Friction
·
2024
·Vol. 12
·期 12
·2679-2691
·
IF 6.3
Sun Yue,Shang Zhenling,Li Chenghao,Guo Jinglun,Chen Zhuo,Zhao Nan,Liu Guoqiang,Zhou Feng,Liu Weimin
Bacterial infection and tissue damage caused by friction are two major threats to patients’ health in medical catheter implantation. Hydrogels with antibacterial and lubrication effects are competitive candidates for catheter coating materials. Photothermal therapy (PTT) is a highly efficient bactericidal method. Here, a composite hydrogel containing MXene nanosheets and hydrophilic 3-sulfopropyl methacrylate potassium salt (SPMK) is reported, which is synthesized through the one-pot method and heat-initiated polymerization. The hydrogel shows excellent antibacterial performance against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) in 3 min in the air or 20 min in the water environment under near-infrared light (NIR; 808 nm) irradiation. The friction coefficient of the hydrogel is about 0.11, which is 48% lower than that without SPMK. The rapid photothermal sterilization is attributed to the outstanding antibacterial ability and thermal effect of photoactivated MXene. The ultra-low friction is the result of the hydration lubrication mechanism. This study provides a potential strategy for the surface coatings of biomedical catheters, which enables rapid sterilization and extremely low interface resistance between catheters and biological tissues.
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Journal of Food Measurement and Characterization
·
2024
·Vol. 18
·期 5
·3868-3880
·
IF 2.9
Mayire Abulitifu,Wei Qin,Wang Yingbo,Bai Xi
The citronellol-rich Origanum vulgare essential oil (OEO), which exhibits excellent antioxidant and antimicrobial activities, has limited use in food packaging owing to its high volatility and instability. This problem can be solved using electrospinning. In this study, OEO was incorporated into the zein matrix via emulsion electrospinning. OEO was obtained by hydro-distillation; gas chromatography–mass spectrometry analysis revealed that citronellol (44.34%) was a predominant compound in OEO. Scanning electron microscopy images demonstrated that the fibers had a bead-free and uniform structure with a diameter ranging from 215 ± 36 to 260 ± 72 nm. The X-ray diffractograms indicate the amorphous structure of the zein fibers. Fourier transform infrared absorption spectroscopy revealed an interaction between OEO and zein. The addition of OEO to the zein nanofibers affected its secondary structure. Thermogravimetric analysis showed that the OEO-loaded (OEO/zein) nanofibers exhibited high thermostability and that the water contact angle was enhanced. The encapsulation efficiency and loading capacity were in the range of 71.56–85.8% and 8.88–40.93%, respectively. The antioxidant activity of the OEO/zein nanofibers ranged from 45.40% to 71.50%. The OEO/zein fibers displayed antimicrobial activity against Staphylococcus aureus and Escherichia coli . In conclusion, OEO/zein nanofibers are promising alternatives for active food packaging.
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JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Zuo Pengli,Peng Jun,Yao Yuyang,Tan Wei,Cheng Lan,Zhang Jinyu,Lu Xiuhua
Due to the unique chemical and biomedical properties of carbon dots (CDs), they have increasingly obtained the attention in many research fields, for example, bioimaging, fluorescence sensing, and drug delivery, etc. Recently, it was found that, under light excitation, CDs can also be exploited as a novel photosensitizer to prepare reactive oxygen species (ROS), which expand their applications in the field of photodynamic therapy for cancer treatment. Nevertheless, the high cost and complex fabrication approach of CDs significantly limit their applications. To address this issue, bottom-up routes usually utilize sustainable and inexpensive carbon precursor as starting materials, employed N,N-dimethylformamide (DMF) or ethanol as an environmental-friendly solvent. Bottom-up approach was energy efficient, and the purification process was relatively simple by dialysis. Therefore, carbon dots (CDs) were facilely fabricated in a one-pot solvothermal process using 1-aminoanthraquinone as a precursor, and their application as photosensitizers for in vitro antitumor cells, especially photodynamic therapy (PDT) was established. Then the photophysical and nanoscale dimensions properties of the fabricated CDs were characterized via TEM, UV–visible, fluorescence, and FT-IR spectroscopy. The synthesized N-doped CDs can easily dissolve in water, possess very low biotoxicity, yellow-light emission (maximum peak at 587 nm). More importantly, PDT studies demonstrated that the obtained CDs possess a high singlet oxygen yield of 35%, and exhibit significant phototoxicity to cancer cells upon 635 nm laser irradiation. These studies highlight that N-doped CDs can be facilely synthesized from only one precursor, and are a potentially novel theranostic agent for in vivo PDT.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Wang Hui,Cui Guoqing,Lu Hao,Li Zeyang,Wang Lei,Meng Hao,Li Jiong,Yan Hong,Yang Yusen,Wei Min
The dry reforming of methane provides an attractive route to convert greenhouse gases (CH 4 and CO 2 ) into valuable syngas, so as to resolve the carbon cycle and environmental issues. However, the development of high-performance catalysts remains a huge challenge. Herein, we report a 0.6% Ir/CeO 2− x catalyst with a metal-support interface structure which exhibits high CH 4 (~72%) and CO 2 (~82%) conversion and a CH 4 reaction rate of ~973 μmol CH4 g cat −1 s −1 which is stable over 100 h at 700 °C. The performance of the catalyst is close to the state-of-the-art in this area of research. A combination of in situ spectroscopic characterization and theoretical calculations highlight the importance of the interfacial structure as an intrinsic active center to facilitate the CH 4 dissociation (the rate-determining step) and the CH 2 * oxidation to CH 2 O* without coke formation, which accounts for the long-term stability. The catalyst in this work has a potential application prospect in the field of high-value utilization of carbon resources.
