ECOTOXICOLOGY
·
2024
·
IF 2.4
Wang Jie,Huang Hexi,Yang Hailin,Wang Su,Li Mengnan,Zhu Zhengyang,Trumble John T.,Di Ning,Zang Liansheng
Cadmium (Cd), a widely distributed environmental pollutant in agroecosystems, causes negative effects on crops and herbivores through bottom-up processes. The gut microbial community of an insect can play a critical role in response to metal stress. To understand how microbiota affect the stress responses of organisms to heavy metals in agroecosystems, we initially used 16S rRNA sequencing to characterize the larval gut microbiota of Chilo suppressalis , an important agricultural pest, exposed to a diet containing Cd. The species richness, diversity, and composition of the gut microbial community was then analyzed. Results revealed that while the richness (Chao1 and ACE) of gut microbiota in larvae exposed to Cd was not significantly affected, diversity (Shannon and Simpson) was reduced due to changes in species distribution and relative abundance. Overall, the most abundant genus was Enterococcus , while the abundance of the genera Micrococcaceae and Faecalibaculum in the control significantly superior to that in Cd-exposed pests. Phylogenetic investigation of microbial communities by the reconstruction of unobserved states (PICRUSt) showed that the intestinal microorganisms appear to participate in 34 pathways, especially those used in environmental information processing and the metabolism of the organism. This study suggests that the gut microbiota of C. suppressalis are significantly impacted by Cd exposure and highlights the importance of the gut microbiome in host stress responses and negative effects of Cd pollution in agroecosystems.
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高影响因子
Nano Research
·
2024
·Vol. 17
·期 6
·5595-5603
·
IF 9.5
Zhou Runhui,Huang Jiaoya,Li Zemin,Wang Yushu,Chen Ziyu,Pan Caofeng
Stretchable hybrid systems have been attracting tremendous attention for their essential role in soft robotics, on-skin electronics, and implantable devices. Both rigid and soft functional modules are typically required in those devices. Consequently, ensuring stable electrical contact between rigid and soft modules is a vital part. Here, we propose a simple, universal, and scalable strategy for the stretchable hybrid system through a highly precise printable liquid metal particle-based conductor and adhesive fluorine rubber substrate. The properties of liquid metal particle-based conductors could be easily tuned to realize high-precision patterning, large-scale printing, and the ability to print on various substrates. Additionally, the fluorine rubber substrate could form strong interfacial adhesion with various components and materials through simply pressing and heating, hence enabling stable electrical contact. Furthermore, we prepared a stretchable hybrid light-emitting diode (LED) display system and employed it in on-skin visualization of pressure levels, which perfectly combined rigid and soft modules, thus demonstrating the promising potential applications in complex multifunctional stretchable hybrid systems for emerging technologies.
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IRANIAN POLYMER JOURNAL
·
2024
·
IF 2.4
Wang Jiawei,Chen Yanming,Li Liang,Wang Liyan,Qian Xin
Chemical depolymerization and recycling of waste polyethylene terephthalate (PET) fibers represent an optimal sustainable approach. However, the presence of dyes in the fibers and the use of conventional homogeneous catalysts may have a detrimental impact on the depolymerization products. In this investigation, solvent extraction was employed to meticulously remove dispersed dyes from waste PET fibers, serving as a crucial preparatory step for subsequent chemical depolymerization. This process was followed by the synthesis of spherical hexagonal Wurtzite zinc oxide (ZnO) nanocrystals through a meticulously refined solution chemical method, with careful consideration given to the potential impacts of surface modification and the alcohol-water ratio on the morphological attributes and particle size distribution of these nanocrystals. These ZnO nanocrystals were subsequently utilized as a pseudo-heterogeneous catalyst, catalyzing the glycolysis of decolorized waste PET fabrics. Systematic investigations were conducted to elucidate the intricate relationships between the morphologies, particle sizes, and concentrations of ZnO nanocrystals and their corresponding catalytic activities, leading to the identification of optimal reaction conditions through a series of conditional experiments. Under these optimized conditions, namely a catalyst concentration of 0.5% (by weight), a reaction temperature of 195 °C, and a duration of 30 min, a remarkable yield of bis (2-hydroxyethyl) terephthalate (BHET) was achieved, reaching 82.07%, with a corresponding mass fraction of 97.62%. Graphical abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-9
·
IF 5.3
Li Yunpeng,Shi Zhuanzhuan,Wu Xiaoshuai,Miao Wenting,Yang Zhengyi,Lou Xinyu,Sun Wei,Guo Chunxian,Li Chang Ming
