Food Bioscience
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2025
·
IF 5.9
Xiu-Zhen Li,Jin-Rui Qiao,Yi-Rui Wu,Dong-Yan Zhou,Yu-Dan Shi,Shu-Meng Zhu,Qiu-Han Bai,Xiao-Lei Xia,Wei-Ming Chai
This research investigated the inhibitory effect and mechanism of 6,7-dimethoxy-3H-quinazolin-4-one (DMQ) on polyphenol oxidase (PPO) and bacteria ( Escherichia coli and Staphylococcus aureus ), as well as its anti-browning properties on fresh-cut apples. The findings demonstrated that DMQ potently inhibited PPO activity with an IC 50 of 98 ± 3 μmol L −1 . Subsequently, the inhibitory mechanism of DMQ against PPO was elucidated through enzyme kinetics, fluorescence analysis, as well as computer molecular simulation. The results revealed that the interaction between DMQ and PPO led to structural elongation and relaxation of the enzyme, and influenced the microenvironment of amino acid residues at the binding region. These changes modified secondary structure and molecular conformation of PPO, ultimately resulting in the reduction of catalytic activity. Antibacterial experiments demonstrated that DMQ exhibited remarkable antibacterial properties by enhancing cell membrane permeability in E . coli and S . aureus , contributing to cellular contents leakage and bacterial cell death. Furthermore, DMQ delayed the enzymatic browning of fresh-cut apples by controlling phenolic metabolism. In particular, it was confirmed by cytotoxicity and stability tests that DMQ was safe at experimental concentrations and had good thermal stability and photostability. These discoveries offered a theoretical framework for the potential application of DMQ in food preservation.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Yun Wu,Shuting Yang,Yanqun Yang,Lijuan Long,Shuixin Ding,Chunyan Su,Linchun Bao,Qianchun Zhang
A novel magnetic nanocomposite (FPB@PEI@PDA@Fe 3 O 4 ) was synthesized for selective enrichment of HPAHs. • The MSPE-UHPLC-MS/MS method was developed to quantify nine trace HPAHs in urine and serum. • The Langmuir model governs adsorption, involving π–π, hydrogen bonding, electrostatic, and boronate affinity interactions. Hydroxylated polycyclic aromatic hydrocarbons (HPAHs) are bioaccumulative and environmentally persistent contaminants, recognized for their significant carcinogenic potential. However, accurate analysis remains challenging due to the inherent complexity of biological matrices (e.g., high protein content and numerous interfering compounds) and the ultra-trace concentrations (ng/L or pg/L levels) at which HPAHs typically occur. The efficient isolation of these analytes therefore requires a specially designed sorbent capable of strong interactions with HPAHs. To address this challenge, we designed and synthesized a novel magnetic adsorbent, 4-carboxy-3-fluorophenylboronic acid-functionalized polyethylenimine-coated polydopamine@Fe 3 O 4 (FPB@PEI@PDA@Fe 3 O 4 ), for use in magnetic solid-phase extraction (MSPE). Leveraging the properties of this novel material, an efficient MSPE-ultra-high pressure liquid chromatography-mass spectrometry method was developed to isolate and quantify nine HPAHs in urine and serum, with high sensitivity and selectivity, a wide linear range (0.0050–10 μg/L), and low detection limits (1.5–40 ng/L). To validate its applicability for human biomonitoring, urine and serum samples were analyzed, and four HPAHs, 1-naphthol, 9-phenanthrol, 1-phenanthrol, and 4-phenanthrol, were identified and quantified. The method exhibited satisfactory accuracy and precision, with recoveries of 80.3%–114% and relative standard deviations of 2.4%–13%. These results enable further understanding of the distribution and potential risks of HPAHs, and the method facilitates more accurate human health assessment and environmental monitoring. Download: Download high-res image (135KB) Download: Download full-size image
