ACS Applied Materials & Interfaces
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2025
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IF 8.2
Jin Qian,Sai Bai,Guoping Xiang,Dandan Zhang,Junmei Zhou,Minxian Cheng,Xiaohong Zhao,Xinying Chen,Yichu Zhang,Yueping Bao,Xiangning Xu
In this study, cobalt-encapsulated nitrogen-doped carbon hollow nanospheres (Co@NCs) were synthesized for peroxymonosulfate (PMS) activation and tetracycline (TC) degradation. Co@NCs synthesized at a high pyrolysis temperature exhibited relatively higher graphitic N and C═C contents, which effectively regulated the electron density of Co sites, enhancing the PMS activation efficiency. In the Co@NCs-900/PMS system, remarkable TC removal efficiency (97.14%, kobs = 0.179 min–1) and TOC removal (63.62%) were achieved within 60 min. Based on the quenching tests, EPR technology, and electrochemical measurements, a synergistic radical and nonradical pathway was unveiled, with SO4•–, 1O2, and ETP dominated. Co@NCs-900/PMS showed efficient catalytic performance and practical application potentials without interference from organic and inorganic compounds under the experimental background. Additionally, over 80% TC removal could be achieved after the seven-cycle catalytic reaction and showed negligible Co2+ leaching, indicating superior recyclability. Chemical analysis and DFT calculation revealed that PMS adsorption and activation could be strengthened by modulating the electron density with Co and N serving as the active sites. Overall, this study provides valuable insights into the incorporation of metal sites on N-doped carbonaceous catalysts for Fenton-like reactions in water purification applications.
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RENEWABLE ENERGY
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2025
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IF 9.1
Zhixin Shang,Dongyin Ren,Yajie Tian,Zhen Shang
The doping of heteroatoms during the preparation of hydrothermal carbon represents an effective technology for the improvement of doped carbon materials for supercapacitors (SCs). In this study, N/S-doped hydrothermal carbon was prepared via a glucose-assisted glucose self-doping process during the hydrothermal carbonization stage. In addition, heteroatom-doped carbon materials for supercapacitors were prepared by KOH activation treatment, and their high specific surface area and microporous structure rate can be attributed to the stable structure of glucose and the large amount of heteroatoms in grapevines. It exhibited an amazing specific capacitance of 521.0 F/g at a current density of 0.5 A/g, an energy density of 49.6 W h/kg for symmetric devices, and a power density of 0.5 kW/kg. After 25,000 charge and discharge cycles under constant current conditions, the capacitance retention rate can still reach 86.99 %. This study proposes a new method for preparing heteroatom-doped carbon materials for supercapacitors using waste biomass.
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Journal of Cleaner Production
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2025
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IF 10
Duo Xu,Bowen Du,Xuan Jiang,Jiaxin Ling,Shengwei Xiao,Huimin Sun,Xianqiang Yin
Diclofenac sodium (DCF) and venlafaxine (VLF), as widely used and environmentally persistent pharmaceutical pollutants, are frequently detected in water bodies and exhibit bioaccumulation and ecotoxicity, which may threaten the stability of ecosystems by disrupting the endocrine systems of aquatic organisms and neural signaling. The combination of these pollutants with microplastics (MPs) not only enhances the migration of the pollutants, but also amplifies the risk of exposure to high trophic level organisms via the food chain, which is an important warning significance for the study of the safety of the aquatic environment and the mechanism of pollutant coupling in the global “plastic circle”. This study delved into the sorption behavior and mechanisms of DCF and VLF on two different MPs ( i.e. , polystyrene (PSMPs) and polylactic acid (PLAMPs)). Batch sorption experiments were used to quantify sorption capacity under controlled solution chemistry conditions, examining sorption kinetics, isotherms, and thermodynamics. The maximum sorption capacity of PLAMPs and PSMPs for DCF was 2.994 and 3.296 mg g −1 , respectively, while that of PLAMPs and PSMPs for VLF was 5.864 and 6.234 mg g −1 , respectively. The sorption of DCF and VLF on both MPs mainly depended on physical interactions, with the kinetic model in agreement with the pseudo-first-order model, the isotherms were consistent with the Langmuir model. Fourier infrared spectroscopy and X-ray photoelectron spectroscopy demonstrated variations regarding surface functional groups upon MPs before and after sorption. Both MPs showed a significant increase in oxygen and nitrogen-based functional groups after sorption of DCF and VLF, with the most obvious variations being the increase in C-O and C=O. Density-functional theory was used to detect the main sorption mechanisms and the binding energies between PhACs and MPs. In summary, our study found the sorption of DCF and VLF on MPs is controlled by electrostatic interactions, followed by some weaker interactions ( i.e. , van der Waals forces, hydrogen bonding, and hydrophobic interactions). This study provides new insights into the mechanisms of effective separation and interaction between complex pollutants.
