JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-20
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IF 12.6
Shen Jiayi,Luo Yuwen,Hu Wuming,Zhang Susu,Yang Yu,Lan Linwen,Liu Enqian,Xu Jian,Hu Tingting,Nie Jingjun,Chen Dafu,Liang Ruizheng,Lyu Lingchun
Myocardial ischemia/reperfusion (I/R) injury represents a major global health concern, driven by excessive reactive oxygen species (ROS), which closely correlates with subsequent myocardial infarction and fibrosis. Combining ROS scavenging with ischemic myocardium revascularization holds therapeutic promise. However, developing multifunctional therapeutic agents that can simultaneously scavenge ROS and promote angiogenesis remains unreported. Herein, we propose MgSrCeAl-layered double hydroxide (LDH) nanosheets as a multifunctional ROS scavenger and angiogenesis promoter for efficient myocardial I/R injury treatment. MgSrCeAl-LDH nanosheets not only exhibit exceptional hydroxyl radicals (·OH) and superoxide anions (·O 2 − ) scavenging capabilities, which is 1.78 times and 1.61 times that of CeO 2 , respectively, but also respond to the ischemia-induced acidic microenvironment to release angiogenic Sr 2+ with a concentration of 32.65 ppm (pH 5.0), which is conducive to efficient angiogenesis. Specifically, the ROS levels in I/R-injured myocardium decreased to 66.2% of its original value following intervention with MgSrCeAl-LDH nanosheets, while the vascular density in the peri-ischemic myocardium increased by approximately 3.6-fold. Ultimately, the infarcted myocardial area is reduced 60.9% compared to the group without MgSrCeAl-LDH intervention. Mechanistically, MgSrCeAl-LDH nanosheets alleviate myocardial infarction and fibrosis caused by I/R injury through activating PI3K/Akt pathway and inhibiting TGF-β pathway, ultimately improving cardiac function and inhibiting ventricular remodeling. Graphical abstract
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Emergent Materials
·
2025
·
IF 4.1
Ali Romzan,Amin Ruhul,Khaleque Abdul,Zohra Fatema-Tuj,Aly Saad Aly Mohamed,Khan Zaved H.
Metronidazole (MZ) is a nitroimidazole antibiotic utilized to cure a numerous infection. But metronidazole presents significant health risks for both animals and human, due to its mutagenic, carcinogenic, and genotoxic properties. Furthermore, long-term use can lead to severe central nervous system issues. Thus, the concentration level of the drug must be monitored to avoid such health complications, highlighting the significance of developing rapid, accurate, and highly sensitive methods for detecting metronidazole levels. Herein, a polyglutamic acid (PGA) functionalized carbon black nanoparticle (CB NPs), CB NPs/PGA nanocomposite modified electrode-based electrochemical sensor for the quantification of MZ in animal feed is developed. The electrochemical performance of the proposed sensor was evaluated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and impedance spectroscopic analysis. The proposed sensor displayed a wide linear range of 500–10 4 nM with a 0.17 µM limit of detection, and 0.35 µM limit of quantification. This is the first to report on the synthesis of CB NPs/PGA nanocomposite and its application for the detection of MZ. The selectivity of the modified electrode to detect MZ while minimizing interference from various ions was assessed, exhibiting remarkable resilience, remaining unaffected even when the interfering ions were present at 100-fold concentrations. Additionally, after two successive weeks of storage, the proposed sensor showed no discernible reduction current (< 1.4%), demonstrating an excellent stability. The developed sensor successfully detected MZ within 2 min in differ animal feeds with recovery rates range of 96–99%. The proposed sensor lays a groundwork in critical domains like food safety regulation, veterinary medicine, and agricultural monitoring. Graphical abstract
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-15
·
IF 3.9
Li Jiameng,Liu Xiaodan,Sun Chaofan,Wang Mingyang,Zhang Qianqian,Wang Hongyu,Ji Xu,Jin Erhui,Zhang Feng