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CATALYSIS LETTERS
·
2024
·
IF 2.3
Yu Lihua,Zhao Yaling,Guo Shuai,Xue Juanqin
Metal–organic frameworks (MOFs) were used as precursors to prepare iron-based heterogeneous Fenton catalysts Fe@C, FeCu@C, and FeCu@N–C via pyrolysis. The catalytic activities were evaluated by measuring the decomposition rate of hydrogen peroxide (H 2 O 2 ). The morphology, structure, and physical properties of the catalysts were analyzed through X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and nitrogen adsorption. The results showed that at 60 min, the decomposition rates of H 2 O 2 by FeCu@C and FeCu@N–C were 95.4% and 92.5%, respectively, which were 18.5% and 15.6% higher than that by Fe@C, respectively. It was speculated that the iron and copper species present in the bimetallic nanoparticles were available active sites for the Fenton reaction. The synergistic effects between them can promote the activation and decomposition of H 2 O 2 . In addition, the nitrogen-doped catalysts FeCu@N–C had better pH applicability, better reusability, and lower iron leaching than FeCu@C. Nitrogen-doped carbon contributed to the enhanced catalytic performance. This can be attributed to the well dispersibility of Fe and Cu species on the N-doped carbon matrix. The FeCu@N–C was applied to the treatment of enrofloxacin (ENR) antibiotic wastewater. The results indicated that a 90% degradation rate can be achieved in 60 min under the initial concentration of ENR 20 mg/L, catalyst dosage 20 mg/L, H 2 O 2 concentration 1.5 mM, the initial solution pH 3.60, 25 ℃. The rapid degradation of ENR was more relevant to the surface-bound ٠OH rather than free ٠OH and the heterogeneous Fenton reaction played the dominant role. This work provides a potential heterogeneous Fenton catalyst for antibiotics wastewater treatment. Graphical Abstract
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Friction
·
2024
·Vol. 12
·期 8
·1716-1727
·
IF 6.3
Meng Yan,Wen Xiangli,Cheng Jie,Bai Pengpeng,Meng Yonggang,Tian Yu
Most studies of liquid lubricants were carried out at temperatures below 200 °C. However, the service temperature of lubricants for aerospace and aeroengine has reached above 300 °C. In order to investigate the friction mechanism and provide data for high temperature lubrication, the friction and wear properties of chlorophenyl silicone oil (CPSO)-lubricated M50 steel and Si 3 N 4 friction pairs were investigated herein. Ball-on-disk experimental results show that the lubrication performance of CPSO varies significantly with temperature. Below 150 °C, coefficient of friction (COF) remains at 0.13–0.15 after the short running-in stage (600 s), while the COF in the running-in stage is 0.2–0.3. At 200 °C and above, the running-in time is much longer (1,200 s), and the initial instantaneous maximum COF can reach 0.5. Under this condition, the COF gradually decreases and finally stabilizes at around 0.16–0.17 afterwards. This phenomenon is mainly due to the different thickness of boundary adsorption film. More importantly, the wear rate of M50 steel increases significantly with the temperature, while the wear rate barely changes at temperatures above 200 °C. The anti-wear mechanism is explained as tribochemical reactions are more likely to occur between CPSO and steel surface with the increased temperature, generating the FeCl 2 protective film on the metal surface. Accordingly, FeCl 2 tribochemical film improves the lubrication and anti-wear capacity of the system. At high temperatures (200–350 °C), FeCl 2 film becomes thicker, and the contact region pressure becomes lower due to the larger wear scar size, so the wear rate growth of M50 steel is much smaller compared with that of low temperatures (22–150 °C). The main findings in this study demonstrate that CPSO lubricant has good anti-wear and lubrication capacity, which is capable of working under temperatures up to 350 °C.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Agha Hasan M.,Abdulhameed Ahmed Saud,Jawad Ali H.,Khadiran Tumirah,ALOthman Zeid A.,Wilson Lee D.