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Scientific Reports
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2025
·Vol. 15
·期 1
·1-11
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IF 3.9
Kong Linghong,Wang Hui,Jiang Weiwei,Chen Yun,Du Zhuoling,Zhang Qiong,Dong Jianyue,Zeng Changchun,Liu Hanping
Advanced Glycation End Products (AGEs) are the molecular mediators that contribute to the progression of diabetic complications. However, there is a paucity of research on effective AGEs inhibitors and strategies for blocking the AGEs-RAGE pathway. To solve the problem, we synthesized polymetformin (PL), which for the first time proved the ability to inhibit AGEs formation and block the AGEs-RAGE pathway to protect the vascular from being damaged. Based on gene ontology (GO) analysis and Kegg enrichment, we found that PL could antagonize AGEs. Molecular docking and dynamics analyses showed that PL formed stable structures with AGEs through electrostatic interactions and hydrogen bonding. PL treatment altered AGEs structures have been proven in FT-IR results. The study discovered that PL interacted with AGEs via both non-covalent and covalent modifications, altering AGEs’ binding sites and antagonizing the AGEs-RAGE pathway. Immunofluorescence assays indicated lower levels of RAGE, IL-1β, and TNFα, while ROS assays demonstrated lower ROS levels, highlighting PL’s inhibitory effects and biocompatibility. Our work underscores PL’s potential to treat diabetic complications by elucidating its mechanism of action against the AGEs-RAGE pathway and inflammatory factors for the first time. This research provides insights for managing chronic illnesses linked to the AGEs-RAGE pathway beyond diabetes complications.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
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2025
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IF 3.9
Da Wang,Miao Zhang,Qingjie Xie,Song Han,Sisi Xiao,Huijuan Wang
In this study the indigenous materials in plateau areas were used to cope with the challenge of increasing antibiotics pollution in Qinghai-Xizang Plateau. The barely straw was chosen as the raw material to prepare the manganese modified biochar (XBSMBC) and then combined with peroxymonosulfate (PMS) to set up the PMS/XBSMBC system to treat the enrofloxacin (ENR) in water. The study showed that there was a higher PMS activation and thus ENR degradation of the manganese modified biochar prepared from the barley straw than those from Xizang wheat straw and Henan wheat straw. The preparation parameters of the XBSMBC, including the mass ratio of barley straw to manganese and the pyrolysis temperature, for the PMS activation as well as the ENR degradation were reviewed and found that the 1:1 and 900°C were the optimal preparing conditions (XBSMBC-900 (1:1)). The influence of the XBSMBC-900 (1:1) additive amount, PMS dosage and solution initial pH on the ENR degradation was also ascertained. Results of quenching experimental studies and electron paramagnetic resonance demonstrated that ENR degradation in the PMS/XBSMBC system was achieved by a combined effect of SO 4 ·- , ·OH, ·O 2 - and 1 O 2 . Four possible pathways of ENR degradation were provided, and the toxicity analysis predictions were applied to infer the validity of the PMS/XBSMBC process for the ENR solution treatment.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Jun Zhu,Jingjing Chen,Congcong Wang,Dehong Yu,Minghao Chao,Hanrong Yan,Ruqi Huang,Zhenxin Wang,Bin Pan,Fenglei Gao