Enterotoxigenic Escherichia coli (ETEC) causes diarrhea and triggers intestinal inflammation posing a significant threat to children which is a global health concern. Berberine (BBR) has diverse pharmacological properties can alleviate diarrhea and intestinal damage. This metabolomics study analyzed the effects of berberine on the hepatic function, lipid metabolism, and inflammatory responses in weaned piglet model infected with ETEC. A total of 18 piglets were randomly divided into three groups: basal diet (BD) + Saline, BD + ETEC, and BBR + ETEC. Compared with the BD + Saline group, ETEC infection significantly increased the contents of aspartate aminotransferase (AST), AST/alanine aminotransferase (ALT), total protein, globulin, triglycerides, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-8, IL-12, interferon γ (IFN-γ), IL-4, IL-10, and transforming growth factor β (TGF-β) and significantly decreased the contents of total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) in the serum of weaned piglets. There were 14 metabolites upregulated and 21 metabolites downregulated after ETEC infection, and total cholesterol, LDL, IL-1β, IL-8, and TGF-β were correlated with fructose and mannose metabolism. Compared with the BD + ETEC group, dietary berberine significantly increased the contents of total cholesterol, LDL, and HDL and significantly decreased the contents of AST, AST/ALT, total protein, globulin, triglycerides, TNF-α, IL-1β, IL-6, IL-8, IL-12, IFN-γ, and IL-4 in the serum of weaned piglets. There were 111 metabolites upregulated and 48 metabolites downregulated after berberine addition, and total protein, IL-1β, IL-6, IL-8, and IL-12 were correlated with cholinergic synapse. Both ETEC infection and berberine addition can induce changes in taste transduction and affect the physiological functions of weaned piglets through metabolic pathways.
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IONICS
·
2025
·
IF 2.6
Gu Bonwun,Kang Chankyu
In this study, the flash points and ionic conductivity of three ternary electrolyte solvents (ethylene carbonate (EC); diethyl carbonate (DEC); and dimethyl carbonate (DMC)) were investigated in lithium-ion batteries. The flash points of the solvent mixtures were experimentally measured and compared with predictions using Raoult’s law and multiple regression analysis. These results indicate that EC increases flash point temperature and ionic conductivity owing to its high dielectric constant and boiling point. In contrast, DMC has a lower flash point because of its low boiling point and high reactivity. The coefficient of determination ( R 2 ) and mean absolute error (MAE) suggest that Raoult’s law better predicts overall trends in flash points. Simultaneously, multiple regression analysis provided higher accuracy for specific mixture compositions. Additionally, the ionic conductivities of the ternary electrolyte mixtures were analyzed, demonstrating that DMC maintained high conductivity through polar conformers despite its low dielectric constant. The optimal mixture ratio of EC: DEC: DMC at 7:2:1 achieved a balance with a high flash point (55.5 °C) and high ionic conductivity (9.0 mS cm⁻ 1 ), enhancing battery safety and ionic conductivity. This study highlights the critical role of solvent composition in optimizing lithium-ion battery electrolytes for improved safety and ionic conductivity. Graphical
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
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2025
·
IF 3.2
Li Die,Wang Ting,Zhao Ruike,Wang Weiqun,Zhang Yu,Long Ai,Bi Haojie,Wang Hanying,Wang Daoshuang,Shi Jingpei,Li Yupeng,Lyu Lechun
