Nanomaterials
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2024
·Vol. 14
·期 7
·587
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IF 4.4
Mengyao Guo,Ming Lin,Jingwei Xu,Yongjiao Pan,Chen Ma,Guohua Chen
Lightweight and low-cost one-dimensional carbon materials, especially biomass carbon fibers with multiple porous structures, have received wide attention in the field of electromagnetic wave absorption. In this paper, graphene-coated N-doped porous carbon nanofibers (PCNF) with excellent wave absorption properties were successfully synthesized via electrostatic spinning, electrostatic self-assembly, and high-temperature carbonization. The obtained results showed that the minimum reflection loss of the absorbing carbon fiber obtained under the carbonization condition of 800 °C is −51.047 dB, and the absorption bandwidth of reflection loss below −20 dB is 10.16 GHz. This work shows that carbonization temperature and filler content have a certain effect on the wave-absorbing properties of fiber, graphene with nanofiber, and the design and preparation of high-performance absorbing materials by combining the characteristics of graphene and nanofibers and multi-component coupling to provide new ideas for the research of absorbing materials.
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DIAMOND AND RELATED MATERIALS
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2024
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IF 4.3
Hao Xiong,Lichao Gu,Chengzhe Niu,Junwei Zhang,Xin Ge,Ruiguang Xing,Gaofei Pan
The application of phase change materials (PCMs) in energy storage and temperature control systems holds significant promise for enhancing energy efficiency and environmental sustainability. Herein, the development of a boron nitride nano-aerogel-supported PCM, reinforced by carboxymethyl chitosan (CMCS) and oxidized corn starch (DCS) cross-linking was reported. This approach involved the utilization of polydopamine-modified boron nitride nanosheets (PDA@BNNS) for the fabrication of a thermally conductive skeleton, while carboxymethyl chitosan (CMCS) and oxidized corn starch (DCS) were utilized as reinforcing material and cross-linking agent, respectively. The skeleton was prepared via a sol-gel method and freeze-drying technique, while polyethylene glycol (PEG) was subsequently encapsulated using a vacuum impregnation method. Notably, the prepared skeleton exhibits a compressive stress of 12.18 MPa at 80 % strain, much higher than other boron nitride nanosheets aerogels reported in literature. The cross-linked boron nitride skeleton enhances the thermal conductivity of the composites by 137.4 % compared to pure PEG. Furthermore, due to the highly porous structure of the skeleton, the PEG mass fraction reaches 96.0 wt%, resulting in a phase change enthalpy of 181.5 J/g. The results suggest that this composite material is a promising PCM candidate for thermal energy storage applications .
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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2024
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IF 2.6
Jingmou Yu,Mengqi Liu,Chao Zhang,Lizhen Cheng,Changchun Peng,Dengzhao Jiang,Wenbo Liu,Hongguang Jin,Jin Ren
Herein, we designed and synthesized novel reactive oxygen species (ROS)-responsive glycol chitosan-doxorubicin (DOX) prodrug via a ROS-cleavable thioketal (TK) linker. The obtained GC-TK-DOX formed self-assembled nanoparticles of 312 nm in aqueous media. Photosensitizers zinc phthalocyanine (ZnPc)-loaded GC-TK-DOX (GC-TK-DOX/ZnPc) nanoparticles were fabricated by using a dialysis approach. The GC-TK-DOX and GC-TK-DOX/ZnPc nanoparticles were nearly spherical by transmission electron microscopy (TEM) observation. Under 660-nm laser irradiation, GC-TK-DOX/ZnPc could generate singlet oxygen. Further, GC-TK-DOX/ZnPc nanoparticles exhibited ROS-sensitive release of DOX and ZnPc in vitro. GC-TK-DOX/ZnPc with laser irradiation showed more drug uptake and higher cytotoxic effects than GC-TK-DOX/ZnPc without irradiation, free DOX and GC-TK-DOX in HeLa tumor cells. Overall, these findings suggested that GC-TK-DOX/ZnPc could be a promising nanoarchitecture for synergetic chemo-photodynamic therapy against tumors.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Xiaoting Yu,Yannan Chen,Mingqian Tan
The controlled release of antioxidant substances at the intestinal oxidative damage site is crucial for alleviating intestine-related diseases. Herein, the novel ROS-responsive carrier was synthesized through simple amidation reaction between carboxymethyl chitosan (CMC) and methionine (Met), a natural organic compound containing ROS-responsive linkages (thioether). Initially, astaxanthin (AXT) nanoparticles (AXT 2 @CMT) with excellent stability and drug loading capacity (39.68 ± 0.23 μg/mL) were prepared by optimizing various reaction conditions. In the simulated high-concentration ROS environment of the intestine, CMT achieved a transition from hydrophobic groups (thioether) into hydrophilic groups (sulfone), which was conducive to the controlled release of AXT. In vitro cell experiments revealed that AXT 2 @CMT could effectively alleviate the oxidative damage in intestinal epithelioid cell line No. 6 (IEC-6 cell) caused by H 2 O 2 . This study achieved a straightforward preparation of ROS-responsive nanocarrier through food ingredients, offering a theoretical foundation for the controlled release of AXT at the intestinal oxidative damage site.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Wen Jiang,Chuqing Wang,Shiyu Zhai,Wentao Zhu,Juxiu Li
