MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 2
·1-11
·
IF 5.3
Tang Jiazhen,Chen Jiawei,Xu Ruijie,Xu Junhui,Peng Xiaolun,Wang Yazhen
An electrochemical sensor is presented for the detection of the chloramphenicol (CAP) based on a bimetallic MIL-101(Fe/Co) MOF electrocatalyst. The MIL-101(Fe/Co) was prepared by utilizing mixed-valence Fe (III) and Co (II) as metal nodes and terephthalic acid as ligands with a simple hydrothermal method and characterized by SEM, TEM, XRD, FTIR, and XPS. Electrochemical measurements such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) showed that bimetallic MIL-101(Fe/Co) had the faster electron transfer, larger electroactive area, and higher electrocatalytic activity compared with their monometallic counterparts due to the strong synergistic effect between bimetals. Inspired by these results, the MIL-101(Fe/Co)-based sensor was used to detect CAP. Some experiment parameters of pH, Fe and Co molar ratio, MIL-101(Fe/Co) volume, and DPV quiet time were optimized. The direct reduction mechanism of CAP was verified to involve four electrons and four protons process. Finally, the sensitive and selective CAP detection in the concentration range 1 to 200 μM with a detection limit of 0.3 μM was realized by the proposed sensor. The satisfactory recoveries in tap water and lake water indicated the practicability of the proposed electrochemical sensor. It is expected that this work may open up a paradigm for the preparation of MOF-based electrode modifiers with desired electrocatalytic performance for environmental pollution monitoring.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Ren Zhihao,Shi Xiaoyu,Yang Qing,Li Chunsheng,Liu Hanqing,Bai Tiesheng,Ma Yuan,Das Pratteek,Liu Haofeng,Yang Endian,Jin Shengye,Feng Liang,Shi Quan,Bao Xinhe,Cheng Hui-Ming,Wu Zhong-Shuai
For electronics to be wearable, contactless charging and overall deformability are necessary pre-conditions. However, the current heterogeneous integration based on different active materials and separate manufacturing often leads to mechanical mismatch. Here, we report an ultrastretchable all-in-one integrated MXene-based microsystem comprising wireless coils, micro-supercapacitors (MSCs) and strain sensors. The seamless configuration without any connecting interface dramatically improves the structural integrity of the microsystem, and a pre-crumpled structure endows it with superior stretchability. Attributed to these, our MSCs can be wirelessly charged in ~20 s under various types of deformation and are capable of powering strain sensors, responding rapidly to body motion signals. Moreover, the MSCs display a high specific capacitance of 76.82 F cm –3 , and superb mechanical stability with 98.5% capacitance retention after biaxial stretching 1000 cycles from 0% to 500% areal strain. Therefore, this work sheds new insights into design and implementation of skin-attachable wireless microelectronics.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 10.6
Zhang Liding,Cao Kai,Xie Jun,Liang Xiaohan,Gong Hui,Luo Qingming,Luo Haiming
Amyloid-β (Aβ) readily misfolds into neurotoxic aggregates, generating high levels of reactive oxygen species (ROS), leading to progressive oxidative damage and ultimately cell death. Therefore, simultaneous inhibition of Aβ aggregation and scavenging of ROS may be a promising therapeutic strategy to alleviate Alzheimer’s disease pathology. Based on the previously developed antibody 1F12 that targets all forms of Aβ 42 , we developed an Aβ 42 and ROS dual-targeting nanocomposite using biodegradable mesoporous silica nanoparticles as carriers to load ultra-small cerium oxide nanocrystals (bMSNs@Ce-1F12). By modifying the brain-targeted rabies virus glycoprotein 29 (RVG29-bMSNs@Ce-1F12), this intelligent nanocomposite can efficiently target brain Aβ-rich regions. Combined with peripheral and central nervous system treatments, RVG29-bMSNs@Ce-1F12 can significantly alleviate AD symptoms by inhibiting Aβ 42 misfolding, accelerating Aβ 42 clearance, and scavenging ROS. Furthermore, this synergistic effect of ROS scavenging and Aβ clearance exhibited by this Aβ 42 and ROS dual-targeted strategy also reduced the burden of hyperphosphorylated tau, alleviated glial cell activation, and ultimately improved cognitive function in APP/PS1 mice. Our findings indicate that RVG29-bMSNs@Ce-1F12 is a promising nanodrug that can facilitate multi-target treatment of AD.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Li Juanhua,Liu Yiren,Wu Tianyu,Xiao Zihan,Du Jianhang,Liang Hongrui,Zhou Cuiping,Zhou Jianhua
Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is essential for the timely warnings of AMI. However, it is a challenge to achieve an ultra-fast and highly-sensitive assay for cTnI (hs-cTnI) using current LFA, due to the limited performance of chromatographic membranes. Here, we propose a barbed arrow-like structure membrane (BAS Mem), which enables the unidirectional, fast flow and low-residual of liquid. The liquid is rectified through the forces generated by the sidewalls of the barbed arrow-like grooves. The rectification coefficient of liquid flow on BAS Mem is 14.5 (highest to date). Using BAS Mem to replace the conventional chromatographic membrane, we prepare batches of lateral-flow strips and achieve LFA of cTnI within 240 s, with a limit of detection of 1.97 ng mL −1 . The lateral-flow strips exhibit a specificity of 100%, a sensitivity of 93.3% in detecting 25 samples of suspected AMI patients. The lateral-flow strips show great performance in providing reliable results for clinical diagnosis, with the potential to provide early warnings for AMI.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-12