Post-inflammatory hyperpigmentation (PIH) is a reaction process caused by an increase in melanin or abnormal melanin distribution due to inflammatory skin diseases, skin disease treatments, and external stimuli. Ultraviolet radiation can exacerbate PIH. It stimulates melanocytes, increases melanin production and deposition, and deepens the color and prolongs the duration of PIH. This study aims to investigate the inhibitory effects of Coelonin, an extract from Dendrobium officinale, on melanin production and its underlying mechanisms. Through molecular docking analysis, we found that Coelonin has significantly stronger binding capabilities to tyrosinase (TYR) and melanocortin 1 receptor (MC1R) than kojic acid, a well-known whitening agent. This stronger binding ability suggests that Coelonin may inhibit melanin production by regulating the activity of melanin metabolism-related proteins, thereby exerting its whitening effect. Compared with kojic acid, Coelonin demonstrates superior binding characteristics at the molecular level, providing stronger evidence for its potential as a whitening active ingredient. In cell experiments, Coelonin had no significant effect on the proliferation of B16-F10 melanoma cells within the concentration range of 20–40 µM, but it could significantly reduce the intracellular reactive oxygen species (ROS) levels and inhibit TYR activity and melanin production. Western blot results showed that Coelonin could downregulate the expression of TYR, MITF, TRP-1, and TRP-2 proteins. In in vivo experiments, a guinea pig model of PIH was established by Ablative Fractional Resurfacing CO₂ Laser (AFR CO 2 ) combined with UV-B irradiation. It was found that Coelonin treatment could significantly improve skin pigmentation, reduce melanin granule deposition, and did not cause skin inflammation or hyperplasia and other side effects. This study indicates that Coelonin is an efficient and safe melanin synthesis inhibitor and has the potential to be developed as a plant-derived skin whitening agent.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 11
·1-18
·
IF 2.4
Zheng Chenyu,Sun Dayu,Gan Jingyi,Wang Rui,Gao Lijing,Wei Ruiping,Xiao Guomin
Lignin, a promising sustainable biopolymer, exhibits immense potential as a renewable feedstock for aromatic chemicals and advanced materials, offering a green alternative to fossil resources. However, its complex aromatic structure and recalcitrant β-O-4 ether bond pose significant challenges for efficient depolymerization. In this study, a series of Ce-modified Cu-Ni-Al layered double hydroxide (LDH) catalysts (CuNiAlCe x ) were designed for the catalytic transfer hydrogenolysis (CTH) of enzymatic hydrolysis lignin (EHL) using ethanol as a hydrogen donor, aiming to produce low-molecular-weight lignin oil (LO) enriched with phenolic hydroxyl groups. Structural and surface analyses revealed that Ce modification enhanced oxygen vacancy concentration through dynamic Ce 3+ /Ce 4+ redox cycling and optimized acid site distribution, synergistically facilitating C-O bond cleavage. The highest LO yield of 71.8% was attained under optimized reaction parameters, accompanied by a marked reduction in molecular weight and concurrent increases in phenolic hydroxyl and carboxyl groups. GC-MS analysis identified diverse aromatic monomers (total yield: 21.34%), predominantly guaiacyl derivatives. This study reveals the synergistic interaction between oxygen vacancies and acid sites in CuNiAlCe x catalysts, providing a green strategy for the selective valorization of lignin into aromatic compounds, thereby advancing sustainable biorefinery technology. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Xue Wenjie,Jiang Hui,Liu Jinlong,Chen Xinqing,Tang Conghui,Xia Bao Yu,You Bo
Ethylene (C 2 H 4 ), a cornerstone of the chemical industry, is produced predominantly via fossil-intensive high-temperature processes that contribute significantly to global energy consumption and CO 2 emissions. Here, we report an ambient bipolar C 2 H 4 electrosynthesis system that concurrently decarboxylates propanoic acid, a prevalent biorefinery waste, at nanoporous Pt microparticles-coated anode and reduces CO 2 at W-doped CuO x -loaded cathode. Physicochemical and operando spectroscopy characterizations, along with theoretical modeling reveal that the polarized Pt-PtO 2 interface formed in situ downshifts the d-band relative to Fermi level which favors the desorption of *CH 2 CH 2 intermediate to promote selective propanoic acid decarboxylation toward C 2 H 4 . Remarkably, the resulting electrocatalyst couple delivers an unprecedented C 2 H 4 faradaic efficiency (FE C2H4 ) of 118.7% and a large current density of 1000 mA cm −2 , and sustains a FE C2H4 exceeding 103.4% for over 265 h at an industrial current density of 400 mA cm −2 , offering a promising pathway to carbon-neutral C 2 H 4 production from waste feedstocks.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-13