Protein-polysaccharide combinations frequently demonstrate functional attributes that surpass those of the individual biopolymers. This study aimed to elucidate the physicochemical, structural, and functional properties of two types of lactoferrin (LF)-carboxymethyl chitosan (CMCS) complexes formed by physical mixing and enzymatic glycosylation. LF and CMCS interactions were characterized using phase behavior, particle size, and zeta-potential analysis. The results indicated the formation of an electrostatic complex with a size of <150 nm at pH 8. SDS-PAGE and Fourier transform infrared spectroscopy confirmed that TGase catalyzed the cross-linking and glycosylation of LF, with the extent of glycosylation dependent on the concentration of CMCS. The introduction of CMCS has been observed to result in alterations to the secondary, tertiary, and microstructure of LF, which impact the functional characteristics of LF. The incorporation of CMCS markedly enhances the thermal stability of LF, with a denaturation temperature of 126.66 °C. The addition of CMCS (0.5 wt%) to LF resulted in a significant ( P < 0.05) improvement in the emulsifying activity of LF, but it did not improve its foaming properties. This study offers novel ideas and approaches for developing protein and polysaccharide complexes with improved functional properties, thereby expanding the potential applications of edible proteins.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Chenxi Li,Wenwen Shang,Yuzhe Huang,Jing Ge,Jinqiu Ye,Xin Qu,Quanyi Guo,Ce Wang,Ping Hu,Yong Liu
Cartilage repair remains a significant challenge in tissue engineering. The Sodium alginate/Chitosan hydrogel scaffold, fabricated from natural polymers, has the potential to promote tissue regeneration. However, its poor mechanical performance limits its application. Research has shown that integrating nanomaterials into three-dimensional network materials can significantly enhance mechanical properties, which is particularly important for osteochondral replacement scaffolds. In this study, biodegradable polylactic acid-glycolic acid copolymer/polycaprolactone/gelatin (PLGA/PCL/GEL) nanofibers were prepared via electrospinning and integrated as a reinforcing phase. This enhancement significantly improved the mechanical performance of the sodium alginate/chitosan hydrogel, achieving a maximum compressive modulus of 665 kPa and compressive stress of 342 kPa. Moreover, the inherent biocompatibility of the composite scaffold remained high. This work demonstrates the potential of nanofiber/hydrogel scaffolds, contributing to the development of safe and multifunctional materials for clinical application.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Xiaojia Wang,Hongyu Zhu,Yina Yang,Guoqiao Lai,Xiongfa Yang
Food safety and food freshness issues have become important concerns for consumers and hydrogels with high antibacterial efficiency, low toxicity and pH−sensitive colorimetric intelligence are one of candidates to meet the requirement of food package and food spoilage monitoring. Nevertheless, hydrogels prepared only by assembling the ingredients with non−covalent interactions through time−consuming molding process usually encounter drawbacks such as relatively poor mechanical properties, stability and thermal stability, which always restrict their further applications. To overwhelm these shortcomings, UV−curable choline chloride (ChCl) and bromophenol red (BR) covalent functionalized antibacterial and pH−sensitive cross−linked hydrogels (UV−hydrogels) were developed in this paper. The UV−hydrogels possessed good thermal stability because the initiated thermal decomposition temperature (T d5 ) is in the range of 135.8–184.7 °C. The DMA analysis revealed that the UV−hydrogels are with good mechanical properties because the elongation at break is in the range of 117–525% and the tensile strength is in the range of 0.8–2.7 MPa. The UV−hydrogels with BR groups exhibited naked eye visible color variation from yellow to dark blue-green with the variation of the pH values from 2 to 14. The antibacterial efficiency of the UV−hydrogels against S . aureus , E . coli and M . albican increased with the increment of covalent−grafted ChCl amount. Cytotoxicity assay demonstrated that the UV−hydrogels are low toxicity against L929 cells. The experiment of monitoring freshness of beef denoted the UV−hydrogels have potential application in animal–derived high protein food packaging and freshness monitoring.
