JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2024
·Vol. 35
·期 1
·1-10
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IF 4.2
Yuan Xinyuan,Wu Tingting,Lu Teliang,Ye Jiandong
Both silicon (Si) and zinc (Zn) ions are essential elements to bone health and their mechanisms for promoting osteogenesis have aroused the extensive attention of researchers. Thereinto, the mechanism by which dual ions promote osteogenic differentiation remains to be elucidated. Herein, the effects of Si and Zn ions on the cytological behaviors of mBMSCs were firstly studied. Then, the molecular mechanism of Si-Zn dual ions regulating the osteogenic differentiation of mBMSCs was investigated via transcriptome sequencing technology. In the single-ion system, Si ion at the concentration of 1.5 mM (Si-1.5) had better comprehensive effects of cell proliferation, ALP activity and osteogenesis-related gene expression levels (ALP, Runx2, OCN, Col-I and BSP); Zn ion at the concentration of 50 μM (Zn-50) demonstrated better combining effects of cell proliferation, ALP activity and same osteogenic genes expression levels. In the dual-ion system, the Si (1.5 mM)-Zn (50 μM) group (Si1.5-Zn50) synthetically enhanced ALP activity and osteogenesis genes compared with single-ion groups. Analysis of the transcriptome sequencing results showed that Si ion had a certain effect on promoting the osteogenic differentiation of mBMSCs; Zn ion had a stronger effect of contributing to a better osteogenic differentiation of mBMSCs than that of Si ion; the Si-Zn dual ions had a synergistic enhancement on conducting to the osteogenic differentiation of mBMSCs compared to single ion (Si or Zn). This study offers a blueprint for exploring the regulation mechanism of osteogenic differentiation by dual ions. Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Liu Ya,Yang Jiajia,Wang Yuxian,Zhu Wanli,Hu Kunsheng,Liu Zhang,Yeung Kinglun,Zhu Zhong-Shuai,Chen Chunmao,Duan Xiaoguang,Wang Shaobin
Compositional heterogeneity in metal/nitrogen-doped carbons (M-N-Cs) complicates the fundamental elucidation of the intricate interplay between the active metal species that rule the reactivity of single atomic catalysts (SACs). This study unveils the electronic disruptions of cobalt nanoparticles (Co NPs) to the catalytic behaviors of cobalt single-atom (Co SA). The intense electronic communications between high-density Co NPs and Co SA sites lead to dissociation O 3 on the high-spin Co SA sites to generate surface-confined hydroxyl radicals ( • OH). However, the tandem electron transfer yields superoxide radical (O 2 •– ) with low reactivity and remarkably reduce ozone utilization efficiency (OUE). In contrast, independent Co SA sites far or free from adjacent Co NPs induce a nonradical O 3 activation regime, which markedly improves electron utilization efficiency (~2.9-fold), OUE ( ~ 3.0-fold), and turnover frequency (TOF, ~2.5-fold) of Co SA. The nonradical catalytic ozonation process demonstrates high adaptability to complex water matrices and maintains long-term stability in the treatment of real petrochemical wastewater. The deciphered electronic interplays between metal nanoparticles and single atom sites advance a new paradigm to regulate the selectivity of single atom catalysis.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 13
·1-17
·
IF 3
Zhang Shoucun,Li Zhuomin,Yang Ning,Wu Wenli,Wang Yuan
As an important intermediate, p -nitrophenol has been widely used in the production of various chemicals, including pharmaceuticals, insecticides, and dyes, etc. However, it exhibits significant ecological toxicity and has a tendency to accumulate in organisms, even at very low concentrations. Therefore, it is essential to remove p -nitrophenol as thoroughly as possible from wastewater before discharging it into the environment. Among various treatment methods, physical adsorption stands out as a safe, reliable, and widely applicable approach, particularly suitable for small-scale water treatment applications. In this study, a melamine/terephthalaldehyde-based material (PMT) with a rich mesoporous structure was synthesized. The presence of abundant nitrogen elements within the material’s structure enhances its adsorption capacity for p -nitrophenol. Subsequently, PMT was dispersed as the dispersed phase into a hydrogel (HGel) structure through post-polymerization, which improved the material’s stability during use. Experimental results demonstrated that the gel composite material achieved a 97.6% adsorption removal rate for p -nitrophenol-contained wastewater. Moreover, after six cycles of reuse, the material retained an adsorption removal rate of 84.2%, highlighting its excellent adsorption performance and reusability.