·
IF 21.8
Liu Min,Ma Weihua,Zhang Mai,Huang Shuyi,Lin Shishi,Liao Jianjun,Zhang Ping,Zhang Linlin
Marine environmentally friendly antifouling materials are emerging as a viable and promising alternative to the conventional toxic antifouling agents. Within this field, the exploration of natural antifouling substances has become a significant research focus, representing an auspicious avenue for innovation in eco-friendly technologies. In this study, we delve into the development of eco-friendly antifouling coatings through a novel chemical modification process. By incorporating natural antifouling agents onto an acrylic acid substrate through a grafting process, we have successfully synthesized three distinct varieties of natural antifouling coatings: isobornyl acrylate polymer (IBAP), acrylate indole polymer (AIP), and indole isobornyl co-modified acrylate polymer (IAA-IBOMA). Through meticulous surface characterization, structural analysis, and a comprehensive suite of antifouling performance tests, our findings indicate that these coatings exhibit superior antifouling properties. Notably, the IAA-IBOMA coating demonstrated exceptional anti-adhesion effects. The specific inhibition rates against E. coli , S. aureus , and Pseudoalteromonas aeruginosa were impressive, achieving 93.5%, 92.8%, and 95.7%, respectively. Moreover, the anti-mussel selective adhesion inhibition rate was found to be 93.3%. Furthermore, environmental toxicity assessments have validated the eco-friendly and stable nature of the IAA-IBOMA coating. These results underscore the potential of these natural product-based coatings as sustainable solutions for the marine industry. This work offers valuable insights and holds significant implications for guiding the future development of environmentally friendly antifouling coatings, steering the industry towards a more sustainable and eco-conscious direction.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 7
·1-11
·
IF 2.6
Zhang Jingxuan,Huang Yeming,Wang Xin,Wang Dunju
3,4-Dinitrofurazanfuroxan (DNTF) is widely used in fusion-cast-based explosive carriers owing to its low melting point, high energy, and excellent stability. To reduce the susceptibility of DNTF and improve the thermal properties, core–shell composites (DNTF@PDA@HTPB) were synthesized using the oxidative self-polymerization reaction of dopamine. The results showed that hydroxyl-terminated polybutadiene (HTPB) was tightly coated on the surface of DNTF@PDA crystals, and the crystal structure of the high-energy crystals did not experience any significant changes during the encapsulation process. Compared with the raw DNTF, the thermal decomposition of DNTF in the DNTF@PDA and DNTF@PDA are delayed by 13.3℃ and 17.1℃, respectively. This phenomenon indicates that the thermal stability of DNTF@PDA and DNTF@PDA@HTPB composites is improved. The ignition speed of DNTF@PDA@HTPB is faster, and the flame activity is more vigorous. Meanwhile, the friction susceptibility of DNTF@PDA@HTPB is reduced by 44% compared to DNTF, and the impact susceptibility is significantly reduced by 75%. This study provides a new idea to improve fused-cast explosives' structure and combustion performance.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-18
·
IF 21.8
Chang Yu,Huang Kexin,Tang Han,Yao Yuwei,Min Jie,Quan Hong,Xu Kai,Wang Hongbo,Zhang Jiaming,Zhao Yingchao
Radiation therapy (RT) remains the primary treatment modality for advanced cervical cancer, however, recurrence due to radioresistance presents a significant challenge. Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) are key contributors to this resistance, driven by their inherent radioresistance and radiation-induced phenotypic adaptations. Addressing this issue requires strategies specifically designed to target CAFs and enhance their radiosensitivity. In this study, we developed a biomimetic metal–organic framework (MOF) nanoplatform for the dual-targeted co-delivery of the FAK inhibitor IN10018 and Bismuth (Bi), aimed at improving radiosensitivity in cervical cancer. The IN10018 and Bi-loaded zeolitic imidazolate framework 8 (ZIF-8) nanoparticles (IZB) were further coated with hybrid membranes derived from CAFs and cancer cells, enabling precise targeting of both cell types. Upon exposure to an acidic environment, the nanoparticles disassemble, releasing IN10018, which reduces CAFs infiltration and enhances radiosensitivity. Simultaneously, the incorporation of Bi enhances radiation absorption efficiency, further sensitizing tumor cells to radiotherapy. This dual-target strategy represents a promising approach to overcoming radioresistance in cervical cancer and exemplifies how integrating nanotechnology with targeted therapies can enhance RT efficacy and improve patient outcomes. Graphic Schematic Illustration of IZB@CCM Construction and Application for Cervical Cancer to Improve Radiosensitivity. (1) IZB was fabricated through the one-pot method. (2) Preparation of hybrid CAF-cancer cell membrane. (3) IZB@CCM were obtained by co-extrusion of IZB and hybrid membrane (CCM). (4) IZB@CCM demonstrated the ability to target CAFs and cancer cells. (5) IZB@CCM inhibited the expression of FAK and released radiosensitizer Bi to enhance the radiosensitivity of cervical cancer.