Insufficient generation of reactive oxygen species and the highly active cholesterol metabolism of tumors are two major barriers limiting the efficacy of conventional ferroptosis-based cancer therapies. Here, we engineered a single-atom iron nanozyme (Fe-NC@TASIN-30@FA, abbreviated as FTF) to overcome ferroptosis resistance and sensitize tumors to apoptosis-coupled catalytic therapy by simultaneously delivering a distal cholesterol synthesis inhibitor and catalytically amplifying ROS production. FTF is constructed by loading a selective 7-dehydrocholesterol (7-DHC) synthesis inhibitor, TASIN-30, onto an iron single-atom nanozyme and further functionalizing it with folate-modified polyethylene glycol (SH-PEG-FA) to confer tumor-targeting capability. Notably, TASIN-30 is incorporated with a drug-loading rate of 22.5%, providing efficient payload delivery without compromising nanozyme activity. The iron active centers in FTF exhibit dual enzyme-mimetic activities. One of them is peroxidase-like activity that breaks down H 2 O 2 into hydroxyl radicals, and the other is glutathione peroxidase-like activity that catalyzes the oxidation of reduced glutathione to oxidized glutathione, thereby increasing intracellular ROS levels and consuming antioxidants to achieve a coordinated iron apoptosis effect. In addition, by inhibiting 7-DHC and cholesterol biosynthesis, FTF accelerates the consumption of excess intracellular cholesterol in tumor cells, disrupts the integrity of lipid rafts, and consequently suppresses tumor cell proliferation. In 143B tumor-bearing nude mice, FTF achieves an in vivo tumor inhibition rate of approximately 82.5%, while exhibiting a maximum tolerated dose of 7.5 mg/kg. Overall, this study proposes a new therapeutic strategy that integrates cholesterol metabolic interference with catalytic nanozyme therapy, providing a potent ferroptosis-apoptosis synergistic modality for tumors refractory to conventional treatments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
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IF 8.7
Ying Yu,Yonggang Peng,Sekar Vijayakumar,Yikai Chen,Yangfan Mao,Meihua Xin,Mingchun Li
This study aims to develop a novel chitosan-based pH-responsive hydrogel for sustained curcumin (Cur) delivery. Chitosan was modified with norbornene dicarboxylic anhydride to introduce reactive double bonds and enhance solubility, while cysteine-modified Pluronic F127 was crosslinked via UV-induced thiol–ene chemistry to form a stable three-dimensional network. The hydrogel structure was tuned by adjusting the CSNB/CPC ratio and characterized using 1 H NMR, solid-state 13 C NMR, FTIR, TGA, XRD, SEM, and rheology. The optimized hydrogel achieved a drug loading capacity of 13.3 mg/g and exhibited pH-responsive release in simulated gastrointestinal fluids, with kinetics well-fitted to the Peppas–Sahlin model (R 2 > 0.98), dominated by Fickian diffusion. Functional evaluation showed that NC4 displayed nearly 90% DPPH radical scavenging efficiency, and its antioxidant potential was further supported by the Folin–Ciocalteu (GAE) assay and the phosphomolybdenum (AAE) assay, indicating enhanced overall reducing capacity and total antioxidant capacity. NC4 also exhibited strong antibacterial activity against Staphylococcus aureus and Escherichia coli . Biocompatibility was confirmed by CCK-8 and hemolysis assays, with cell viability exceeding 90% and hemolysis rates below 0.35%. Collectively, this multifunctional hydrogel integrates sustained release, antioxidant, antibacterial, and excellent biocompatibility, providing a promising material platform for oral controlled drug delivery and wound healing applications.
