APPLIED THERMAL ENGINEERING
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2025
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IF 6.9
Jielin Zeng,Jiayi Han,Yuxin Zhang,Yutong Yang,Yapeng Wang,Shaoxiang Li,Jiaji Cheng
In order to save building energy consumption and improve the comfort of building occupancy, functional building coatings are widely used. Introducing microencapsulated phase change materials into epoxy resin coatings can endow them with temperature-control properties. To enhance the fire safety of buildings, this study, for the first time, couples P-N-Si three-element synergistic flame retardancy with phase-change thermal control. Hexachlorocyclotriphosphazene (HCCP) and silane coupling agent (3-Aminopropyl)triethoxysilane (APTES) was used as raw materials to prepare a new type of P-N-Si synergistic flame retardant (APZ) through nucleophilic substitution reaction. The introduction of APZ endows epoxy resin (APZ-PCM/EP) with excellent flame-retardant properties, and the peak heat release rate and total smoke production of APZ-PCM/EP are reduced by 22.9 % and 27.3 % respectively. Furthermore, the thermal responsiveness and phase change properties of the microcapsules modified with APZ (APZ-PCM) are enhanced, with the onset temperature of phase change occurring 1.5 °C earlier than that of MPCM. More importantly, the indoor temperature in the small-scale model room using APZ-PCM/EP is reduced by 29.5 % compared to that of the pure epoxy resin. This study presents a viable route to integrate fire safety with thermal comfort and offers a new strategy for smart temperature-control intumescent coatings on building exterior walls.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Ke Wang,Yuqing Huang,Shiyong Sun,Haoming Tang,Lin Gong,Dongdong Wang,Xueyan Zhang,Sen Lin
The detoxification and valorization of toxic p-nitrophenol (p-NP) and its ester derivatives into high-value p-aminophenol (p-AP) present a significant challenge in green chemistry. This work addresses this challenge by developing a hybrid catalyst through the co-immobilization of lipase and a novel bimetallic Cu/Mn aminoclay nanozyme (CMAC) onto montmorillonite (Mt). The key innovation lies in the multifunctional design of CMAC, which serves not only as a highly active laccase-mimicking nanozyme but also as an intrinsic immobilization matrix for lipase, while the Mt support simultaneously prevents nanozyme aggregation and enhances structural stability. This integrated lipase-CMAC@Mt. platform enables efficient substrate channeling, whereby the p-NP intermediate generated from lipase-catalyzed hydrolysis of p-NPP is directly reduced by adjacent CMAC to p-AP, minimizing intermediate accumulation and overcoming diffusion limitations. As a result, the hybrid catalyst achieves efficient one-pot conversion of p-NPP to p-AP, without requiring harsh reagents or intermediate separation. Remarkably, it exhibits exceptional reusability (76.8 % activity retention after 10 cycles) and storage stability (82.4 % activity retained over 30 days), substantially outperforming conventional free enzyme systems. This study demonstrates a strategic bio-nano synergy that combines the specificity of enzymes with the robustness of nanozymes, offering a scalable and economically viable platform for simultaneous toxic waste elimination and resource recovery.
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Advanced Electronic Materials
·
2025
·Vol. 11
·期 8
·2400738
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IF 5.3
Guodong Han,Song Zhao,Sai Sui,Bo Feng,Yudeng Wang,Junxiang Zhou,Zhuolun Li,Xiaoxia Tian,Yuxiang Jia,Jiafu Wang,Shaobo Qu
Metal–Organic-Frameworks (MOFs) are commonly used as microwave-absorbing materials after pyrolysis treatment. Rare researchers treat MOFs as non-conductive materials and use them as absorbing materials directly. In this paper, MOFs@P-C-800 composite materials are prepared adopt to hydrothermal and ultrasonic dispersion methods by regulating the morphological characteristics of MOFs and the content of P-C-800. As for the Co-BDC-P-C-800, the maximum reflection loss reaches −18.4 dB at 14.29 GHz and the effective absorption bandwidth (EAB) achieves 3.87 GHz from 13.5 to 17.37 GHz. After the contents of P-C-800 is adjusted, the Co-BDC-P-C-800 (0.05 g) exhibited excellent microwave absorption performance, the maximum RL value of −60 dB at 13 GHz with a thickness of 2.0 mm, and the EAB achieves 5.91 GHz from 12.02 to 17.93 GHz. This paper not only provides new application direction for MOFs, but also offers a promising direction for the research and development of absorbing materials.