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Natural Products and Bioprospecting
·
2025
·Vol. 15
·期 1
·1-13
·
IF 4.9
Zang Hao-Jing,Bai Xiao-Lin,Sui Xue-Yi,Zhai Xiao-Rui,Wang Yong-Cui,Xin Zhong-Quan,Yin Qiu-Yuan,Hao Xiao-Jiang,Wang Yue-Hu,Liao Xun,Di Ying-Tong
Parkinson’s disease (PD), the second most common neurodegenerative disorder globally, arises from selective dopaminergic neuron degeneration. While current therapies address symptoms, disease-modifying agents remain an unmet need. Herein, we investigated Nicotiana tabacum L. (Solanaceae), a plant linked epidemiologically to reduced PD risk, as a source of multi-target neuroprotective compounds. From ultra-low nicotine (< 0.04%) tobacco leaves, we isolated 22 molecules, including a novel 21-norsesterterpenoid (Nicotiazanorpenoid A) and eight previously unreported compounds. Systematic evaluation revealed three synergistic neuroprotective mechanisms: (1) Antioxidant activity: Scopoletin ( 3 ) and isoferulic acid ( 6 ) showed significant radical scavenging capacity (ABTS assay; IC 50 = 27.74, and 18.13 μM, respectively); (2) Neuronal protection: cis -11,14,17-Eicosatrienoic acid methyl ester ( 14 ) enhanced survival (93.94% vs. control) in 6-OHDA-induced PC12 cells, surpassing rasagiline (88.36% at equivalent concentrations); (3) MAO-B inhibition: five compounds displayed selective inhibition, with scopoletin ( 3 ) exhibiting highest potency ( K i = 20.7 μM). Notably, plant prostaglandins ( 10/11 ) were identified as competitive MAO-B inhibitors first time through molecular docking and 100-ns MD simulations, revealing stable binding at the FAD site (ΔG = − 10.42, and − 9.75 kcal/mol, respectively). Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
He Bo,Hu Yanhao,Liu Dongshan,Zang Xin,He Xu,Chen Wang,Yang Jingfang,Feng Mingfeng,Chen Ping,Wei Lirong,Li Yu,Yan Wei,Li Jun,Feng Zhike,Zhou Jiahai,Ye Yonghao
Dihydroxyacid dehydratase (DHAD), a key enzyme in branched-chain amino acid synthesis in plants, is a promising yet unexploited herbicide target. Inspired by the natural DHAD inhibitor aspterric acid, we design benzoxazinone derivatives with α-hydroxycarboxylic acid moieties as potential inhibitors and develop an eco-friendly α-C(sp³)-H hydroxylation method for accessing carbonyl compounds. Among the derivatives, 7-fluoro-2-hydroxy-3-oxo-4-propyne-3,4-dihydro-2 H -benzo[ b ][1,4]oxazine-2-carboxylic acid ( I-6e) completely inhibits Arabidopsis thaliana germination and suppress six weed species by > 50%, with 100% efficacy against Avena fatua and Setaria viridis at 150 g ai/ha. This broad-spectrum activity and rice crop safety highlight its potential as an herbicide lead compound. Compound I-6e exhibits stronger affinity for DHAD ( K d = 1 µM) than that of the natural substrate ( K d = 5.39 µM). The 2.19 Å cocrystal structure of the At DHAD– I-6e complex reveals a unique binding mechanism, confirming the critical role of the α-hydroxycarboxylic acid scaffold. This study provides a blueprint for rational DHAD inhibitor design.
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Microsystems & Nanoengineering
·
2025
·Vol. 11
·期 1
·1-12
·
IF 9.9
Wang Fang,Zhou Liangyu,Guo Wei,Lin Haisong,Zhang Ruotong,Kuang Shaolong,Liu Yuan,Fan Xiaoxue,Chan Yau Kei,Deng Hui,Shum Ho Cheung
The plasma-derived reactive oxygen and nitrogen species (RONS) enable cold atmospheric plasma (CAP) to combat cancer and infectious wounds. Achieving therapeutic outcomes with CAP necessitates precise treatment doses. Current CAP devices are constrained by their capability of delivering a single dose to a single sample, limiting dose optimization. We propose a novel “one exposure, multiple-dose delivery” strategy by programming gas flows. This approach facilitates efficient screening of optimal CAP dose by distributing feed gas through boundary-conditioned transport channels to generate multiple, flux-varied gas streams, which ignite plasmas with diverse chemical compositions and dose gradients across samples. Our developed demonstration device, capable of administering three doses to sixteen samples, significantly reduces experimental complexity, particularly when handling large candidate doses or samples for treatment. Leveraging multiplexed treatment, we capably optimize the CAP dose to effectively eradicate the liver cancer cell line of Huh7 and bacteria of S. aureus within one exposure. Furthermore, we find manipulating gas flow velocities allows targeted generation of short-lived species. This approach disentangles the roles of short-lived and long-lived RONS in therapeutic applications, offering critical insights into their bio-functional mechanisms. The concept of multiplexed dose treatment with fluidic manipulation promises to catalyze the development of high-efficiency CAP devices and advance research in CAP-based therapies.
