SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Zhima Yangcuo,Xiaodan Zheng,Yajuan Zhang,Xin Yang,Xinyi Zheng,Hang Zhu,Wenhui Chen,Qihong Cai
Under alkaline conditions with sodium hydroxide (NaOH), both 1-naphthol (1-NAP) and 2-naphthol (2-NAP) transitioned from their molecular forms to ionic forms, resulting in redshifts of their fluorescence spectra. Thus, not only the interference of 2-NAP raman peak was eliminated, but the fluorescence intensity of two naphthols was also enhanced, thereby improving the selectivity and sensitivity of their analysis. Due to their structural similarity, the conventional fluorescence spectra of 1-NAP and 2-NAP overlapped and interfered with each other, precluding their simultaneous measurement without prior separation. In this study, the wavelength difference (Δλ) = 140 nm was selected for synchronous fluorescence spectrometry (SFS) scanning to simplify the spectra. However, the interference of 2-NAP on 1-NAP remained significant. So, the second-order derivative technique combined with SFS was adopted. The method that eliminated the severe interference between 1-NAP and 2-NAP and wastewater background by utilizing spectral parameters. Finally, a new second-order derivative SFS for simultaneous determination of 1-NAP and 2-NAP was first established. The detection limits were 0.0850 ng·mL −1 for 1-NAP and 0.1066 ng·mL −1 for 2-NAP, with linear ranges of 0.5–80 ng·mL −1 and 0.5–50 ng·mL −1 , respectively. Recoveries of two naphthols in wastewater were 87.53%–93.50% (1-NAP) and 89.85%–104.00% (2-NAP). The new SFS established in this research has been successfully applied to the analysis and detection of 1-NAP and 2-NAP residues in wastewater, achieving satisfactory results. It is expected to become a new routine detection method for 1-NAP and 2-NAP.
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SENSORS AND ACTUATORS A-PHYSICAL
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2026
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IF 5.1
Bo Lin,Wenjuan Wang,Juan Ma,Yuxian Chen,Wentao Wu,Zhe Xing,Jie Fu,Yanan Bai,Jiyu Li,Wenzhu Liu,Zhangqi Feng,Zhenhua Wu,Hongju Mao
The development of wearable health monitoring systems is constrained by the limited energy storage of traditional lithium-ion batteries in miniaturized devices. While ambient energy harvesting enables self-powered operation, existing systems lack modular designs, hindering synchronous multi-parameter monitoring and facing trade-offs between energy efficiency and sensor sensitivity. Targeting personalized, scenario‑adaptable sensing, this study develops a solar‑powered modular sensor network to overcome battery and rigidity limitations—enabling rapid, cost‑effective system assembly via flexible modular design, with high-efficiency energy storage (93.5% at 2500 lux). Via a reconfigurable hardware interface with multi-pin multiplexing, it seamlessly incorporates four high-precision sub-modules: posture (posture classification accuracy >99.3%), physiological (SpO₂ and heart rate), GSR (response time <0.1 s), and movement (joint signal resolution 0.125 mV). These sub-modules can be individually combined with the base modules and deployed at specific body locations to form a distributed health monitoring network. Experimental results show an average operating current of 10.48 mA (1.64 mA in sleep mode) under 3.3 V, supporting distributed synchronous acquisition of multi-dimensional biophysical signals. The system has demonstrated functionalities in fall alerting and learning state assessment, achieving stable self-powered operation. While it offers a foundation for a health monitoring platform, its evolution into a high-precision, universal solution for comprehensive use in complex environments is contingent upon further validation with more extensive and diverse real-world data.