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JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
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2024
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IF 3.6
Kainan Yu,YaChao Wang,Shuqi Zhang,JiangPing Zhao
Titanium powder easily accumulates during industrial processes, and its high reactivity poses unavoidable hazards to both industrial operations and human safety. To suppress the explosion of titanium powder, zinc phytate (Zn-PA) and chitosan (CS) are mixed and prepared into a new bio-inhibitor using hydrothermal-solvothermal synthesis. The suppression effects of Zn-PA@CS bio-powder on the explosion pressure and temperature of titanium powder under different inerting ratios (α) are investigated using a 20 L spherical explosion testing system. The results show that when the α of Zn-PA@CS bio-powder is 0.8, the maximum explosion pressure ( P max ) and the maximum rate of pressure rise (( dP / dt ) max ) of titanium powder decrease by 82.8% and 91.2%, respectively. Moreover, the maximum flame temperature ( T p ) drops from the initial 647 °C–38 °C. Combined with TG-DSC analysis, Zn-PA@CS bio-powder produces phosphorus-containing substances during high-temperature thermal decomposition, which consume a large number of free radicals essential for the explosion. Furthermore, Zn-PA@CS bio-powder generates solid and gaseous substances, leading to the formation of a dense carbonaceous residue that covers the titanium powder, acts as an effective barrier, and dilutes oxygen concentration, thereby further inhibiting the explosion reaction. The Zn-PA@CS bio-powder exhibits a synergistic effect in both physical and chemical suppression. This study provides technical support for developing biomass explosion suppression powder and for preventing and controlling explosion accidents in industrial production.
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CARBOHYDRATE POLYMERS
·
2025
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IF 12.5
Zuhan Chen,Huanjing Bi,Jingwen Wang,Ruiyang Ma,Ying Wang,Boqing Dong,Cuinan Lu,Jiale Wang,Yang Li,Jin Zheng,Fang Xie,Xiaoming Ding
Islet transplantation offers a promising therapeutic strategy for type 1 diabetes patients with inadequate glycemic control or severe complications. Islet encapsulation using biocompatible materials presents a potential solution to reduce immune rejection. This study fabricated and characterized Schiff base hydrogels (CMOCs) composed of varying ratios of carboxymethyl chitosan (CMCS) and oxidized carboxymethyl starch (OCMS). CMOCs exhibited desirable mechanical properties, injectability, self-healing properties, antibacterial properties, biocompatibility, and controlled-release capabilities. CMOC3, with the highest CMCS content, was selected for loading Fasudil and further islet encapsulation experiments. In vitro studies demonstrated that CMOC3 and CMOC3-Fasudil hydrogel (CMOC3-Fas) not only supported islet survival and insulin secretion but also increased insulin bioavailability through chelating the zinc ions from the insulin hexamers. CMOC3-Fas exhibited pro-angiogenic and anti-inflammatory properties, and effectively reduced islet cell death under hypoxic conditions. Finally, transplantation of islets encapsulated within CMOC3-Fas achieved prolonged normoglycemia and increased body weight in diabetic mice. This study demonstrates the synergistic protective effect of Schiff-base hydrogel co-delivering fasudil for islet encapsulation, potentially paving the way for improved islet transplantation therapy in type 1 diabetes.
