COLLOIDS AND SURFACES B-BIOINTERFACES
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2018
·
IF 3.997
Botao Song
Drug delivery systems with high drug encapsulation efficiency and controlled release are of great importance in biomedical fields. Herein, we report an ingenious approach inspired from the lotus leaf possessing the ability of strong repellency to water, which enables the rapid fabrication of drug-loaded calcium alginate (Ca-Alg) particles with high drug encapsulation efficiency and controlled drug delivery. The design is achieved by introducing aqueous droplets containing the mixture of dilute sodium alginate solution, dilute calcium chloride solution, and drug onto the superhydrophobic substrate. Due to water evaporation both the concentration of sodium alginate and calcium chloride within the droplets will gradually increase, and the ionic crosslinking reaction of sodium alginate with Ca 2+ is further occurred to form the drug-embedded Ca-Alg hydrogel particles. The results indicate that the controllable fabrication of Ca-Alg particles can be easily achieved on the superhydrophobic surface, and the swelling behavior can be tuned by the pH of the buffer solution. Importantly, the drug encapsulation efficiencies are measured to be over 88% and the drug exhibits obvious pH responsive release. Findings from this study are expected to contribute to the rational design of drug delivery systems with high drug encapsulation efficiency and controlled release for pharmaceutic science and tissue engineering.
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ANALYTICA CHIMICA ACTA
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2018
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IF 5.123
Yuan Jiao,Xiaojuan Gong,Hui Han,Yifang Gao,Wenjing Lu,Yang Liu,Ming Xian,Shaomin Shuang,Chuan Dong
High-efficient orange fluorescence nitrogen-doped carbon dots (N-CDs) were facilely prepared from P-phenylenediamine as a precursor via hydrothermal method . The as-prepared N-CDs with an average diameter of 3.65 nm displayed excitation-independent emission at 590 nm. The N-CDs demonstrated a remarkable fluorescence enhancement behavior with the increase of pH. A sigmoidal curve was well fitted using BiDoseResp equation with pK a1 3.57 and pK a2 6.01, which can be ascribed to the unique surface properties of N-CDs. Two-segment linear ranges of 2.6–4.6 and 5.0–6.8 broaden the response range to pH of the orange-emission N-CDs to some extent. The confocal fluorescent microscopic images of SMMC7721 cells were performed successfully, which demonstrating that N-CDs possess exceptional cell membrane permeability and can implement as biosensing platform to monitor pH fluctuations in living cells.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
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IF 5.091
Jinsuo Gao,Shouchun Wu,Yanling Han,Feng Tan,Yong Shi,Mengyao Liu,Xinyong Li
Increasing the amount of surface active sites of the material may be a feasible way to improve the efficiency of the generation of Fe 2+ in the photo-Fenton process. In this work, a simple synthesis method was adopted to synthesize 3D ordered mesoporous CuFe 2 O 4 with large specific surface area by using ferric nitrate and copper nitrate as the precursor and KIT-6 as the template. The synthesized materials were characterized by nitrogen adsorption-desorption, XRD , TEM , FT-IR and UV–vis DRS . The catalytic properties of the mesoporous material were thoroughly evaluated by activating hydrogen peroxide to remove sulfonamides in near neutral water. Some of the reaction factors, such as the dose of hydrogen peroxide, catalyst usage and pollute concentration, were cautiously tested and discussed. When the catalyst dose is 0.2 g/L, the substrate concentration is 10 mg/L and the concentration of hydrogen peroxide is 10 mM, sulfamethoxazole is almost completely transformed within two hours and its mineralization level reached 31.42%. In the further study of mechanism, hydroxyl radical is proved to be the main active free radical based on EPR . Moreover, mesoporous copper ferric has good circulation, which indicates that it may have excellent application in the field of photo-Fenton.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 29
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IF 1.768
Lei Wang,Wen Huang,Shijie Wang,Yuezhi Cui,Pengfei Yang,Xiaodeng Yang,Jonathan V. M. Weaver
pH-Responsive amphiphilic branched copolymers were prepared from poly(ethylene glycol) methyl ether methacrylate (PEGMA), 2-(diethylamino)ethyl methacrylate (DEAEMA), 2-( tert -butylamino)ethyl methacrylate ( t BAEMA), and ethylene glycol dimethacrylate (EGDMA) utilizing a thiol-modified free radical polymerization. The molecular structures of copolymers were confirmed by proton nuclear magnetic resonance spectroscopy ( 1 H NMR) and triple-detection gel permeation chromatography (tri-GPC). The aqueous solution behaviors of the obtained copolymers were investigated by dynamic light scattering (DLS). The DLS data showed that about 16 nm polymer particles comprising of hydrophobic poly( tert -butylamino)ethyl methacrylate (P t BAEMA) and poly(diethylaminoethyl methacrylate (PDEAEMA) core, hydrophilic PEGMA corona were formed above pH 8. With the decrease of pH from 8 to 6, a dramatic increase in the hydrodynamic radius of polymer particles from 16 nm to 130 nm was observed resulting from the protonation of the PDEAEMA segment. Moreover, in vitro drug release behaviors of the resulting polymer assemblies at different pH values were also investigated to evaluate their potential as sustained release drug carriers. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42183.