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Biomaterials Advances
·
2026
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IF 6.7
Changxu Wang,Shenghao Shi,Fei Wang,Chong Yuan,Di Liu,Yifei Liu
Osteoporosis is a prevalent metabolic bone disorder characterized by an imbalance between bone resorption and formation. Current therapeutic options are constrained by side effects and low bioavailability. Icariin (ICA), a naturally derived osteotropic flavonoid, exhibits osteogenic and anti-osteoclastogenic properties; however, its clinical application is limited due to poor solubility and low oral bioavailability. This study introduces β-cyclodextrin-modified gold nanoclusters (CGNCs) as a nanocarrier for efficient delivery of ICA. The synthesized ICA-loaded CGNCs (ICA-CGNCs) have a hydrodynamic diameter of approximately 2.16 nm, demonstrating excellent dispersity, sustained release kinetics, and storage stability. In vitro, ICA-CGNCs showed good cytocompatibility in both MC3T3-E1 pre-osteoblasts and RAW264.7 macrophages. In MC3T3-E1 cells, ICA-CGNCs promoted osteogenic differentiation, as indicated by increased ALP activity, enhanced mineralization, and upregulated osteogenic genes (ALP, BMP2, RUNX2, and COL1A1 ); immunofluorescence further showed elevated nuclear β-catenin and RUNX2 signals, supporting the involvement of osteogenic pathway-associated events in this cell model. In RAW264.7 cells, ICA-CGNCs suppressed RANKL-induced osteoclastogenesis by reducing TRAP-positive multinucleated osteoclast formation, disrupting F-actin ring organization, and downregulating osteoclast markers ( TRAP, CTSK, MMP9, and NFATc1 ), which was supported by decreased bone resorption pit formation and attenuated nuclear accumulation of NF-κB p65 and NFATc1·In a glucocorticoid-induced zebrafish osteoporosis model, ICA-CGNCs effectively promoted cranial and vertebral bone mineralization without systemic toxicity, outperforming both free ICA and CGNCs alone. This study establishes the ICA-CGNC platform as a dual-action nanotherapeutic strategy with significant potential for osteoporosis treatment and bone regeneration.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Fengxian Luo,Xinchuang Wang,Tao Chen,Lihang Chen,Dan Zhang,Qingping Shi,Jinling Xu,Jiangning Hu
Inflammatory bowel disease (IBD) represents a chronic inflammatory disorder characterized by excessive reactive oxygen species (ROS) generation, persistent inflammatory response, and gut microbiota dysbiosis. Herein, a novel colon-targeted composite hydrogel (FTS/Gel) consisting of metal-polyphenol nanozymes (FTS) embedded in an inulin-based gel was developed for efficient oral treatment of IBD. This nanozyme (FTS) was synthesized by coordination between Fe 3+ ions and the anti-inflammatory drugs taxifolin (Tax) and L- Se -methylselenocysteine (SeMC), exhibiting remarkable superoxide dismutase (SOD)-like and catalase (CAT)-like activities. Moreover, FTS nanozymes significantly scavenged intracellular ROS and suppressed inflammation in RAW264.7 cells. Incorporating FTS into an inulin hydrogel notably enhanced colon-targeting efficiency, bio-adhesion, and retention time in vivo. Oral administration of FTS/Gel effectively alleviated colitis, as evidenced by increased colon length, reduced splenomegaly, restored intestinal epithelial barrier integrity, and enhanced mucin secretion. Furthermore, FTS/Gel treatment rebalanced gut microbiota composition by promoting beneficial bacteria and suppressing pernicious bacteria. Collectively, this study presents a promising therapeutic strategy combining antioxidant nanozymes and prebiotic-based hydrogel delivery systems for effectively managing and treating IBD.