PEDOT:PSS has been used as a biomimetic uric acid (UA) sensor but suffers from unfortunate low detection limit (LOD), narrow detection range and poor stability. Herein, we get graphdiyne (GDY) marry PEDOT:PSS to create a very stable GDY@PEDOT:PSS heterostructure for a biomimetic UA sensor, which accomplishes the lowest LOD (6 nM), the widest detection range (0.03 μM-7 mM) and the longest stability (98.1% for 35 days) among the related UA sensors. The sensor was successfully used to in situ real-time detection of UA in sweat. The enhancement mechanisms of the sensor were investigated, and results discover that C≡C of GDY and C = C of PEDOT:PSS can cross-link each other by π–π interactions, making not only the former strongly resistant against oxidation deterioration, but also causes the latter to efficiently prevent water swelling of polymer for poor conductivity, thereby leading to high stability from both components. While the stabilized heterostructure can also offer more active sites by enhanced absorption of UA via π-π interactions for highly sensitive detection of UA. This work holds great promise for a practical sweat UA sensor while providing scientific insight to design a stable and electrocatalytically active structure from two unstable components. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Liu Ye,Gao Anqi,Wang Tiantian,Zhang Yongqian,Zhu Gaoxiang,Ling Sida,Wu Zhaozhao,Jin Yuhong,Chen Haoke,Lai Yuming,Zhang Rui,Yang Yuchen,Han Jianyong,Deng Yulin,Du Yanan
Cultured meat needs edible bio-scaffolds that provide not only a growth milieu for muscle and adipose cells, but also biomimetic stiffness and tissue-sculpting topography. Current meat-engineering technologies struggle to achieve scalable cell production, efficient cell differentiation, and tissue maturation in one single culture system. Here we propose an autoclaving strategy to transform common vegetables into muscle- and adipose-engineering scaffolds, without undergoing conventional plant decellularization. We selected vegetables with natural anisotropic and isotropic topology mimicking muscle and adipose microstructures respectively. We further adjusted vegetable stiffness by autoclaving, to emulate the mechanical properties of animal tissues. Autoclaved vegetables preserve rich cell-affinitive moieties, yielding a good cell culture effect with simplified processing. Autoclaved Chinese chive and Shiitake mushroom with anisotropic micro-patterns support the scalable expansion of muscle cells, improved cell alignment and myogenesis. Autoclaved isotropic loofah encourages adipocyte proliferation and lipid accumulation. Our engineered muscle- and fat-on-vegetables can further construct meat stuffing or layered meat chips. Autoclaved vegetables possess tissue-mimicking stiffness and topology, and bring biochemical benefits, operational ease, cost reduction and bioreactor compatibility. Without needing decellularization, these natural biomaterials may see scale-up applications in meat analog bio-fabrication.
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VETERINARY RESEARCH
·
2025
·Vol. 56
·期 1
·1-17
·
IF 3.5
Zhang Yanwei,Jia Zhao,Yuan Gaoliang,Chen Kangyong,Cen Jing,Wang Junya,Feng Hao,Adamek Mikolaj,Zou Jun
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of 34–120 kDa nuclear proteins that have recently been reported to participate in virus replication. The hnRNP family contains approximately 20 members, including hnRNP A1, hnRNP A2, hnRNP A2B1, hnRNPC, hnRNPD and hnRNPK. HnRNPC plays important roles in RNA biology, including expression, stability, mRNA splicing, nonspecific sequence export and 3’-end processing; however, the mechanisms underlying hnRNPC regulatory roles are not fully understood. Here, we found that zebrafish hnRNPC promoted spring viraemia of carp virus (SVCV) replication by increasing the stability of SVCV phosphoprotein while inhibiting the K48-linked ubiquitination of virus phosphoprotein, thereby suppressing the type I interferon (IFN) response. Mechanistically, hnRNPC could interact with the mediator of IFN regulatory factor 3 activation (MITA) to activate K48-linked ubiquitination for MITA degradation through the C-terminal domain of hnRNPC. We also showed that human hnRNPC could interact with MITA and that the overexpression of human hnRNPC decreased MITA protein in HEK293 cells, suggesting that the negative regulatory effects of hnRNPC on the type I IFN response are evolutionarily conserved. Collectively, our data indicate that hnRNPC promotes virus replication by suppressing IFN production activated by MITA and increasing the availability of viral proteins. Our work reveals an evolutionarily conserved mechanism that controls the IFN-mediated antiviral response by a member of the hnRNP family in vertebrates.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-20
·
IF 10.6
Guo Hong,Li Xia,Mao Dengxuan,Wang Hong,Wei Liangyin,Qu Ding,Qin Xiaoying,Li Xiaoqi,Liu Yuping,Chen Yan
The insufficient abundance and weak activity of tumour-infiltrating lymphocytes (TILs) are two important reasons for the poor efficacy of PD-1 inhibitors in hepatocellular carcinoma (HCC) treatment. The combined administration of tanshinone II A (TSA) and astragaloside IV (As) can up-regulate the abundance and activity of TILs by normalising tumour blood vessels and reducing the levels of immunosuppressive factors respectively. For enhancing the efficacy of PD-1 antibody, a magnetic metal–organic framework (MOF) with a homologous tumour cell membrane (Hm) coating (Hm@TSA/As-MOF) is established to co-deliver TSA&As into the HCC microenvironment. Hm@TSA/As-MOF is a spherical nanoparticle and has a high total drug-loading capacity of 16.13 wt%. The Hm coating and magnetic responsiveness of Hm@TSA/As-MOF provide a homologous-magnetic dual-targeting, which enable Hm@TSA/As-MOF to counteract the interference posed by ascites tumour cells and enhance the precision of targeting solid tumours. Hm coating also enable Hm@TSA/As-MOF to evade immune clearance by macrophages. The release of TSA&As from Hm@TSA/As-MOF can be accelerated by HCC microenvironment, thereby up-regulating the abundance and activity of TILs to synergistic PD-1 antibody against HCC. This study presents a nanoplatform to improve the efficacy of PD-1 inhibitors in HCC, providing a novel approach for anti-tumour immunotherapy in clinical practice.