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FOOD HYDROCOLLOIDS
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2025
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IF 12.4
Zi-Quan Wang,Hui-Xian Chen,Yu-Cang Zhang,Yan-Zhen Zheng
In this study, to enhance the water resistance, mechanical properties and functional properties of the chitosan (CS) film, the deep eutectic solvents-based propolis extract (DPE) containing polyphenols was directly incorporated into the chitosan-based films. The total polyphenol and the total flavonoid content in the DPE achieved increases of 289.9% and 216.6% compared to conventional ethanol–water propolis extract for polyphenol and flavonoid content, respectively. Effect of incorporating DPE into a chitosan matrix on the structural, physicochemical, and functional properties of the resulting composite films was comprehensively investigated. SEM, FTIR, XRD, and TGA analyses confirmed the uniform dispersion of DPE within the CS matrix via hydrogen bonding, resulting in improved structural homogeneity, modified crystallinity, and enhanced thermal stability. Optical analyses revealed an increase in film coloration and excellent UV-blocking ability due to the aromatic structures of polyphenols. Mechanical tests demonstrated that DPE incorporation significantly increased film flexibility (62.3% for CS/DPE60 (the adding of DPE was 60% dry weight of the chitosan)) while moderately reducing tensile strength (36.6 MPa for CS/DPE60) compared to pure chitosan film, indicating suitability for flexible packaging applications. Additionally, the CS/DPE films exhibited improved water barrier properties, antioxidant capacity, and antibacterial activity. A practical application in strawberry preservation showed that the CS/DPE film effectively reduced spoilage, minimized moisture loss, and delayed texture deterioration during storage. These findings highlighted the potential of CS/DPE composite films as multifunctional active packaging materials for food preservation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xue Zhang,Jinchang Liu,Jialin Jia,Hao Xing,Junkang Yang,Tao He,Huajie Liu,Tao Zhang,Wenna Wu
Although the natural antibacterial agent, cinnamaldehyde, has been extensively studied in the field of food packaging, its water solubility and instability limit its further applications. The controllable responsive release can be achieved through encapsulation in responsive emulsion systems based on carboxymethyl chitosan. Herein, a pH-responsive antibacterial emulsion gel was constructed from cinnamaldehyde-loaded oil-in-water emulsion templates. The interfacial imidization between carboxymethyl chitosan and cinnamaldehyde forms a pH-responsive Schiff base and further stabilizes the emulsion. To immobilize the droplets, acrylamide was subsequently added and polymerized. Such a double network design gives materials adjustable mechanical strength in addition to sealing off the cinnamaldehyde droplets in the network to postpone their release. According to the results of the tensile and compressive cycle, this material has good fatigue resistance. Furthermore, the antibacterial results showed that this material has a 15-day antibacterial cycle and long-lasting antibacterial qualities. In practical applications, acidic moisture from the fruits' respiration decomposes Schiff base bonds and accelerates the release of cinnamaldehyde. The results of cinnamaldehyde release proved that the emulsion gel was pH-responsive, and the dynamic covalent network and emulsion encapsulation technology prolonged the release period of cinnamaldehyde. The mechanical test results proved that the acrylamide network structure gave the material good mechanical properties. Using longan and citrus fruits as examples, we found emulsion gel can significantly prolong the life of fruits by two to three times.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Nannan Cui,Zhikun Wang,Fengting Li,Huiling Su,Wentao Qu,Miantuo Li,Shuangqing Sun,Songqing Hu
Micro/nanocontainers, as smart carriers of corrosion inhibitors, capable of intelligently detecting corroded areas and dispensing inhibitors precisely for targeted corrosion control. Here, pH-responsive chitosan- grafted -β-cyclodextrin (CS- g -β-CD) microspheres (CgCM) loaded with various corrosion inhibitors are prepared via an emulsification cross-linking method. By FT-IR and 1 H NMR characterizations, the successful loading of corrosion inhibitor BTA into β-CD is achieved, with the obtained BTA@β-CD being further grafted on the CS chain by degree 28.8 %. The prepared CgCM possess a size range from 15 to 20 μm, and a surface zeta potential range from positive in acidic solution (33.7 mV at pH = 3) to negative in alkaline solution (−20.4 mV at pH = 10). In addition to loading BTA into β-CD, three compound agents (AIM, AMIM-Cl, and 3-SAMA) are selected to be loaded into the crosslinking gaps of the CgCM, with the loading ratios of BTA, AIM, AMIM-Cl, and 3-SAMA determined to be 31.59 %, 13.85 %, 16.93 %, and 19.30 %, respectively. When subjected to acidic stimulation, the CgCM undergo swelling and dissociation, leading to the responsive release of the four loaded inhibitors into the solution, for which the accumulative release ratios (48 h, pH = 3) are determined to be 93 %, 86 %, 84 %, and 81 %, respectively. Weight loss and electrochemical evaluations firmly establish that these CgCM, laden with inhibitors, are adept at forming dense protective barriers on steel surfaces, achieving a corrosion inhibition efficiency exceeding 90 %. Corrosion morphology, surface elemental distribution, and binding status reveal a compact compounding protective layer formation on the steel/solution interface, by a physicochemical synergistic adsorption pattern. Density functional theory (DFT) calculations and molecular dynamics (MD) simulations reinforce the findings, revealing that all three CgCM systems exhibit targeted, stimulus-responsive release capabilities, coupled with robust adsorption strengths and remarkable corrosion resistance characteristics.
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