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RARE METALS
·
2025
·
IF 11
Huang Huoshuai,Wei Zhidong,Yan Jiawei,Chi Jiasheng,Su Qianxiang,Ma Linlin,Chen Mingxia,Jiang Zhi,Sun Yangzhou,Shangguan Wenfeng
Photocatalytic hydrogen evolution, a promising clean energy conversion technology, faces efficiency limitations due to the mismatched timescales between sub-picosecond bulk photocarrier recombination and microsecond-scale surface reaction. Herein, a dual-strategy involving selenium decoration and NiS x cocatalyst loading was proposed to ameliorate the carrier dynamics bottleneck in CdS-based photocatalysts. The in situ loading of NiS x cocatalysts established an interfacial built-in electric field (BIEF) that enabled spatially oriented carrier separation and transfer, while the selenium modification optimized the light absorption range and Fermi energy level, obtaining an increase in the photocarrier concentration and further modulated the BIEF. Femtosecond transient absorption spectroscopy revealed a dual-channel carrier dynamics enhancement mechanism that BIEF-driven directional charge migration synergistically coupled with NiS x -mediated holes trapping. This synergistic effect achieved an approximately tenfold enhancement of hydrogen evolution rate (461.71 μmol h −1 ) relative to that of bare CdS under visible light (> 420 nm). This study elucidated the regulatory mechanism of element decoration and cocatalyst loading on carrier dynamics, providing an insight for designing high-performance photocatalysts.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Ma Wencheng,Cheng Yankui,Fan Qinglu,Zhao Xiaoying,Zhang Meng,Jiang Yong,Chen Zehua
Lithium (Li)-metal anode undergoes large volume expansion during repeated charging and discharging processes, which leads to serious damage to the structural integrity of the Li-metal surface, uneven current density distribution at the interface, and the generation of uncontrollable Li dendrites or inactive Li. Herein, we have designed an easily scalable, low-cost iodine-containing electrolyte engineering for releasing inactive Li and constructing high-integrity interfacial Li-metal anodes. X-ray photoelectron spectroscopy (XPS) verifies that the LiI is involved in the composition of solid–electrolyte interphase (SEI) in the battery after activation. Furthermore, density functional theory (DFT) calculations indicate that the LiI has higher electronic insulation and ionic conductivity compared with the conventional inorganic component of SEI, which not only inhibits the inhomogeneous nucleation of Li + , but also improves the interfacial migration kinetics. Benefiting from this elaborated iodine-containing electrolyte, an ultra-long-cycle number of 1370 cycles at a current density of 5 mA cm −2 were achieved in Li symmetric battery, and the structural integrity of the Li anode surface was still maintained. In addition, to verify the feasibility of this strategy for practical applications, the Li-metal full batteries assembled with highly loaded LiFePO 4 (17.4 mg cm −2 , 3.0 mAh cm −2 ) cathode also demonstrated satisfactory long cycle stability and capacity retention.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-12
·
IF 7.8
Yu Xiaolong,Zhang Shengtao,Wei Zhiqi,Xu Qiang
Osteoporosis is a metabolic disorder characterized by progressive bone loss, particularly affecting postmenopausal women. Excessive osteoclast activity contributes to bone resorption and skeletal fragility. Celastrol, a natural triterpene, has demonstrated anti-inflammatory and anti-resorptive effects, but its clinical application is limited by poor solubility and systemic toxicity. In this study, we engineered a bone-targeted nano-sustained-release system using mesoporous silica nanoparticles loaded with celastrol. The nanocarrier displayed high bone affinity, sustained drug release, and favorable biocompatibility. In vitro, it suppressed RANKL-induced osteoclast formation and function by downregulating NF-κB and MAPK signaling. In vivo, treatment of ovariectomized rats improved bone mineral density, preserved trabecular microarchitecture, and reduced osteoclast numbers without apparent systemic toxicity. These findings demonstrate that bone-targeted celastrol nanoparticles provide an efficient and safe therapeutic strategy for postmenopausal osteoporosis by inhibiting osteoclastogenesis and protecting bone structure.