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Drug Metabolism and Pharmacokinetics
·
2013
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IF 2.071
Qiuxia Chen,Yicong Bian,Su Zeng
Caco-2 is a widely used cell model in drug absorption and P-glycoprotein (P-gp,MDR1) substrate identification. Long term vinblastine treatment of Caco-2 cells could increase the expression of P-gp, thus, the vinblastine resistant Caco-2 (Caco-2 vbl) cells can be used as a rapid and sensitive alternative model in identifying P-gp substrates. The mechanism of P-gp induction in this model is not clear, this study was therefore intended to clarify the possible factors involved in P-gp up- regulation in Caco-2 vbl cells. Since vinblastine is the inducer of both activator protein-1 (AP-1) and nuclear factor kappa B(NF-κB), we investigated the role of AP-1 and NF-κB in regulation of MDR1 gene expression. Our results indicated that the AP-1 and NF-κB luciferase activity was higher in Caco-2 vbl cells than that in Caco-2 cells by reporter gene assay. The mRNA expression of AP-1 subunit c-Jun and NF-κB was increased in Caco-2 vbl cells. The c-Jun inhibitor SP600125 and NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells. In conclusion, this study provides the evidence that AP-1 and NF-κB are involved in the P-gp induction in Caco-2 vbl cells.
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Frontiers in Nutrition
·
2025
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IF 5.1
Yanan Wang,Xinyi Qian,Lingzhi Chen,Ling Yang,Zhenjiang Zhang,Zhilong Qu,Yuhan Yang,Yihao Li,Zaizhong Ni,Ying Shao,Anhui Chen
Introduction Although Phellinus igniarius has been shown to treat hyperuricemia (HUA) and gout, a self-inflammatory disease caused by purine metabolism disorders, the underlying mechanisms remain unclear. Polysaccharides are among the main components of P. igniarius with anti-inflammatory and immunoregulatory properties. Methods Here, we examined the therapeutic effects of polysaccharide SH-P-1-1 isolated from P. igniarius on HUA and gout, and explored the underlying mechanism, focusing on gut microbiota and metabolite regulation. Results SH-P-1-1 significantly decreased uric acid and creatinine levels, reduced xanthine oxidase and adenosine deaminase activities, alleviated kidney damage, and reduced urate deposition in joints in model rats. It increased the abundance of Blautia and Muribaculaceae but reduced that of the Lachnospiraceae_NK4A136_group , Lactobacillus , and Turicibacter . SH-P-1-1 also significantly modulated the metabolic profile and was closely related to some metabolic pathways, such as tryptophan metabolism, relevant to HUA and gout. The beneficial activities of SH-P-1-1 correlated with gut microbiota composition and differential metabolites, including short-chain fatty acids. Discussion Overall, this study demonstrates the potential of SH-P-1-1 as a natural supplement for preventing and managing HUA and gout.
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Processes
·
2025
·Vol. 14
·期 1
·55
·
IF 2.8
Bao Fan,Jiale Xiong,Cuiluan Ma,Yu-Cai He
Gastrodin is a bioactive component of traditional Chinese medicine, exhibiting anti-cancer, anti-inflammatory, antioxidant and neuroprotective properties. It has broad application prospects in health foods, pharmaceuticals and cosmetics. In recent years, the conversion of biomass-derived aldehydes into high-value-added chemicals has garnered widespread attention. In this study, gastrodin was biosynthesized via a dual-enzyme coupling system consisting of UGTBL1-Δ60 and KpADH. Specifically, lignin-derivedp-hydroxybenzaldehyde was used as the substrate. First, the glycosylation ofp-hydroxybenzaldehyde by UGTBL1-Δ60 yieldedp-hydroxybenzaldehydeβ-glucoside, generating the glycosylation reaction solution. Subsequently, bioreduction of the glycosylation product by KpADH produced gastrodin. Under the optimal reaction conditions (0.05 g/mL KpADH whole cells, 50 mM glucose, pH 7.5 and 30 °C) a gastrodin yield of 82.8% was achieved within 12 h. Moreover, both UGTBL1-Δ60 and KpADH retained high catalytic activity after multiple reaction cycles. This study establishes a green and efficient biocatalytic approach for gastrodin synthesis, and also provides new insights into the high-value utilization of lignin.
