Frontiers in Pharmacology
·
2023
·
IF 5.6
Huang Yaxian,Wu Jinyan,Zhan Chi,Liu Rong,Zhou Zhaocai,Huang Xin,Tian Yaguang,Lin Zhengmei,Song Zhi
The enhanced osteoclastogenesis contributes to alveolar bone resorption in periodontitis, which increases the risk of tooth loss. To reduce bone destruction, the inhibition of osteoclast development is proposed as a feasible treatment. CD40L-CD40-TRAF6 signal transduction plays a crucial role in inflammation, but how it regulates osteoclast activity in periodontitis has not been elucidated. In this study, we showed the potential role of CD40L-CD40-TRAF6 signaling in periodontitis. CD40L obviously promoted osteoclast formation and bone resorption capacity in vitro. Mechanistically, we found that osteoclastogenesis was enhanced by the overexpression of NFATc1 and NF-κB activation. Importantly, osteoclast activity was effectively suppressed by TRAF-STOP, a small molecular inhibitor of TRAF6. Furthermore, local injection of TRAF-STOP-loaded injectable PLGA-PEG-PLGA hydrogel could alleviate ligation-induced periodontitis in vivo. Taken together, TRAF-STOP shows promising clinical efficacy in periodontitis through alleviating osteoclastogenesis.
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Journal of the American Chemical Society
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2023
·
IF 15
Yu Yin,Yifan Song,Yinhang Jia,Juntao Xia,Ruiliang Bai,Xueqian Kong
Sodium ions are essential for the functions of biological cells, and they are maintained at the balance between intra- and extracellular environments. The quantitative assessment of intra- and extracellular sodium as well as its dynamics can provide crucial physiological information on a living system. 23Na nuclear magnetic resonance (NMR) is a powerful and noninvasive technique to probe the local environment and dynamics of sodium ions. However, due to the complex relaxation behavior of the quadrupolar nucleus in the intermediate-motion regime and because of the heterogeneous compartments and diverse molecular interactions in the cellular environment, the understanding of the 23Na NMR signal in biological systems is still at the early stage. In this work, we characterize the relaxation and diffusion of sodium ions in the solutions of proteins and polysaccharides, as well as in the in vitro samples of living cells. The multi-exponential behavior of 23Na transverse relaxation has been analyzed according to the relaxation theory to derive the crucial information related to the ionic dynamics and molecular binding in the solutions. The bi-compartment model of transverse relaxation and diffusion measurements can corroborate each other to quantify the fractions of intra- and extracellular sodium. We show that 23Na relaxation and diffusion can be used to monitor the viability of human cells, which offers versatile NMR metrics for in vivo studies.
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Nano Energy
·
2023
·
IF 17.6
Lei Shi,Ze Li,Wenyue Zhao,Zhao Wang,Yazhou Peng,Chang Gao,Wenjing Hua,Jie Wang,Xiaoxia Yang,Weidong Fei,Yu Zhao
Photovoltaic effects of single-layer films, with simple structure and low cost, are generally found in ferroelectric films , but their applications in solar cell are restricted by the large band gap of ferroelectrics . Here, we demonstrate a large photovoltaic effect can be obtained in paraelectric single-layer BiVO 4 (BVO) film based on the gradient distribution of charges. The circuit current density ( J SC ) and open circuit voltage ( V OC ) of the BVO film with best performance are 1.63 mA/cm 2 and 0.38 V, respectively. The J SC of BVO film kept 86% of the maximum value after continuous operation for 16 h. The high thermal stability of BVO is proved by long time operation and stable photovoltaic performance at high temperature. This work not only proposes a novel built-in electric field mechanism, but also indicates that the single-layer paraelectrics can be used as the next generation photovoltaic materials.