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 30
·期 12
·34636-34648
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IF 5.19
Zheng Zhijuan,Xu Ke,Lu Feifei,Zhong Baohua,You Lijun,Xiong Weijie,Tang Ting,Wang Shaoyun
A magnetic covalent organic framework Fe 3 O 4 @BM was prepared with melamine and 4–4′-biphenyldialdehyde as monomers and used as adsorbent for Ag NP removal. Fe 3 O 4 @BM was characterized by zeta potential analysis, transform infrared spectrometry, X-ray diffraction, thermogravimetric analysis, contact angle, and N 2 adsorption–desorption. Fe 3 O 4 @BM possessed plentiful amino groups, positive potential, and rapid separation performance, making it a promising adsorbent for silver nanoparticles. The adsorption process followed the pseudo-second-order kinetic equation and Langmuir isotherm model. The maximum adsorption capacity of Ag NPs calculated by the Langmuir isotherm model was 544.9 mg/g. The adsorption product Fe 3 O 4 @BM@Ag could be recycled and efficiently catalyze the degradation of 4-nitrophenol within 6 min. Meanwhile, the recycled Fe 3 O 4 @BM@Ag could also be used as a surface-enhanced Raman substrate for DTNB detection, and the limit of detection of DTNB reached as low as 10 –7 mol/L. This work prepared a promising adsorbent Fe 3 O 4 @BM for Ag NP adsorption and provided a sustainable approach for the recycling of the adsorption product Fe 3 O 4 @BM@Ag.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Guangping Lei,Yang Lu,Zihan Liu,Yayun Zhang,Guojun Xi,Huiyuan Cheng,Wenji Rao,Xuhuan Guo
The greenhouse effect associated with excessive CO 2 emission has led to a series of environmental issues, thus developing excellent adsorbents for CO 2 capture from flue gas offers a sustainable approach. To combine the merit of multiple functional components, novel FeTPP@MIL-101(Cr) was prepared by incorporation of 5,10,15,20-tetrakis(4-methylphenyl)porphyrinato iron (III) chloride (FeTPP) into MIL-101(Cr) cages via in-situ packaging strategy. The cage-confined FeTPP can both regulate the pore structures of MIL-101(Cr) and provide additional binding sites for CO 2 adsorption. Profiting from extra interactions for CO 2 component and the “sieving effect” for N 2 component induced by incorporation of FeTPP, the discrepancy of isosteric heat for CO 2 and N 2 was largely amplified. Notably, the CO 2 /N 2 selectivity (15/85, v / v ) calculated by ideal adsorbed solution theory (IAST) increased from 17.1 (MIL-101 (Cr)) to 41.8 (FeTPP@MIL-101 (Cr) with FeTPP loading of 4.98 wt%) at 273 K, 100 kPa, which is 2.44 times larger than that of pristine MIL-101 (Cr) and also exceeds most reported adsorbents.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Qiu-feng Lan,Wen-chang Wang,Xiao-hui Chen,Zhi-dong Chen
The poly(3-amino-4-hydroxybenzenesulfonic acid)/Ru(bpy) 3 2+ modified glassy carbon electrode (PAHBS/Ru(bpy) 3 2+ /GCE) is a novel solid-state electrochemiluminescence (ECL) sensor. It was prepared by electropolymerization of 3-amino-4-hydroxybenzenesulfonicacid (AHBS) followed by soaking into Ru(bpy) 3 2+ solution. Ru(bpy) 3 2+ was entrapped on the electrode via the electrostatic interactions between sulfonic acid groups and Ru(bpy) 3 2+ cation. The morphology and composition of the modified electrodes were analysed using scanning electron microscope and energy-dispersed spectrum. Cyclic voltammetry and electrochemical impedance spectroscopy were used to compare the electrochemical behavior of the electrodes before and after modification. Under the optimal conditions, the ECL intensity of the quenching value (ΔECL) versus the logarithm of the concentration of malachite green (MG) was linear over a concentration range from 5.0 × 10 -8 to 1.0 × 10 -5 mol L -1 ( r = 0.9931) and the limit of detection (LOD) was 2.5 × 10 -8 mol L -1 . This method has been successfully applied to the determination of MG in pond water.