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ACS Catalysis
·
2025
·
IF 13.1
Fang Huang,Aihao Xu,Xiangyu Chen,Huanhuan Sun,Siyu He,Dong Wei,Boran Wang,Anxiang Guan,Xucai Yin,Jing Xu,Huibing He
The direct electrocatalytic conversion of carbon dioxide to methane using water as a medium is a reliable way to store intermittent renewable energy and solve environmental problems. However, in such multielectron/proton transfer reactions, the role of water is often overlooked. Specifically, the sluggish kinetics of water dissociation limit the effective proton supply during methane formation. Here, we propose a copper-doped CeO2 catalyst with frustrated Lewis pairs (FLPs), which can effectively reduce carbon dioxide to methane. Combined experimental analysis and theoretical calculations reveal that the synergistic interaction between Cu and FLPs forms an f-p-d gradient orbital coupling system, which significantly promotes water dissociation to generate active protons and optimizes the adsorption behavior of the *H and *COOH intermediates. Even at the large current density of −273 mA cm–2, the Faraday efficiency of Cu/CeO2-FLPs for methane was as high as 78.0%, with a conversion frequency of 15784.1 h–1 in the flow cell. This work provides a strategy for the rational design of efficient multipoint catalytic systems.
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PROGRESS IN ORGANIC COATINGS
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2025
·
IF 7.3
Shenghua Yang,Jinming Guo,Hongyu Yuan,Haixia Xiao,Xiaming Feng,Hongyu Yang,Cheng Yan,Wei Cai
Intumescent flame-retardant (IFR) systems are attractive alternatives to conventional halogenated flame retardants due to their halogen-free composition, efficiently reduced heat release, and low toxicity generation. Herein, a nitrogen–boron (N B) dual-element flame retardant, melamine borate (MB), was synthesized and subsequently incorporated into a UV-curable resin based on bis(2-methacryloxyethyl) phosphate to construct a ternary synergistic N/P/B IFR coating system. The structure, thermal stability, and flame-retardant properties of the resulting coatings were systematically investigated by various techniques and combustion tests. Increasing MB content raised the glass transition temperature (T g ), indicating enhanced network compactness and stability. The coating containing only 4 wt% MB achieved a UL-94 V -0 rating and exhibited a 56.35 % reduction in total smoke production (TSP), along with significantly improved thermal stability in terms of decomposition temperature and char residue. The synergistic contributions of phosphorus, nitrogen, and boron promote catalytic charring, gas release, and glass-phase reinforcement, leading to the formation of a dense, stable char barrier. This eco-friendly ternary IFR system overcomes the high loading requirements and toxicity concerns of conventional flame retardants, providing a promising strategy for the efficient and sustainable flame-retardant modification of polymeric coatings.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Guowei Huang,Ruichao Wang,Wenchao Wu,Wangle Xue,Peng Wang,Hongli Li,Zhenbin Gong
Nanofriction plays an important role in the performance and lifetime of n-type or p-type TMD-based semiconductor nanodevices. However, the mechanism of nanofriction in n-type and p-type TMD semiconductors under an electric field is still blurry. In this paper, monolayers of n-MoSe2 and p-WSe2 materials were prepared by chemical vapor deposition (CVD), and their nanofriction behavior under positive electric field was investigated. Atomic force microscopy (AFM) was used to analyze the nanofriction by the positive voltage applied through the needle tip: both the friction and the friction coefficient of MoSe2 increased with the increase of the applied voltage, while the friction and the friction coefficient of WSe2 decreased with the increase of the applied voltage. As the applied voltage increases, the friction force and energy dissipation exhibit corresponding trends in relation to the surface potential. The accumulation and dissipation of carriers represent significant factors influencing friction change. The diverse types of carriers give rise to variations in the friction laws. Our experiments have revealed the differences and mechanisms of friction in TMD materials dominated by different carrier types at positive voltages. It provides guidance for the application and modulation of n- and p-type two-dimensional semiconductor materials in the field of friction.