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Cell Communication and Signaling
·
2025
·Vol. 23
·期 1
·1-17
·
IF 8.9
Song Ke,Jing Tao,Yang Xinyan,Xia Junjun,Wang Zehui,Luo Fang,Qiu Chunhua,Liu Zhaoting,Zhao Xiao-Yang,Wang Guang,Ou Xianghong
Type 2 diabetes mellitus (T2DM) is frequently associated with testosterone deficiency, which affects male reproductive function. Currently, exogenous testosterone replacement therapy poses inherent risks, underscoring the need to develop safer and more effective treatment strategies. This study aimed to elucidate the mechanism by which ML221, a potent apelin receptor (APJ) functional antagonist, promotes testosterone secretion, and alleviates reproductive dysfunction. Diabetic mouse models demonstrated reduced testosterone levels, impaired spermatogenesis, and low sperm quality. Elevated APLN expression impaired Leydig cell function and testosterone synthesis. Treatment with ML221 restored testosterone levels and spermatogenesis in diabetic mice. Mechanistically, ML221 regulated Leydig cell metabolism by elevating S-D-lactoylglutathione levels, reducing mitochondrial reactive oxygen species, preserving mitochondrial membrane potential, and enhancing adenosine triphosphate production. At the epigenetic level, ML221 enhanced the binding of nuclear receptor subfamily 2 group F member 2 to the promoters of testosterone-synthesizing genes, thereby facilitating testosterone biosynthesis. These findings advance the understanding of the male reproductive system in the context of diabetes and highlight ML221 as a potential therapeutic approach for T2DM-induced testosterone deficiency.
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PHARMACEUTICAL RESEARCH
·
2025
·
IF 4.3
Bai Wanting,Li Yang,You Feng,Duan Xiaoyan,Hu Jiahuan,Wu Jinjin,Sun Tao,Wang Xing,Lan Pei,Hu Jinping
Objective Bicyclol, a hepatoprotective agent, is often used in combination with other drugs for liver diseases, including drug-induced liver injury (DILI), raising concerns about potential drug-drug interactions (DDIs). This study investigates the interaction between bicyclol and key transporters (OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1, MATE2-K, P-gp, BCRP, BSEP) to predict transporter-related DDI risks. Methods Transporter interaction studies were conducted using cell lines or membrane vesicles overexpressing human uptake and efflux transporters. The substrate and inhibitory potential of bicyclol were systematically evaluated through transport and inhibition assays. The static model and criteria were applied to assess the risk of transporter-related DDIs in vivo . Results Bicyclol was not a substrate of above-mentioned transporters. Regarding inhibition, it was not an inhibitor of OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, or BSEP (IC 50 s > 100 μM). However, it was a marginal inhibitor of OCT2 (IC 50 = 76.2 μM), a weak inhibitor of P-gp (IC 50 = 123 μM), and a strong inhibitor of BCRP (IC 50 = 8.5 μM). The static model predicted that only BCRP would be inhibited in vivo by bicyclol, suggesting dose optimization might be required for BCRP substrates. Conclusions Here, we systematically elucidated the substrate and inhibition potential of bicyclol on major human drug transporters for the first time, which may provide the basis for rational co-administration of bicyclol, potentially broadening its clinical application.
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BMC Pharmacology & Toxicology
·
2025
·Vol. 26
·期 1
·1-13
·
IF 2.7
Fu Wenying,Lu Hui,Yan Ying,Shu Chongchong,Xu Chenxin,Chen Yinghua,Xia Yiqun,Chen Jundixia,Chen Yunzhi,Zou Peng,Cui Ri,Ni Daoyong
Section
Background
Lung cancer continues to rank as a leading cause of cancer-related mortality worldwide. Despite notable advances in medical research, therapeutic options for advanced-stage lung cancer remain inadequate. Heat shock protein 90 (HSP90) has been identified as a potential therapeutic target in multiple malignancies, such as lung and colon cancers, owing to its pivotal role in stabilizing numerous oncoproteins. Nonetheless, the clinical application of HSP90 inhibitors has faced challenges, including suboptimal efficacy and the development of resistance mechanisms. B-AP15 is a promising small molecule in cancer therapy that functions by inhibiting deubiquitinating enzymes, which regulate protein degradation through the proteasome pathway. In this study, we aim to investigate its combinatorial activity with the HSP90 inhibitor tanespimycin (TAU) in lung cancer cells.
Section
Methods
The levels of the specified molecules were measured by Western blot analysis. Reactive oxygen species (ROS) levels were determined using the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) probe. 53BP1 foci formation and C/EBP homologous protein (CHOP) expression were assessed by immunofluorescence. Autophagic flux was monitored using mRFP-GFP-tagged microtubule-associated protein 1 light chain 3 (LC3) lentivirus.
Section
Results
Our findings reveal that the combination of TAU and B-AP15 induces significant synergistic antitumor effects, characterized by substantial accumulation of ROS. This ROS accumulation serves as a crucial mediator of the enhanced therapeutic response elicited by the combination treatment. Mechanistic analyses further demonstrated that the combined treatment induces cell death via activation of endoplasmic reticulum (ER) stress and the c-Jun N-terminal kinase (JNK) pathway.
Section
Conclusion
In summary, our study provides robust evidence supporting the potential of combining TAU with B-AP15 as a viable therapeutic option for lung cancer treatment.
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