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Polymer Chemistry
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2013
·Vol. 4
·期 10
·3012-3019
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IF 5.231
Haibo Wang,Fangming Xu,Yin Wang,Xiangsheng Liu,Qiao Jin,Jian Ji
The pH-triggered biodegradable micelles based on poly(β-amino ester)-graft-12-acryloyloxy dodecyl phosphorylcholine (PAE-graft-ADPC) were explored as an efficient acid-triggered anticancer drug delivery system. A pH-responsive biodegradable polymer was synthesized by using hydrophilic 12-acryloyloxy dodecyl phosphorylcholine (ADPC) and poly(β-amino ester) (PAE) via Michael addition reaction. Micelles with phosphorylcholine shells were prepared in aqueous solution and doxorubicin (DOX) was loaded into the core of the micelles with high efficiency (73%). Dynamic light scattering (DLS) and transmission electron microscopy (TEM) demonstrated that the size of the drug-loaded micelles was about 230 nm. DOX-loaded micelles were stable in the physiological environment, whereas they disassembled at pH 6.5 which is similar to the extracellular pH of most tumors. In vitro drug release showed that DOX release from micelles was faster at pH 6.5 than at 7.4. Intracellular uptake demonstrated that DOX was delivered into the cells effectively after the cells were incubated with DOX-loaded micelles at pH 6.5. Moreover, an in vitro cytotoxicity study indicated that the growth of HepG2 cells was inhibited remarkably when the cells were preincubated with DOX-loaded micelles at pH 6.5. The results indicated that the pH-triggered biodegradable micelles could serve as promising drug carriers for cancer therapy.
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MACROMOLECULAR BIOSCIENCE
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2013
·Vol. 13
·期 4
·494-502
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IF 3.742
Jun Shi,Chao Du,Jin Shi,Yaming Wang,Shaokui Cao
Hollow multilayer microcapsules made of aliphatic poly(urethane-amine) (PUA) and sodium poly(styrene sulfonate) (PSS), templated on PSS-doped CaCO 3 particles, are prepared for pH-/thermally responsive drug delivery. The electrostatic interaction and hydrogen bonding under weak-acid conditions between aliphatic PUA and PSS contribute to the formation of multilayer microcapsules. Scanning electron microscopy (SEM) results demonstrate an obvious variation of the hollow multilayer microcapsules in response to changes in temperature and pH value. Drug-release behaviors using DOX as a model drug demonstrate that the drug release increases on decreasing the pH value because of the interaction weakness between aliphatic PUA and PSS in acidic conditions. Moreover, the drug release is higher at 55 °C than that at 37 °C for the sake of the shrinkage of aliphatic PUA above its lower critical solution temperature (LCST).
