ACS Sustainable Chemistry & Engineering
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2016
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IF 5.267
Yanbing Wang,Kai Yu,Da Lei,Wei Si,Yajun Feng,Lan-Lan Lou,Shuangxi Liu
An environmentally benign and homogeneous base-free route for 5-hydroxymethyl-2-furfural (HMF) aerobic oxidation to 2,5-furandicarboxylic acid (FDCA) in water was reported using Mg–Al–CO3 hydrotalcite-supported Pd nanoparticles (xPd/HT-n) as catalyst. The influences of the Mg/Al molar ratio of hydrotalcite and Pd loading amount on the catalytic performance of these catalysts were originally systematically investigated. These catalysts exhibited excellent catalytic activity and FDCA selectivity in the HMF oxidation, especially for 2%Pd/HT-5 and 2%Pd/HT-6; >99.9% FDCA yields were achieved for 8 h under ambient pressure and homogeneous base-free conditions. The remarkably improved catalytic performance could be attributed to the suitable basicity of the Mg–Al–CO3 hydrotalcite and the abundant OH– groups on the surface of hydrotalcite. The plausible reaction mechanism was proposed based on the results of a series of controlled experiments. Furthermore, these catalysts were quite stable and could be reused at least five times without obvious loss in reaction activity.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2024
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IF 6
Li-Yuan Wei,Yu-Wei Lin,Jia-Chun Luo,Yi-Xian Li,Yu-Tao Hu,Shi-Yao Guo,Zhi Jiang,Dan-Dan Zhao,Shuo-Bin Chen,Zhi-Shu Huang
ABSTRACT Due to the emerging global epidemic of obesity, developing safe and effective agents for anti-obesity is urgently needed. Our previous study found that 2-pyrimidinylindole derivative Wd3d exhibited potential anti-obesity activity. Herein, to further optimize the potential moiety, structural modifications were proceeded for two rounds in this study. Firstly, we designed, synthesized, and evaluated 36 new derivatives of 2-pyrimidinylindole scaffold with different substituents on the indole ring and pyrimidine ring to investigate their structure-activity relationship (SAR). Then, analogs with potent activity had the aldehyde group replaced with the acylhydrazone group to reduce cytotoxicity and improve metabolic stability. Detailed SAR studies and animal evaluation experiments led to the discovery of the compound 9ga , which significantly reduced TG accumulation with an EC 50 value of 0.07 μM and showed relatively low cytotoxicity with an IC 50 value of around 24 μM. Oral administration of 9ga effectively prevented the excessive growth of body weight and lessened fat mass as well as liver mass, decreased lipid accumulation in the liver and blood, and improved the heart injury parameter in the diet-induced obesity mouse model significantly better than Wd3d . A mechanism study showed that 9ga regulated the lipid metabolism during early adipogenesis by inhibiting PPARγ pathway. In conclusion, our study further highlights the anti-obesity potential of 2-pyrimidinylindole derivatives in diet-induced obesity.
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MOLECULAR NEUROBIOLOGY
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2024
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IF 4.6
Wang Ajun,Li Nan,Zhang Nan,Liu Jian,Yang Tao,Li Dongxue,Li Changwen,Li Rui,Jiang Tongcui,Xia Chengyu
The pathogenesis and development of Moyamoya disease are still unclear. This study aimed to investigate the effect of desmoglein-2 (DSG2) on Moyamoya disease and determine the inhibitory effect of DSG2 in vascular remodeling in Moyamoya disease. RNA sequencing, immunohistochemistry (IHC), and western blotting were used to detect the expression of DSG2 in the superficial temporal artery (STA) tissues of Moyamoya disease. The association between DSG2 and endothelial cells’ biological activities was investigated by cell counting kit-8 (CCK-8), migration assay, tube formation assay, flow cytometry with Annexin V-FITC/PI staining, and TUNEL apoptotic cell detection kit. Pathways affected by overexpression or knockdown of DSG2 were identified in endothelial cells. The expression of DSG2 in the STA tissues of Moyamoya disease was lower than that in normal controls. Overexpression of DSG2 inhibits the proliferation and migration but promotes apoptosis in endothelial cells, and low DSG2 levels result in impaired angiogenesis. In addition, there was an interaction between DSG2 and MMP-9, and DSG2 acted through the PI3K signaling in endothelial cells. Our results indicate that DSG2 affects PI3K signaling in vascular endothelial cells, and MMP-9 is involved in DSG2-mediated vascular changes in Moyamoya disease.