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Materials Advances
·
2023
·Vol. 4
·期 23
·6092-6117
·
IF 5
Shadi Asgari,Ghodsi Mohammadi Ziarani,Alireza Badiei,Siavash Iravani
The emergence of piezocatalysts has led to advancements in catalyst design through the development of new technologies. Electron/hole piezocatalysis, a novel form of catalysis, utilizes piezoelectric materials that are stimulated by mechanical energy. This stimulation generates electrons and holes, which prove highly effective in promoting inefficient reactions, designing new reactions, and facilitating challenging chemical reactions and transformations. This review provides a concise historical account of electron/hole catalysis and the concept of piezoelectricity. Additionally, it explores various types of piezocatalysts, including piezoceramics (both lead-free and lead-based), piezopolymers, and piezocomposites. Notably, lead-free piezoceramics such as barium titanate and zinc oxide, as well as piezopolymers like polyvinylidene fluoride in β-phase and polyacrylonitrile in planar zigzag conformation, have gained significant recognition. The piezoelectric coefficient of polymers can be enhanced by adjusting the processing parameters and employing techniques such as blending, filler addition, stretching, and composite formation with piezo/non-piezo additives. Furthermore, piezoelectricity has been observed in unique materials such as ionic liquids, metal–organic frameworks, graphitic carbon nitride, black phosphorus, and MXenes. This review also presents recent research findings on the utilization of piezoelectric materials in various applications, including water splitting, water remediation, organic synthesis, and polymerization/crosslinking.
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JOURNAL OF PHYSICAL CHEMISTRY B
·
2023
·
IF 3.3
Jianbang Ge,Biwu Cai,Fei Zhu,Yang Gao,Xinrui Wang,Qianjin Chen,Mingyong Wang,Shuqiang Jiao
Molten salt electrochemistry has been widely used in many fields, especially for metal extraction/refinement. The understanding of mass transfer in molten salts under harsh operation conditions is of great importance to reveal reaction mechanisms and advance fine technologies. It has been generally assumed that natural convection is negligible in stagnant molten salt electrochemistry. Herein, we report an abnormal natural convection in molten LiCl–KCl, with the arising time from 2.37 s at 873 K to 10.13 s at 673 K. Using the concentration correction factor, the derived thickness of the natural convection–diffusion layer (δconv.) was found to be ranging from 128 to 163 μm, much thinner than those in aqueous solutions (∼200 μm). The simulations showed that the notable natural convection resulted from convection–diffusion layer (CDL) convection dominated over the density-driven convection even at high redox concentrations, implying the severe vibration of molten salt systems. To suppress the intense natural convection, we predicted that the use of microelectrodes (with radii less than 23.2 μm for δconv. = 150 μm) would be a promising tool, regardless of their inferior stabilities in high-temperature molten salts at this stage. These innovative findings offer insights into the impact of natural convection on mass transfer in molten salts that have not been previously revealed.
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Science China-Technological Sciences
·
2020
·Vol. 63
·期 6
·992-1004
·
IF 2.302
Shi Shun,Yu ShuangJiang,Li Gao,He ChaoLiang,Chen XueSi
A lack of biological activity hinders the application of synthetic hydrogels in tissue engineering and regenerative medicine. However, the use of glycopolypeptides in hydrogel synthesis may provide the materials with the desired biological activities. Herein, we prepared three in situ -forming hydrogels from various phenol-functionalized glycopolypeptides. The gelation time, mechanical properties, degradation properties, and biocompatibility of the hydrogels were assessed. Gelation time ranged from 11 to 380 s, depending on the concentration of horseradish peroxidase. The galactose-modified polypeptide hydrogel showed the highest storage modulus with an obvious stress relaxation phenomenon. The prepared hydrogels exhibited good degradation properties and compatibility to cells and tissues. Furthermore, the rate of immune cell accumulation around the mannose-modified polypeptide hydrogel was the fastest among the hydrogels.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Qing Guo,Ying Yang,Lin Zhao,Jian Chen,Guangxin Duan,Zaixing Yang,Ruhong Zhou
The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W 1118 flies as a model organism to study GO toxicity at relatively low concentrations. We found that GO exposure led to remarkable weight loss, delayed development, retarded motion, and shortened lifespan of these flies. On the other hand, the GO influence on their sex ratio and the total number of pupae and adults were insignificant. The toxicological effect of GO was shown to be related to its serious compromise of the nutrient absorption in flies due to the severe damages in midguts. These damages were then attributed to the excessive accumulation of reactive oxygen species (ROS), which triggers the oxidative stress. These findings reveal the underlying mechanisms of GO biotoxicities in fruit flies, which might provide a useful reference to assess the risks of these newly invented nanomaterials likely never encountered by various species before.