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RESEARCH ON CHEMICAL INTERMEDIATES
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2013
·Vol. 40
·期 1
·385-397
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IF 0.88
Wang Yong,Chen Guihua,Zhang Fumin,Li Liquan
Ni-incorporated SBA-15 magnetic composites were two-stage hydrothermal synthesized from initial strong acidic media through a pH-adjusting method. The structure, morphology, surface area and pore size distribution of the samples were systematically characterized by using XRD, FT-IR, SEM, TEM and N 2 physical adsorption techniques. It was found that, when pH was adjusted to 7, the obtained sample still could exhibit hexagonal mesostructure, very similar to that of the pristine SBA-15 except for a slightly reduced long-range ordering and surface area. However, an increase in the unit cell and wall thickness of the samples suggested the more Ni species were incorporated into the framework of SBA-15. A further increase in pH to 9 produced deterioration of long-range ordering of the sample, possibly resulting from the blocking of some mesopores. Thus, the pH-adjusting method played an important role on the structure of Ni–SBA-15 composites. Measurements taken with increasing applied field revealed the samples having superparamagnetic behaviors. Furthermore, the saturation magnetization values were increased with the more Ni species transforming into magnetic nanoparticles by the increasing pH.
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RSC Advances
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2014
·Vol. 4
·期 98
·55139-55149
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IF 3.708
Jinlong Yang,Chunmei Gao,Shaoyu Lü,Xinggang Wang,Mingjia Chen,Mingzhu Liu
A novel amphiphilic polymer (mPEGylated starch-deoxycholic acid, mPEG-St-DCA) was successfully prepared by grafting hydrophobic deoxycholic acid (DCA) into mPEGylated starch. According to the characterization of 1H NMR and FTIR, mPEG-St-DCA polymers could self-assemble into micelles with spherical core–shell structures. With the degree of substitution (DS) of DCA increasing, the average size of micelles (pH 7.4) decreased to below 200 nm. Correspondingly, the critical micelle concentration (CMC) decreased from 0.048 to 0.022 mg mL−1. And zeta potential values were near −2 mV. But under the condition of pH 6.5, the size and CMC showed an increasing trend. Doxorubicin (DOX), a model anticancer drug, was efficiently loaded into mPEG-St-DCA micelles, and in vitro release exhibited that DOX-loaded micelles had a good in vitro pH-induced drug release. MTT assays confirmed that mPEG-St-DCA micelles were biocompatible with HeLa cells, and DOX-loaded micelles had a relatively better cytotoxicity against HeLa cells with a remarkably high IC50 of 5.74 μg mL−1. Confocal laser scanning microscopy (CLSM) analyses demonstrated that mPEG-St-DCA micelles could be internalized efficiently by HeLa cells to realize intracellular DOX release, which further enhanced the inhibition of cell proliferation. On the basis of the above results, it was indicated that novel amphiphilic mPEG-St-DCA micelles with pH-response could be used as drug delivery carriers for cancer therapy.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2015
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IF 3.65
Naxin Ma,Baohua Zhang,Jing Liu,Pei Zhang,Zhonghao Li,Yuxia Luan
A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5′-phosphate sodium salt dihydrate as a reducing reagent and stabilizer without any other reagent. The fabricated nano-rGO was systematically evaluated for its application as nano-carrier for pH-sensitive drug delivery. The hemolytic toxicity test indicated the as-prepared nano-rGO had negligible hemolytic activity, which demonstrating its safety in drug delivery system. Doxorubicin hydrochloride (DOX) as a model drug was successfully attached onto the surface of nano-rGO via strong π–π stacking interaction. Compared with common carriers, the obtained DOX-loaded nano-rGO nanohybrid exhibited characteristics of high drug loading content, good stability, pH-sensitive and sustainable release of drugs. Cytotoxicity assay results suggested such nanohybrid exhibited effective cytotoxicity to MCF-7 and A549 cells by nonspecific endocytosis mechanism. Therefore, the present green fabricated rGO could be a good candidate as an ideal nano-carrier for drug delivery and controlled release.