A biopolymer matrix of chitosan (CTS) and algae (AGA) was chemically modified with a natural genipin (GEN) cross-linker agent via hydrothermal process. The resulting green adsorbent (CTS-GEN/AGA) was evaluated for removal of the cationic dye (methyl violet, MV) from aqueous media. The optimization of MV adsorption onto CTS-GEN/AGA was performed using the Box–Behnken design (BBD), considering the variables of adsorbent dose (0.02–0.1 g/100 mL), pH (4–10), and time (20–300 min). The CTS-GEN/AGA demonstrated the highest MV removal (76.49%) for optimal operational parameters: CTS-GEN/AGA dosage (0.0938 g/100 mL), pH (8.4), and contact time (215.3 min). The adsorption isotherm analysis revealed a close fit between the experimental data of MV adsorption and the Temkin model. Furthermore, the adsorption kinetics are well-described by the pseudo-second-order model. The maximum adsorption capacity of CTS-GEN/AGA was 71.9 mg/g at 25 °C. The probable adsorption mechanism can be assigned to H-bonding, electrostatic forces, and n–π stacking interactions. These findings highlight the potential of CTS-GEN/AGA as an effective adsorbent for treatment of wastewater for the removal of organic dyes.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Li Yunfan,Yang Zhiwang,Guan Jie,Chen Zhengpeng,He Xin,Cao Zhengshuai,Yan Qibin,Zhao Jiaheng,Lei Ziqiang
The traditional inorganic flame-retardant magnesium hydroxide (MH) has since many years been dominating in flame-retardant applications. However, due to its poor compatibility with the epoxy resin matrix, it seriously affects the mechanical properties of the matrix. In the present study, MH has been organically modified to investigate the potential of a novel organic–inorganic hybrid as a flame-retardant curing agent (CEPPM-MH) for flame retardancy of epoxy resins. CEPPM-MH and ammonium polyphosphate (APP) were synergistically introduced into the epoxy thermosets to improve the fire resistance of the composites. For the S7 composite samples that contained 10% of APP and 10% of CEPPM-MH, the LOI was increased to 30.1. Also, the UL-94 test rating was increased to V-0, and the peak heat release rate (pHRR), total heat release (THR), total smoke production (TSP), and peak CO production rate(pCOPR)were reduced by 86%, 53%, 69%, and 79%, respectively, as compared with the pure sample S1. In addition, the flexural strength and flexural modulus were found to be improved by 76.8% and 45.1%, respectively, in the flexural performance test. Furthermore, the organic–inorganic hybrid curing agent, which was prepared by modifying the magnesium hydroxide with water as the only solvent, could be introduced into epoxy resins as both curing agent and flame retardant, which not only effectively reduced the fire risk but also improved the comprehensive performance of the materials. This provides a new idea for the preparation of intrinsically flame-retardant epoxy resins.
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BMC Pulmonary Medicine
·
2024
·Vol. 24
·期 1
·1-14
·
IF 2.6
Wu Yuanlin,Zhang Jiandong,Zhao Junjun,Wang Bin
Cisplatin (DDP) resistance, often leading to first-line chemotherapy failure in non-small cell lung cancer (NSCLC), poses a significant challenge. MiR-219a-5p has been reported to enhance the sensitivity of human NSCLC to DDP. However, free miR-219a-5p is prone to degradation by nucleases in the bloodstream, rendering it unstable. In light of this, our study developed an efficient nanodrug delivery system that achieved targeted delivery of DDP and miR-219a-5p by modifying liposomes with folate (FA). Based on the results of material characterization, we successfully constructed a well-dispersed and uniformly sized (approximately 135.8 nm) Lipo@DDP@miR-219a-5p@FA nanodrug. Agarose gel electrophoresis experiments demonstrated that Lipo@DDP@miR-219a-5p@FA exhibited good stability in serum, effectively protecting miR-219a-5p from degradation. Immunofluorescence and flow cytometry experiments revealed that, due to FA modification, Lipo@DDP@miR-219a-5p@FA could specifically bind to FA receptors on the surface of tumor cells (A549), thus enhancing drug internalization efficiency. Safety evaluations conducted in vitro demonstrated that Lipo@DDP@miR-219a-5p@FA exhibited no significant toxicity to non-cancer cells (BEAS-2B) and displayed excellent blood compatibility. Cellular functional experiments, apoptosis assays, and western blot demonstrated that Lipo@DDP@miR-219a-5p@FA effectively reversed DDP resistance in A549 cells, inhibited cell proliferation and migration, and further promoted apoptosis. In summary, the Lipo@DDP@miR-219a-5p@FA nanodrug, through specific targeting of cancer cells and reducing their resistance to DDP, significantly enhanced the anti-NSCLC effects of DDP in vitro, providing a promising therapeutic option for the clinical treatment of NSCLC.