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COLLOID AND POLYMER SCIENCE
·
2012
·Vol. 291
·期 4
·789-803
·
IF 2.331
Zhang Xiaojing,Wang Chaojun,Fang Shaoming,Sun Jiashu,Li Chong,Hu Yuelei
In this paper, a series of hybrid star PLLA (sPLLA) with different arm lengths was synthesized via the hydrosilylation between octakis(dimethylsiloxy) silsesquioxane (Q 8 M 8 ) and functionalized PLLA macromolecules with vinyl end groups (mPLLA). mPLLA was synthesized by ring-opening polymerization of l -lactide using 2-hydroxyethylmethacryl as an initiator in the presence of stannous 2-ethylhexanoate as a catalyst. The obtained sPLLA has low polydispersity with polydispersity index values from 1.29 to 1.30. The arm numbers of sPLLA vary from 5 to 7 and decrease with the increase in the length of the mPLLA arm due to the steric hindrance, which are estimated by 1 H NMR analysis. The branched structure of sPLLA is also evidenced by the lower intrinsic viscosity when compared with the linear mPLLA with similar molecular weight. Both the glass transition temperatures ( T
g ’s) and melting temperatures ( T
m ’s) of sPLLAs are higher than those of the mPLLA arms. The incorporation of polyhedral oligomeric silsesquioxane (POSS) does not change the crystalline structure of PLLA, while the crystallinity of sPLLA is enhanced as the result that the POSS core acts as a heterogeneous nucleating agent in the matrix to promote the crystallization ability of PLLA. High-resolution transmission electron microscopy observation suggests that POSS disperses in the crystalline PLLA matrix as 5–20 nm aggregates. Microspheres of sPLLA with mean diameter 1 to 2 μm were prepared via emulsion solvent evaporation method. The sPLLA microspheres have higher loading capacity and encapsulation efficiency and lower drug release rate than mPLLA microspheres.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-11
·
IF 5.3
Zhang Jiajing,An Jia,Han Yaqin,Fang Junan,Liu Yufei
Catecholamines (epinephrine, norepinephrine, and levodopa) are a kind of neurotransmitter with similar structure, which orchestrates the regulation of emotional balance, stress adaptation, cardiovascular system optimization, and energy metabolism coordination. To satisfy the actual requirements for rapid, accurate, and on-site detection of multiple catecholamines, we propose a programmable paper-based microfluidic chip, which is loaded with diethanolamine as a multifunctional and efficient non-fluorescent detection probe. Specifically, diethanolamine reacts with epinephrine, norepinephrine, and levodopa to generate polymer carbon dots with yellow, green, and blue fluorescence. On this basis, the integration of paper-based microfluidics with smartphone-assisted technology enables the intelligent visual fluorescence detection of multiple catecholamines. The analytical device exhibits a good linear relationship in the detection of epinephrine (0.008 ~ 0.5 mM), norepinephrine (0 ~ 0.2 mM), and levodopa (0.004 ~ 0.06 mM), with lower limits of detection of 7.4, 19.6, and 1.6 μM, respectively. The practicability and efficiency of the analytical detection device were further demonstrated through the analysis of human serum samples. The intelligent analytical device for the individual quantitative detection and visual differentiation of epinephrine, norepinephrine, and levodopa provides a novel and exciting avenue for accurate detection of multiple catecholamines. Graphical
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Discover Oncology
·
2025
·Vol. 16
·期 1
·1-18
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IF 2.9
Guo Lin,Zhang Jia,Li Yuqiang,Gao Yuehong,Huang Jiali,Liu Mengru,Li Jing,Chai Wenshu,Li Yubin