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SENSORS AND ACTUATORS A-PHYSICAL
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2024
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IF 4.1
Jiaping Yang,Junpeng Deng,Yansheng Liu,Zhenle Qin,Jin Zhou,Xiaobo Jia,Guofu Wang,Yuqiang Weng,Feng Ling,Bin Zhou
Developing an efficient and sensitive method for detecting the coronavirus disease (COVID-19) is crucial. In this study, a phase-dependent SPR biosensor has been developed to detect the SARS-CoV-2 S protein with high sensitivity. The phase shifts of the SPR spectral interferogram are extracted using the windowed Fourier transform (WFT) method. The summation of the phase shifts of the prominent frequency, which make up the SPR spectral interferogram, is used as a numerical index to reflect the “negative” or “positive” results. The SARS-CoV-2 S protein antibody is modified onto an Au film, which serves as a sensing surface when detecting the SARS-CoV-2 S protein. The SARS-CoV-2 S protein antibody functionalized Au nanoparticles are used to form a (anti-S@AuNPs)-(SARS-CoV-2 S protein)-(Au film) sandwich structure, which reduces the SPR detection limitation to 1 ag/mL. An external laser is then used to induce the localized surface plasmon resonance (LSPR) between the AuNPs and the Au film in the sandwich structure, enhancing the detecting sensitivity by 357 %. This study provides a label-free method for detecting the SARS-CoV-2 S protein with low concentrations, indicating its potential in detecting the SARS-CoV-2 virus and viral disease diagnosis.
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CERAMICS INTERNATIONAL
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2024
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IF 5.1
Wenwu Zhao,Jinqiang Liu,Haijing Zhou,Jianyuan Yu,Bin Hao,Jian Liu
The efficient photogenerated carriers separation is the key factor in enhancing the activity of photocatalysts to solve environmental pollution problems. The internal polarized electric fields in polar materials most likely provide a more direct and stronger driving force for photogenerated carriers separation. Here, we investigate polar ε -Cd(IO 3 ) 2 (CIO) with two different morphologies as an efficient photocatalyst for the photodegradation of antibiotics and dyes. According to the theoretical calculation of the ratios of m h */ m e * along three different crystal axis directions, the photogenerated carrier separation efficiency along the c -axis direction is the largest, which matches the direction of the polarized electric field in the crystal. The internal polarized electric field promotes the separation of photogenerated carriers, leading to a high transfer efficiency of the catalyst. Moreover, photodegradation experiments demonstrate that the photocatalytic activity of CIO-1 is approximately 3 times that of TiO 2 P25. This study provides some insights that might aid the development of polar photocatalysts with superior performance.
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CERAMICS INTERNATIONAL
·
2017
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IF 2.986
Jindou Hu,Yali Cao,Jing Xie,Dianzeng Jia
To reduce the cost of the traditional noble metal-loaded photocatalysts for H 2 production, low-cost Ni(OH) 2 -TiO 2 nanocomposites were designed and synthesized by a simple room-temperature solid-state chemical method (RSCM), which is a facile, low-cost and eco-friendly manipulation. Various testing methods and tools were used to characterize the crystal structure, elemental composition, morphology, light absorption ability, fluorescent performance, photocurrent density, and photocatalytic activity of the obtained nanocomposites. The results indicated that RSCM can be used to synthesize Ni(OH) 2 -TiO 2 nanocomposites with a small size (50 nm) and good dispersity. Compared to pure TiO 2 , the obtained nanocomposites displayed excellent photocatalytic performance for H 2 production by photocatalytic water-splitting. The amount of hydrogen needed for the optional nanocomposite NOT-1 was 9180 μmol/g, which is 29 times that of the commercial P25. The reason for the improved performance for photocatalytic hydrogen production is that the existing Ni(OH) 2 in nanocomposites promoted the separation between the photogenerated electron and holes.