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Microorganisms
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2026
·Vol. 14
·期 2
·322
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IF 4.2
Yifan Chen,Li Zhang,Yan Chen,Wenpei Ge,Hongling Wang,Zhanying Xue,Xinran Cui,Xin Wang,Aimei Liao,Yuansen Hu,Na Liu
Fusarium solani , a widely distributed plant pathogenic fungus, poses a significant threat to various crops due to its complex pathogenic mechanisms and being difficult to control. In this study, LC–TOF–MS analysis identified 4-(4-hydroxyphenyl)-2-butanone (RK) as a metabolite detected in Bacillus amyloliquefaciens strain M1, and a commercially available RK standard was subsequently used to evaluate its antifungal activity against F. solani . Antifungal assays demonstrated that RK effectively suppressed fungal growth. Further physiological and biochemical assays confirmed that RK disrupts the cell membrane and mitochondrial function, leading to intracellular reactive oxygen species (ROS) accumulation. This study offers new perspectives on the antifungal mechanism of RK and offers theoretical support for the development of innovative agricultural disease management strategies.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2026
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IF 5.9
Jinglang Gong,Beijia Wang,Huihui Liu,Pinghua Cheng,Xiaolian Sun,Dan Su
Cerenkov radiation-induced photodynamic therapy (CR-PDT) addresses the tissue penetration limitations of traditional photodynamic therapy for deep-seated tumors. However, continuous phototoxicity in normal tissues and inefficient tumor accumulation of co-delivery of radionuclides and photosensitizer remain the main challenges to the therapy efficacy of lung cancer. Here, we developed a novel pulmonary delivered 131 I-labeled GSH-responsive chlorin e6 (Ce6)-conjugated Bovine Serum Albumin (BSA) nanoassembly ( 131 I-CBA ) for efficient and selective tumor therapy in orthotopic lung cancer. The 131 I-CBA, with a stable diameter of around 150 to 200 nm, were designed to show minimal phototoxicity in normal tissues due to the aggregation-caused quenching (ACQ). Under tumor intracellular reductive glutathione (GSH) conditions, the dissociation of nanosystem happened, restoring the quenched photoactivity of Ce6 to produce singlet oxygen. After pulmonary delivery in orthotopic lung cancer, 131 I-CBA showed high lung accumulation and great tumor inhibition capability with excellent biosafety. We believe that this pulmonary delivered 131 I-labeled GSH-responsive nanosystem could provide a promising strategy for lung cancer.
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Research
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2026
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IF 12.9
Yuan Wei,Haoyu Zou,Yanyan Fu,Yueze Hong,Chak Kwong Cheng,Yue Wang,Meixia Zhang,Rifang Luo,Fanjun Zhang,Yunbing Wang
Bacterial keratitis is a rapidly progressive, invasive corneal infection, necessitating the urgent development of more effective antibacterial therapies. Cationic polymers, which exert bactericidal effects by disrupting bacterial membranes, represent a promising candidate; however, their clinical application is limited by cytotoxicity associated with their positive charge. Here, we proposed a “detachable polyanionic protective shell (DPPS)” strategy to shield the positive charges of cationic polymers. Specifically, the quaternary ammonium salt (QAS)-modified polylysine was co-assembled with the photosensitizer chlorin e6 (Ce6) to obtain nanoassemblies (PQC), and then the PQC was encapsulated with polythioctic acid (PTA) to form DPPS, obtaining PQCT with functional adaptability. PQCT maintains a net negative charge under physiological conditions with good biocompatibility. In a bacterial infection environment, the reactive oxygen species (ROS) produced by Ce6 under laser irradiation will cause PTA to break bonds and degrade, DPPS to crack and be removed, the net charge of the nano-assembly to change from negative to positive, and QAS exposed to exert bactericidal functions with ROS. Both in vitro and in vivo studies demonstrated the outstanding antibacterial performance of PQCT after laser irradiation, particularly in the treatment of bacterial keratitis. This work presents a safe and effective strategy for targeted bacterial infection therapy.