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JOURNAL OF MOLECULAR LIQUIDS
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2023
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IF 6
Chunjuan Huang,Ganbing Yao
Equilibrium mole fraction solubility of 2-amino-4-chloro-6-methoxypyrimidine in methanol/ethanol/acetone/ N,N -Dimethylformamide (DMF) plus water was experimentally measured by isothermal saturation method at 278.15–323.15 K under 101.2 kPa. The mixed solvents with low moisture and high temperature played a supportive role in the dissolution of 2-amino-4-chloro-6-methoxypyrimidine. The amount of 2-amino-4-chloro-6-methoxypyrimidine dissolved in DMF + water was more than that in other three systems and the ranges of values for the solubility (mole fraction) of 2-amino-4-chloro-6-methoxypyrimidine in methanol/ethanol/acetone/DMF + water were 0.0002046–0.009616, 0.0002046–0.01060, 0.0002046–0.04918 and 0.0002046–0.1197, respectively. The Jouyban-Acree (JA), Apelblat-Jouyban-Acree (AJA) and van’t Hoff-Jouyban-Acree (VJA) model were applied to calculate the solubility data of 2-amino-4-chloro-6-methoxypyrimidine in mixtures. The preferential solvation parameter δx 1,3 > 0 in 0.32 < x methanol < 1, 0.24 < x ethanol < 1, 0.21 < x acetone < 1 and 0.19 < x DMF < 1, the 2-amino-4-chloro-6-methoxypyrimidine was preferentially dissolved by cosolvents and the 2-amino-4-chloro-6-methoxypyrimidine was dissolved preferentially by water within δx 1,3 < 0. What’s more, the interaction between solute - solvent molecules and the internal interaction of molecules was analyzed by extend Hildebrand solubility approach (EHSA) and in the concentration range with W > δ 1+2 δ 3 , the hydrophobic groups in the 2-amino-4-chloro-6-methoxypyrimidine played a dominant role, while in other ranges self associations of solute, solvent or both were observed. The dissolution thermodynamic properties were obtained by van’t Hoff plots and the ranges of values for Δ sol H o (kJ∙mol −1 )/ Δ sol G o (kJ∙mol −1 )/ Δ sol S o (J∙mol −1 ) were 9.74 – 31.12, −17.84 – 4.96 and 33.79 – 161.89.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 35
·19091-19106
·
IF 11.9
Xiaoyun Chen,Pengkun Zhang,Dong-Hau Kuo,Qinhan Wu,Adugna Boke Abdeta,Binghong Wu,Zhengjie Su,Longyan Chen,Osman Ahmed Zelekew,Jinguo Lin
Herein, we demonstrated S2− anion incorporation into BiVO4 for converting an oxidative-type BiVO4 photocatalyst into a reductive-type BiV(S,O)4−x (labeled BiVOS) sulfo-oxide photocatalyst for efficient N2 fixation under an ambient environment. BiVOS-2 not only exhibited the highest NH3 production rate of 563.6 μmol g−1 h−1 without sacrificial agents and with durable stability but also had an apparent quantum efficiency (AQE) of 2.18% at 420 nm and a solar-to-ammonia (STA) conversion efficiency of 0.071% in pure water under AM1.5G light irradiation. At the same time, the sulfur-free BiVO4 can't realize N2 to NH3 conversion. The S2− doping introduced Vo, which converted V5+ around Vo into V4+ to keep the electrical neutrality. The active atoms V4+ were exposed and activated N2, and the electron hopping between V5+ and V4+ improved electron transfer. Density functional theory (DFT) calculation indicates that S2− anion doping can enhance adsorption energy, elongate the NN bond of the adsorbed N2 molecule, and facilitate electron transfer to the antibonding orbital of the N2 molecule, leading the BiVOS sulfo-oxide catalyst to have excellent N2 fixation activity. This study provides a promising method for converting an oxidative-type catalyst into a reductive catalyst to extend material applications.