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Journal of Advanced Research
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2025
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IF 13
Meng-han Qi,Hai-yan Zhang,Yun-yi Hou,Ivan Steve Nguepi Tsopmejio,Wei Liu,Wen-guang Chang,Chen Chen,Zi Wang,Wei Li
Introduction Hyperglycemia and hyperlipidemia are the hallmarks of type 2 diabetes mellitus (T2DM). T2DM is a systemic metabolic disease caused by insulin resistance and malfunctioning pancreatic β-cells. Although ginseng (the roots of Panax ginseng C.A. Meyer) can be used to treat T2DM, the underlying mechanism is unclear. Objectives To assess the role and mechanism of, γ-aminobutyric acid-fructosyl-glucose (GABAFG), a maillard reaction product of ginseng, in T2DM treatment. Methods The metabolism of GABAFG in serum and tissues was analyzed via ultra-high performance liquid chromatography-Q exactive-mass spectrometry (UHPLC-QE-MS). The molecular mechanisms of GABAFG in pancreatic β-cells (in vivo and in vitro) were investigated via Western blotting, qPCR and immunofluorescence. In addition, the results were validated via high-throughput sequencing and serum metabolomics. Results GABAFG alleviated the elevation of blood glucose and blood lipids in HFD/STZ-induced T2DM mice. Also, GABAFG reduced the insulin resistance-associated IRS-1 signaling axis in pancreatic β-cells in vitro . Mechanistically, GABAFG targeted the nuclear translocation of TFEB inhibited apoptosis of pancreatic β-cells by enhancing autophagolysosome function. In addition, GABAFG remodeled the gut microbiota. Specifically, GABAFG increased Akkermansia, decreased Romboutsia abundance, and decreased serum glycerophospholipid metabolism, thus alleviating T2DM-induced dyslipidemia. Conclusion This is the first study to assess the pharmacological effects of ginseng-derived GABAFG in T2DM. Therefore, this study provides a new theoretical basis for understanding ginseng effect in metabolic diseases.
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npj Clean Water
·
2024
·Vol. 7
·期 1
·1-9
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IF 10.4
Xiao Jun,Hao Shuang,Qin Yiwen,Qi Pengfei,Zhang Zhaoqian,Hu Yunxia
Many fouling-resistant materials have been grafted or coated on the RO membrane surface for fouling-resistance. However, these modified RO membranes still exhibit a fast flux drop towards small charged organic foulants. Herein, we creatively use the quantum chemistry method to screen the thiol group having a close to zero interaction energy with small charged organic foulants. Thus, we selected a small molecule of 2-aminoethanethiol (AET) having a fouling-resistant thiol group and a reactive amine group for RO membrane surface modification. The water permeance of the AET-grafted RO membrane increases from 2.6 ± 0.1 L m −2 h −1 bar −1 to 3.2 ± 0.05 L m −2 h −1 bar −1 , 23% higher than that of the pristine membrane. Moreover, the AET-grafted RO membrane exhibits excellent fouling resistance against charged surfactants. Our study offers insights on the design of fouling-resistant molecules for antifouling surface modification of RO membranes towards small charged organic foulants.
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CRYSTAL RESEARCH AND TECHNOLOGY
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2024
·Vol. 59
·期 8
·2400012
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IF 1.5
Xinxin Chen,Shujun Zhu,Jiali Han,Tao Zhao,Jianguo Pan,Shangke Pan
The low-dimensional organic-inorganic lead halide compound has garnered significant attention in recent times due to its exceptional optoelectronic properties. However, its application in the field of optoelectronics has been hindered by the toxicity of lead. Here, a novel inorganic-organic compound [Epy] 2 [CuBr 3 ] single crystal material with a 0D structure based on Cu(I) is introduced. The single crystal exhibits a broad band yellow luminescence, a significant Stokes shift, and a microsecond-scale photoluminescence (PL) lifetime, which is mainly attributed to the self-trapped excitons (STEs) excitation. In addition, the relevant PL spectra are measured at 78–348 K. The photoluminescence intensity decreases with increasing temperature due to strong electro-phonon coupling. The exciton binding energy E b of the crystal is 76.43 meV, and the Huang-Rhys factor S is 40.55. It is worth noting that the crystal also shows a good response to X-rays. Overall, [Epy] 2 [CuBr 3 ] displays its good potential.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Nan Ma,Rong Li,Gui-Fang Zhang,Ruo-Han Gao,Dong-Jie Zhang