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IONICS
·
2024
·Vol. 30
·期 7
·4281-4295
·
IF 2.4
Li Lanchen,Peng Xuesong,Jiang Jie,Li Ruopeng,Zhang Jinqiu,Yang Peixia,An Maozhong
With the global proliferation of 5G technology, advancing electronic interconnection technologies has become critically important. The development of high-quality electrolytic copper foils, essential for efficient signal transmission, has garnered considerable attention. To mitigate the "skin effect" that could impair signal transmission and to ensure robust adhesion of electrolytic copper foils to the substrate, it's necessary to roughen the copper foils. This roughening process aims to substantially enhance the peel strength of the copper foils without exceeding the bounds of acceptable roughness. An effective strategy to achieve this involves the use of additives to refine the micro-coarsened surface of the copper foils. In this context, we have explored the impact of additives such as carrageenan, guar gum, and SPS on the surface morphology, roughness, and peel strength of electrolytic copper foils. Three types of additives can improve the performance of micro-roughened copper foil. Through electrochemical tests, it was found that all three types of additives have the effect of increasing cathodic polarization. The adsorption behavior of different additives was studied through theoretical calculations. By hybriding the three additives, two micro-coarsening systems were screened to obtain the lowest roughness and the highest peel strength, respectively. At the same time, the relationship between peel strength and surface area was verified, with the larger surface area resulting in greater peel strength. Finally, the synergistic effect of the three additives on increasing cathodic polarization was verified through chronopotentiometry. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 35
·16472-16485
·
IF 3.5
Tang Hao,Zhang Man,Zhu Yuye,Chen Xuankai,Liu Dekai,Jiang Pingping,Shen Yirui
Phthalate plasticizers are gradually restricted in PVC products due to the escalating demand for health and environmental safeguards. Here, novel poly(glycerol ester) plasticizers(PGE), were synthesized utilizing biomass-derived glycerol and 1,4-cyclohexanedicarboxylic acid as raw materials via an esterification condensation reaction, with n -octanoic acid serving as an end-capping agent, adjustment of reactant ratios yielded PGE-1 and PGE-0.75, subsequently evaluated for their efficacy in PVC applications. FT-IR and GPC analyses elucidated potential structures and molecular weight distributions of the plasticizers, revealing oligomeric PGE with molecular weights spanning 1000–2000 g mol −1 . Mechanical properties, thermal stability, dynamic mechanical analysis, and migration resistance of PVC plasticized with PGE-1 and PGE-0.75 were compared against those employing conventional plasticizers, including di(2-ethylhexyl) phthalate (DEHP), dioctyl terephthalate (DOTP), and acetyl tributyl citrate (ATBC). The hyperbranched network structure and high molecular weight of PGE conferred superior thermal stability and migration resistance to the plasticized PVC samples. Notably, the T 50% of PGE-1/PVC film surpassed that of films plasticized with DEHP, DOTP and ATBC by 107.92, 95.17 and 111.14 °C, respectively. The weight loss of PGE/PVC film in distilled water, anhydrous alcohol and petroleum ether was below 2 wt% during 48 h. Furthermore, the weight loss of each PVC film was below the safety value (5 wt%) during 10 d in three different food simulants. Overall, the obtained poly(glycerol ester) plasticizers exhibit promise as phthalate replacements, owing to their favourable attributes in human health and environmental protection. Graphical abstract The poly(glycerol ester) plasticizers derived from biomass glycerol, 1,4-CHDA and n -octanoic acid exhibited superb thermal stability and migration resistance far more than commercial plasticizers in PVC, resulting from the hyperbranched network structure.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 9
·1-13
·
IF 2.8
Xu Wenwen,Wang Sheng,Ma Wei,Lv WenGuang,Fu Xin
In response to the escalating demand for lightweight, broadband and high-efficiency microwave-absorbing materials driven by the rapid advancement of electronic information technology, this study proposes a novel solution involving the fabrication of aluminum nitride (AlN)-decorated cobalt carbide (CoC) nanocomposites via an oil-bath method. The incorporation of rigid and insulating AlN significantly enhances the thermal stability and microwave absorption (MA) performance of the AlN/CoC composites. Notably, in the 80 wt% AlN/paraffin composite system, a minimum reflection loss (RL min ) of − 43.2 dB and an effective absorption bandwidth of 1.76 GHz (13.92–15.68 GHz) were achieved, which is markedly superior to that of the CoC/paraffin composite under the same filling ratio (− 8.28 dB). The results indicate that the substantial enhancement in the MA properties of the AlN/CoC composites is primarily attributed to the influence of varying AlN contents on the dielectric loss, polarization loss, and impedance matching behavior of the material. This study provides new insights and methodologies for the development of lightweight, broadband, and high-efficiency microwave-absorbing materials. The design strategy of AlN/CoC composites holds great potential for widespread application in fields such as aerospace, electromagnetic shielding, and radar stealth.