·
IF 5.3
Di Huixia,Zhao Min,Cheng Huibin,Wang Yadi,Li Xiaochun
A smartphone-based "monitoring workstation" (SMW) for living cells has been developed, which is coupled with an independent complementary metal–oxide–semiconductor (CMOS) image sensor and is compatible with any smartphone for rapid determination through digital image colorimetry (DIC). This SMW system encompasses multifunctional modules, such as high-quality image acquisition, synchronous data storage, wireless transmission, and automated data analysis. Our focus has been on routine and labor-intensive cell detection tasks, including cell viability, protein quantification, and lipid measurement, which can be achieved rapidly on-site with a custom-developed software installed in a smartphone. Consequently, this SMW system offers a promising platform for colorimetric point-of-care test (POCT) that is rapid, simple, cost-effective, and highly accurate, and it is not limited to any particular type or brand of smartphone. Graphical
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JOURNAL OF ELECTROCERAMICS
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2025
·
IF 2.6
Arunkumar G.,Akepati Deepa,Singla Yogesh Kumar
Magnetorheological elastomers (MREs) have garnered significant interest in recent decades due to their vast potential in engineering applications. Magnetorheological (MR) materials can be rapidly and reversibly tuned by applying a magnetic field, leveraging their viscoelastic and mechanical properties. Unlike MR fluids, which are prone to issues like oil contamination and particle sedimentation, MREs offer a solid alternative that mitigates these drawbacks. This solid-state advantage opens up numerous possibilities for creating intelligent devices across various technical domains, including vibration isolation, vibration reduction, and shock absorption. Because of these benefits, recent studies have investigated the incorporation of MREs into energy harvesting systems like piezoelectric materials. Piezoelectric materials are one of the promising technologies in the field of energy harvesting, which can utilize an external source (Vibration) as an input and harvest electrical energy as an output. This might fulfil the growing demands in the field of sustainable and renewable energy. This review paper provides a comprehensive overview of innovative materials and their types, particularly MREs and piezoelectric elastomers/polymers. It also discusses various manufacturing methods for MREs and piezoelectric materials, shedding light on their potential applications in the realm of energy harvesting and beyond.
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Science China-Life Sciences
·
2025
·
IF 9.5
Feng Yue,Lin Zishen,Wang Haoran,Men Zhaoyue,Shen Jiakun,Ma Xi
Deoxynivalenol (DON) is a prevalent mycotoxin in animal feed that particularly impacts weaned piglets, causing liver damage, growth retardation, and posing significant public health risks. However, the precise mechanisms underlying DON-induced liver damage and optimal treatment approaches remain unclear. The pregnane X receptor (PXR) holds a pivotal position in hepatic xenobiotic elimination and drug metabolism. This research aimed to explore the involvement of PXR in DON-induced liver injury and evaluate the potential of the PXR agonist, 3-indolepropionic acid (IPA), to alleviate liver damage and associated diarrhea in weaned piglets under practical farming conditions. The results demonstrated that DON initiates p53-mediated hepatocyte apoptosis in weaned piglets. RNA-seq and hepatocyte-specific PXR knockout (PXR-HKO) mice revealed PXR’s regulatory role in DON-induced hepatocyte apoptosis. IPA reduces DON-induced hepatocyte apoptosis in piglets, mice, and hepatocyte cell lines by enhancing PXR expression and facilitating nuclear translocation. Furthermore, AlphaFold3 predictions and Co-IP assays demonstrate that DON diminishes PXR-p53 binding, thereby amplifying p53-mediated apoptotic transactivation. In conclusion, this study elucidates a novel mechanism by which PXR decreases its binding to p53 upon DON exposure, thereby promoting hepatocyte apoptosis. Additionally, it validates the positive impact of IPA in mitigating liver damage and diarrhea caused by DON in weaned piglets.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2025