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Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 2
·227-236
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IF 7.5
Rakotomalala Manda Heriniaina,Xia Chen,Yulian Wu,Wenfeng Liao,He Fei,Peipei Wang,Kan Ding
Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), ranks among the most prevalent malignancies and is a leading cause of cancer-related mortality worldwide. Therefore, there is an urgent need to identify novel anti-pancreatic cancer agents. This study reports a newly identified homogeneous polysaccharide, designated ESPPW, isolated from Arthrospira platensis ( A. platensis ). The molecular weight of ESPPW is estimated at 356 kDa, and it consists predominantly of glucose and rhamnose, with minor amounts of mannose, glucuronic acid, galacturonic acid, galactose, xylose, arabinose, and fucose. ESPPW inhibits the proliferation and migration of PDAC cells both in vitro and in vivo . Mechanistic investigations reveal that ESPPW induces apoptosis through activation of caspase-3 and is associated with upregulation of the tumor-suppressor protein p53. Notably, treatment with 2.8 nmol·L −1 of ESPPW leads to significant time-dependent downregulation of galectin-3 (Gal-3) and glypican-6 (GPC-6). These findings are corroborated by immunohistochemical analysis of tumor xenograft tissues. Furthermore, overexpression of Gal-3 and GPC-6 reverses the pro-apoptotic effect of ESPPW, as indicated by restored cycle regulatory proteins (CDK2) expression. In conclusion, these data demonstrate that ESPPW suppresses PDAC cell growth by promoting apoptosis and disrupting the functional activity of Gal-3 and GPC-6.
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DYES AND PIGMENTS
·
2026
·
IF 3.9
Xuemei Sun,Jiahao Li,Suyu Jiang,Lin Zang,Rong-Mei Kong,Yan Zhao,Weiheng Kong
The escalating incidence of antibacterial resistance presents a formidable challenge in managing bacterial infections. Traditional Zn-based antibacterial agents face limitations due to their reliance on ultraviolet activation and potential neurotoxicity. The combination of nanotechnology and traditional Chinese medicine (TCM) not only reduces the side effects of Zn 2+ but also enhances therapeutic efficacy. In this study, we synthesized Zn-baicalein nanoparticles (Zn-BE NPs) that self-assemble through chemical coordination, offering broad-spectrum antibacterial capabilities. The Zn component exhibited inherent antibacterial properties by disrupting the synthesis of bacterial metabolic enzymes and destroying genetic factors. Baicalein (BE), derived from Scutellaria , enhanced the NPs’ antibacterial efficacy by disrupting bacterial membranes and facilitating Zn 2+ influx, leading to cell wall rupture and metabolic disruption. In addition, Zn-BE NPs exhibited excellent photothermal conversion efficiency, enabling effective bactericidal action under near-infrared irradiation. This triple synergistic mechanism not only overcame the limitations of conventional Zn-based therapies but also sustained long-term antibacterial activity by preventing rapid bacterial metabolism. Our findings demonstrated that Zn-BE NPs could achieve complete bacterial eradication, showcasing expected potential in addressing antibacterial resistance. This research laid a foundation for the development of safer and more effective antibacterial agents, with implications for future applications in combating resistant infections.
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Food Bioscience
·
2026
·
IF 6.2
Yini Lin,Xiaohan Ge,Meiru Mao,Jiawen Liu,Zixin Jin,Yi Wang
Coix seed is a medicinal-edible plant rich in bioactive polysaccharides. While coix seed polysaccharide (CSP) exhibits broad pharmacological activities, its neuroprotective potential against neurodegenerative diseases remains underexplored. This study identified CSP as a heteropolysaccharide with two distinct molecular weight peaks (552 Da and 35,011 Da), primarily composed of glucose. It has a triple-helical structure and exhibits strong, dose-dependent antioxidant properties. In vitro antioxidant assays demonstrated strong radical scavenging capacity, with IC 50 values of 2.56 mg/mL for ABTS radical and 2.75 mg/mL for •OH. Crucially, CSP pretreatment significantly protected PC12 cells against H 2 O 2 -induced oxidative damage, evidenced by a 41.56% increase in cell viability at 1.6 mg/mL ( P < 0.05). Additionally, CSP increased the activity of superoxide dismutase (SOD) and catalase (CAT) in a dose-dependent manner, raised glutathione (GSH) levels, and reduced the release of lactate dehydrogenase (LDH) and the content of malondialdehyde (MDA) in PC12 cells exposed to H 2 O 2 . Moreover, CSP significantly reduced reactive oxygen species (ROS) accumulation and attenuated apoptosis. Taken together, these findings elucidate CSP's neuroprotective mechanism via oxidative stress mitigation, supporting its potential development as a therapeutic agent or functional food component for neurodegenerative disorders.
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