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Materials Today Bio
·
2026
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IF 11
Qing Hu,Yingfei Wang,Wei Chen,Nan Feng,Keju Tao,Jie Wu,Ying Liu,Fan Zhou,Qing Hao,Daoping Xiang,Junjie Chi,Hong Liu
Nanomotors are appealing drug carriers with deep tissue penetration to overcome biological barriers. Though high motion efficiency has been achieved with NIR-II light driven nanomotors, insufficient directional control and material biocompatibility limit their broad application. Herein, leveraging commercially available liposomal doxorubicin (DOX) as a platform, we develop a magnetic-steering NIR-II light thermophoretic liposomal nanomotor (LipNM) by asymmetrically incorporating magnetic photothermal Fe 3 O 4 @Cu 9 S 8 nanoparticles into the lipid bilayer, firstly realizing directional nanoscale self-thermophoresis. The embedded Fe 3 O 4 @Cu 9 S 8 nanoparticles respond to a brief magnet stimulation for spatiotemporal steering and NIR-II irradiation with local temperature increase for self-thermophoresis of LipNMs, which further facilitate tumor tissue targeting and deep tumor penetration, respectively. The direction-controllable thermophoretic LipNMs demonstrate good biocompatibility and increase the delivery efficiency of DOX by 186% compared to passive liposomal doxorubicin. Owing to the targeted accumulation and deep tissue penetration at the tumor site, the therapeutic efficiency of LipNMs for breast cancer in vivo is as high as 94.9%, providing a promising strategy for cancer therapy.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Tianqi Dai,Su Zhao,Yufei Qiu,Fei He,Tao Jia,Shuming Li,Jiangai Piao,Yanli Wang,Yanping Zhao,Xutong Wu,Hai Xu,Xiaoyu Zheng
Postoperative immunosuppression, which is closely associated with the oxidative-stress-driven expansion of regulatory T cells (Tregs), increases susceptibility to severe postoperative outcomes, including infectious complications, multiple organ dysfunction syndrome (MODS), and tumor progression. Here, we report a zirconium-based metal–organic framework (MOF) cascade nanozyme, designated “Pt@PCN-224-Fe”, coated with poly(ethylene glycol) (Pt@FeMOF–PEG) that simultaneously mimics superoxide dismutase (SOD) and catalase (CAT) to neutralize excessive reactive oxygen species (ROS). Mechanistically, scavenging ROS reactivates the PI3K–AKT–mTOR signaling axis, suppresses Foxp3 expression, and thereby inhibits both the differentiation of naı̈ve CD4+ T cells into Tregs under Treg-polarizing conditions and their TGF-β1 secretion in vitro. In a murine model of surgical trauma, the single intraperitoneal administration of Pt@FeMOF–PEG reversed immunosuppression within 72 h, evident as a reduced frequency of Tregs, expanded Th17 cells, normalized CD4+/CD8+ ratio, and suppressed M2 macrophage polarization (all p < 0.05). Concurrently, proinflammatory cytokines (IL-1β, IL-6, TNF-α, IFN-γ) increased, whereas anti-inflammatory cytokines (IL-4, IL-10) decreased, indicating the systemic reinvigoration of the innate and adaptive immunity. The nanozyme showed excellent biocompatibility, with negligible hemolysis (<5%), no histological organ damage, and minimal systemic toxicity. In this work, we have developed a dual-enzyme-mimicking nanozyme (Pt@FeMOF–PEG) that precisely targets the ROS–PI3K–Treg axis in a single-dose strategy to reverse postoperative immune dysfunction, thus addressing a long-unmet clinical requirement for surgical recovery.