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MOLECULES
·
2019
·Vol. 24
·期 21
·3931
·
IF 3.06
Yuxiang Wang,Zeyu Kao,Ting Zhang,Yujun Zhang,Lili Qin,Zhihua Zhang,Bin Zhou,Guangming Wu,Jun Shen,Ai Du
The trans-resveratrol (RSV)-loaded silica aerogel (RLSA) was prepared by the sol-gel method, adding the drug during the aging process, solvent replacement and freeze drying. A series of characterizations showed that RSV stays in the silica aerogel in two ways. First, RSV precipitates due to minimal solubility in water during the solvent replacement process. After freeze drying, the solvent evaporates and the RSV recrystallizes. It can be seen from scanning electron microscope (SEM) and transmission electron microscope (TEM) images that the recrystallized RSV with micron-sized long rod-shaped is integrated with the dense silica network skeleton. Second, from small-angle X-ray scattering (SAXS) results, a portion of the RSV molecules is not crystallized and the size is extremely small. This can be attached to the primary and secondary particles of silica to enhance its network structure and inhibit shrinkage, which is why the volume and pore size of RLSA is larger. In addition, the diffusion of RSV in silica alcogel was studied by a one-dimensional model. The apparent diffusion coefficients of inward diffusion, outward diffusion and internal diffusion were calculated by fitting the time- and position-dependent concentration data. It was found that the outward diffusion coefficient (5.25 × 10−10m2/s) is larger than the inward (2.93 × 10−10m2/s), which is probably due to the interface effect. The diffusion coefficients obtained for different concentrations in the same process (inward diffusion) are found to be different. This suggests that the apparent diffusion coefficient obtained is affected by molecular adsorption.Keywords:RLSA;one-dimension diffusion;alcogel;adsorption/desorption;Silica Aerogel
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ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 11
·1807343
·
IF 15.621
Sen Li,Ning Pan,Zijie Zhu,Ruya Li,Baoqing Li,Jiaru Chu,Guanglin Li,Yu Chang,Tingrui Pan
Paper has been utilized as an ideal platform for chemical, biological, and mechanical sensing for its fibrous structures and properties in addition to its low cost. However, current studies on pressure-sensitive papers have not fully utilized the unique advantages of papers, such as printability, cuttability, and foldability. Moreover, the existing resistive, capacitive, and triboelectric sensing modalities have long-standing challenges in sensitivity, noise-proofing, response time, linearity, etc. Here, a novel flexible iontronic sensing mechanism, referred to as iontronic sensing paper (ISP), is introduced to the classic paper substrates by incorporating both ionic and conductive patterns into an all-in-one flexible sensing platform. The ISP can then be structured into 2D or 3D tactile-sensitive origamis only by the paper-specific manipulations of printing, cutting, folding, and gluing. Notably, the ISP device possesses a device sensitivity of 10 nF kPa −1 cm −2 , which is thousands of times higher than that of the commercial counterpart, a resolution of 6.25 Pa, a single-millisecond response time, and a high linearity ( R 2 > 0.996). Benefiting from the unique properties of the fibrous paper structures and its remarkable performances, the ISP devices hold enormous potential for the emerging human–machine interfaces, including smart packaging, health wearables, and pressure-sensitive paper matrix.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2018
·Vol. 135
·期 5
·2869-2877
·
IF 2.209
Wang Dongqing,Sui Jian,Qi Di,Deng Shuping,Wei Yongteng,Wang Xin,Lan XiaoZheng
Confinement effect of nanopores on phase transition of docosane ( n -C 22 H 46 , C 22 ) is studied using differential scanning calorimetry (DSC) and temperature-dependent powdered X-ray diffractions (XRD). The bulk C 22 has a stable rotator phase R I and R II . In the pores of CPGs, SBA-15, C-SBA-15, KIT-6, and MCM-41, the transition temperatures of solid–solid ( T s ) and solid–liquid ( T m ) transitions of C 22 are depressed. The depression of the transition points (Δ T s , Δ T m ) has a linear relation with the reverse diameter. However, the Δ T m values seemingly show weak relation with the polarity of the pore walls but to vary with the pore dimensionality. According to XRD analysis, C 22 confined in CPG (11.5 nm) and SBA-15 (14.4 nm) present low temperature phase and rotator phase as the bulk, but the lamellar packing of molecules is heavily disturbed in the small pores.