·
IF 3.5
Guo Fang,Liu Yijun,Zhong Yu,Feng Wanyun,Shang Xiaoqiang,Chen Yufeng
In order to improve the loading capacity of the drug delivery system based on magadiite for procainamide (PA), the cationic PA was inserted into the interlayer of magadiite by the intercalation of tetra-n-butylammonium ions and multi-step ultrasonic ion exchange. X-ray diffraction, compositional analyses, and IR results confirmed that the cationic PA was successfully loaded into the interlayer of magadiite, and the loading capacity of the drug delivery system based on magadiite for PA was about 25.0%. Thermogravimetric analysis indicated that the thermal stability of PA was obviously improved after it was loaded into the interlayer of magadiite. Drug release revealed the sustained and controlled release of PA from drug delivery system either in phosphate buffer solution (PBS, pH = 7.4, simulating intestinal fluid) or in HCl solution (pH = 1.35, simulating gastric fluid). This sustained release of drugs will be beneficial to improve the availability and efficacy of drugs. Moreover, the kinetic behavior of drug release either in PBS or in HCl can be fitted to ExpAssoc model. Nuclear magnetic resonance (NMR) results indicated that there is an interaction between the magadiite and PA in the drug delivery system, and this interaction may determine the kinetic behavior of drug release. The present work may provide a refer for improving the loading capacity of positively charged drugs in some layered silicates, which would be important in medical field.
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JOURNAL OF CHEMICAL SCIENCES
·
2025
·Vol. 137
·期 3
·1-13
·
IF 2
He Jun,Dou Jianing,Song Wenchao,Song Tao,Chen Jiaqi,Lin Xuan
CeO 2 /chitosan/expanded graphite (CeO 2 /CS/EG) was prepared by hydrothermal synthesis and used for the heterogeneous catalytic ozonation of 4-chlorophenol (4-CP) in wastewater. The catalysts were characterized by XRD, SEM, EDS, BET, XPS and FT-IR. In order to study the catalytic activity of CeO 2 /CS/EG, the catalytic performance of CeO 2 /CS/EG/O 3 system was compared with other reaction systems, and the effects of catalyst dosage, pH, initial 4-CP concentration, O 3 concentration and co-existing ions on the degradation of 4-CP in this system were investigated. The results showed that CeO 2 /CS/EG/O 3 system showed high catalytic activity for 4-CP degradation. Under the optimal conditions (pH > 6.5, catalyst dosage 1.0 g L –1 , initial concentration of 4-CP 100 mg L –1 , ozone concentration 2.5 mg L –1 , reaction time 30 min), the removal rate and mineralization rate of 4-CP reached 99.4% and 70.2%, respectively. This degradation process conformed to first-order reaction kinetics. After five consecutive catalytic cycles, the removal rate of 4-CP was still above 97%, showing the excellent stability and reusability of CeO 2 /CS/EG. The ·OH was identified as the main reactive species causing 4-CP degradation through free radical scavenging experiments. According to the main intermediates measured by the HPLC-MS technique, five possible degradation processes of 4-CP catalytic ozonation were deduced. Graphical abstract CeO 2 /chitosan/expanded graphite (CeO 2 /CS/EG) were prepared by hydrothermal synthesis and used for heterogeneous catalytic ozonation of 4-chlorophenol (4-CP) in wastewater. The results showed that the removal efficiency of 4-CP and total organic carbon (TOC, a key parameter representing the total carbon content in organic compounds that indicates mineralization degree) reached 99.4 and 70.2% under optimal conditions. Besides, OH ⋅ was identified as the main substance causing 4-CP degradation.
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危险品化学品经营许可证（带存储）