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Journal of Energy Chemistry
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2026
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IF 15.6
Yifei Ye,Zhuoshen Huang,Hao Pan,Zhaokun Wang,Wei Xia,Guangtong Hai,Ge Wang,Xiubing Huang
Transition metal oxyhydroxides are crucial for the electrochemical oxidation of 5-hydroxymethylfurfural (HMF), though the co-adsorption and activation mechanisms of HMF and hydroxyl species require further clarification. This study designs cerium-doped Co-based layered double hydroxide (LDH) arrays, including 3%Ce-Co 3 Fe 1− x Al x -LDH/NF, to investigate Fe as a secondary active center and the role of Ce–O–TM (Transition metal) bridges in regulating HMF/OH − adsorption. Theoretical calculations indicate that Ce–O–TM bridges induce f – p – d gradient orbital coupling, optimizing HMF/OH − adsorption configurations and facilitating the HMF oxidation reaction (HMFOR). Synchrotron radiation characterization and in situ Raman spectroscopy reveal that Fe enhances electronic interaction between Ce and Co/Fe sites, strengthening the stability of M–O bonds, suppressing metal dissolution, and further optimizing reactant adsorption. Fe doping also modulates charge distribution and accelerates charge transfer. The optimized 3%Ce-Co 3 Fe 1 -LDH/NF delivers industrial current density (0.1 A cm −2 ) at 1.44 V RHE , with 98.1% HMF conversion, 99.6% FDCA yield, and 99.8% Faradaic efficiency. In an anion exchange membrane (AEM) electrolyzer, it achieves 0.5 A cm −2 at 2.1 V while maintaining high stability across 0.1–0.5 A cm −2 . These results provide an effective strategy for designing high-performance HMFOR catalysts through electronic structure modulation.
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Nature Communications
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2026
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IF 18.1
Zhou Haichuan,Hu Linyu,Liu Guoqiang,Pi Yourui,Wan Fang,Liu Ying,Wang Fei,Dai Chunlong,Lin Zifeng
Rechargeable aqueous batteries show promise for large-scale energy storage, yet suffer from low specific energy and poor low-temperature performance. Existing low-temperature aqueous batteries typically use ion-insertion positive electrodes with limited capacity. While aqueous sulfur-based batteries offer high theoretical capacity, their low-temperature operation remains challenging. Current improvement strategies often compromise room-temperature performance due to the inclusion of non-active additives. Here, we present a low-temperature sulfur-based battery using a Cu(BF 4 ) 2 -based electrolyte, which boasts a low glass transition temperature of −115.1 °C, and an ionic conductivity of 5.16 mS cm −1 at −60 °C. This electrolyte enables faster reaction kinetics and higher overall specific energy than traditional CuSO 4 -based systems. The resulting zinc-sulfur battery delivers a discharge capacity of 348 mA h g (S+Zn) −1 and an specific energy of 339 W h kg (S+Zn) −1 at −50 °C, based on the total mass of both the positive and negative electrodes, competitive with existing aqueous batteries.
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Materials Today Bio
·
2026
·
IF 11
Bin Wang,Na Yin,Xinrui Liu,Yi Guan,Haiyang Xu,Ying Yu,Yang Bai,Yue Cao,Ziqian Wang,Shiqi Bai,Shaopeng Zhang,Donghao Qu,Wanying Li,Zhijia Lv,Yunqian Li,Hongquan Yu,Yinghui Wang
Glioma’s metabolic reprogramming fortifies antioxidant defenses and fosters an immunosuppressive microenvironment, thus resulting in robust resistance to ferroptosis-immunotherapy. In this study, a biomimetic sequentially gated amorphous MOF-based nanotuner (ZB@HM) was constructed, which could cascade depletion of metabolic substrates of ferroptosis defense and redistribution of methionine for reprogramming metabolism-ferroptosis-immunity crosstalk. Specifically, we engineered a methionine-inhibitor-loaded amorphous ZIF-82, followed by coating with E. coli-glioma hybrid membrane to improve its blood-brain barrier penetration and gliomas-targeting. The amorphous MOF undergoes acidic-triggered disintegration, releasing 2-nitroimidazole that is selectively activated via NADPH reduction in hypoxia. The activated ligand subsequently covalently binds with thiol-containing cysteine. The cascade depletion of NADPH and cysteine, synergizing with Zn 2+ overload, effectively triggers robust ferroptosis and immunogenic cell death. Moreover, ZB@HM selectively restricts methionine uptake in gliomas, suppressing the transsulfuration pathway for cysteine biosynthesis and enhancing the competitive uptake of methionine by T cells. The reduced intracellular methionine pool in gliomas diminishes S-adenosylmethionine biosynthesis, downregulating immune checkpoint expression. This cascade reverses T-cell exhaustion and reinforces antitumor immunity. RNA sequencing analysis revealed that treatment with ZB@HM resulted in a modulation of gene signatures associated with the GSH metabolism and tumor immunotherapy. Collectively, ZB@HM reprograms the metabolism-ferroptosis-immune crosstalk through orchestrating multiple key metabolites.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Hu Jingde,Mei Shaoxun,Song Qixiang,Wang Xinru,Yang Shuaiqi,Wu Guohuo,Wang Zhen,Zhang Xiangchun,Ji Yuntao,Jiang Xiasen,Qu Changqing