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CELLULOSE
·
2024
·Vol. 31
·期 14
·9025-9042
·
IF 4.9
Li Wenjian,Luo Fubin,Dai Yumei,Chen Delong,Li Hongzhou
Ramie fibers have poor flame-retardant properties, which limits their application. To improve the flame-retardant properties of ramie fabric (RF), a durable flame-retardant coating was successfully realized on RF by combining covalent bonding and electrostatic adsorption. Si/P/N flame-retardant coatings were constructed on RF using cationic polyethyleneimine (PEI) and anionic sodium hexametaphosphate (PSP) via the layer-by-layer (LBL) assembly approach with the introduction of 3-glycidoxypropyltrimethoxysilane (GPTMS) as an organic cross-linker. Compared with the untreated RF samples, the fabrics treated with the flame-retardant coating PEI/PSP via the LBL method presented reductions of 51.06%, 48.30%, and 40.05% in the fire growth rate, peak heat release rate, and total heat release, respectively, in the cone calorimeter test. In addition, at a weight gain of 31.57%, the fabric self-extinguished in the UL-94 test within 10 s after leaving the ignition source, resulting in a damaged length of 6.13 cm. G-3 retained the limiting oxygen index (LOI) of 26.40% after 6 laundering cycles (LCs). The TG results revealed that the char residue of G-3 at 800 °C reached 30.34 wt%. The surface of the flame-retardant coating of GPTMS-PEI/PSP had good char formation. This study provides a feasible method for realizing durable flame-retardant RFs.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-16
·
IF 10.6
Zhao Yulan,Wu Yang,Xu Quan,Liu Yi,Song Zhiyong,Han Heyou
Reactive oxygen species (ROS) has emerged as potent therapeutic agents for biofilm-associated bacterial infections. Chemodynamic therapy (CDT), involving the generation of high-energy ROS, displays great potential in the therapy of bacterial infections. However, challenges such as insufficient hydrogen peroxide (H 2 O 2 ) and over-expressed glutathione (GSH) levels within the microenvironment of bacterial biofilms severely limit the antibacterial efficacy of CDT. Herein, we have developed a multifunctional nanoplatform (CuS@CaO 2 @Dex) by integrating copper sulfide (CuS) and calcium peroxide (CaO 2 ) into dextran (Dex)-coated nanoparticles. This innovative platform enhanced ROS generation for highly efficient biofilm elimination by simultaneously supplying H 2 O 2 and depleting GSH. The Dex-coating facilitated the penetrability of CuS@CaO 2 @Dex into biofilms, while CaO 2 generated a substantial amount of H 2 O 2 in the acidic biofilm microenvironment. CuS, through a Fenton-like reaction, catalyzed the conversion of self-supplied H 2 O 2 into hydroxyl radicals (•OH) and consumed the overexpressed GSH. Additionally, the incorporation of near-infrared II (NIR II) laser irradiation enhanced the photothermal properties of CuS, improving the catalytic efficiency of the Fenton-like reaction for enhanced antibacterial effects. In vivo experiments have demonstrated that CuS@CaO 2 @Dex exhibited remarkable antibacterial and antibiofilm efficacy, exceptional wound healing capabilities, and notable biosafety. In summary, the Dex-coated nanoplatform proposed in this study, with its self-sterilization capability through ROS, holds significant potential for future biomedical applications.
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