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JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
·
2015
·Vol. 38
·期 5
·508-512
·
IF 1.189
M. Zhao,K.-Z. Xie,H.-S. Guo,A.-H. Li,X. Xie,G.-X. Zhang,G.-J. Dai,J.-Y. Wang
A residue depletion study of ampicillin (AMP) was performed after oral dosing (60.0 mg/kg and 120.0 mg/kg body weight once a day for 5 days) to laying hens, through the use of reversed-phase high-performance liquid chromatography with fluorescence detection (RP-HPLC-FLD) to achieve detection of ampicillin residue in eggs. Limit of detection was 0.5 ng/g, and limit of quantitation was 1.2 ng/g for ampicillin. Extraction recoveries of ampicillin from samples fortified at 5.0–125.0 ng/g levels ranged from 77.5% to 84.6% in albumen, 77.9% to 87.5% in yolk, and 77.9% to 88.6% in whole egg, with coefficients of variation ≤9.3%. The maximum concentrations of ampicillin in albumen, yolk, and whole egg were detected at 1, 2, and 1 day after the last administration of ampicillin, respectively. Ampicillin was not detectable in albumen at day 9 of withdrawal time, at day 10 and 11 in yolk, and day 9 and 11 in whole egg at each of those 2 dose levels. The theoretical withdrawal time of AMP in whole egg was 6.730 and 7.296 days for 60 and 120 mg/kg oral dosage, respectively. This method also proved to be suitable as a rapid and reliable method for the determination of ampicillin in other poultry eggs.
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MACROMOLECULES
·
2016
·
IF 5.554
Kaiyi Zhou,Hui Cao,Pan Gao,Zhigang Cui,Yi Ding,Yuanli Cai
Autocatalytic self-sorting in the biomimetic poly(cystamine methacrylamide hydrochloride) (PCysMA) is presented, whose units comprise lysine-mimetic alkylammonium ions and cystine-mimetic alkyl disulfide spacers. The block copolymer with poly(2-hydroxypropylmethacrylamide) was synthesized directly by RAFT in acidic water under visible light irradiation at 25 °C. Disulfide exchange can be initiated by the terminal thiolates as generated by alkalization-induced aminolysis. 65–67% CysMA units sort into hydrophobic polymer disulfides and water-soluble cystamine at pH 10.5. Moreover, intermediate reactions occur in the presence of copper ions, i.e., Cu(II)–NH2 coordination, aminolysis, NH2-to-SH substitution, and cupric-to-cuprous reduction in metal centers, thus autocatalytic self-sorting with essentially 100% conversion at pH 8.8. UV–vis spectroscopy, 1H NMR, atomic absorption spectroscopy, and elemental analysis confirmed this ideal self-sorting. Dynamic light scattering and atomic force microscopy identified supramolecular-to-supracolloidal self-assembly with concomitant release of cystamine molecules and intermediate cuprous complexes. Such a self-sorting underlines an amazing prospect for the use of a single polymer to achieve artificial reaction complexity, hierarchy, and metabolic process, with minimal synthetic efforts.
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