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CHEMICAL ENGINEERING JOURNAL
·
2022
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IF 16.744
Le Gao,Yawen Li,Guifang Li,Jiaqi Huo,Lishan Jia
Interface engineering as an effective material modification method can regulate local corresponding interfacial geometry and electronic structures, thus enabling a higher intrinsic activity for the oxygen evolution reaction (OER). Herein, we carefully designed p-p heterojunction precursor Co4-MOF@La(HCO 2 ) 3 with internal electric field through electrostatic adherence, which then in-situ transformed into p-p type heterojunction electrocatalyst (Co(OH) 2 )4@La(OH) 3 under KOH activation strategy. The one-step in-situ conversion of (Co(OH) 2 )4@La(OH) 3 generated the interface with significant difference in metal atomic radius and exhibits fascinating nanostructures, which enhances the specific surface area and increases the number of active sites compared with the parent material. Impressively, the obtained material (Co(OH) 2 )4@La(OH) 3 demonstrates satisfying electrocatalytic activity in OER with a low overpotential of only 233 mV to reach a current density of 20 mA cm −2 , and excellent stability for 50 h at 10 mA cm −2 in alkaline medium. In-situ Raman technique indicates that multivalent Co centers are the true active sites during the OER process. Based on density functional theory (DFT) calculation results, La atoms possess empty d orbitals, which are beneficial to facilitate charge transfer from Co to La at the heterojunction interface. Meanwhile, the introduction of La atoms changes the coordinated environment around the adjacent atoms at the interface, which induces the upshift of the d-band center for Co atoms and increases the binding strength of the adsorbed oxygen intermediate.
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CHEMICAL ENGINEERING SCIENCE
·
2022
·
IF 4.889
Jie Liu,Jianhao Cui,Lei Chen,Jingjing Chen,Huidong Zheng,S. Ted Oyama
The conversion of terpinolene epoxide to terpinen-4-ol is a desirable chemical transformation for the production of a valuable intermediate. This paper describes a one-pot, two-step system for the reaction that uses a bifunctional Ni/TiO 2 -SiO 2 catalyst with isomerization and hydrogenation capabilities. The TiO 2 -SiO 2 serves to isomerize the starting epoxide. The Ni component works to hydrogenate the allylic double bond. The tandem system achieves a high 64% yield of terpinen-4-ol. X-ray diffraction analysis showed that TiO 2 -SiO 2 was a mixed binary oxide, and Fourier transform infrared spectroscopy of adsorbed pyridine suggested that acid sites were mainly Lewis acid sites. Electron microscopy showed that the Ni/TiO 2 -SiO 2 catalyst consisted of spherical particles comprising a titanosilicate phase with highly dispersed zero-valent Ni or anatase on the surface. Additionally, there was strong interaction between Ni and the TiO 2 -SiO 2 mixed oxides. Control kinetic experiments demonstrated that the tandem use of the catalysts was more effective than simultaneous operation.
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JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yiwen Wang,Yang Liu,Qiu Han,Haibo Lin,Fu Liu
Extracorporeal membrane oxygenation is a technique that provides short-term supports to the heart and lungs. It removes CO 2 from the blood and provides enough oxygen, which is a huge help in the fight against COVID-19. As the key component, the artificial lung membranes have evolved in three generations including silicon, polypropylene and poly (4-methyl-1-pentene). Herein, we for the first time design and fabricate a novel poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) membrane with the anticoagulant coating composed of poly (sodium 4-styrenesulfonate) and cross-linked poly (vinyl alcohol). Poly (sodium 4-styrenesulfonate) provides sulfonic acid groups to inhibit the coagulant factors (FVIII and FXII), and cross-linked poly (vinyl alcohol) increase the stability of the anticoagulant coating and further improve the hydrophilicity via abundant hydroxyl groups to depress the protein adsorption. Long-term anticoagulant property was demonstrated by whole human blood for 28 days. Blood compatibility was evaluated by hemolysis rate, anticoagulation activity (APTT, TT and PT), complement activation, platelet activation and contact activation. Pure CO 2 , O 2 and N 2 permeation rates were determined to evaluate the mass transfer properties of PMP/PP TFC membranes. Gas permeation results revealed that gas permeation flux increased in the TFC membranes because of the decrease of crystallinity. Overall, the so prepared PMP/PP membrane shows good CO 2 /O 2 selectivity and blood compatibility as novel TFC artificial lung membrane.