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RENEWABLE ENERGY
·
2025
·
IF 9.1
Baoxian Wang,Saiying Li,Zhiwei Wang,Zhenyu Zhou,Lizi Li,Shufang Wu,Weiqi Wei
Developing an efficient and feasible pretreatment is vital for biomass refining. Herein, a kind of p-toluene sulfonic acid (p-TsOH) pretreatment under mild conditions was proposed to convert the sugarcane bagasse (SCB) into glucose, furfural, and activated lignin. After the pretreatment, the cellulose-rich solid was digested by cellulase, and the glucose yield was up to 94.8 %. The pretreated liquid was diluted with deionized water to precipitate the lignin. Notably, the hemicelluloses degradation products in the supernatant, primarily xylose, can be directly converted into furfural without needing a catalyst, achieving a yield of 73.1 %. The recovered lignin exhibits excellent antioxidant properties, with a radical scavenging index (RSI) of 40.0 and significant UV absorbance, which displayed great potential in lignin-based sunscreen preparation. This study, therefore, presents a comprehensive strategy for the valorization of SCB, enhancing its potential for sustainable applications.
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JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Zhangxin Xu,Mingyang Liu,Shuting Zhang,Jinlong Zou,Baojiang Jiang
Rechargeable/flexible zinc-air batteries (ZABs) show great potential for energy storage, yet cathode catalysts currently used lack durability under harsh conditions. Thus, rational catalyst design and the protection of the primary active site in these environments are critical. Here, we have developed an innovative catalyst by encapsulating the Co/Co 3 Fe 7 alloy heterojunction within a N, P co-doped multifunctional carbon nano-armor (Co/Co 3 Fe 7 @PNCNT), employing both armor protection and heterojunction engineering strategies. The formation of the Co/Co 3 Fe 7 heterojunction can adjust the d-band center and induce a local electric field effect to promote ORR (oxygen reduction reaction)/OER (oxygen evolution reaction) activity. The tubular carbon nano-armor effectively prevents metal particle aggregation, corrosion, and ensures long-term stability in strongly alkaline environments. Co-P bonds construct atomic-level electron transfer channels between the metal heterojunction as well as the nano-armor, accelerating charge transfer to promote ORR/OER reaction kinetics. Density functional theory calculations also confirm the construction of an internal electric field at the Co/Co 3 Fe 7 interface and the adjustment of the d-band center via the heterojunction formation. The Co/Co 3 Fe 7 @PNCNT-based rechargeable/flexible ZABs has excellent power density and ultra-long-term cycling stability (1730 h). It exhibits great potential in large-scale energy storage, portable electronics and wearable devices. This work provides a new design route for the precise construction of multifunctional nano-armor and heterojunctions.
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ACS Catalysis
·
2025
·
IF 13.1
Wei An,Zeyang Liu,Tongjun Shen,Yizhang Du,Cun Huang,Boyuan Duan,Chunxia Wang,Guoyong Huang,Yiming Yan,Shengming Xu
To overcome the low current-density efficiency and long-term stability issues of industrial overall water splitting at ampere-level current density, a kind of superwetting Mo-doped nanoarray anchored on nickel foam (NF) (Mo-CoP/NC) with three-dimensional (3D) nanoflower structure is constructed. The incorporation of Mo species induces thermoneutral hydrogen adsorption free energy and creates favorable empty d-orbitals, which enhances the d–p hybridization of Co–O bonds, thereby accelerating the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) kinetics in alkaline media. The optimized Mo-CoP/NC exhibits exceptional electrocatalytic performance, requiring low overpotentials of 198 mV for HER and 384 mV for OER at a current density of 1000 mA cm–2 and achieving maintains robust operation in overall water splitting at 3000 mA cm–2. When employed as a bifunctional catalyst in an alkaline electrolyzer, a cell voltage of 1.87 V can be realized at 1000 mA cm–2 , outperforming commercial benchmarks. Density functional theory (DFT) calculations reveal that Mo doping optimizes hydrogen adsorption energy and reduces energy barriers for water dissociation. The superwetting surface ensures rapid gas bubble detachment and efficient active site regeneration, while N-doped carbon encapsulation endows long-term stability with negligible activity decay over 100 h of continuous operation.
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