Bacterial resistance, recurrent infections, and impaired wound healing pose significant challenges in clinical wound management. Natural biomass-derived carbon dots (CDs) have attracted considerable attention due to their synergistic antibacterial, anti-inflammatory, and biosafety, which facilitate the healing of infected wounds. In this study, carbon dots derived from Toona sinensis gum polysaccharide (TGP-CDs) were integrated into a gelatin-chitosan hydrogel to construct TGP-CDs@Gel. Experimental results demonstrated that TGP-CDs@Gel exhibits strong light-activated ROS generation capability, effectively disrupting bacterial biofilms and compromising membrane integrity through photodynamic antibacterial mechanisms. The composite also significantly promoted L929 fibroblast migration and protected RAW264.7 macrophages and N2 nematodes from oxidative stress. Importantly, TGP-CDs@Gel exhibited potent photodynamic antibacterial activity, as well as the regulation of pro-inflammatory cytokines and angiogenesis-related proteins (i.e., CD31, VEGF) in MRSA-infected wound, thereby significantly accelerating wound healing. Moreover, comprehensive biosafety evaluation confirmed its excellent biocompatibility across multiple models, including in vitro cell cultures, zebrafish, and nematodes. Collectively, TGP-CDs@Gel demonstrates promising photodynamic antibacterial and anti-inflammatory functions, providing a novel strategy for tissue regeneration and extending the application of Toona sinensis gum in biomaterials. Graphical abstract
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Yanhua Zhang,Wen Yao,Jian Guo,Hongyuan Huang,Jie Yang,Jiahuang Qiu,Tianxin Li,Yubo Wei,Xinrong Guo
Background Per- and polyfluoroalkyl substances (PFASs) have significant applications in industrial, military and other sectors, particularly perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), which are classified as “suspected human carcinogens”. However, their release into aquatic environments via both point and non-point sources during production and use poses serious hazards to human health, potentially leading to hepatotoxicity, immunotoxicity, reproductive and developmental toxicity, and carcinogenic effects. PFOS/PFOA levels in tap water from Hong Kong (China) are significantly exceeding the enforceable maximum contaminant level in drinking water of 4 ng/L. Therefore, rapid screening of their concentrations is essential for monitoring water safety. Results In response, dual-color fluorescence probes based on polyphenylamine nanosheets (Y-CNNS/R-CNNS) have been successfully prepared through simple oxidation polymerization and acid polymerization. The fluorescence intensity and absorbance of Y-CNNS increase with rising concentrations of PFOS or PFOA due to radiation transition enhancement and non-radiation transition inhibition. The limits of detection are calculated to be 0.738, 15.4, 0.246 and 3.90 pM, respectively. In contrast, the fluorescence intensity of R-CNNS is quenched after adding PFOS/PFOA, owing to complex formation, with limits of detection calculated at 5.44 and 10.2 pM respectively. These results indicate the capability to detect concentrations well below the health advisory level recommended by the United States Environmental Protection Agency and the Food and Drug Administration (10 ng/L) for PFOA/PFOS. This proposed method exhibits a high sensitivity, broader detection range and lower limits of detection compared to other reported methods. Significance A new “enhanced-quenching” dual-mode and dual-color sensor based on Y-CNNS/R-CNNS has been constructed for the high-sensitively detection of PFOS/PFOA. This proposed method also exhibits good performance in analyzing PFOS/PFOA in environmental water samples included bottled water, tap water, lake water, river water and seawater, providing a new idea for the highly sensitive analysis of other PFASs in water environment.
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