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 5
·1-12
·
IF 2.6
Xing Jinfu,Gu Jun,Liu Bujin,He Li,Jiang Tuanhui
The type and structure of nucleating agents have an important influence on the properties of the final foam as well as on the nucleation of the bubbles during injection foaming. In this study, a simple melt blending method was used to prepare polypropylene/nucleating agents (PP/NAs) composites containing nucleating agents with different structures, and the rheological behavior of the PP/NAs composites was studied using a rotational rheometer. According to the rheological data, the structure of the nucleating agent was not the primary reason for influencing polymer viscosity. Additionally, PP/NAs composite foams were prepared by chemical foaming injection molding process and the bubble dynamics, cell quality and tensile properties were investigated. The results exhibited that polymers with β-cyclodextrin (β-CD), which had a self-contained cavity-circular table structure, as the nucleating agent have better bubble nucleation dynamics. The tensile toughness of PP/β-CD foam was increased from 8.21 MJ/cm 3 to 20.54 MJ/cm 3 , an improvement of 150.34% by comparison with pure PP foam, which was attributed to having an average cell diameter of 23.98 μm and a cell density of 2.36 × 10 7 cells/cm 3 . Therefore, this study provides a reference for the design of efficient nucleating agents for the preparation of structural foam materials with lightweight and tough properties.
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Communications Biology
·
2024
·Vol. 7
·期 1
·1-13
·
IF 5.2
Lin Hui,Lin Shuaijun,Shi Liuhong,Xu Guangsen,Lin Manjie,Li Supeng,Chen Jiale,Li Zhiquan,Nakazibwe Catherine,Xiao Yunbei,Li Xiaokun,Pan Xuebo,Wang Cong
The acquisition of ectopic fibroblast growth factor receptor 1 (FGFR1) expression is well documented in prostate cancer (PCa) progression, notably in conferring tumor growth advantage and facilitating metastasis. However, how FGFR1 contributes to PCa progression is not fully revealed. Here we report that ectopic FGFR1 in PCa cells promotes transferrin receptor 1 (TFR1) expression and expands the labile iron pool (LIP), and vice versa. We further demonstrate that FGFR1 stabilizes iron regulatory proteins 2 (IRP2) and therefore, upregulates TFR1 via promoting IRP2 binding to the IRE of TFR1. Deletion of FGFR1 in DU145 cells decreases the LIP, which potentiates the anticancer efficacy of iron chelator. Intriguingly, forced expression of IRP2 in FGFR1 depleted cells reinstates TFR1 expression and LIP, subsequently restoring the tumorigenicity of the cells. Together, our results here unravel a new mechanism by which FGFR1 drives PCa progression and suggest a potential novel target for PCa therapy.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-21
·
IF 14.7
Xu Ke-Fei,Wu Shun-Yu,Wang Zihao,Guo Yuxin,Zhu Ya-Xuan,Li Chengcheng,Shan Bai-Hui,Zhang Xinping,Liu Xiaoyang,Wu Fu-Gen
Bacteria-mediated cancer therapeutic strategies have attracted increasing interest due to their intrinsic tumor tropism. However, bacteria-based drugs face several challenges including the large size of bacteria and dense extracellular matrix, limiting their intratumoral delivery efficiency. In this study, we find that hyperbaric oxygen (HBO), a noninvasive therapeutic method, can effectively deplete the dense extracellular matrix and thus enhance the bacterial accumulation within tumors. Inspired by this finding, we modify Escherichia coli Nissle 1917 (EcN) with cypate molecules to yield EcN-cypate for photothermal therapy, which can subsequently induce immunogenic cell death (ICD). Importantly, HBO treatment significantly increases the intratumoral accumulation of EcN-cypate and facilitates the intratumoral infiltration of immune cells to realize desirable tumor eradication through photothermal therapy and ICD-induced immunotherapy. Our work provides a facile and noninvasive strategy to enhance the intratumoral delivery efficiency of natural/engineered bacteria, and may promote the clinical translation of bacteria-mediated synergistic cancer therapy.
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