paraffin capsules with systematically varied core–shell geometries are fabricated using an endocytosis-like droplet-impact route. Thermal loading induces internal pressurization within the confined core, and rupture occurs when the resulting shell stress exceeds the load-bearing capacity of the shell. Experimental results and theoretical analysis support a pressure-driven rupture mechanism and explain the geometry dependence of the triggering threshold. As a simple demonstration, capsule rupture is used to actuate an electrical switch, illustrating its potential as a one-shot thermal response unit. This work establishes a structure-driven route to programmed thermal rupture in capsules and highlights geometric confinement as a design principle for rupture-based systems.
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Small Methods
·
2026
·Vol. 10
·期 17
·e70954
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IF 8.7
Dongdong Fan,Wenna Liu,Xiaocheng Huang,Zhenbo Wang,He Xu,Lian Huang,Yu Li,Chenke Gao,Yumin Ye
Ice and frost accumulation blocks light transmission and destabilizes outdoor photovoltaic and optoelectronic systems. Current passive anti-icing coatings still struggle to simultaneously achieve transparency, anti-icing performance, and long-term durability. Liquid-like coatings are promising for transparent anti-icing surfaces, yet their high interfacial mobility often comes at the expense of mechanical robustness. Here, we report a durable, transparent, gradient liquid-like coating fabricated by a one-step plasma-enhanced chemical vapor deposition process that addresses this trade-off through biomimetic gradient interface engineering. Hexamethyltrisiloxane is identified as an effective precursor for constructing a water-repellent, highly mobile liquid-like surface, while 1,3,5,7-tetramethylcyclotetrasiloxane forms a crosslinked supporting framework underneath. Interfacial characterizations using atomic force measurements reveal a more compliant and lower-friction near-surface liquid-like region with substantially reduced water pinning. The resulting coating delivers a rare combination of prolonged freezing delay, low ice adhesion, and outstanding durability over 100 icing/deicing cycles and 40 000 abrasion cycles, while preserving high transparency. When applied to solar cells, it effectively suppresses frosting and retains a power conversion efficiency of 10.01% under frosting, compared with 5.18% for the uncoated device. This work establishes gradient plasma-polymerized liquid-like interfaces as a practical strategy for durable transparent anti-icing and anti-frosting protection of outdoor photovoltaic and optoelectronic systems.
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