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GREEN CHEMISTRY
·
2023
·Vol. 25
·期 11
·4565-4576
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IF 9.8
Tihang Liu,Jiangang Wang,Hongyou Cui,Jinghua Wang
1,1,2-Trialkoxyethanes (TriAE) are a class of value-added chemicals that are desirably derived from biomass-derived sugars. However, it has been a big challenge to efficiently and selectively break the C–C bond in hexose to synthesize TriAE. In this study, a series of metal salts of phosphotungstic acid (HPW) were prepared to catalyze several biomass-derived sugars. The effects of the atomic ratio of Cs/H in CsxH3−xPW12O40 (x = 1–3), the reaction temperature, and the reaction time were highlighted. The influences of different biomass-derived sugars (glucose, fructose, mannose, cellulose disaccharide, and cellulose) and different alcohols (methanol, ethanol, 1-propyl alcohol, 2-propyl alcohol, and 1-butanol) were also investigated. It was found that alkali and alkaline earth metal monohydrogen salts of HPW were effective catalysts and the stronger the alkalinity of the metal elements, the higher the catalytic activity. Cs2HPW showed the best activity in catalyzing the conversion of glucose to TriAE via [2 + 4] retro-aldol condensation and as high as 88.44% yield of 1,1,2-trimethoxyethane and 72.56% yield of 1,1,2-triethoxyethane were achieved when reacting in methanol and ethanol, respectively. The catalyst deactivation was due to the coking coverage over the active sites rather than the leaching loss of the active components. This research provides new insights into the selective cleavage of the C2–C4 bonds in hexose and a novel approach to biomass-derived sugar valorization.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Danilo de Souza Costa,Carla Monteiro Leal,Rayssa A. Cajas,Matheus Coutinho Gazolla,Lívia Mara Silva,Lara Soares Aleixo de Carvalho,Bruna L. Lemes,Renato Oliveira de Moura,Juliana de Almeida,Josué de Moraes,Ademar A. da Silva Filho
Ethnopharmacological relevance Roots of Pothomorphe umbellata (L.) Miq. are used in traditional medicine of Africa and South America for the treatment of malaria and helminthiasis . However, neither P. umbellata nor its isolated compounds have been evaluated against Schistosoma species. Aims of this study To investigate the antischistosomal effects of P. umbellata root extracts and the isolated compound 4-nerolidylcatechol (4-NC) against Schistosoma mansoni ex vivo and in murine models of schistosomiasis. Materials and methods The crude hydroalcoholic (PuE) and hexane (PuH) extracts of P. umbellata roots were prepared and initially submitted to an ex vivo phenotypic screening against adult S. mansoni . PuH was analyzed by HPLC-DAD, characterized by UHPLC-HRMS/MS, and submitted to chromatographic fractionation, leading to the isolation of 4-NC. The anthelmintic properties of 4-NC were assayed ex vivo against adult schistosomes and in murine models of schistosomiasis for both patent and prepatent S. mansoni infections. Praziquantel (PZQ) was used as a reference compound. Results PuE (EC 50 : 18.7 μg/mL) and PuH (EC 50 : 9.2 μg/mL) kill adult schistosomes ex vivo . The UHPLC–HRMS/MS analysis of PuH, the most active extract, revealed the presence of 4-NC, peltatol A, and peltatol B or C. After isolation from PuH, 4-NC presented remarkable in vitro schistosomicidal activity with EC 50 of 2.9 μM (0.91 μg/mL) and a selectivity index higher than 68 against Vero mammalian cells, without affecting viability of nematode Caenorhabditis elegans . In patent S. mansoni infection, the oral treatment with 4-NC decreased worm burden and egg production in 52.1% and 52.3%, respectively, also reducing splenomegaly and hepatomegaly . 4-NC, unlike PZQ, showed in vivo efficacy against juvenile S. mansoni , decreasing worm burden in 52.4%. Conclusions This study demonstrates that P. umbellata roots possess antischistosomal activity, giving support for the medicinal use of this plant against parasites. 4-NC was identified from P. umbellata roots as one of the effective in vitro and in vivo antischistosomal compound and as a potential lead for the development of novel anthelmintics.
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