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. In lung cancer, AHR activation stimulates cancer cell proliferation and promotes tissue invasion and metastasis, and targeting the AHR pathway is an effective way to prevent and treat lung cancer. In lung cancer, AHR binds to the NRF2 promoter region to promote carcinogenesis, but treatment research based on AHR/NRF2 pathway is insufficient. 3,3′-diindolylmethane (DIM), an active phytochemical derivative extracted from cruciferous vegetables, is a modulator of AHR. In this study, We investigated the medicinal value of DIM in NSCLC (non-small cell lung cancer) by in vivo and in vitro experiments and explored the underlying mechanisms. In vitro studies showed that DIM inhibited the viability of NSCLC and induced apoptosis and cycle arrest in cancer cells. DIM inhibited the migration and invasion of NSCLC cells by reversing the epithelial-mesenchymal transition. DIM induced ferroptosis in NSCLC cells; increased cellular Fe 2+ , ROS (reactive oxygen species), and MDA; decreased cellular GSH, AHR, NRF2, and GPX4; and disrupted the mitochondrial membrane potential. The effect of DIM-induced ferroptosis can be reversed by the AHR receptor antagonist CH-223191, ferroptosis inhibitor Fer-1, and ROS scavenger NAC. Overexpression of NRF2 reversed DIM-induced ferroptosis. Identical results were obtained in a nude mouse xenograft model. In summary, we have confirmed that DIM has significant potential in the treatment of non-small cell lung cancer. DIM induces cancer cell ferroptosis through the AHR/NRF2/GPX4 axis. These findings provide experimental basis for DIM treatment and future clinical research in non-small cell lung cancer.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 9
·1-12
·
IF 2.8
Luan Saiwei,Tang Miao,Mu Hanze,Yu Jie,Wang Pengfei,Zhang Lei
Highly tetragonal BaTiO 3 nanopowder serves as a pivotal raw material for manufacturing high-performance miniaturized multilayer ceramic capacitors (MLCCs). In this study, barium acetate and tetrabutyl titanate were used as reactants, isopropanol served as the titanium source stabilizer and dispersant, and oxalic acid was employed as the precipitant to investigate the preparation process of tetragonal-phase BaTiO 3 nanopowder. The optimal process parameters were identified, and the reaction mechanism for synthesizing BaTiO 3 via oxalate co-precipitation was explored. The experimental results indicate that, with a Ba/Ti stoichiometric ratio of 1.000 and a solution pH of 2.33, following the appropriate sequence of experimental reagent additions, the precursor underwent a precipitation reaction at 25 °C. After calcination at 950 °C, BaTiO 3 powder with an average particle size of 56 nm and a tetragonality of 1.0075 was successfully synthesized. The BaTiO 3 ceramic sintered at 1250 °C exhibits a density of 96.5% and an exceptional dielectric performance, with a dielectric constant of 9369 at the Curie temperature (125 °C). This study provides valuable insights for addressing the complex hydrolysis and residual chloride ion issues associated with the chloride method.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 17
·1-11
·
IF 2.8
Huang Jie-Ping,Pan Qiu-Ren,Jiang Hui-Huan,Zhou Xiao-Feng,Li Nan
Efficient and cost-effective non-precious metal catalysts play a crucial role in the evolution of energy storage and conversion technologies. This work introduces a novel cobalt–nickel bimetallic catalyst (Co x /Ni y –N–C), synthesized via SiO 2 spheres as templates and ZIF-8 as precursors, aiming to address this critical need. The Co 1 Ni 1 –N–C catalyst, synthesized with a 1:1 Co to Ni doping ratio, displayed exceptional electrocatalytic activity for oxygen reduction. Its impressive half-wave potential of 0.81 V and limiting current density of 4.89 mA cm −2 nearly approached those of Pt/C catalysts (0.82 V and 5.09 mA cm −2 ), showcasing its competitive edge. Integration of the Co 1 Ni 1 –N–C catalyst into a zinc-air battery demonstrated substantial promise, yielding a commendable power density of 185.17 mW cm −2 , marginally trailing behind the commercial Pt/C catalyst (198.33 mW cm −2 ). By offering a cost-effective alternative without compromising efficiency, this research significantly contributes to the wider adoption of sustainable energy technologies.
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