Quinoa β-glucan (QBG) has shown potential benefits in treating type 2 diabetes mellitus (T2DM); however, comprehensive evaluations of its effects remain limited. This study investigates the impact of QBG—derived from hot water extraction (Q-) and microbial fermentation enrichment (Q+)—on serum glucose levels, lipid profiles, appetite-regulating hormones, fecal short-chain fatty acids (SCFAs), and gut microbiota composition and function in streptozotocin/high-fat diet (STZ/HFD)-induced T2DM mice. The results indicate that QBG treatment significantly reduced fasting blood glucose, insulin levels, triglycerides (TG) and total cholesterol (TC), while concurrently increasing high-density lipoprotein cholesterol (HDL C) levels. Additionally, liver and pancreatic function improved, as evidenced by decreased levels of malondialdehyde (MDA), aspartate transaminase (AST), and alanine transaminase (ALT). SCFA levels were significantly higher in QBG-treated groups compared to MC group. QBG treatment also reduced the abundance of Firmicutes and Patescibacteria, along with the Firmicutes/Bacteroidota ratio, while increasing levels of Bacteroidota and Actinobacteria. These findings suggest that QBG can regulate the dysbiosis of SCFAs production in T2DM mice and may indirectly modulate the secretion of appetite-regulating hormones by influencing gut microbiota composition. Furthermore, PICRUSt analysis revealed that QBG treatment, particularly Q + _H, could enhance disrupted metabolism and improve gut microbiota functions, helping restore normal physiological function.
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CHEMICAL PHYSICS LETTERS
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2024
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IF 2.8
Xu Gao,Aihu Feng,Le Mi,Yang Yu,Yun Yu
Adsorption is one of the most effective methods for controlling the concentration of VOCs pollution. In this work, the hierarchical NaY zeolites with size-controlled mesopores in the range of 2–5 nm are obtained via NH 4 HF 2 -etching and surfactant-templating process. By using the different cationic surfactant (C n TAB), we fabricate the surfactant-templated zeolite with controllable mesopores, and improve its adsorption capacity for toluene. In addition, the modified zeolite’s hydrophobicity is enhanced, and it maintains a high adsorption capacity in a complex humid environment.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
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IF 4.7
Dan Wang,Yimeng Zou,Tianqi Zhao,Weiyue Cao,Jiachi Han,Qing Wu,Zhitong Li,Xinyu Li,Peijing Liu,Lin Bai,Guiping Ren
Background The blood FGF21 expression has been previously suggested to increase in patients developing atopic dermatitis (AD) and asthma. However, its impact on atopic march is rarely analyzed. The present work focused on investigating the role of Fibroblast Growth Factor 21(FGF21) in atopic march mice and its underlying mechanisms. Methods The models were induced with Diisononyl phthalate (DINP) and OVA in wild-type C57BL/6 and FGF21 −/− mice. RAW264.7 cells were induced by LPS with/without FGF21 or KLB-SiRNA for in vitro analyses. Results The data indicated that there were more severe allergic reactions including IgE levels and the proportion of mast cells in the blood of FGF21 −/− mice in relative to WT model mice during the progression from AD to asthma. However, exogenous administration of FGF21 inhibited allergies. In this study, we reported that FGF21 mitigated AD-like lesions and Th1/2 or Th17/Treg cell imbalance in AD mice, and significantly decreased TSLP, IL-33, IL-4, IL-5, IL-13 and IL-17A expression on skin. During the asthma phase, FGF21 improved airway remodeling by downgrading inflammatory factors IL-4, IL-5, IL-13 and IL-17A; fibrotic markers α-SMA and Collagen I; and oxidative products MDA and ROS in wild-type model mice. Compared with WT model mice, the adverse consequences were aggravated in FGF21 −/− asthmatic mice. From the mechanistic perspective, FGF21 suppressed NF-κB/NLRP3, TGF-β1/Smad3 and JNK signaling pathways and increased Nrf2 expression in vivo and in vitro. In addition, β-Klotho knockdown attenuated the ameliorative impact of FGF21 on cellular damage. Blocking AMPKα in the LPS-treated RAW264.7 cells inhibited the reduction of FGF21 and the phosphorylation of JNK. Conclusions To conclude, FGF21 alleviated atopic march by inhibiting Th2/17 immune response, and reduced airway remodeling by regulating NF-κB/NLRP3, TGF-β1/Smad3 and AMPKα/JNK pathways. Moreover, this study provides a rationale and novel ideas for applying FGF21 in treating AD and asthma.
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