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ACS Applied Materials & Interfaces
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2015
·
IF 6.723
Liyi Fu,Chunyang Sun,Lifeng Yan
Theranostic polymeric nanomaterials are of special important in cancer treatment. Here, novel galactose targeted pH-responsive amphiphilic multiblock copolymer conjugated with both drug and near-infrared fluorescence (NIR) probe has been designed and prepared by a four-steps process: (1) ring-opening polymerization (ROP) of N-carboxy anhydride (NCA) monomers using propargylamine as initiator; (2) reversible addition–fragmentation chain transfer (RAFT) polymerization of oligo(ethylene glycol) methacrylate (OEGMA) and gal monomer by an azido modified RAFT agent; (3) combing the obtained two polymeric segments by click reaction; (4) NIR copolymer prodrug was synthesized by chemical linkage of both cyanine dye and anticancer drug doxorubicin to the block copolymer via amide bond and hydrazone, respectively. The obtained NIRF copolymers were characterized by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), and its was measured by means of micelles dynamic light scattering (DLS), field emission transmission electron microscopy (FETEM), and UV–vis and fluorescence spectrophotometry. The prodrug has strong fluorescence in the near-infrared region, and a pH sensitive drug release was confirmed at pH of 5.4 via an in vitro drug release experiment. Confocal laser scanning microscopy (CLSM) and flow cytometry experiments of the prodrug on both HepG2 and NIH3T3 cells reveal that the galactose targeted polymeric prodrug shows a fast and enhanced endocytosis due to the specific interaction for HepG2 cells, indicating the as-prepared polymer is a candidate for theranosis of liver cancer.
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MATERIALS CHEMISTRY AND PHYSICS
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2014
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IF 2.129
Liang Cui,Rui Wang,Xuqiang Ji,Ming Hu,Bin Wang,Jingquan Liu
The preparation of pH responsive, biodegradable, biocompatible and cross-linked polymer capsules for controlled drug release is presented. These capsules were prepared using silica particles as templates for surface grafting of poly (acrylic acid) (PAA) and PAA-co-poly(polyethylene glycol) acrylate) (PAA-PPEGA) block copolymer via reversible addition fragmentation chain transfer (RAFT) polymerization directly from silica particles, followed by cross-linking with cystamine dihydrochloride and removal of the silica template in the presence of hydrofluoric acid, respectively. The resultant polymer capsules were water soluble, biocompatible with a mean diameter of approximately 260 ± 10 nm, and non-toxic to human cells at low concentration, which are favorable to be utilized as drug carriers for pH responsive and biodegradation controlled drug release. Doxorubicin hydrochloride (DOX) was chosen as a model drug to test the drug loading and releasing properties of the polymer capsules. It was found that the DOX could be effectively loaded into the PAA and PAA-PPEGA capsules with a loading capacity up to 52.24% and 36.74%, respectively. The pH and biodegradation controlled release behaviors of DOX loaded PAA-PPEGA capsules were also explored. The results imply that both PAA and PAA-PPEGA capsules are promising platforms for pH and biodegradation controlled drug delivery systems, while the PAA-PPEGA capsules exhibit less cytotoxicity.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2015
·Vol. 26
·期 8
·1-13
·
IF 2.587
Ma Shengnan,Zhou Jie,Wali Aisha Roshan Mohamed,He Yiyan,Xu Xianghui,Tang James Zhenggui,Gu Zhongwei
Abstract
In this study, the amphiphilic fluorinated peptide dendrons functionalized dextran (FPD-HZN-Dex) via an acid-sensitive hydrazone linkage was successfully designed and prepared for the first time. We demonstrated a spontaneous self-assembly of amphiphilic FPD-HZN-Dex into the well-defined nanoparticles with the core-shell architecture in aqueous media, which is attributed to the efficient amphiphilic functionalization of dextran by the hydrophobic fluorinated peptide dendrons. The spherical morphology, uniform particle size and good storage stability of the prepared FPD-HZN-Dex nanoparticles were characterized by dynamic light scattering and transmission electron microscopy, respectively. In vitro drug release studies showed a controlled and pH dependent hydrophobic drug release profile. The cell viability assays show excellent biocompatibility of the FPD-HZN-Dex nanoparticles for both normal cells and tumor cells. Moreover, the FPD-HZN-Dex self-assembled systems based on pH-sensitive hydrazone linkage also can serve as stimulus bioresponsive carriers for on-demand intracellular drug delivery. These self-assembled nanoparticles exhibit a stimulus-induced response to endo/lysosome pH (pH 5.0) that causes their disassembly over time, enabling controlled release of encapsulated DOX. This work has unveiled a unique non-covalent interaction useful for engineering amphiphilic dendrons or dendrimers self-assembled systems. Graphical Abstract
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危险品化学品经营许可证（带存储）